Details of the Target

General Information of Target

Target ID LDTP06536
Target Name Serine/threonine-protein kinase N2 (PKN2)
Gene Name PKN2
Gene ID 5586
Synonyms
PRK2; PRKCL2; Serine/threonine-protein kinase N2; EC 2.7.11.13; PKN gamma; Protein kinase C-like 2; Protein-kinase C-related kinase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKEL
KIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR
TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL
QDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM
KLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVA
ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWS
PSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK
FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN
PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV
PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG
QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC
AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL
VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY
RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW
WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL
GASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP
REPRILSEEEQEMFRDFDYIADWC
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
Subcellular location
Cytoplasm
Function
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis.; (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
TTD ID
T94197
Uniprot ID
Q16513
DrugMap ID
TTTHO0M
Ensemble ID
ENST00000370513.9
HGNC ID
HGNC:9406
ChEMBL ID
CHEMBL3032

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C4II SNV: p.L489R DBIA    Probe Info 
CCK81 Deletion: p.L720WfsTer2 DBIA    Probe Info 
DU145 SNV: p.E941D DBIA    Probe Info 
HCT116 SNV: p.R459Q DBIA    Probe Info 
HEC1 SNV: p.G154C DBIA    Probe Info 
HSC3 SNV: p.M40R DBIA    Probe Info 
LS180 SNV: p.E102G DBIA    Probe Info 
MKN1 SNV: p.R878G .
NCIH2286 SNV: p.D426Y .
SH4 SNV: p.E216Q .
SNGM SNV: p.T73I DBIA    Probe Info 
SUDHL6 SNV: p.M311V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K171(6.71); K272(8.33); K288(4.19)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K690(2.89)  LDD3494  [3]
BTD
 Probe Info  		C804(2.12)  LDD2099  [4]
DA-P3
 Probe Info  		4.19  LDD0180  [5]
DBIA
 Probe Info  		C338(0.96)  LDD0078  [6]
ATP probe
 Probe Info  		K171(0.00); K77(0.00)  LDD0199  [7]
IA-alkyne
 Probe Info  		C118(0.00); C131(0.00)  LDD0032  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
TFBX
 Probe Info  		C659(0.00); C660(0.00)  LDD0027  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
IPM
 Probe Info  		C118(0.00); C131(0.00); C338(0.00); C804(0.00)  LDD0147  [10]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
Acrolein
 Probe Info  		C338(0.00); C804(0.00); C394(0.00); C444(0.00)  LDD0217  [16]
Methacrolein
 Probe Info  		C394(0.00); C338(0.00); C804(0.00); C704(0.00)  LDD0218  [16]
AOyne
 Probe Info  		14.30  LDD0443  [17]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [19]
DA-2
 Probe Info  		N.A.  LDD0070  [20]
STS-1
 Probe Info  		N.A.  LDD0068  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C804(1.16)  LDD2117  [4]
 LDCM0214  AC1 HCT 116 C131(1.19); C338(1.02); C804(1.31); C818(0.75)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C118(1.25); C131(1.46); C338(1.02); C659(1.98)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C131(1.35); C338(0.93); C659(0.46); C660(0.46)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C131(1.28); C338(1.04); C659(0.44); C660(0.44)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C131(1.17); C338(0.99); C659(0.75); C660(0.75)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C131(1.43); C338(1.15); C659(0.39); C660(0.39)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C131(1.23); C338(1.08); C659(0.91); C660(0.91)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C131(1.26); C338(1.28); C659(0.48); C660(0.48)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C131(1.58); C338(1.11); C659(0.45); C660(0.45)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C131(1.54); C338(1.07); C659(0.47); C660(0.47)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C131(0.99); C338(0.94); C659(0.45); C660(0.45)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C131(0.83); C338(0.98); C659(0.58); C660(0.58)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C118(1.16); C131(1.18); C338(0.93); C659(0.76)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C131(1.04); C338(1.12); C659(0.45); C660(0.45)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C131(1.16); C338(1.10); C659(0.49); C660(0.49)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C131(1.34); C338(1.10); C659(0.45); C660(0.45)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C131(1.02); C659(0.93); C660(0.93); C804(1.01)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C131(1.31); C659(0.77); C660(0.77); C804(0.89)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C131(1.62); C659(0.80); C660(0.80); C804(0.81)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C131(1.52); C659(0.80); C660(0.80); C804(0.80)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C131(1.17); C659(0.84); C660(0.84); C804(0.91)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C131(1.22); C659(0.78); C660(0.78); C804(0.96)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C131(1.17); C659(0.93); C660(0.93); C804(0.89)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C118(1.00