Details of the Target

General Information of Target

Target ID LDTP06487
Target Name Syntaxin-binding protein 2 (STXBP2)
Gene Name STXBP2
Gene ID 6813
Synonyms
UNC18B; Syntaxin-binding protein 2; Protein unc-18 homolog 2; Unc18-2; Protein unc-18 homolog B; Unc-18B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED
INKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR
SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLC
ATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPV
SPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVS
KKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGS
VEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEE
NLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIK
DVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMG
GVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP
Target Bioclass
Other
Family
STXBP/unc-18/SEC1 family
Function
Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
Uniprot ID
Q15833
Ensemble ID
ENST00000221283.10
HGNC ID
HGNC:11445

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.A297T DBIA    Probe Info 
HUH7 SNV: p.P67T .
ICC137 SNV: p.R575L .
Ishikawa (Heraklio) 02 ER SNV: p.Y343C .
KU1919 SNV: p.L460M .
KYSE30 SNV: p.S344C .
MCC13 SNV: p.L271P
Substitution: p.Q509Ter		 .
MELHO SNV: p.D492G DBIA    Probe Info 
MFE319 SNV: p.E419G .
MOLT4 SNV: p.L583V IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K13(9.39); K320(7.06); K324(5.51); K331(8.13)  LDD0277  [1]
Probe 1
 Probe Info  		Y99(20.59); Y266(5.93)  LDD3495  [2]
BTD
 Probe Info  		C311(0.57)  LDD2109  [3]
AHL-Pu-1
 Probe Info  		C158(2.47)  LDD0170  [4]
DBIA
 Probe Info  		C45(51.43)  LDD0209  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C110(0.00); C158(0.00); C365(0.00); C180(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C110(0.00); C158(0.00); C44(0.00); C45(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
IPM
 Probe Info  		N.A.  LDD2156  [12]
TFBX
 Probe Info  		N.A.  LDD0148  [13]
Ox-W18
 Probe Info  		N.A.  LDD2175  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
NAIA_5
 Probe Info  		C110(0.00); C158(0.00); C353(0.00); C365(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C173
 Probe Info  		6.02  LDD1853  [16]
FFF probe11
 Probe Info  		8.54  LDD0472  [17]
FFF probe3
 Probe Info  		6.23  LDD0465  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C311(1.35)  LDD2117  [3]
 LDCM0025  4SU-RNA DM93 C158(2.47)  LDD0170  [4]
 LDCM0214  AC1 HCT 116 C110(0.79); C44(1.16); C45(1.16)  LDD0531  [18]
 LDCM0215  AC10 HCT 116 C110(0.76); C44(0.98); C45(0.98)  LDD0532  [18]
 LDCM0216  AC100 HCT 116 C110(1.32); C44(1.34); C45(1.34)  LDD0533  [18]
