Details of the Target

General Information of Target

Target ID LDTP08084
Target Name BRCA1-associated protein (BRAP)
Gene Name BRAP
Gene ID 8315
Synonyms
RNF52; BRCA1-associated protein; EC 2.3.2.27; BRAP2; Impedes mitogenic signal propagation; IMP; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; Renal carcinoma antigen NY-REN-63
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVSLVVIRLELAEHSPVPAGFGFSAAAGEMSDEEIKKTTLASAVACLEGKSPGEKVAII
HQHLGRREMTDVIIETMKSNPDELKTTVEERKSSEASPTAQRSKDHSKECINAAPDSPSK
QLPDQISFFSGNPSVEIVHGIMHLYKTNKMTSLKEDVRRSAMLCILTVPAAMTSHDLMKF
VAPFNEVIEQMKIIRDSTPNQYMVLIKFRAQADADSFYMTCNGRQFNSIEDDVCQLVYVE
RAEVLKSEDGASLPVMDLTELPKCTVCLERMDESVNGILTTLCNHSFHSQCLQRWDDTTC
PVCRYCQTPEPVEENKCFECGVQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQL
TNHRVWDYAGDNYVHRLVASKTDGKIVQYECEGDTCQEEKIDALQLEYSYLLTSQLESQR
IYWENKIVRIEKDTAEEINNMKTKFKETIEKCDNLEHKLNDLLKEKQSVERKCTQLNTKV
AKLTNELKEEQEMNKCLRANQVLLQNKLKEEERVLKETCDQKDLQITEIQEQLRDVMFYL
ETQQKINHLPAETRQEIQEGQINIAMASASSPASSGGSGKLPSRKGRSKRGK
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Uniprot ID
Q7Z569
Ensemble ID
ENST00000419234.9
HGNC ID
HGNC:1099

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.V536A .
HCT15 SNV: p.F128Y .
HT115 SNV: p.E186K .
JHH4 SNV: p.G321C .
KMCH1 Deletion: p.K38del .
LNCaP clone FGC SNV: p.S286I .
MDAMB453 SNV: p.S289N .
SKNAS SNV: p.H61R .
SW756 SNV: p.Q323Ter .
U2OS SNV: p.Q475K; p.L483H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.05  LDD0402  [1]
Alkylaryl probe 2
 Probe Info  		11.00  LDD0390  [2]
BTD
 Probe Info  		C473(0.47)  LDD2091  [3]
DA-P3
 Probe Info  		4.02  LDD0179  [4]
AHL-Pu-1
 Probe Info  		C396(2.06)  LDD0170  [5]
HHS-465
 Probe Info  		Y373(8.07)  LDD2237  [6]
Acrolein
 Probe Info  		N.A.  LDD0222  [7]
DBIA
 Probe Info  		C391(1.13); C396(1.13); C264(0.98); C267(0.98)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C452(0.00); C473(0.00); C234(0.00); C47(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C473(0.00); C306(0.00); C234(0.00); C47(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C221(0.00); C473(0.00); C47(0.00); C306(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		N.A.  LDD0147  [13]
TFBX
 Probe Info  		C47(0.00); C473(0.00)  LDD0148  [13]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
AOyne
 Probe Info  		15.00  LDD0443  [15]
NAIA_5
 Probe Info  		C473(0.00); C164(0.00); C47(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C173
 Probe Info  		5.54  LDD1853  [16]
C204
 Probe Info  		8.57  LDD1879  [16]
C206
 Probe Info  		18.25  LDD1881  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C396(2.06)  LDD0170  [5]
 LDCM0214  AC1 HCT 116 C221(0.90); C264(0.89); C267(0.89); C300(0.63)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C221(1.21); C264(0.93); C267(0.93); C300(0.92)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C221(0.59); C264(0.84); C267(0.84); C300(0.82)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C221(0.64); C264(0.85); C267(0.85); C300(0.88)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C221(0.71); C264(0.86); C267(0.86); C300(0.69)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C221(0.66); C264(0.76); C267(0.76); C300(0.77)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C221(0.67); C264(1.00); C267(1.00); C300(0.74)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C221(0.66); C264(0.72); C267(0.72); C300(0.75)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C221(0.62); C264(0.70); C267(0.70); C300(0.86)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C221(0.71); C264(0.82); C267(0.82); C300(0.79)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C221(0.54); C264(0.77); C267(0.77); C300(0.84)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C221(0.98); C264(1.04); C267(1.04); C300(0.78)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C221(0.96); C264(0.92); C267(0.92); C300(0.85)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C221(0.61); C264(0.91); C267(0.91); C300(0.74)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C221(0.86); C264(0.80); C267(0.80); C300(0.80)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C221(0.69); C264(0.87); C267(0.87); C300(0.81)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C221(1.10); C300(0.87); C303(0.87); C306(0.94)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C221(0.94); C300(0.99); C303(1.12); C306(0.97)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C221(1.04); C300(1.12); C303(1.00); C306(1.04)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C221(1.12); C300(1.05); C303(1.02); C306(0.99)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C221(1.13); C300(1.11); C303(0.91); C306(1.16)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C221(1.12); C300(1.07); C303(0.80); C306(1.12)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C221(1.32); C300(1.01); C303(0.99); C306(0.94)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C221(1.16); C264(0.94); C267(0.94); C300(1.08)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C221(1.01); C300(0.99); C303(0.92); C306(0.90)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C221(1.11); C300(1.30); C303(1.00); C306(1.12)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C221(1.13); C300(1.02); C303(0.90); C306(0.97)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C221(1.07); C300(1.54); C303(0.85); C306(1.30)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