); C131(1.04); C338(0.98); C659(1.11)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C131(1.15); C659(0.81); C660(0.81); C804(0.89)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C131(1.17); C659(0.89); C660(0.89); C804(1.02)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C131(1.03); C659(0.76); C660(0.76); C804(0.92)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C131(1.08); C659(0.74); C660(0.74); C804(1.16)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C131(1.11); C659(0.83); C660(0.83); C804(1.04)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C131(1.28); C659(0.88); C660(0.88); C804(0.92)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C131(1.41); C659(0.96); C660(0.96); C804(0.87)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C131(1.40); C659(0.89); C660(0.89); C804(0.91)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C131(1.96); C338(1.13); C659(2.17); C660(2.17)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C131(1.36); C338(0.79); C659(1.69); C660(1.69)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C131(1.61); C338(0.92); C659(1.70); C660(1.70)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C131(1.55); C338(0.76); C659(1.09); C660(1.09)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C131(1.48); C338(0.88); C659(0.75); C660(0.75)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C131(1.52); C338(0.84); C659(1.09); C660(1.09)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C131(1.91); C338(1.03); C659(0.47); C660(0.47)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C131(2.09); C338(0.81); C659(0.73); C660(0.73)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C131(1.25); C338(0.99); C659(0.62); C660(0.62)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C131(1.07); C338(0.83); C659(0.78); C660(0.78)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C131(1.63); C338(0.89); C659(0.39); C660(0.39)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C131(1.59); C338(0.80); C659(0.52); C660(0.52)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C118(1.06); C131(1.06); C338(0.98); C659(1.42)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C131(2.05); C338(0.90); C659(0.38); C660(0.38)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C131(1.63); C338(1.02); C659(0.38); C660(0.38)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C131(1.33); C338(0.77); C659(0.75); C660(0.75)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C338(0.96); C804(1.01); C984(1.04); C131(1.26)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C338(0.80); C804(0.95); C659(1.07); C660(1.07)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C338(0.90); C984(1.15); C804(1.25); C659(1.34)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C338(0.89); C804(1.06); C984(1.18); C659(1.24)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C659(0.94); C660(0.94); C804(1.01); C338(1.10)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C338(0.84); C659(0.95); C660(0.95); C804(0.99)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C338(0.78); C804(0.84); C659(0.89); C660(0.89)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C818(0.92); C804(0.99); C338(1.00); C984(1.23)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C659(0.84); C660(0.84); C804(1.11); C984(1.16)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C659(0.82); C660(0.82); C804(0.93); C984(1.26)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C659(0.97); C660(0.97); C804(0.98); C338(1.11)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C338(0.76); C659(0.81); C660(0.81); C804(0.95)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C131(1.41); C338(1.07); C659(0.87); C660(0.87)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C131(1.68); C338(1.46); C659(1.31); C660(1.31)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C131(1.25); C338(1.06); C659(0.85); C660(0.85)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C131(1.20); C338(1.27); C659(0.98); C660(0.98)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C118(0.86); C338(0.97); C659(0.99); C660(0.99)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C659(0.67); C660(0.67); C118(0.72); C338(0.83)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C118(0.75); C659(0.81); C660(0.81); C338(0.84)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C818(0.85); C804(0.98); C338(1.09); C984(1.20)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C659(0.66); C660(0.66); C338(0.91); C984(1.12)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C118(0.70); C659(0.71); C660(0.71); C131(0.98)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C659(0.83); C660(0.83); C118(0.85); C338(1.01)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C659(0.73); C660(0.73); C118(0.78); C338(0.91)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C118(0.66); C659(0.87); C660(0.87); C984(0.89)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C118(0.89); C804(0.93); C659(0.94); C660(0.94)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C659(0.71); C660(0.71); C804(0.85); C118(1.12)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C659(0.65); C660(0.65); C804(0.88); C118(1.24)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C659(0.55); C660(0.55); C804(0.84); C118(1.05)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C659(0.42); C660(0.42); C804(0.79); C118(0.88)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C818(0.93); C804