 LDCM0217  AC101 HCT 116 C110(1.32); C44(0.88); C45(0.88)  LDD0534  [18]
 LDCM0218  AC102 HCT 116 C110(1.09); C44(1.04); C45(1.04)  LDD0535  [18]
 LDCM0219  AC103 HCT 116 C110(1.03); C44(1.12); C45(1.12)  LDD0536  [18]
 LDCM0220  AC104 HCT 116 C110(1.16); C44(1.06); C45(1.06)  LDD0537  [18]
 LDCM0221  AC105 HCT 116 C110(1.06); C44(1.05); C45(1.05)  LDD0538  [18]
 LDCM0222  AC106 HCT 116 C110(1.08); C44(1.19); C45(1.19)  LDD0539  [18]
 LDCM0223  AC107 HCT 116 C110(1.18); C44(1.16); C45(1.16)  LDD0540  [18]
 LDCM0224  AC108 HCT 116 C110(1.17); C44(1.13); C45(1.13)  LDD0541  [18]
 LDCM0225  AC109 HCT 116 C110(1.02); C44(1.08); C45(1.08)  LDD0542  [18]
 LDCM0226  AC11 HCT 116 C110(0.82); C44(0.94); C45(0.94)  LDD0543  [18]
 LDCM0227  AC110 HCT 116 C110(1.01); C44(1.11); C45(1.11)  LDD0544  [18]
 LDCM0228  AC111 HCT 116 C110(1.01); C44(1.00); C45(1.00)  LDD0545  [18]
 LDCM0229  AC112 HCT 116 C110(1.16); C44(0.98); C45(0.98)  LDD0546  [18]
 LDCM0230  AC113 HCT 116 C44(1.03); C45(1.03)  LDD0547  [18]
 LDCM0231  AC114 HCT 116 C44(0.90); C45(1.03)  LDD0548  [18]
 LDCM0232  AC115 HCT 116 C44(1.10); C45(1.04)  LDD0549  [18]
 LDCM0233  AC116 HCT 116 C44(0.94); C45(0.98)  LDD0550  [18]
 LDCM0234  AC117 HCT 116 C44(0.91); C45(0.84)  LDD0551  [18]
 LDCM0235  AC118 HCT 116 C44(1.02); C45(0.95)  LDD0552  [18]
 LDCM0236  AC119 HCT 116 C44(1.17); C45(0.95)  LDD0553  [18]
 LDCM0237  AC12 HCT 116 C110(0.90); C44(1.04); C45(1.04)  LDD0554  [18]
 LDCM0238  AC120 HCT 116 C44(0.86); C45(1.03)  LDD0555  [18]
 LDCM0239  AC121 HCT 116 C44(0.87); C45(0.90)  LDD0556  [18]
 LDCM0240  AC122 HCT 116 C44(0.94); C45(1.04)  LDD0557  [18]
 LDCM0241  AC123 HCT 116 C44(0.81); C45(0.77)  LDD0558  [18]
 LDCM0242  AC124 HCT 116 C44(1.07); C45(0.92)  LDD0559  [18]
 LDCM0243  AC125 HCT 116 C44(1.06); C45(1.02)  LDD0560  [18]
 LDCM0244  AC126 HCT 116 C44(1.07); C45(1.01)  LDD0561  [18]
 LDCM0245  AC127 HCT 116 C44(0.90); C45(0.90)  LDD0562  [18]
 LDCM0246  AC128 HCT 116 C365(0.51)  LDD0563  [18]
 LDCM0247  AC129 HCT 116 C365(1.07)  LDD0564  [18]
 LDCM0249  AC130 HCT 116 C365(0.70)  LDD0566  [18]
 LDCM0250  AC131 HCT 116 C365(0.65)  LDD0567  [18]
 LDCM0251  AC132 HCT 116 C365(0.82)  LDD0568  [18]
 LDCM0252  AC133 HCT 116 C365(0.61)  LDD0569  [18]
 LDCM0253  AC134 HCT 116 C365(0.53)  LDD0570  [18]
 LDCM0254  AC135 HCT 116 C365(0.69)  LDD0571  [18]
 LDCM0255  AC136 HCT 116 C365(0.57)  LDD0572  [18]
 LDCM0256  AC137 HCT 116 C365(0.56)  LDD0573  [18]
 LDCM0257  AC138 HCT 116 C365(0.65)  LDD0574  [18]
 LDCM0258  AC139 HCT 116 C365(0.66)  LDD0575  [18]
 LDCM0259  AC14 HCT 116 C110(0.87); C44(0.79); C45(0.79)  LDD0576  [18]
 LDCM0260  AC140 HCT 116 C365(0.63)  LDD0577  [18]
 LDCM0261  AC141 HCT 116 C365(1.07)  LDD0578  [18]
