Details of the Target

General Information of Target

Target ID LDTP11609
Target Name Endoplasmic reticulum junction formation protein lunapark (LNPK)
Gene Name LNPK
Gene ID 80856
Synonyms
KIAA1715; LNP; Endoplasmic reticulum junction formation protein lunapark; ER junction formation factor lunapark
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLCGLSRETPGEADDGPYSKGGKDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLG
LTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVG
ERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTY
VRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTV
ANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSI
DGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPSEAVKVQRSEQLHRWDPCVP
SCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRT
TMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATET
LSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLE
VEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTL
EPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELK
RYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAI
HLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSV
DSAVESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPA
DESFPEEEEEDDWEPPTSPAPGPAREEGFWRMFGEALEDLESCGQSELLRELEASIMTGT
VQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDG
LLEKGVYVHTVRPDGPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIIS
RKPHTAHSSRAPRSPGPSSPRML
Target Bioclass
Transporter and channel
Family
Lunapark family
Subcellular location
Endoplasmic reticulum membrane
Function
Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network. May be involved in limb development. Is involved in central nervous system development.
Uniprot ID
Q9C0E8
Ensemble ID
ENST00000272748.9
HGNC ID
HGNC:21610

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.M124I DBIA    Probe Info 
HCT15 SNV: p.A307T .
SKOV3 SNV: p.R253Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.54  LDD0402  [1]
TH211
 Probe Info  		Y262(20.00)  LDD0260  [2]
STPyne
 Probe Info  		K324(7.44)  LDD0277  [3]
BTD
 Probe Info  		C149(0.46)  LDD2089  [4]
DA-P3
 Probe Info  		12.73  LDD0179  [5]
AHL-Pu-1
 Probe Info  		C149(2.13)  LDD0168  [6]
DBIA
 Probe Info  		C149(1.16)  LDD0531  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
NHS
 Probe Info  		N.A.  LDD0010  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		25.28  LDD1785  [13]
C165
 Probe Info  		15.78  LDD1845  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C149(0.70)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C149(0.81)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C149(0.75)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C149(0.94)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C149(0.71)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C149(0.76)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C149(1.03)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C149(0.59)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C149(0.72)  LDD2131  [4]
 LDCM0025  4SU-RNA HEK-293T C149(2.13)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C149(3.56)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C149(1.16)  LDD0531  [7]
 LDCM0215  AC10 HEK-293T C149(1.02)  LDD1508  [14]
 LDCM0216  AC100 HCT 116 C149(1.01)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C149(1.11)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C149(0.77)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C149(1.03)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C149(1.48)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C149(1.04)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C149(1.35)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C149(1.35)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C149(1.41)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C149(1.31)  LDD0542  [7]
 LDCM0226  AC11 HEK-293T C149(0.91)  LDD1509  [14]
 LDCM0227  AC110 HCT 116 C149(1.70)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C149(1.25)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C149(1.42)  LDD0546  [7]
 LDCM0237  AC12 HEK-293T C149(0.95)  LDD1510  [14]
 LDCM0246  AC128 HCT 116 C149(0.68)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C149(0.82)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C149(0.91)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C149(0.81)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C149(1.06)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C149(0.74)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C149(0.88)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C149(1.04)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C149(1.00)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C149(0.71)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C149(0.84)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C149(0.99)  LDD0575  [7]
 LDCM0259  AC14 HEK-293T C149(0.78)  LDD1512  [14]
 LDCM0260  AC140 HCT 116 C149(1.32)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C149(1.01)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C149(0.76)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C149(1.09)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C149(1.09)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C149(0.83)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C149(0.91)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C149(0.94)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C149(0.90)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C149(1.07)  LDD0586  [7]
 LDCM0270  AC15 HEK-293T C149(0.84)  LDD1513  [14]
 LDCM0271  AC150 HCT 116 C149(1.00)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C149(1.55)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C149(0.93)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C149(0.99)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C149(1.24)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C149(1.10)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C149(1.09)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C149(0.89)  LDD2161  [7]
 LDCM0276  AC17 HEK-293T C149(0.91)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C149(0.93)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C149(1.05)  LDD1517  [14]
 LDCM0279  AC2 HCT 116 C149(1.78)  LDD0596  [7]
 LDCM0280  AC20 HEK-293T C149(0.98)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C149(0.98)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C149(0.82)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C149(0.86)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C149(0.92)  LDD1523  [14]
 LDCM0285  AC25 HCT 116 C149(0.74)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C149(1.05)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C149(1.17)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C149(1.70)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C149(1.36)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C149(1.19)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C149(1.27)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C149(1.16)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C149(1.50)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C149(0.92)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C149(1.07)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C149(0.81)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C149(1.10)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C149(0.91)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C149(0.99)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C149(1.00)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C149(1.32)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C149(0.90)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C149(1.07)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C149(1.07)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C149(1.35)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C149(0.95)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C149(0.92)  LDD0624  [7]