(1.03); C338(1.04); C984(1.24)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C659(0.36); C660(0.36); C804(0.92); C118(1.12)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C659(0.58); C660(0.58); C804(0.83); C118(1.12)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C659(0.39); C660(0.39); C804(0.77); C118(1.24)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C659(0.61); C660(0.61); C804(0.79); C118(1.19)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C659(0.64); C660(0.64); C804(0.79); C131(1.26)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C338(0.93); C131(0.94); C659(1.07); C660(1.07)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C659(0.89); C660(0.89); C338(0.93); C131(1.14)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C338(0.89); C659(0.95); C660(0.95); C804(1.02)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C659(0.83); C660(0.83); C984(0.95); C338(0.99)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C659(0.80); C660(0.80); C338(0.93); C131(1.17)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C818(1.04); C338(1.06); C804(1.11); C984(1.37)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C659(0.74); C660(0.74); C338(0.95); C804(0.99)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C659(0.56); C660(0.56); C984(0.86); C804(0.87)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C659(0.57); C660(0.57); C984(0.93); C338(0.94)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C659(0.75); C660(0.75); C804(0.78); C338(0.93)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C659(0.81); C660(0.81); C804(0.85); C338(0.91)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C338(0.90); C659(0.95); C660(0.95); C804(0.98)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C804(0.87); C338(1.02); C659(1.05); C660(1.05)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C659(0.96); C660(0.96); C984(0.99); C338(1.06)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C804(0.98); C338(1.00); C984(1.08); C131(1.29)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C804(0.84); C659(0.99); C660(0.99); C338(1.02)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C818(0.92); C804(1.15); C338(1.19); C131(1.33)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C804(0.93); C338(0.96); C659(1.09); C660(1.09)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C984(0.90); C659(0.94); C660(0.94); C804(1.00)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C659(0.68); C660(0.68); C804(0.94); C338(1.04)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C659(0.81); C660(0.81); C804(0.93); C338(0.99)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C338(0.91); C804(0.99); C659(1.26); C660(1.26)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C659(0.63); C660(0.63); C338(0.97); C804(1.13)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C804(0.90); C659(0.96); C660(0.96); C338(1.17)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C804(0.84); C338(0.93); C659(1.15); C660(1.15)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C804(0.83); C338(0.90); C659(1.33); C660(1.33)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C804(0.77); C338(0.79); C659(1.05); C660(1.05)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C804(0.84); C818(0.87); C338(0.99); C659(1.07)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C804(0.73); C659(0.84); C660(0.84); C338(0.89)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C804(0.77); C338(0.91); C659(1.16); C660(1.16)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C804(0.76); C338(0.86); C659(0.98); C660(0.98)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C338(0.88); C804(0.89); C659(0.99); C660(0.99)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C804(0.77); C338(0.87); C659(0.96); C660(0.96)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C804(0.77); C338(0.86); C659(1.00); C660(1.00)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C804(0.79); C338(0.87); C659(1.14); C660(1.14)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C804(0.73); C338(0.84); C659(0.91); C660(0.91)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C338(0.91); C984(0.94); C804(0.97); C131(1.00)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C338(0.82); C984(0.95); C804(1.17); C131(1.28)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C338(0.89); C118(0.96); C804(1.10); C984(1.15)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C338(0.83); C984(0.87); C804(1.04); C659(1.47)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C984(0.85); C338(0.93); C804(1.08); C131(1.11)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C338(0.82); C804(0.98); C984(1.00); C131(1.30)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C804(0.99); C338(1.04); C984(1.08); C659(1.39)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C984(0.93); C338(1.07); C659(1.14); C660(1.14)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C804(0.99); C338(1.22); C659(1.26); C660(1.26)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C338(0.77); C984(0.86); C804(1.15); C131(1.16)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C338(0.77); C984(0.93); C804(1.04); C659(1.45)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C338(0.80); C984(0.95); C659(1.07); C660(1.07)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C338(0.88); C804(0.96); C984(1.02); C659(1.23)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C338(0.90); C818(0.92