 LDCM0262  AC142 HCT 116 C365(0.68)  LDD0579  [18]
 LDCM0263  AC143 HCT 116 C44(0.67); C45(0.67)  LDD0580  [18]
 LDCM0264  AC144 HCT 116 C45(0.77); C44(1.13)  LDD0581  [18]
 LDCM0265  AC145 HCT 116 C45(0.75); C44(0.88)  LDD0582  [18]
 LDCM0266  AC146 HCT 116 C44(0.63); C45(0.76)  LDD0583  [18]
 LDCM0267  AC147 HCT 116 C45(0.92); C44(0.97)  LDD0584  [18]
 LDCM0268  AC148 HCT 116 C45(0.54); C44(0.76)  LDD0585  [18]
 LDCM0269  AC149 HCT 116 C45(0.72); C44(0.90)  LDD0586  [18]
 LDCM0270  AC15 HCT 116 C110(0.77); C44(0.86); C45(0.86)  LDD0587  [18]
 LDCM0271  AC150 HCT 116 C45(0.71); C44(0.89)  LDD0588  [18]
 LDCM0272  AC151 HCT 116 C45(0.72); C44(0.92)  LDD0589  [18]
 LDCM0273  AC152 HCT 116 C45(0.68); C44(0.78)  LDD0590  [18]
 LDCM0274  AC153 HCT 116 C44(0.49); C45(0.56)  LDD0591  [18]
 LDCM0621  AC154 HCT 116 C44(0.89); C45(0.73)  LDD2158  [18]
 LDCM0622  AC155 HCT 116 C44(0.71); C45(0.64)  LDD2159  [18]
 LDCM0623  AC156 HCT 116 C44(0.77); C45(0.78)  LDD2160  [18]
 LDCM0624  AC157 HCT 116 C44(0.64); C45(0.64)  LDD2161  [18]
 LDCM0276  AC17 HCT 116 C110(0.94); C365(1.02); C44(1.40); C45(1.54)  LDD0593  [18]
 LDCM0277  AC18 HCT 116 C110(0.34); C45(1.13); C365(1.16); C44(1.27)  LDD0594  [18]
 LDCM0278  AC19 HCT 116 C110(0.87); C45(1.03); C44(1.19); C365(1.32)  LDD0595  [18]
 LDCM0279  AC2 HCT 116 C110(0.93); C44(1.07); C45(1.07)  LDD0596  [18]
 LDCM0280  AC20 HCT 116 C365(1.09); C110(1.24); C44(1.48); C45(1.78)  LDD0597  [18]
 LDCM0281  AC21 HCT 116 C110(0.57); C365(1.08); C44(1.35); C45(1.56)  LDD0598  [18]
 LDCM0282  AC22 HCT 116 C110(0.70); C365(0.98); C44(1.35); C45(1.57)  LDD0599  [18]
 LDCM0283  AC23 HCT 116 C365(1.10); C110(1.13); C45(1.49); C44(1.52)  LDD0600  [18]
 LDCM0284  AC24 HCT 116 C110(1.04); C365(1.05); C44(1.56); C45(1.69)  LDD0601  [18]
 LDCM0285  AC25 HCT 116 C110(0.82); C44(1.32); C45(1.32)  LDD0602  [18]
 LDCM0286  AC26 HCT 116 C110(0.87); C44(1.21); C45(1.21)  LDD0603  [18]
 LDCM0287  AC27 HCT 116 C110(0.74); C44(0.97); C45(0.97)  LDD0604  [18]
 LDCM0288  AC28 HCT 116 C110(0.81); C44(1.08); C45(1.08)  LDD0605  [18]
 LDCM0289  AC29 HCT 116 C44(0.95); C45(0.95); C110(1.09)  LDD0606  [18]
 LDCM0290  AC3 HCT 116 C110(0.93); C44(1.07); C45(1.07)  LDD0607  [18]
 LDCM0291  AC30 HCT 116 C110(0.81); C44(0.94); C45(0.94)  LDD0608  [18]
 LDCM0292  AC31 HCT 116 C110(0.71); C44(1.01); C45(1.01)  LDD0609  [18]
 LDCM0293  AC32 HCT 116 C110(0.67); C44(1.00); C45(1.00)  LDD0610  [18]
 LDCM0294  AC33 HCT 116 C110(0.73); C44(0.97); C45(0.97)  LDD0611  [18]
 LDCM0295  AC34 HCT 116 C110(0.80); C44(1.02); C45(1.02)  LDD0612  [18]
 LDCM0296  AC35 HCT 116 C365(1.01); C110(1.13); C45(1.30); C44(1.30)  LDD0613  [18]