 LDCM0308  AC46 HEK-293T C149(0.83)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C149(0.91)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C149(0.96)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C149(0.96)  LDD1550  [14]
 LDCM0312  AC5 HCT 116 C149(1.13)  LDD0629  [7]
 LDCM0313  AC50 HEK-293T C149(1.01)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C149(1.04)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C149(0.97)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C149(1.00)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C149(0.91)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C149(0.86)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C149(1.01)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C149(0.97)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C149(0.94)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C149(1.08)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C149(1.06)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C149(1.05)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C149(0.98)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C149(1.02)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C149(0.84)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C149(1.02)  LDD1567  [14]
 LDCM0332  AC68 HCT 116 C149(0.85)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C149(0.78)  LDD0650  [7]
 LDCM0334  AC7 HEK-293T C149(0.96)  LDD1568  [14]
 LDCM0335  AC70 HCT 116 C149(0.58)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C149(0.76)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C149(0.99)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C149(0.86)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C149(0.85)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C149(1.09)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C149(0.96)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C149(0.95)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C149(0.81)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C149(0.93)  LDD0661  [7]
 LDCM0345  AC8 HEK-293T C149(1.06)  LDD1569  [14]
 LDCM0346  AC80 HCT 116 C149(0.90)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C149(0.72)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C149(1.18)  LDD0665  [7]
 LDCM0365  AC98 HCT 116 C149(1.97)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C149(0.99)  LDD0683  [7]
 LDCM0545  Acetamide MDA-MB-231 C149(0.36)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C149(0.57)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C149(1.01)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C149(0.91)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C149(0.98)  LDD1514  [14]
 LDCM0498  BS-3668 MDA-MB-231 C149(0.83)  LDD2091  [4]
 LDCM0632  CL-Sc Hep-G2 C149(0.69)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C149(0.93)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C149(0.39)  LDD1572  [14]
 LDCM0369  CL100 HCT 116 C149(1.30)  LDD0686  [7]
 LDCM0370  CL101 HEK-293T C149(0.99)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C149(0.83)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C149(0.99)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C149(0.93)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C149(0.95)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C149(0.82)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C149(0.93)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C149(0.91)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C149(1.00)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C149(0.37)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C149(0.84)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C149(0.94)  LDD1585  [14]
 LDCM0382  CL112 HCT 116 C149(0.88)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C149(1.26)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C149(1.08)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C149(1.19)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C149(1.13)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C149(1.03)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C149(0.96)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C149(1.00)  LDD0706  [7]
 LDCM0390  CL12 HEK-293T C149(0.61)  LDD1594  [14]
 LDCM0391  CL120 HCT 116 C149(1.03)  LDD0708  [7]
 LDCM0392  CL121 HEK-293T C149(0.92)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C149(0.97)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C149(0.85)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C149(0.95)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C149(0.94)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C149(1.07)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C149(1.01)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C149(1.11)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C149(0.99)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C149(0.79)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C149(0.81)  LDD1606  [14]
 LDCM0403  CL16 HCT 116 C149(1.12)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C149(0.92)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C149(1.08)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C149(0.90)  LDD0723  [7]
 LDCM0407  CL2 HEK-293T C149(0.73)  LDD1611  [14]
 LDCM0408  CL20 HCT 116 C149(0.93)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C149(0.87)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C149(0.90)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C149(1.14)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C149(0.99)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C149(1.09)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C149(1.18)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C149(1.00)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C149(1.12)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C149(1.05)  LDD0734  [7]
 LDCM0418  CL3 HEK-293T C149(0.89)  LDD1622  [14]
 LDCM0419  CL30 HCT 116 C149(1.10)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C149(2.22)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C149(1.13)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C149(2.62)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C149(2.38)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C149(1.09)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C149(5.32)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C149(1.50)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C149(1.42)  LDD0745  [7]
 LDCM0429  CL4 HEK-293T C149(0.93)  LDD1633  [14]
 LDCM0430  CL40 HCT 116 C149(3.63)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C149(1.63)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C149(1.98)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C149(1.66)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C149(1.17)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C149(6.94)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C149(1.30)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C149(1.27)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C149(1.13)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C149(1.44)  LDD0756  [7]
 LDCM0440  CL5 HEK-293T C149(0.85)  LDD1644  [14]
 LDCM0441  CL50 HCT 116 C149(1.16)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C149(1.19)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C149(1.33)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C149(1.11)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C149(1.12)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C149(1.11)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C149(1.03)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C149(1.12)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C149(1.20)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C149(1.08)  LDD0767  [7]