); C804(0.96); C118(1.06)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C338(0.84); C984(0.88); C131(0.95); C804(1.06)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C338(0.81); C984(0.90); C804(1.07); C131(1.19)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C984(1.00); C804(1.06); C131(1.36); C659(1.38)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C659(0.87); C660(0.87); C804(0.99); C338(1.02)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C659(0.75); C660(0.75); C338(0.96); C804(1.07)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C659(0.76); C660(0.76); C338(0.97); C984(0.98)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C659(0.74); C660(0.74); C804(0.92); C131(0.94)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C659(0.71); C660(0.71); C118(0.81); C131(0.98)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C659(0.72); C660(0.72); C338(1.02); C804(1.11)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C659(0.76); C660(0.76); C804(0.95); C338(1.00)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C118(0.57); C659(0.74); C660(0.74); C804(1.01)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C338(0.98); C804(1.08); C659(1.15); C660(1.15)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C659(1.02); C660(1.02); C338(1.12); C804(1.20)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C659(0.71); C660(0.71); C131(0.97); C338(1.04)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C118(0.91); C984(1.01); C131(1.06); C338(1.11)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C659(0.73); C660(0.73); C118(0.94); C338(0.98)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C118(0.87); C338(1.02); C984(1.03); C804(1.20)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C659(0.72); C660(0.72); C804(0.96); C338(1.06)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C659(0.42); C660(0.42); C804(0.65); C338(1.14)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C659(0.39); C660(0.39); C984(0.81); C804(0.83)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C118(1.28); C131(1.07); C338(0.99); C659(1.38)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C818(0.96); C338(1.00); C131(1.02); C804(1.07)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C818(0.75); C804(0.95); C338(1.02); C659(1.38)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.50  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C338(0.96)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C338(0.00); C804(0.00); H97(0.00); C394(0.00)  LDD0222  [16]
 LDCM0367  CL1 HCT 116 C984(0.88); C118(1.02); C131(1.08); C659(1.16)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C118(0.79); C818(0.82); C804(0.89); C984(1.23)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C818(0.79); C338(1.03); C804(1.12); C984(1.18)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C338(0.88); C804(0.90); C818(0.95); C118(1.23)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C338(0.75); C818(0.92); C804(1.01); C118(1.08)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C338(0.88); C984(1.00); C131(1.12); C818(1.21)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C338(0.94); C804(0.96); C818(1.12); C659(1.15)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C659(0.70); C660(0.70); C338(0.82); C131(0.88)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C338(0.79); C659(0.87); C660(0.87); C131(0.91)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C659(0.80); C660(0.80); C338(0.82); C118(1.05)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C338(0.81); C131(0.95); C659(1.02); C660(1.02)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C659(0.77); C660(0.77); C338(0.91); C131(1.10)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C818(0.60); C804(0.94); C118(0.97); C984(1.38)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C338(0.75); C659(0.80); C660(0.80); C118(0.91)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C659(0.60); C660(0.60); C118(0.68); C338(0.82)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C659(0.60); C660(0.60); C804(0.94); C118(0.97)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C659(0.36); C660(0.36); C804(0.75); C118(1.03)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C659(0.37); C660(0.37); C804(0.82); C118(1.04)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C659(0.40); C660(0.40); C804(0.72); C118(0.99)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C659(0.64); C660(0.64); C804(0.82); C118(0.89)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C659(0.69); C660(0.69); C338(0.95); C804(1.16)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C804(0.91); C338(0.92); C659(0.93); C660(0.93)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C659(0.73); C660(0.73); C338(0.93); C804(0.93)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C818(0.65); C804(0.86); C118(1.10); C659(1.40)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C659(0.79); C660(0.79); C338(0.95); C804(1.00)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C804(0.78); C659(0.80); C660(0.80); C338(0.87)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C659(0.71); C660(0.71); C804(0.84); C338(0.96)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C338(0.97); C984(1.05); C804(1.06); C131(2.52)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C659(0.83); C660(0.83); C804(0.83); C338(1.00)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C338(0.95); C804(0.95