Details of the Target

General Information of Target

Target ID LDTP12216
Target Name Chromobox protein homolog 8 (CBX8)
Gene Name CBX8
Gene ID 57332
Synonyms
PC3; RC1; Chromobox protein homolog 8; Polycomb 3 homolog; Pc3; hPc3; Rectachrome 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALVRPARFVVRPLLQVVQAWDLDARRWVRALRRSPVKVVFPSGEVVEQKRAPGKQPRK
APSEASAQEQREKQPLEESASRAPSTWEESGLRYDKAYPGDRRLSSVMTIVKSRPFREKQ
GKILLEGRRLISDALKAGAVPKMFFFSRLEYLKELPVDKLKGVSLIKVKFEDIKDWSDLV
TPQGIMGIFAKPDHVKMTYPKTQLQHSLPLLLICDNLRDPGNLGTILRSAAGAGCSKVLL
TKGCVDAWEPKVLRAGMGAHFRMPIINNLEWETVPNYLPPDTRVYVADNCGLYAQAEMSN
KASDHGWVCDQRVMKFHKYEEEEDVETGASQDWLPHVEVQSYDSDWTEAPAAVVIGGETY
GVSLESLQLAESTGGKRLLIPVVPGVDSLNSAMAASILLFEGKRQLRGRAEDLSRDRSYH
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Uniprot ID
Q9HC52
Ensemble ID
ENST00000269385.9
HGNC ID
HGNC:15962
ChEMBL ID
CHEMBL3232684