 LDCM0297  AC36 HCT 116 C365(1.08); C110(1.15); C44(1.23); C45(1.23)  LDD0614  [18]
 LDCM0298  AC37 HCT 116 C365(1.01); C45(1.08); C44(1.10); C110(1.36)  LDD0615  [18]
 LDCM0299  AC38 HCT 116 C45(1.02); C44(1.04); C365(1.10); C110(1.29)  LDD0616  [18]
 LDCM0300  AC39 HCT 116 C110(0.91); C365(1.02); C45(1.09); C44(1.11)  LDD0617  [18]
 LDCM0301  AC4 HCT 116 C110(0.81); C44(1.14); C45(1.14)  LDD0618  [18]
 LDCM0302  AC40 HCT 116 C110(0.85); C365(0.89); C45(0.98); C44(1.00)  LDD0619  [18]
 LDCM0303  AC41 HCT 116 C110(0.86); C45(0.98); C44(1.00); C365(1.04)  LDD0620  [18]
 LDCM0304  AC42 HCT 116 C45(1.04); C44(1.05); C365(1.09); C110(1.33)  LDD0621  [18]
 LDCM0305  AC43 HCT 116 C44(0.94); C45(0.95); C365(1.01); C110(1.12)  LDD0622  [18]
 LDCM0306  AC44 HCT 116 C110(0.86); C45(0.98); C44(1.01); C365(1.08)  LDD0623  [18]
 LDCM0307  AC45 HCT 116 C110(0.66); C365(0.91); C45(0.91); C44(0.94)  LDD0624  [18]
 LDCM0308  AC46 HCT 116 C110(0.80); C44(0.83); C45(0.83); C365(0.93)  LDD0625  [18]
 LDCM0309  AC47 HCT 116 C44(0.84); C45(0.84); C365(0.97); C110(1.00)  LDD0626  [18]
 LDCM0310  AC48 HCT 116 C110(0.70); C44(0.83); C45(0.83); C365(0.88)  LDD0627  [18]
 LDCM0311  AC49 HCT 116 C365(0.69); C44(0.70); C45(0.70); C110(0.74)  LDD0628  [18]
 LDCM0312  AC5 HCT 116 C110(0.79); C44(1.16); C45(1.16)  LDD0629  [18]
 LDCM0313  AC50 HCT 116 C110(0.67); C365(0.72); C44(0.86); C45(0.86)  LDD0630  [18]
 LDCM0314  AC51 HCT 116 C44(0.78); C45(0.78); C110(1.21); C365(1.81)  LDD0631  [18]
 LDCM0315  AC52 HCT 116 C110(0.74); C44(0.81); C45(0.81); C365(0.96)  LDD0632  [18]
 LDCM0316  AC53 HCT 116 C365(0.79); C110(0.87); C44(1.04); C45(1.04)  LDD0633  [18]
 LDCM0317  AC54 HCT 116 C110(0.69); C365(0.76); C44(0.84); C45(0.84)  LDD0634  [18]
 LDCM0318  AC55 HCT 116 C110(0.61); C365(0.70); C44(1.28); C45(1.28)  LDD0635  [18]
 LDCM0319  AC56 HCT 116 C110(0.70); C365(0.83); C44(0.85); C45(0.85)  LDD0636  [18]
 LDCM0320  AC57 HCT 116 C365(0.61); C44(1.12); C45(1.12)  LDD0637  [18]
 LDCM0321  AC58 HCT 116 C365(0.54); C44(1.15); C45(1.15)  LDD0638  [18]
 LDCM0322  AC59 HCT 116 C365(0.51); C44(1.05); C45(1.05)  LDD0639  [18]
 LDCM0323  AC6 HCT 116 C44(0.77); C45(0.77); C110(0.77)  LDD0640  [18]
 LDCM0324  AC60 HCT 116 C365(0.53); C44(0.93); C45(0.93)  LDD0641  [18]
 LDCM0325  AC61 HCT 116 C365(0.53); C44(1.02); C45(1.02)  LDD0642  [18]
 LDCM0326  AC62 HCT 116 C365(0.59); C44(1.06); C45(1.06)  LDD0643  [18]
 LDCM0327  AC63 HCT 116 C365(0.49); C44(1.20); C45(1.20)  LDD0644  [18]
 LDCM0328  AC64 HCT 116 C365(0.59); C44(1.22); C45(1.22)  LDD0645  [18]
 LDCM0329  AC65 HCT 116 C365(0.69); C44(0.93); C45(0.93)  LDD0646  [18]
 LDCM0330  AC66 HCT 116 C365(0.71); C44(1.06); C45(1.06)  LDD0647  [18]