); C131(1.01); C984(1.10)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C804(0.87); C338(1.00); C659(1.10); C660(1.10)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C804(0.84); C338(0.98); C659(1.11); C660(1.11)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C804(0.78); C338(0.89); C659(1.43); C660(1.43)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C818(0.72); C804(0.84); C118(0.89); C131(1.18)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C818(0.81); C804(0.95); C984(0.95); C118(0.98)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C818(0.76); C804(0.96); C118(1.07); C984(1.11)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C818(0.66); C804(0.77); C659(0.84); C660(0.84)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C818(0.59); C659(0.84); C660(0.84); C804(0.87)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C818(0.45); C804(0.76); C659(1.00); C660(1.00)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C818(0.75); C804(0.78); C659(1.04); C660(1.04)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C984(0.93); C818(0.98); C131(1.07); C804(1.13)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C818(0.63); C804(0.70); C338(0.90); C659(1.15)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C818(0.60); C804(0.76); C338(0.93); C659(1.36)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C818(0.73); C804(0.76); C338(0.81); C659(1.12)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C818(0.70); C804(0.78); C338(0.86); C659(0.87)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C818(0.49); C804(0.71); C659(0.89); C660(0.89)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C131(1.73); C338(1.08); C659(0.87); C660(0.87)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C131(1.40); C338(1.07); C659(0.97); C660(0.97)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C131(1.42); C338(0.94); C659(1.08); C660(1.08)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C131(1.70); C338(0.88); C659(1.02); C660(1.02)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C131(2.00); C338(0.81); C659(1.16); C660(1.16)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C118(0.93); C131(1.08); C659(1.77); C660(1.77)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C131(1.30); C338(1.02); C659(0.90); C660(0.90)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C131(1.13); C338(1.04); C804(1.12); C818(0.87)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C131(1.03); C659(0.83); C660(0.83); C804(1.00)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C131(1.38); C659(0.88); C660(0.88); C804(1.01)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C131(1.71); C659(1.04); C660(1.04); C804(0.92)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C131(2.19); C659(1.07); C660(1.07); C804(0.92)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C131(1.85); C659(0.88); C660(0.88); C804(0.98)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C131(2.38); C659(1.01); C660(1.01); C804(0.96)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C131(1.76); C659(0.77); C660(0.77); C804(1.10)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C118(1.20); C131(1.12); C659(1.54); C660(1.54)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C131(1.79); C659(1.64); C660(1.64); C804(1.09)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C131(1.68); C659(0.95); C660(0.95); C804(0.94)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C131(2.09); C659(0.98); C660(0.98); C804(1.22)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C131(2.46); C659(0.92); C660(0.92); C804(1.03)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C131(1.81); C659(1.67); C660(1.67); C804(1.07)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C131(1.60); C659(1.10); C660(1.10); C804(1.08)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C131(0.79); C804(0.84); C818(1.89); C984(0.88)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C131(0.63); C804(0.91); C818(1.58); C984(0.88)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C131(0.80); C804(0.93); C818(1.68); C984(0.82)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C131(1.33); C804(1.08); C818(1.66); C984(0.88)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C118(0.98); C131(1.14); C659(1.53); C660(1.53)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C131(1.06); C804(0.97); C818(1.72); C984(0.76)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C131(0.85); C804(1.05); C818(2.77); C984(1.06)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C131(1.28); C804(0.90); C818(1.68); C984(0.94)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C131(0.99); C804(0.89); C818(1.20); C984(0.76)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C131(0.89); C804(0.92); C818(1.23); C984(0.85)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C131(0.93); C804(1.14); C818(1.15); C984(0.87)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C131(1.02); C804(0.95); C818(1.05); C984(0.87)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C131(0.79); C804(0.92); C818(1.68); C984(0.85)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C131(0.82); C804(0.89); C818(1.07); C984(0.90)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C131(1.25); C804(1.04); C818(2.07); C984(0.86)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C118(0.93); C131(1.36); C659(1.18); C660(1.18)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C131(0.87); C804(0.89); C818