 LDCM0451  CL6 HEK-293T C149(0.83)  LDD1654  [14]
 LDCM0452  CL60 HCT 116 C149(1.16)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C149(0.83)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C149(1.00)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C149(0.97)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C149(0.87)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C149(0.88)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C149(0.89)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C149(0.60)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C149(0.86)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C149(0.77)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C149(0.58)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C149(0.55)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C149(0.44)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C149(0.68)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C149(0.87)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C149(0.98)  LDD1670  [14]
 LDCM0469  CL76 HCT 116 C149(1.02)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C149(1.48)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C149(0.89)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C149(1.28)  LDD0789  [7]
 LDCM0473  CL8 HEK-293T C149(0.66)  LDD1676  [14]
 LDCM0474  CL80 HCT 116 C149(1.14)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C149(1.11)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C149(1.24)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C149(1.12)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C149(1.81)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C149(0.82)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C149(0.92)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C149(1.23)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C149(1.26)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C149(1.39)  LDD0800  [7]
 LDCM0484  CL9 HEK-293T C149(0.79)  LDD1687  [14]
 LDCM0485  CL90 HCT 116 C149(1.06)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C149(1.30)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C149(1.12)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C149(1.50)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C149(1.08)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C149(1.56)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C149(1.14)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C149(1.28)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C149(1.31)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C149(0.96)  LDD0811  [7]
 LDCM0028  Dobutamine HEK-293T 6.16  LDD0180  [5]
 LDCM0027  Dopamine HEK-293T 12.73  LDD0179  [5]
 LDCM0495  E2913 HEK-293T C149(0.90)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C149(1.42)  LDD1702  [4]
 LDCM0625  F8 Ramos C149(1.49)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C149(1.51)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C149(2.75)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C149(0.89)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C149(1.02)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C149(1.03)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C149(1.00)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C149(1.08)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C149(1.37)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C149(1.17)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C149(0.92)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C149(1.29)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C149(1.17)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C149(0.96)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C149(0.96)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C149(1.30)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C149(1.10)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C149(4.36)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C149(1.38)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C149(1.18)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C149(1.13)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C149(1.19)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C149(1.03)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C149(1.01)  LDD1497  [14]
 LDCM0024  KB05 COLO792 C26(0.95)  LDD3310  [16]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C149(0.70)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C149(0.44)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C149(0.46)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C149(1.15)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C149(0.86)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C149(0.66)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C149(0.91)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C149(2.61)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C149(1.39)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C149(0.95)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C149(0.56)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C149(0.81)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C149(1.92)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C149(0.94)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C149(1.33)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C149(0.68)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C149(0.70)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C149(0.65)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C149(0.62)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C149(1.19)  LDD2110  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C149(0.80)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C149(0.95)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C149(2.26)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C149(1.76)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C149(1.23)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C149(1.04)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C149(2.59)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C149(0.65)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C149(2.37)  LDD2124  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C149(0.85)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C149(0.93)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C149(0.57)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C149(0.36)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C149(1.18)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C149(0.50)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C149(0.66)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C149(0.73)  LDD2137  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C149(0.82)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C149(1.06)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C149(0.98)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C149(3.61)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C149(0.51)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C149(3.83)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C149(0.25)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C149(3.01)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C149(0.35)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C149(2.35)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C149(1.31)  LDD2153  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A1 (ANXA1) Annexin family P04083
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleolar complex protein 4 homolog (NOC4L) CBF/MAK21 family Q9BVI4
Perilipin-3 (PLIN3) Perilipin family O60664
Protein YIF1A (YIF1A) YIF1 family O95070
Kelch-like protein 12 (KLHL12) . Q53G59

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840