 LDCM0331  AC67 HCT 116 C365(0.53); C44(0.98); C45(0.98)  LDD0648  [18]
 LDCM0332  AC68 HCT 116 C110(0.58); C365(0.81); C45(0.93); C44(1.12)  LDD0649  [18]
 LDCM0333  AC69 HCT 116 C365(0.62); C110(0.82); C45(1.03); C44(1.26)  LDD0650  [18]
 LDCM0334  AC7 HCT 116 C110(0.83); C44(0.91); C45(0.91)  LDD0651  [18]
 LDCM0335  AC70 HCT 116 C110(0.62); C365(0.88); C45(1.04); C44(1.29)  LDD0652  [18]
 LDCM0336  AC71 HCT 116 C110(0.78); C365(0.80); C45(1.08); C44(1.26)  LDD0653  [18]
 LDCM0337  AC72 HCT 116 C110(0.55); C365(0.73); C45(1.00); C44(1.19)  LDD0654  [18]
 LDCM0338  AC73 HCT 116 C110(0.64); C365(0.85); C45(0.95); C44(1.08)  LDD0655  [18]
 LDCM0339  AC74 HCT 116 C110(0.81); C45(1.04); C365(1.14); C44(1.23)  LDD0656  [18]
 LDCM0340  AC75 HCT 116 C365(0.74); C110(0.76); C45(0.94); C44(1.07)  LDD0657  [18]
 LDCM0341  AC76 HCT 116 C110(0.51); C365(0.87); C45(1.07); C44(1.41)  LDD0658  [18]
 LDCM0342  AC77 HCT 116 C110(0.52); C45(0.94); C365(1.01); C44(1.09)  LDD0659  [18]
 LDCM0343  AC78 HCT 116 C365(0.61); C110(0.72); C45(0.92); C44(1.13)  LDD0660  [18]
 LDCM0344  AC79 HCT 116 C365(0.62); C110(0.76); C45(0.95); C44(1.10)  LDD0661  [18]
 LDCM0345  AC8 HCT 116 C110(0.75); C44(0.90); C45(0.90)  LDD0662  [18]
 LDCM0346  AC80 HCT 116 C365(0.58); C110(0.68); C44(0.97); C45(0.97)  LDD0663  [18]
 LDCM0347  AC81 HCT 116 C110(0.88); C365(1.08); C45(1.09); C44(1.47)  LDD0664  [18]
 LDCM0348  AC82 HCT 116 C365(0.69); C110(0.86); C45(1.03); C44(1.12)  LDD0665  [18]
 LDCM0349  AC83 HCT 116 C365(0.62); C44(0.78); C45(0.78)  LDD0666  [18]
 LDCM0350  AC84 HCT 116 C365(0.63); C44(0.81); C45(0.81)  LDD0667  [18]
 LDCM0351  AC85 HCT 116 C365(0.62); C44(0.91); C45(0.91)  LDD0668  [18]
 LDCM0352  AC86 HCT 116 C365(0.95); C44(0.99); C45(0.99)  LDD0669  [18]
 LDCM0353  AC87 HCT 116 C365(0.88); C44(1.03); C45(1.03)  LDD0670  [18]
 LDCM0354  AC88 HCT 116 C365(0.81); C44(1.09); C45(1.09)  LDD0671  [18]
 LDCM0355  AC89 HCT 116 C365(0.70); C44(0.89); C45(0.89)  LDD0672  [18]
 LDCM0357  AC90 HCT 116 C44(1.24); C45(1.24); C365(1.38)  LDD0674  [18]
 LDCM0358  AC91 HCT 116 C365(0.61); C44(0.82); C45(0.82)  LDD0675  [18]
 LDCM0359  AC92 HCT 116 C365(0.65); C44(0.85); C45(0.85)  LDD0676  [18]
 LDCM0360  AC93 HCT 116 C365(0.77); C44(0.96); C45(0.96)  LDD0677  [18]
 LDCM0361  AC94 HCT 116 C365(0.73); C44(1.13); C45(1.13)  LDD0678  [18]
 LDCM0362  AC95 HCT 116 C365(0.70); C44(0.84); C45(0.84)  LDD0679  [18]
 LDCM0363  AC96 HCT 116 C365(0.68); C44(0.99); C45(0.99)  LDD0680  [18]
 LDCM0364  AC97 HCT 116 C365(0.63); C44(0.79); C45(0.79)  LDD0681  [18]
 LDCM0365  AC98 HCT 116 C44(0.94); C45(0.94); C110(0.94)  LDD0682  [18]
 LDCM0366  AC99 HCT 116 C110(0.99); C44(1.12); C45(1.12)  LDD0683  [18]