C221(1.34); C300(0.95); C303(0.86); C306(1.01)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C221(0.94); C300(1.00); C303(0.97); C306(0.96)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C221(1.02); C300(1.16); C303(1.16); C306(0.97)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C221(1.10); C300(1.11); C303(1.09); C306(0.95)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C221(1.45); C264(1.42); C267(1.42); C300(0.96)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C221(1.19); C264(0.94); C267(0.94); C300(1.19)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C221(1.04); C264(0.93); C267(0.93); C300(0.89)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C221(1.40); C264(1.02); C267(1.02); C300(0.95)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C221(0.88); C264(1.21); C267(1.21); C300(1.04)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C221(1.01); C264(1.14); C267(1.14); C300(0.97)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C221(1.29); C264(1.31); C267(1.31); C300(0.98)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C221(1.15); C264(1.08); C267(1.08); C300(1.05)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C221(0.97); C264(0.95); C267(0.95); C300(0.99)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C221(1.08); C264(0.95); C267(0.95); C300(1.09)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C221(1.69); C264(1.11); C267(1.11); C300(0.94)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C221(0.92); C264(1.07); C267(1.07); C300(1.03)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C221(1.18); C264(0.94); C267(0.94); C300(0.92)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C221(1.08); C264(1.15); C267(1.15); C300(0.96)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C221(1.21); C264(0.94); C267(0.94); C300(1.02)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C221(1.07); C264(1.07); C267(1.07); C300(1.02)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C221(0.65); C264(1.30); C267(1.30); C300(1.05)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C221(0.42); C306(0.85); C303(0.87); C300(0.88)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C221(0.76); C396(0.94); C306(0.94); C303(1.00)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C221(0.48); C300(0.80); C303(0.84); C306(1.03)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C221(0.57); C391(0.94); C396(0.95); C306(0.99)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C221(0.37); C303(0.94); C300(0.98); C306(0.99)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C221(0.37); C303(0.82); C300(0.82); C306(0.85)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C300(0.84); C303(0.84); C264(0.91); C267(0.91)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C221(0.60); C303(0.79); C300(0.81); C391(0.90)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C221(0.62); C306(0.85); C303(0.92); C300(0.95)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C221(0.41); C306(0.82); C391(0.85); C396(0.86)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C221(0.34); C300(0.84); C306(0.93); C303(0.95)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C221(0.63); C264(1.61); C267(1.61); C300(0.90)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C221(0.52); C264(1.41); C267(1.41); C300(0.93)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C221(0.66); C264(1.27); C267(1.27); C300(0.91)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C221(0.82); C264(1.73); C267(1.73); C300(1.18)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C452(0.85); C306(0.96); C300(1.02); C303(1.02)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C452(0.74); C300(0.99); C303(0.99); C264(1.05)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C452(0.84); C264(0.89); C267(0.89); C300(1.08)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C300(0.90); C303(0.90); C391(0.90); C396(0.90)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C300(0.89); C303(0.89); C452(0.90); C306(1.08)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C452(0.91); C300(0.95); C303(0.95); C306(1.01)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C300(0.98); C303(0.98); C391(1.00); C396(1.00)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C452(0.90); C306(0.97); C264(0.97); C267(0.97)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C452(1.00); C391(1.10); C396(1.10); C306(1.16)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C306(0.88); C47(0.90); C391(0.96); C396(0.96)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C221(0.88); C306(0.95); C47(0.96); C391(0.98)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C221(0.89); C47(0.91); C300(0.99); C303(0.99)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C221(0.78); C306(0.93); C47(0.94); C452(1.04)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C264(0.88); C267(0.88); C306(0.93); C221(0.97)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C300(0.86); C303(0.86); C221(0.87); C391(0.88)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C306(0.81); C221(0.82); C391(1.00); C396(1.00)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C391(0.95); C396(0.95); C300(0.97); C303(0.97)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C221(0.76); C306(0.86); C300(0.96); C303(0.96)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C306(0.85); C300(0.95); C303(0.95); C47(0.99)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C300(0.80); C303(0.80); C306(0.83); C221(0.91)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C452(0.69); C306(0.99); C391(1.05); C396(1.05)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C306(0.88); C221(0.89); C452(0.93); C264(0.95)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C306(0.89); C452(0.98); C300(1.07); C303(1.07)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C306(0.89); C452(0.94); C221(0.98); C300(0.98)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C221(0.88); C391(0.98); C396(0.98); C306(1.01)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C391(0.82); C396(0.82); C300(0.88); C303(0.88)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C306(0.92); C221(0.97); C300(1.03); C303(1.03)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C306(0.91); C300(0.94); C303(0.94); C221(0.95)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C300(0.98); C303(0.98); C306(1.00); C391(1.07)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C221(0.86); C300(0.87); C303(0.87); C306(1.05)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C391(1.00); C396(1.00); C306(1.01); C221(1.11)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C306(0.97); C221(1.02); C391(1.05); C396(1.05)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C221(0.82); C306(0.96); C452(1.04); C300(1.04)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C221(0.92); C391(1.06); C396(1.06); C452(1.13)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C300(0.73); C303(0.73); C221(0.85); C391(0.86)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C300(0.93); C303(0.93); C306(0.97); C391(1.08)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C391(0.72); C396(0.72); C300(0.83); C303(0.83)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C221(0.84); C300(0.99); C303(0.99); C306(1.04)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C391(1.01); C396(1.01); C221(1.02); C452(1.10)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C221(0.78); C306(1.01); C391(1.02); C396(1.02)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C221(0.91); C300(1.04); C303(1.04); C306(1.04)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C221(0.93); C306(1.02); C391(1.05); C396(1.05)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C221(0.94); C300(1.02); C303(1.02); C391(1.08)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C221(0.87); C300(0.96); C303(0.96); C306(1.05)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C221(0.57); C391(0.89); C396(0.89); C264(0.98)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C221(0.64); C391(0.84); C396(0.84); C306(1.03)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C221(0.69); C391(1.03); C396(1.03); C264(1.09)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C300(0.81); C303(0.81); C264(0.93); C267(0.93)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C221(0.50); C391(0.82); C396(0.82); C264(0.83)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C221(0.42); C391(0.77); C396(0.77); C264(1.02)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C221(0.59); C264(0.86); C267(0.86); C300(1.06)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C221(0.46); C264(0.88); C267(0.88); C391(0.89)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C221(0.57); C264(0.87); C267(0.87); C391(0.94)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C221(0.66); C264(1.00); C267(1.00); C391(1.00)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C221(0.63); C391(0.93); C396(0.93); C264(0.95)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C221(0.39); C264(0.78); C267(0.78); C391(0.91)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C221(0.87); C391(0.89); C396(0.89); C300(0.96)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C221(0.79); C391(0.79); C396(0.79); C306(1.03)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C391(0.91); C396(0.91); C300(0.94); C303(0.94)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C221(0.78); C391(0.91); C396(0.91); C300(0.96)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C391(0.66); C396(0.66); C221(0.86); C300(0.99)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C391(0.85); C396(0.85); C221(0.91); C300(0.94)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C221(0.75); C391(0.94); C396(0.94); C300(0.96)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C391(0.68); C396(0.68); C221(0.76); C300(0.99)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C221(0.75); C300(0.93); C303(0.93); C391(1.03)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C391(0.85); C396(0.85); C221(0.91); C306(1.08)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C221(0.82); C306(0.91); C300(0.92); C303(0.92)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C221(0.75); C264(0.97); C267(0.97); C391(0.98)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C221(0.87); C300(0.94); C303(0.94); C391(1.04)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C300(0.79); C303(0.79); C264(0.85); C267(0.85)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C221(0.84); C391(0.87); C396(0.87); C306(0.99)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C221(0.71); C391(0.87); C396(0.87); C452(0.98)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C221(0.80); C391(0.89); C396(0.89); C300(1.07)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