(1.56); C984(0.89)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C338(1.20); C804(0.91); C818(1.12); C984(1.20)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C338(0.62); C804(0.96); C818(0.77); C984(1.15)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C338(0.96); C804(0.87); C818(0.77); C984(1.06)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C338(1.06); C804(0.93); C818(1.01); C984(1.41)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C338(0.75); C804(1.17); C818(0.79); C984(1.00)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C338(1.05); C804(0.93); C818(0.53); C984(1.62)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C338(0.93); C804(0.99); C818(0.59); C984(1.27)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C338(1.00); C804(0.79); C818(0.73); C984(1.19)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C338(0.69); C804(0.81); C818(0.71); C984(1.07)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C118(0.81); C131(1.19); C659(2.53); C660(2.53)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C338(0.76); C804(0.92); C818(0.67); C984(1.31)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C338(0.90); C804(1.02); C818(0.80); C984(1.19)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C338(1.04); C804(0.78); C818(0.97); C984(1.11)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C338(0.74); C804(0.92); C818(0.83); C984(1.14)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C338(0.73); C804(0.97); C818(0.67); C984(1.19)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C118(1.10); C659(1.13); C660(1.13); C804(1.19)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C118(1.26); C659(0.98); C660(0.98); C804(1.10)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C118(1.06); C659(1.08); C660(1.08); C804(1.12)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C118(1.21); C659(1.26); C660(1.26); C804(1.16)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C118(1.07); C131(2.07); C659(1.60); C660(1.60)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C118(0.93); C659(1.32); C660(1.32); C804(1.29)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C118(1.06); C659(1.87); C660(1.87); C804(1.23)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C118(0.90); C659(1.54); C660(1.54); C804(1.24)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C118(1.11); C659(1.25); C660(1.25); C804(1.15)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C118(1.04); C659(1.17); C660(1.17); C804(1.01)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C118(0.99); C659(1.20); C660(1.20); C804(1.07)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C118(1.08); C659(1.01); C660(1.01); C804(1.10)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C118(1.08); C659(1.85); C660(1.85); C804(1.14)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C118(1.14); C659(1.71); C660(1.71); C804(1.16)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C118(0.89); C659(1.58); C660(1.58); C804(1.19)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C118(1.17); C131(1.11); C659(1.42); C660(1.42)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C118(1.22); C659(1.62); C660(1.62); C804(1.19)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C131(1.32); C338(1.00); C804(0.97); C818(0.89)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C131(1.23); C338(0.97); C804(1.11); C818(0.85)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C131(1.23); C338(1.14); C804(1.22); C818(0.83)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C131(1.51); C338(0.96); C804(1.01); C818(0.78)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C131(1.65); C338(1.03); C804(1.04); C818(0.86)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C131(1.36); C338(1.02); C804(0.93); C818(0.79)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C131(1.38); C338(0.91); C804(0.87); C818(0.82)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C131(1.59); C338(0.97); C804(1.01); C818(0.87)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C131(1.45); C338(1.06); C804(1.02); C818(0.80)  LDD0811  [6]
 LDCM0634  CY-0357 Hep-G2 C131(0.31)  LDD2228  [9]
 LDCM0028  Dobutamine HEK-293T 4.19  LDD0180  [5]
 LDCM0495  E2913 HEK-293T C131(0.95); C704(1.06); C118(0.98); C804(1.05)  LDD1698  [22]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.00  LDD0183  [5]
 LDCM0468  Fragment33 HCT 116 C338(1.18); C804(0.87); C818(0.73); C984(1.35)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C131(2.23); C659(1.17); C660(1.17); C804(1.09)  LDD0744  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C338(1.76); C804(2.09); C984(1.08)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C338(1.73); C804(2.17); C984(1.13)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C338(2.41); C804(2.02); C984(1.10)  LDD0082  [6]
 LDCM0030  Luteolin HEK-293T 8.82  LDD0182  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C804(2.12)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C804(1.15)  LDD2107  [4]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [19]
 LDCM0021  THZ1 HCT 116 C131(1.10)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) PDK/BCKDK protein kinase family Q15118

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid20471253c32 Small molecular drug D0N1UU

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
20 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
21 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402