 LDCM0248  AKOS034007472 HCT 116 C110(0.88); C44(0.93); C45(0.93)  LDD0565  [18]
 LDCM0356  AKOS034007680 HCT 116 C110(0.81); C44(0.87); C45(0.87)  LDD0673  [18]
 LDCM0275  AKOS034007705 HCT 116 C110(0.70); C44(0.96); C45(0.96)  LDD0592  [18]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C110(4.95)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C44(0.93); C45(0.93); C365(1.27)  LDD0684  [18]
 LDCM0368  CL10 HCT 116 C44(1.11); C45(1.11); C365(1.24)  LDD0685  [18]
 LDCM0369  CL100 HCT 116 C110(0.80); C44(1.09); C45(1.09)  LDD0686  [18]
 LDCM0370  CL101 HCT 116 C110(0.77); C44(0.86); C45(0.86)  LDD0687  [18]
 LDCM0371  CL102 HCT 116 C44(0.90); C45(0.90); C110(0.95)  LDD0688  [18]
 LDCM0372  CL103 HCT 116 C110(0.85); C44(0.95); C45(0.95)  LDD0689  [18]
 LDCM0373  CL104 HCT 116 C110(0.82); C44(0.86); C45(0.86)  LDD0690  [18]
 LDCM0374  CL105 HCT 116 C110(0.72); C365(1.03); C44(1.33); C45(1.48)  LDD0691  [18]
 LDCM0375  CL106 HCT 116 C110(0.58); C365(1.20); C45(1.40); C44(1.42)  LDD0692  [18]
 LDCM0376  CL107 HCT 116 C110(0.73); C365(1.10); C44(1.20); C45(1.22)  LDD0693  [18]
 LDCM0377  CL108 HCT 116 C110(0.73); C365(1.21); C44(1.42); C45(1.45)  LDD0694  [18]
 LDCM0378  CL109 HCT 116 C110(0.97); C45(1.04); C365(1.08); C44(1.20)  LDD0695  [18]
 LDCM0379  CL11 HCT 116 C365(1.14); C44(1.30); C45(1.30)  LDD0696  [18]
 LDCM0380  CL110 HCT 116 C110(0.84); C365(1.04); C45(1.62); C44(1.63)  LDD0697  [18]
 LDCM0381  CL111 HCT 116 C110(0.81); C45(1.01); C365(1.16); C44(1.23)  LDD0698  [18]
 LDCM0382  CL112 HCT 116 C110(0.82); C44(1.06); C45(1.06)  LDD0699  [18]
 LDCM0383  CL113 HCT 116 C110(0.77); C44(0.96); C45(0.96)  LDD0700  [18]
 LDCM0384  CL114 HCT 116 C110(0.78); C44(0.93); C45(0.93)  LDD0701  [18]
 LDCM0385  CL115 HCT 116 C110(0.88); C44(0.91); C45(0.91)  LDD0702  [18]
 LDCM0386  CL116 HCT 116 C110(0.93); C44(0.97); C45(0.97)  LDD0703  [18]
 LDCM0387  CL117 HCT 116 C110(0.73); C365(0.83); C45(1.03); C44(1.05)  LDD0704  [18]
 LDCM0388  CL118 HCT 116 C110(0.75); C45(0.94); C44(0.96); C365(1.11)  LDD0705  [18]
 LDCM0389  CL119 HCT 116 C110(0.74); C365(0.91); C45(0.95); C44(0.95)  LDD0706  [18]
 LDCM0390  CL12 HCT 116 C44(1.13); C45(1.13); C365(1.38)  LDD0707  [18]
 LDCM0391  CL120 HCT 116 C110(0.78); C365(1.05); C44(1.07); C45(1.07)  LDD0708  [18]
 LDCM0392  CL121 HCT 116 C365(0.74); C110(0.90); C44(0.92); C45(0.92)  LDD0709  [18]
 LDCM0393  CL122 HCT 116 C44(0.78); C45(0.78); C365(0.85); C110(1.08)  LDD0710  [18]
 LDCM0394  CL123 HCT 116 C110(0.64); C365(0.78); C44(0.87); C45(0.87)  LDD0711  [18]
 LDCM0395  CL124 HCT 116 C110(0.57); C365(0.74); C44(0.76); C45(0.76)  LDD0712  [18]