C221(0.30); C264(0.85); C267(0.85); C306(0.86)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C221(0.30); C300(0.81); C303(0.81); C264(0.84)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C221(0.39); C264(0.83); C267(0.83); C452(0.91)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C221(0.34); C264(0.82); C267(0.82); C306(0.94)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C221(0.34); C264(0.93); C267(0.93); C452(0.98)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C221(0.34); C452(0.97); C300(1.01); C303(1.01)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C221(0.32); C264(0.80); C267(0.80); C300(0.92)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C264(0.83); C267(0.83); C221(0.87); C300(1.00)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C221(0.40); C264(0.85); C267(0.85); C300(1.00)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C221(0.42); C264(0.87); C267(0.87); C306(1.00)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C221(0.56); C264(0.76); C267(0.76); C452(0.80)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C221(0.52); C452(0.81); C306(1.05); C264(1.06)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C221(0.26); C300(0.93); C303(0.93); C452(1.03)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C221(0.55); C264(0.81); C267(0.81); C306(1.09)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C221(0.29); C264(0.76); C267(0.76); C300(0.92)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C221(0.61); C300(0.72); C303(0.72); C264(0.79)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C221(0.65); C300(0.78); C303(0.78); C452(0.80)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C221(1.34); C264(1.04); C267(1.04); C300(0.95)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C264(0.89); C267(0.89); C221(0.94); C300(0.97)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C300(0.79); C303(0.79); C221(0.93); C264(0.96)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 9.40  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C391(1.13); C396(1.13); C264(0.98); C267(0.98)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C473(0.47)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0632  CL-Sc Hep-G2 C110(20.00); C47(1.24)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C300(0.84); C303(0.84); C264(0.94); C267(0.94)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C221(0.58); C300(0.97); C303(0.97); C264(0.98)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C300(0.76); C303(0.76); C264(0.87); C267(0.87)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C264(0.84); C267(0.84); C300(0.95); C303(0.95)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C264(0.88); C267(0.88); C300(0.88); C303(0.88)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C306(1.03); C264(1.04); C267(1.04); C452(1.06)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C300(0.79); C303(0.79); C452(1.05); C264(1.05)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C452(0.82); C300(0.82); C303(0.82); C221(0.97)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C300(0.72); C303(0.72); C221(0.77); C264(0.89)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C300(0.85); C303(0.85); C452(1.00); C391(1.03)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C300(0.82); C303(0.82); C452(1.06); C391(1.13)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C221(0.78); C300(0.81); C303(0.81); C264(0.90)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C221(0.64); C300(0.95); C303(0.95); C264(1.01)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C452(0.89); C300(0.96); C303(0.96); C221(1.02)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C452(0.78); C300(0.83); C303(0.83); C264(0.86)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C306(0.85); C452(0.89); C47(0.90); C221(0.98)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C264(0.86); C267(0.86); C306(0.89); C300(0.93)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C306(0.75); C264(0.75); C267(0.75); C221(0.75)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C264(0.79); C267(0.79); C306(0.82); C221(0.87)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C306(0.81); C264(0.83); C267(0.83); C300(0.88)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C300(0.86); C303(0.86); C221(0.90); C306(0.91)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C300(0.91); C303(0.91); C221(0.99); C452(1.03)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C452(0.97); C221(1.00); C264(1.07); C267(1.07)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C221(0.90); C264(0.96); C267(0.96); C300(1.06)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C306(0.91); C300(0.94); C303(0.94); C264(0.96)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C452(0.75); C221(0.84); C306(0.89); C391(1.98)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C221(0.72); C300(0.79); C303(0.79); C391(0.81)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C300(0.84); C303(0.84); C221(0.86); C452(1.15)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C221(0.75); C300(0.95); C303(0.95); C306(1.04)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C221(0.79); C264(0.80); C267(0.80); C452(0.95)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C221(0.78); C391(0.90); C396(0.90); C264(0.90)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C221(0.61); C264(0.