Details of the Target

General Information of Target

Target ID LDTP10111
Target Name Proline-rich AKT1 substrate 1 (AKT1S1)
Gene Name AKT1S1
Gene ID 84335
Synonyms
PRAS40; Proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVIC
GVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQ
KEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVN
LKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGG
SGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function
Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site. In response to insulin and nutrients, AKT1S1 dissociates from mTORC1. Its activity is dependent on its phosphorylation state and binding to 14-3-3. May also play a role in nerve growth factor-mediated neuroprotection.
Uniprot ID
Q96B36
Ensemble ID
ENST00000344175.10
HGNC ID
HGNC:28426
ChEMBL ID
CHEMBL1255161

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.26  LDD0402  [1]
BTD
 Probe Info  		C44(0.59)  LDD2089  [2]
DA-P3
 Probe Info  		8.01  LDD0180  [3]
DBIA
 Probe Info  		C61(6.20)  LDD0209  [4]
Acrolein
 Probe Info  		N.A.  LDD0223  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
1d-yne
 Probe Info  		N.A.  LDD0358  [7]
IA-alkyne
 Probe Info  		C61(0.00); C44(0.00)  LDD0162  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C44(1.23)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C44(1.44)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C44(1.08)  LDD2103  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C44(0.47)  LDD2132  [2]
 LDCM0214  AC1 HEK-293T C61(1.00); C44(0.94)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C61(0.84); C44(1.05)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C61(1.00); C44(1.29)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C61(1.06); C44(1.10)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C61(1.07); C44(1.21)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C61(1.12); C44(0.84)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C61(1.42); C44(1.04)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C61(0.97); C44(1.11)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C61(1.48); C44(1.06)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C61(0.93); C44(0.88)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C61(1.35); C44(1.08)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C61(1.28); C44(0.94)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C61(1.30); C44(1.20)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C61(1.28); C44(1.05)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C61(1.30); C44(1.03)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C61(1.07); C44(0.99)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C61(0.83); C44(0.92)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C61(0.86); C44(0.98)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C61(0.98); C44(0.91)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C61(1.03); C44(0.98)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C61(0.77); C44(1.05)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C61(0.81); C44(1.12)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C61(0.93); C44(0.82)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C61(1.19); C44(1.09)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C61(1.70); C44(1.13)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C61(1.21); C44(0.92)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C61(1.39); C44(1.22)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C61(1.44); C44(1.30)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C61(1.06); C44(1.27)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C61(1.19); C44(1.23)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C61(1.19); C44(0.90)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C61(0.74); C44(1.01)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C61(1.31); C44(1.11)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C61(1.41); C44(1.01)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C61(0.83); C44(1.00)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C61(1.38); C44(1.27)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C61(1.23); C44(1.01)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C61(1.09); C44(1.04)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C61(1.03); C44(1.34)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C61(1.12); C44(1.00)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C61(1.26); C44(1.20)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C61(1.20); C44(1.04)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C61(1.05); C44(1.05)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C61(0.91); C44(1.01)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C61(1.04); C44(0.91)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C61(1.30); C44(1.17)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C61(1.28); C44(1.01)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C61(1.34); C44(1.41)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C61(1.31); C44(1.12)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C61(1.43); C44(1.22)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C61(1.07); C44(1.21)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C61(0.89); C44(0.92)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C61(1.04); C44(0.92)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C61(0.80); C44(1.27)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C61(1.06); C44(1.16)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C61(1.00); C44(1.02)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C61(1.22); C44(1.22)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C61(1.07); C44(0.96)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C61(0.92); C44(1.16)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C61(0.81); C44(0.92)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C61(0.80); C44(0.94)  LDD1569  [13]
 LDCM0545  Acetamide MDA-MB-231 C44(0.61)  LDD2138  [2]
 LDCM0248  AKOS034007472 HEK-293T C61(1.14); C44(1.22)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C61(1.11); C44(1.00)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C61(1.03); C44(1.13)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 12.57  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C61(20.00); C61(0.87)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C61(1.08); C44(1.15)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C61(0.67); C44(0.62)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C61(1.02); C44(1.06)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C61(1.08); C44(0.90)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C61(0.71); C44(1.08)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C61(1.21)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C61(0.90); C44(1.07)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C61(1.34); C44(1.07)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C61(1.07); C44(0.93)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C61(1.16)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C61(1.05); C44(1.07)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C61(0.88); C44(0.88)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C61(0.92); C44(0.64)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C61(0.76); C44(0.97)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C61(0.86)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C61(0.79); C44(1.04)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C61(1.34); C44(1.79)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C61(0.79); C44(0.95)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C61(0.97)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C61(1.32); C44(1.06)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C61(1.26); C44(1.03)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C61(0.97); C44(1.13)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C61(0.99)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C61(1.20); C44(0.90)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C61(1.13); C44(1.08)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C61(1.35); C44(1.12)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C61(1.09); C44(1.05)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C61(1.03)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C61(0.98); C44(1.06)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C61(0.95); C44(1.03)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C61(0.99); C44(1.02)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C61(0.98)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C61(1.03); C44(1.14)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C61(1.37); C44(1.71)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C61(1.01); C44(1.35)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C61(1.17)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C61(1.16); C44(1.09)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C61(1.21); C44(1.02)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C61(1.11); C44(0.85)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C61(1.23); C44(1.05)