Details of the Target

General Information of Target

Target ID LDTP08322
Target Name Valacyclovir hydrolase (BPHL)
Gene Name BPHL
Gene ID 670
Synonyms
MCNAA; Valacyclovir hydrolase; VACVase; Valacyclovirase; EC 3.1.-.-; Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Bph-rp; Breast epithelial mucin-associated antigen; MCNAA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVAVLGGRGVLRLRLLLSALKPGIHVPRAGPAAAFGTSVTSAKVAVNGVQLHYQQTGEGD
HAVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPADFFERDAKD
AVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIR
DVSKWSERTRKPLEALYGYDYFARTCEKWVDGIRQFKHLPDGNICRHLLPRVQCPALIVH
GEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFADEFNKLAEDFLQ
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
AB hydrolase superfamily, Lipase family
Function
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.
TTD ID
T05806
Uniprot ID
Q86WA6
DrugMap ID
TTTZ3EU
Ensemble ID
ENST00000380375.4
HGNC ID
HGNC:1094
ChEMBL ID
CHEMBL3308924

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO679 SNV: p.L15M DBIA    Probe Info 
EGI1 SNV: p.I24M DBIA    Probe Info 
HT1376 SNV: p.W185C DBIA    Probe Info 
NCIH446 SNV: p.M267I .
RKO SNV: p.L11Ter DBIA    Probe Info 
TOV21G Insertion: p.E115Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K126(5.04); K217(9.82); K257(4.46); K271(6.55)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C225(1.18)  LDD3310  [3]
BTD
 Probe Info  		C234(0.85)  LDD2092  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C225(0.00); C234(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C225(0.00); C234(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C173
 Probe Info  		10.41  LDD1853  [9]
C251
 Probe Info  		40.22  LDD1924  [9]
C391
 Probe Info  		19.70  LDD2050  [9]
STS-1
 Probe Info  		1.22  LDD0137  [10]
STS-2
 Probe Info  		1.00  LDD0139  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C234(0.73)  LDD2117  [4]
 LDCM0214  AC1 HEK-293T C225(0.95); C234(0.95)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C225(1.03); C234(0.93)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C225(0.98); C234(0.93)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C225(0.96); C234(0.91)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C225(0.94); C234(1.00)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C225(0.90); C234(0.95)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C225(0.96); C234(0.99)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C225(0.97); C234(0.98)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C225(1.30); C234(0.98)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C225(0.99); C234(0.95)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C225(1.07); C234(0.92)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C225(0.91); C234(1.11)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C225(1.06); C234(1.07)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C225(0.91); C234(0.96)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C225(0.96); C234(0.99)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C225(0.99); C234(0.98)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C225(0.99); C234(1.02)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C225(0.98); C234(0.94)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C225(1.05); C234(0.99)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C225(0.95); C234(1.06)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C225(0.96); C234(0.92)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C225(0.97); C234(1.04)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C225(0.93); C234(0.91)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C225(0.97); C234(0.98)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C225(0.96); C234(0.88)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C225(1.03); C234(0.93)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C225(0.96); C234(0.91)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C225(0.94); C234(0.92)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C225(0.94); C234(1.00)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C225(0.96); C234(1.02)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C225(0.91); C234(0.90)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C225(1.08); C234(0.95)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C225(0.94); C234(0.93)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C225(0.95); C234(0.89)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C225(0.97); C234(1.00)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C225(0.99); C234(0.90)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C225(0.99); C234(0.91)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C225(0.90); C234(1.00)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C225(0.94); C234(1.02)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C225(0.92); C234(0.93)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C225(0.94); C234(1.03)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C225(0.97); C234(0.88)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C225(0.92); C234(0.99)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C225(0.99); C234(0.93)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C225(0.96); C234(0.91)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C225(0.99); C234(0.90)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C225(0.92); C234(0.96)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C225(0.95); C234(1.05)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C225(0.92); C234(0.90)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C225(0.94); C234(0.94)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C225(1.03); C234(0.95)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C225(1.02); C234(0.91)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C225(0.95); C234(0.93)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C225(0.99); C234(1.02)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C225(1.00); C234(0.92)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C225(0.98); C234(1.00)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C225(0.81); C234(0.99)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C225(0.96); C234(0.92)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C225(0.95); C234(0.93)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C225(0.92); C234(0.89)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C225(0.96); C234(0.97)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C225(0.93); C234(0.99)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C225(0.95); C234(0.89)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C225(0.98); C234(0.96)  LDD1514  [11]
 LDCM0020  ARS-1620 HCC44 C225(1.02)  LDD2171  [12]
 LDCM0367  CL1 HEK-293T C225(0.97); C234(1.02)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C225(1.25); C234(1.41)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C225(0.95); C234(0.92)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C225(0.92); C234(0.88)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C225(0.98); C234(1.10)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C225(0.96); C234(0.93)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C225(1.01); C234(0.94)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C225(0.98); C234(0.99)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C225(0.92); C234(1.05)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C225(0.91); C234(0.97)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C225(1.00); C234(0.98)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C225(0.93); C234(1.01)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C225(0.98); C234(1.11)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C225(0.95); C234(1.18)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C225(0.98); C234(1.05)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C225(1.06); C234(1.02)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C225(0.93); C234(0.84)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C225(1.12); C234(1.18)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C225(0.96); C234(0.98)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C225(0.93); C234(0.87)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C225(0.98); C234(0.83)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C225(0.96); C234(0.90)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C225(1.04); C234(0.99)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C225(1.09); C234(0.93)