96); C267(0.96); C306(1.05)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C221(0.72); C264(1.07); C267(1.07); C300(1.07)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C391(0.70); C396(0.70); C221(0.72); C306(0.98)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C221(0.88); C264(0.97); C267(0.97); C306(1.01)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C221(0.63); C264(0.89); C267(0.89); C306(0.99)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C264(0.79); C267(0.79); C300(0.81); C303(0.89)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C221(0.84); C300(0.84); C306(0.91); C264(1.16)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C300(0.73); C221(0.75); C391(0.79); C396(0.79)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C221(0.83); C391(0.91); C396(0.91); C306(0.94)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C264(0.81); C267(0.81); C306(0.97); C300(1.08)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C221(0.91); C300(1.00); C391(1.12); C396(1.12)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C300(0.87); C221(0.93); C306(1.02); C391(1.16)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C221(0.91); C300(1.01); C264(1.11); C267(1.11)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C300(0.64); C303(0.70); C391(1.06); C396(1.06)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C300(0.92); C221(1.00); C391(1.05); C396(1.05)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C221(0.76); C264(0.93); C267(0.93); C300(0.87)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C221(1.17); C264(1.02); C267(1.02); C300(0.83)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C221(0.98); C264(1.11); C267(1.11); C300(0.95)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C221(0.88); C264(1.06); C267(1.06); C300(0.93)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C221(0.79); C264(1.11); C267(1.11); C300(1.06)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C221(0.69); C264(0.89); C267(0.89); C300(0.97)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C221(1.10); C264(0.96); C267(0.96); C300(1.12)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C221(1.32); C300(0.78); C303(0.78); C306(0.99)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C221(0.47); C264(0.71); C267(0.71); C300(0.54)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C221(0.54); C264(0.97); C267(0.97); C300(0.56)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C221(0.67); C264(0.85); C267(0.85); C300(0.77)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C221(0.81); C264(0.89); C267(0.89); C300(0.75)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C221(0.65); C264(0.88); C267(0.88); C300(0.84)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C221(0.67); C264(1.08); C267(1.08); C300(0.83)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C221(0.88); C264(1.22); C267(1.22); C300(0.70)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C221(0.81); C264(0.94); C267(0.94); C300(0.94)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C221(0.71); C264(0.90); C267(0.90); C300(0.71)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C221(1.03); C264(0.66); C267(0.66); C300(0.85)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C221(0.57); C264(1.10); C267(1.10); C300(0.72)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C221(0.79); C264(1.00); C267(1.00); C300(0.68)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C221(0.54); C264(1.21); C267(1.21); C300(0.59)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C221(0.56); C264(1.05); C267(1.05); C300(0.57)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C221(1.00); C264(0.98); C267(0.98); C300(1.14)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C221(0.89); C264(0.98); C267(0.98); C300(1.16)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C221(1.44); C264(0.93); C267(0.93); C300(1.16)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C221(1.16); C264(1.15); C267(1.15); C300(1.30)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C221(0.75); C264(1.07); C267(1.07); C300(0.94)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C221(1.08); C264(0.91); C267(0.91); C300(1.12)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C221(1.04); C264(1.05); C267(1.05); C300(1.18)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C221(1.19); C264(1.05); C267(1.05); C300(1.23)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C221(1.08); C264(1.10); C267(1.10); C300(0.93)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C221(1.02); C264(0.98); C267(0.98); C300(1.00)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C221(1.18); C264(1.04); C267(1.04); C300(1.04)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C221(0.90); C264(0.96); C267(0.96); C300(1.07)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C221(0.77); C264(1.04); C267(1.04); C300(1.15)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C221(1.14); C264(0.92); C267(0.92); C300(1.23)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C221(0.99); C264(1.20); C267(1.20); C300(1.21)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C221(0.60); C264(1.13); C267(1.13); C300(0.97)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C221(0.96); C264(0.97); C267(0.97); C300(1.31)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C221(0.89); C306(0.94); C391(1.13); C396(1.13)