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C61(1.01); C44(1.17)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C61(1.28); C44(0.89)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C61(1.39); C44(1.12)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C61(1.09); C44(1.00)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C61(1.11); C44(0.83)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C61(1.21); C44(1.01)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C61(1.32); C44(1.06)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C61(1.40); C44(1.22)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C61(1.15)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C61(1.14); C44(0.96)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C61(1.28); C44(0.98)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C61(0.78)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C61(1.02); C44(0.87)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C61(1.07); C44(0.84)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C61(1.33); C44(0.72)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C61(1.14); C44(0.89)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C61(1.08); C44(0.83)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C61(1.10); C44(0.63)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C61(1.26); C44(1.25)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C61(1.45); C44(0.97)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C61(1.17)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C61(0.87); C44(0.94)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C61(1.32); C44(1.01)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C61(1.18); C44(0.99)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C61(0.92); C44(0.84)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C61(1.11); C44(0.79)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C61(1.08); C44(0.75)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C61(1.23); C44(0.92)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C61(1.05); C44(0.86)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C61(1.12); C44(0.67)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C61(1.49); C44(1.13)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C61(1.12); C44(1.12)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C61(0.95); C44(0.99)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C61(1.14); C44(1.02)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C61(0.97); C44(1.09)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C61(1.17); C44(0.91)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C61(0.95); C44(0.85)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C61(1.21); C44(0.92)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C61(1.25); C44(0.71)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C61(1.22); C44(0.91)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C61(1.20); C44(0.89)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C61(1.17); C44(0.94)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C61(0.79); C44(0.69)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C61(1.60); C44(1.08)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C61(1.38); C44(1.37)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C61(1.09); C44(1.17)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C61(1.26)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C61(1.14); C44(1.24)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C61(1.53); C44(1.09)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C61(1.04); C44(0.93)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C61(1.05); C44(0.93)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C61(1.14); C44(0.88)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C61(1.32); C44(1.13)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C61(0.95); C44(0.96)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C61(1.26); C44(0.90)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C61(1.01); C44(0.75)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C61(1.72); C44(1.37)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C61(0.97); C44(1.19)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C61(0.87); C44(1.21)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C61(1.05); C44(0.98)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C61(0.91); C44(1.08)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C61(0.81); C44(0.81)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C61(0.90); C44(0.82)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C61(0.85); C44(0.75)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C61(0.84); C44(0.83)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C61(1.41); C44(1.13)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C61(0.81); C44(0.84)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C61(0.91); C44(0.62)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C61(0.92); C44(0.94)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C61(1.33); C44(1.14)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C61(1.08); C44(1.94)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C61(0.99)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C61(1.04); C44(1.08)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C61(1.25); C44(1.05)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C61(0.92); C44(0.91)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C61(0.86); C44(1.01)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C61(1.03); C44(0.82)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C61(1.19); C44(0.93)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C61(1.20); C44(1.04)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C61(1.21); C44(1.05)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C61(0.93); C44(0.89)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C61(0.96); C44(1.18)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C61(0.98); C44(1.02)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C61(0.76); C44(1.02)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C61(0.86)  LDD1697  [13]
 LDCM0028  Dobutamine HEK-293T 8.01  LDD0180  [3]
 LDCM0495  E2913 HEK-293T C61(1.26)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C61(0.92)  LDD1702  [2]
 LDCM0625  F8 Ramos C44(0.46)  LDD2187  [14]
 LDCM0573  Fragment11 Ramos C44(2.71)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C44(0.75)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C44(1.91)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C44(0.86)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C44(0.63)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C44(0.61)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C44(0.62)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C44(1.01)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C44(1.84)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C44(0.80)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C44(1.16)  LDD2200  [14]
 LDCM0468  Fragment33 HEK-293T C61(0.92)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C44(1.85)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C44(0.74)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C61(1.20); C44(1.23)  LDD1631  [13]
 LDCM0610  Fragment52 Ramos C44(0.78)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C44(0.54)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C44(0.62)  LDD2186  [14]
 LDCM0022  KB02 HEK-293T C61(1.04); C44(0.88)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C61(6.20)  LDD0209  [4]
 LDCM0024  KB05 G361 C81(1.98)  LDD3311  [15]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C44(0.47)  LDD2102  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C44(0.78)  LDD2121  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C44(0.59)  LDD2089  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C44(1.14)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C44(0.88)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C44(1.50)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C44(0.51)  LDD2094  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C61(1.19)  LDD2097  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C44(0.98)  LDD2098  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C44(1.01)  LDD2105  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C44(1.08)  LDD2111  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C44(0.51)  LDD2114  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C44(1.70)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C61(0.73)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C44(1.00)  LDD2125  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C44(1.03)  LDD2129  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C44(1.44)  LDD2140  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C44(0.49)  LDD2150  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C44(1.78)  LDD2153  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C44(0.57)  LDD2207  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein eta (YWHAH) 14-3-3 family Q04917

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.