 LDCM0396  CL125 HCT 116 C44(0.92); C45(0.92); C365(0.96)  LDD0713  [18]
 LDCM0397  CL126 HCT 116 C365(0.74); C44(0.88); C45(0.88)  LDD0714  [18]
 LDCM0398  CL127 HCT 116 C365(0.81); C44(0.82); C45(0.82)  LDD0715  [18]
 LDCM0399  CL128 HCT 116 C365(0.57); C44(1.01); C45(1.01)  LDD0716  [18]
 LDCM0400  CL13 HCT 116 C44(1.00); C45(1.00); C365(1.52)  LDD0717  [18]
 LDCM0401  CL14 HCT 116 C44(0.97); C45(0.97); C365(1.15)  LDD0718  [18]
 LDCM0402  CL15 HCT 116 C44(0.94); C45(0.94); C365(1.36)  LDD0719  [18]
 LDCM0403  CL16 HCT 116 C44(0.84); C45(0.84)  LDD0720  [18]
 LDCM0404  CL17 HCT 116 C44(0.99); C45(0.99)  LDD0721  [18]
 LDCM0405  CL18 HCT 116 C44(0.88); C45(0.88)  LDD0722  [18]
 LDCM0406  CL19 HCT 116 C44(1.07); C45(1.07)  LDD0723  [18]
 LDCM0407  CL2 HCT 116 C44(0.96); C45(0.96); C365(1.18)  LDD0724  [18]
 LDCM0408  CL20 HCT 116 C44(0.96); C45(0.96)  LDD0725  [18]
 LDCM0409  CL21 HCT 116 C44(1.09); C45(1.09)  LDD0726  [18]
 LDCM0410  CL22 HCT 116 C44(0.75); C45(0.75)  LDD0727  [18]
 LDCM0411  CL23 HCT 116 C44(0.70); C45(0.70)  LDD0728  [18]
 LDCM0412  CL24 HCT 116 C44(0.79); C45(0.79)  LDD0729  [18]
 LDCM0413  CL25 HCT 116 C44(0.61); C45(0.61)  LDD0730  [18]
 LDCM0414  CL26 HCT 116 C44(0.65); C45(0.65)  LDD0731  [18]
 LDCM0415  CL27 HCT 116 C44(0.83); C45(0.83)  LDD0732  [18]
 LDCM0416  CL28 HCT 116 C44(0.69); C45(0.69)  LDD0733  [18]
 LDCM0417  CL29 HCT 116 C44(0.80); C45(0.80)  LDD0734  [18]
 LDCM0418  CL3 HCT 116 C365(1.15); C44(0.98); C45(0.98)  LDD0735  [18]
 LDCM0419  CL30 HCT 116 C44(0.73); C45(0.73)  LDD0736  [18]
 LDCM0420  CL31 HCT 116 C110(0.90); C44(1.27); C45(1.27)  LDD0737  [18]
 LDCM0421  CL32 HCT 116 C110(0.68); C44(0.93); C45(0.93)  LDD0738  [18]
 LDCM0422  CL33 HCT 116 C110(0.58); C44(0.91); C45(0.91)  LDD0739  [18]
 LDCM0423  CL34 HCT 116 C110(0.70); C44(1.01); C45(1.01)  LDD0740  [18]
 LDCM0424  CL35 HCT 116 C110(0.63); C44(0.80); C45(0.80)  LDD0741  [18]
 LDCM0425  CL36 HCT 116 C110(0.58); C44(0.95); C45(0.95)  LDD0742  [18]
 LDCM0426  CL37 HCT 116 C110(0.61); C44(0.98); C45(0.98)  LDD0743  [18]
 LDCM0428  CL39 HCT 116 C110(0.65); C44(1.31); C45(1.31)  LDD0745  [18]
 LDCM0429  CL4 HCT 116 C365(1.23); C44(0.95); C45(0.95)  LDD0746  [18]
 LDCM0430  CL40 HCT 116 C110(0.66); C44(1.07); C45(1.07)  LDD0747  [18]
 LDCM0431  CL41 HCT 116 C110(0.70); C44(0.90); C45(0.90)  LDD0748  [18]
 LDCM0432  CL42 HCT 116 C110(0.66); C44(1.05); C45(1.05)  LDD0749  [18]
 LDCM0433  CL43 HCT 116 C110(0.73); C44(1.07); C45(1.07)  LDD0750  [18]
 LDCM0434  CL44 HCT 116 C110(0.68); C44(0.96); C45(0.96)  LDD0751  [18]
 LDCM0435  CL45 HCT 116 C110(0.66); C44(1.00); C45(1.00)  LDD0752  [18]
 LDCM0436  CL46 HCT 116 C110(0.66); C44(0.92); C45(0.92)  LDD0753  [18]