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C221(0.94); C306(0.82); C391(0.98); C396(0.98)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C221(0.89); C306(1.03); C391(1.04); C396(1.04)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C221(1.07); C306(0.97); C391(1.08); C396(1.08)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C221(1.12); C306(0.96); C391(0.91); C396(0.91)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C221(1.13); C306(0.99); C391(0.92); C396(0.92)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C221(1.26); C306(0.89); C391(0.92); C396(0.92)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C221(1.39); C306(0.82); C391(0.93); C396(0.93)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C221(0.92); C306(0.78); C391(1.03); C396(1.03)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C221(0.66); C264(1.28); C267(1.28); C300(1.25)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C221(1.06); C306(0.80); C391(0.96); C396(0.96)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C221(0.99); C306(0.84); C391(1.03); C396(1.03)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C221(0.93); C306(0.83); C391(1.05); C396(1.05)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C221(1.31); C306(0.83); C391(1.08); C396(1.08)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C221(1.15); C306(0.89); C391(1.05); C396(1.05)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C221(0.85); C264(1.26); C267(1.26); C300(0.83)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C221(1.20); C264(1.15); C267(1.15); C300(1.45)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C221(0.84); C264(1.06); C267(1.06); C300(1.01)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C221(0.79); C264(1.10); C267(1.10); C300(0.95)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C221(0.87); C264(0.81); C267(0.81); C300(0.79)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C221(0.79); C264(1.07); C267(1.07); C300(0.87)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C221(0.90); C264(0.98); C267(0.98); C300(1.59)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C221(0.74); C264(1.31); C267(1.31); C300(1.14)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C221(0.85); C264(1.30); C267(1.30); C300(0.57)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C221(0.75); C264(1.06); C267(1.06); C300(0.68)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C221(0.86); C264(1.12); C267(1.12); C300(0.64)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C221(0.90); C264(1.28); C267(1.28); C300(0.71)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C221(0.81); C264(1.45); C267(1.45); C300(0.97)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C221(0.86); C264(1.36); C267(1.36); C300(0.89)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C221(0.69); C264(1.22); C267(1.22); C300(0.89)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C221(1.03); C264(0.88); C267(0.88); C300(1.11)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C221(0.85); C264(1.23); C267(1.23); C300(0.77)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C221(0.86); C264(1.07); C267(1.07); C300(0.87)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C221(0.98); C264(0.95); C267(0.95); C300(0.78)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C221(0.92); C264(1.22); C267(1.22); C300(0.95)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C221(0.78); C264(0.96); C267(0.96); C300(0.74)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C221(0.80); C264(0.90); C267(0.90); C300(0.76)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C221(0.77); C264(1.02); C267(1.02); C300(0.91)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C221(0.83); C264(1.02); C267(1.02); C300(0.84)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C221(0.71); C264(0.91); C267(0.91); C300(0.79)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C221(0.81); C264(0.87); C267(0.87); C300(0.80)  LDD0811  [8]
 LDCM0027  Dopamine HEK-293T 4.02  LDD0179  [4]
 LDCM0495  E2913 HEK-293T C110(1.08); C306(1.06); C47(0.93); C452(1.09)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C47(1.42)  LDD1702  [3]
 LDCM0625  F8 Ramos C47(0.59)  LDD2187  [18]
 LDCM0573  Fragment11 Ramos C47(0.95); C110(20.00)  LDD2190  [18]
 LDCM0576  Fragment14 Ramos C47(0.53); C110(0.83)  LDD2193  [18]
 LDCM0586  Fragment28 Ramos C110(0.75)  LDD2198  [18]
 LDCM0468  Fragment33 HCT 116 C221(0.93); C306(0.98); C391(0.94); C396(0.94)  LDD0785  [8]
 LDCM0566  Fragment4 Ramos C47(0.94); C110(1.19)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C221(0.68); C264(1.16); C267(1.16); C300(0.81)  LDD0744  [8]
 LDCM0569  Fragment7 Ramos C47(1.07); C110(0.96)  LDD2186  [18]
 LDCM0022  KB02 HCT 116 C391(6.15); C396(6.15); C264(1.45); C267(1.45)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C391(4.37); C396(4.37); C264(2.05); C267(2.05)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C391(3.08); C396(3.08); C264(1.59); C267(1.59)  LDD0082  [8]
 LDCM0099  Phenelzine HEK-293T 11.00  LDD0390  [2]
 LDCM0021  THZ1 HCT 116 C391(0.97); C396(0.97)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GTPase HRas (HRAS) Ras family P01112
BRCA1-associated protein (BRAP) . Q7Z569
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 3 (AKAP3) AKAP110 family O75969
Splicing factor YJU2 (YJU2) CWC16 family Q9BW85

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578