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.94  LDD0403  [1]
BTD
 Probe Info  		C261(0.89)  LDD2100  [2]
AHL-Pu-1
 Probe Info  		C142(2.06)  LDD0168  [3]
DBIA
 Probe Info  		C142(0.97); C261(0.97)  LDD0078  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		C142(0.00); C261(0.00)  LDD2226  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
TFBX
 Probe Info  		C261(0.00); C142(0.00)  LDD0027  [6]
DA-P3
 Probe Info  		N.A.  LDD0178  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		N.A.  LDD0005  [10]
VSF
 Probe Info  		C261(0.00); C142(0.00)  LDD0007  [10]
Phosphinate-6
 Probe Info  		C261(0.00); C142(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		C142(0.00); C261(0.00)  LDD0217  [12]
Crotonaldehyde
 Probe Info  		C261(0.00); C142(0.00)  LDD0219  [12]
Methacrolein
 Probe Info  		C261(0.00); C142(0.00)  LDD0218  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C261(0.75)  LDD2117  [2]
 LDCM0025  4SU-RNA HEK-293T C142(2.06)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C261(2.72)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C142(0.97)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C142(1.32)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C142(1.00)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C142(0.99)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C142(0.82)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C142(1.21)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C142(0.90)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C142(1.21)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C142(1.34)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C142(1.29)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C142(0.97)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C142(0.79)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C142(1.17)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C142(0.86)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C142(0.96)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C142(0.97)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C142(1.07)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C142(1.20)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C142(1.29)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C142(1.32)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C142(1.14)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C142(1.11)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C142(1.09)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C142(1.06)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C142(0.87)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C142(1.12)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C142(1.16)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C142(1.04)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C142(1.07)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C142(1.18)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C142(1.44)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C142(1.49)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C142(1.53)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C142(1.56)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C142(1.72)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C142(1.44)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C142(1.20)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C142(1.36)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C142(1.56)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C142(1.55)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C142(1.06)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C142(0.90)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C142(1.28)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C142(1.35)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C142(1.06)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C142(1.56)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C142(1.37)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C142(1.11)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C142(1.22)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C142(1.54)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C142(1.17)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C142(1.35)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C142(1.46)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C142(1.80)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C142(1.53)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C142(1.19)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C142(1.08)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C142(1.13)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C142(1.25)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C142(2.30)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C142(1.50)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C142(1.29)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C142(1.16)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C142(1.29)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C142(1.09)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C142(0.92)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C142(1.16)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C142(0.95)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C142(0.99)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C142(1.12)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C142(0.99)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C142(1.00)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C142(0.99)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C142(0.97)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C142(1.20)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C142(1.40)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C142(1.28)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C142(1.43)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C142(0.91)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C142(1.28)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C142(1.43)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C142(1.63)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C142(1.47)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C142(1.53)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C142(0.82)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C142(0.94)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C142(0.91)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C142(1.06)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C142(0.92)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C142(0.97)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C142(1.04)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C142(1.07)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C142(1.06)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C142(1.06)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C142(1.12)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C142(1.23)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C142(1.15)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C142(1.01)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C142(1.17)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C142(1.34)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C142(0.88)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C142(1.50)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C142(0.94)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C142(1.03)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C142(1.31)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C142(1.11)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C142(1.39)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C142(1.81)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C142(1.31)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C142(1.52)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C142(1.27)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C142(1.38)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C142(1.51)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C142(1.26)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C142(1.38)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C142(1.33)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C142(1.31)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C142(0.83)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C142(0.73)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C142(0.78)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C142(1.48)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C142(1.60)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C142(0.97)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C142(1.81)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C142(1.25)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C142(1.72)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C142(2.15)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C142(1.59)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C142(2.20)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C142(1.66)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C142(1.98)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C142(1.58)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C142(1.64)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C142(0.91)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C142(1.38)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C142(1.36)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C142(1.82)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C142(1.48)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C142(1.31)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C142(1.09)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C142(1.26)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C142(1.12)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C142(1.22)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C142(1.55)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C142(1.05)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C142(1.76)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C142(1.69)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C142(1.13)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C142(1.15)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C142(1.47)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C142(1.68)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C142(1.43)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C142(1.52)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C142(0.86)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C142(1.14)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C142(1.26)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C142(1.99)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 11.94  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C142(0.97); C261(0.97)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa C261(0.00); C142(0.00)  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C142(1.02)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C142(1.69)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C142(1.04)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C142(1.21)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C142(1.05)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C142(1.06)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C142(1.13)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C142(1.01)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C142(1.14)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C142(1.15)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C142(1.04)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C142(1.07)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C142(1.96)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C142(1.06)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C142(0.98)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C142(1.09)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C142(1.40)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C142(1.36)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C142(1.44)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C142(1.29)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C142(1.36)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C142(1.09)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C142(1.12)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C142(2.18)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C142(1.10)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C142(0.87)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C142(1.02)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C142(1.10)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C142(1.29)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C142(1.01)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C142(1.03)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C142(1.00)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C142(1.35)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C142(1.67)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C142(1.44)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C142(1.46)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C142(1.04)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C142(1.05)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C142(1.56)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C142(1.22)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C142(1.06)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C142(1.51)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C142(1.73)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C142(2.37)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C142(1.38)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C142(1.74)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C142(1.84)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C142(1.33)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C142(1.56)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C142(1.53)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C142(1.67)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C142(1.11)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C142(1.33)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C142(0.91)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C142(1.01)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C142(1.12)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C142(0.92)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C142(1.03)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C142(1.04)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C142(1.11)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C142(1.03)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C142(1.06)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C142(0.98)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C142(0.96)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C142(0.89)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C142(1.04)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C142(0.98)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C142(0.98)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C142(1.06)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C142(1.04)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C142(0.99)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C142(1.08)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C142(1.20)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C142(1.13)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C142(1.18)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C142(1.18)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C142(1.03)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C142(1.08)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C142(1.03)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C142(0.97)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C142(1.24)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C142(1.03)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C142(1.08)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C142(1.37)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C142(1.03)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C142(1.17)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C142(1.13)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C142(1.38)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C142(1.48)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C142(1.05)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C142(1.45)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C142(1.22)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C142(1.37)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C142(1.33)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C142(1.57)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C142(1.32)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C142(1.30)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C142(1.18)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C142(1.31)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C142(1.45)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C142(1.13)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C142(0.89)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C142(1.08)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C142(1.39)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C142(1.93)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C142(1.17)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C142(1.33)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C142(1.65)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C142(1.28)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C142(1.48)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C142(0.98)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C142(0.71)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C142(1.00)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C142(1.34)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C142(1.54)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C142(1.30)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C142(0.99)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C142(1.19)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C142(1.00)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C142(0.98)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C142(1.37)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C142(1.12)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C142(1.01)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C142(0.90)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C142(1.01)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C142(1.02)  LDD0811  [4]
 LDCM0028  Dobutamine HEK-293T 6.09  LDD0180  [8]
 LDCM0495  E2913 HEK-293T C142(1.19); C261(1.01)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C142(1.25)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C142(1.16)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C142(1.08)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C261(1.78); C142(1.53)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C261(1.18); C142(1.13)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C261(1.69); C142(1.40)  LDD0082  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C261(0.89)  LDD2100  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C261(0.85)  LDD2141  [2]
 LDCM0131  RA190 MM1.R C261(1.37)  LDD0304  [14]
 LDCM0021  THZ1 HCT 116 C261(1.04); C142(1.73)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Helicase MOV-10 (MOV10) DNA2/NAM7 helicase family Q9HCE1
Nucleotidyltransferase MB21D2 (MB21D2) Mab-21 family Q8IYB1
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Ubiquitin carboxyl-terminal hydrolase 11 (USP11) Peptidase C19 family P51784
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Phosphatase and actin regulator 1 (PHACTR1) Phosphatase and actin regulator family Q9C0D0
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 SUMO-protein ligase CBX4 (CBX4) . O00257
E3 ubiquitin-protein ligase RING1 (RING1) . Q06587
E3 ubiquitin-protein ligase RING2 (RNF2) . Q99496
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Polycomb complex protein BMI-1 (BMI1) . P35226
Polycomb group RING finger protein 1 (PCGF1) . Q9BSM1
Polycomb group RING finger protein 2 (PCGF2) . P35227
Polycomb group RING finger protein 3 (PCGF3) . Q3KNV8
Polycomb group RING finger protein 5 (PCGF5) . Q86SE9
Polycomb group RING finger protein 6 (PCGF6) . Q9BYE7
pre-mRNA splicing regulator USH1G (USH1G) . Q495M9
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
TSC22 domain family protein 4 (TSC22D4) TSC-22/Dip/Bun family Q9Y3Q8
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Transcription factor SOX-5 (SOX5) . P35711
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger and BTB domain-containing protein 9 (ZBTB9) . Q96C00
Other
Click To Hide/Show 40 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BCL-6 corepressor (BCOR) BCOR family Q6W2J9
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Histone H1.5 (H1-5) Histone H1/H5 family P16401
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Vimentin (VIM) Intermediate filament family P08670
Janus kinase and microtubule-interacting protein 1 (JAKMIP1) JAKMIP family Q96N16
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Colorectal mutant cancer protein (MCC) MCC family P23508
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1) RPGRIP1 family Q96KN7
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
SEC14 domain and spectrin repeat-containing protein 1 (SESTD1) SOLO family Q86VW0
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
Four and a half LIM domains protein 3 (FHL3) . Q13643
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Heat shock factor 2-binding protein (HSF2BP) . O75031
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
PRKCA-binding protein (PICK1) . Q9NRD5
Protein AF-9 (MLLT3) . P42568
Ras association domain-containing protein 3 (RASSF3) . Q86WH2
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
Zinc finger protein 185 (ZNF185) . O15231

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.