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C225(0.97); C234(0.93)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C225(0.93); C234(0.89)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C225(1.00); C234(1.01)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C225(1.02); C234(1.18)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C225(1.06); C234(0.99)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C225(0.94); C234(0.87)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C225(0.96); C234(1.07)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C225(0.98); C234(0.93)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C225(1.03); C234(0.93)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C225(1.00); C234(0.91)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C225(0.93); C234(0.93)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C225(1.12); C234(1.25)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C225(0.98); C234(0.90)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C225(1.04); C234(1.27)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C225(1.00); C234(0.95)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C225(0.96); C234(0.95)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C225(0.92); C234(1.01)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C225(0.94); C234(0.97)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C225(1.10); C234(1.41)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C225(0.97); C234(1.05)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C225(0.94); C234(1.00)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C225(1.05); C234(1.02)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C225(1.12); C234(1.11)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C225(1.12); C234(0.97)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C225(0.99); C234(0.94)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C225(0.99); C234(0.96)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C225(0.95); C234(1.00)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C225(0.94); C234(1.06)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C225(0.99); C234(0.94)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C225(0.96); C234(1.01)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C225(0.93); C234(1.04)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C225(1.39); C234(1.63)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C225(0.99); C234(1.14)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C225(0.96); C234(0.99)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C225(1.06); C234(1.12)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C225(1.04); C234(0.98)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C225(0.96); C234(1.10)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C225(0.99); C234(0.98)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C225(1.03); C234(0.94)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C225(1.06); C234(1.06)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C225(1.04); C234(0.99)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C225(0.97); C234(1.01)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C225(1.06); C234(1.03)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C225(1.09); C234(1.23)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C225(1.09); C234(1.16)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C225(0.93); C234(1.02)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C225(1.02); C234(1.00)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C225(0.92); C234(0.85)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C225(0.92); C234(0.95)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C225(1.03); C234(0.99)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C225(0.98); C234(0.92)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C225(1.14); C234(1.15)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C225(1.11); C234(1.13)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C225(0.99); C234(0.90)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C225(1.01); C234(0.93)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C225(1.03); C234(1.35)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C225(0.98); C234(1.14)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C225(0.98); C234(0.99)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C225(1.07); C234(1.25)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C225(1.03); C234(1.03)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C225(0.96); C234(0.79)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C225(0.93); C234(0.95)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C225(0.92); C234(0.93)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C225(1.08); C234(1.17)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C225(0.94); C234(0.89)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C225(0.95); C234(0.96)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C225(1.05); C234(0.92)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C225(1.07); C234(0.95)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C225(0.95); C234(1.19)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C225(0.97); C234(0.96)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C225(1.03); C234(1.01)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C225(0.98); C234(1.00)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C225(1.10); C234(1.00)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C225(1.10); C234(0.95)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C225(0.98); C234(0.93)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C225(0.97); C234(0.95)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C225(1.02); C234(1.15)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C225(0.97); C234(0.99)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C225(0.96); C234(0.96)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C225(1.51); C234(1.56)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C225(1.02); C234(0.95)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C225(0.96); C234(1.07)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C225(0.90); C234(1.09)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C225(1.00); C234(1.03)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C225(1.10); C234(0.97)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C225(0.90); C234(0.85)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C225(0.96); C234(0.89)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C225(0.92); C234(0.98)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C225(0.95); C234(0.88)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C225(0.91); C234(0.86)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C225(0.98); C234(1.10)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C225(1.53); C234(1.71)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C225(0.97); C234(0.94)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C225(1.07); C234(1.02)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C225(1.00); C234(1.06)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C225(0.97); C234(1.00)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C225(1.25); C234(1.32)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C225(1.15); C234(0.95)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C225(1.01); C234(0.97)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C225(0.93); C234(1.03)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C225(0.93); C234(0.99)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C225(0.88); C234(1.01)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C225(0.93); C234(0.95)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C225(0.98); C234(0.99)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C225(0.97); C234(0.91)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C225(1.07); C234(0.94)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C225(1.18)  LDD3310  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C234(0.85)  LDD2092  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C234(0.69)  LDD2099  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C234(1.07)  LDD2111  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C234(0.76)  LDD2146  [4]
 LDCM0021  THZ1 HCT 116 C225(1.02)  LDD2173  [12]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-tyrosinamide Small molecular drug D0DO9W
L-tyrosinamide Small molecular drug DB03380

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.