 LDCM0437  CL47 HCT 116 C110(0.84); C44(1.22); C45(1.22)  LDD0754  [18]
 LDCM0438  CL48 HCT 116 C110(0.78); C44(0.93); C45(0.93)  LDD0755  [18]
 LDCM0439  CL49 HCT 116 C110(0.89); C44(0.84); C45(0.84)  LDD0756  [18]
 LDCM0440  CL5 HCT 116 C365(1.32); C44(0.96); C45(0.96)  LDD0757  [18]
 LDCM0441  CL50 HCT 116 C110(1.21); C44(0.85); C45(0.85)  LDD0758  [18]
 LDCM0442  CL51 HCT 116 C110(0.75); C44(1.07); C45(1.07)  LDD0759  [18]
 LDCM0443  CL52 HCT 116 C110(0.71); C44(0.86); C45(0.86)  LDD0760  [18]
 LDCM0444  CL53 HCT 116 C110(0.72); C44(1.00); C45(1.00)  LDD0761  [18]
 LDCM0445  CL54 HCT 116 C110(0.84); C44(1.06); C45(1.06)  LDD0762  [18]
 LDCM0446  CL55 HCT 116 C110(0.69); C44(1.19); C45(1.19)  LDD0763  [18]
 LDCM0447  CL56 HCT 116 C110(0.83); C44(1.20); C45(1.20)  LDD0764  [18]
 LDCM0448  CL57 HCT 116 C110(0.91); C44(1.03); C45(1.03)  LDD0765  [18]
 LDCM0449  CL58 HCT 116 C110(0.83); C44(0.79); C45(0.79)  LDD0766  [18]
 LDCM0450  CL59 HCT 116 C110(0.87); C44(1.02); C45(1.02)  LDD0767  [18]
 LDCM0451  CL6 HCT 116 C365(1.34); C44(0.93); C45(0.93)  LDD0768  [18]
 LDCM0452  CL60 HCT 116 C110(0.73); C44(0.85); C45(0.85)  LDD0769  [18]
 LDCM0453  CL61 HCT 116 C44(0.84); C45(0.84)  LDD0770  [18]
 LDCM0454  CL62 HCT 116 C44(0.81); C45(0.81)  LDD0771  [18]
 LDCM0455  CL63 HCT 116 C44(0.87); C45(0.87)  LDD0772  [18]
 LDCM0456  CL64 HCT 116 C44(0.86); C45(0.86)  LDD0773  [18]
 LDCM0457  CL65 HCT 116 C44(0.97); C45(0.97)  LDD0774  [18]
 LDCM0458  CL66 HCT 116 C44(0.89); C45(0.89)  LDD0775  [18]
 LDCM0459  CL67 HCT 116 C44(1.00); C45(1.00)  LDD0776  [18]
 LDCM0460  CL68 HCT 116 C44(0.90); C45(0.90)  LDD0777  [18]
 LDCM0461  CL69 HCT 116 C44(0.78); C45(0.78)  LDD0778  [18]
 LDCM0462  CL7 HCT 116 C365(1.28); C44(1.07); C45(1.07)  LDD0779  [18]
 LDCM0463  CL70 HCT 116 C44(0.91); C45(0.91)  LDD0780  [18]
 LDCM0464  CL71 HCT 116 C44(0.97); C45(0.97)  LDD0781  [18]
 LDCM0465  CL72 HCT 116 C44(0.83); C45(0.83)  LDD0782  [18]
 LDCM0466  CL73 HCT 116 C44(0.86); C45(0.86)  LDD0783  [18]
 LDCM0467  CL74 HCT 116 C44(1.02); C45(1.02)  LDD0784  [18]
 LDCM0469  CL76 HCT 116 C110(0.89); C44(1.43); C45(1.17)  LDD0786  [18]
 LDCM0470  CL77 HCT 116 C110(0.90); C44(1.19); C45(1.03)  LDD0787  [18]
 LDCM0471  CL78 HCT 116 C110(0.74); C44(1.06); C45(1.04)  LDD0788  [18]
 LDCM0472  CL79 HCT 116 C110(1.18); C44(1.35); C45(1.21)  LDD0789  [18]
 LDCM0473  CL8 HCT 116 C365(1.42); C44(0.90); C45(0.90)  LDD0790  [18]
 LDCM0474  CL80 HCT 116 C110(0.98); C44(1.08); C45(1.13)  LDD0791  [18]
 LDCM0475  CL81 HCT 116 C110(1.00); C44(1.49); C45(1.25)  LDD0792  [18]
 LDCM0476  CL82 HCT 116 C110(1.13); C44(1.75); C45(1.42)  LDD0793  [18]
 LDCM0477  CL83 HCT 116 C110(1.41); C44(1.76); C45(1.31)  LDD0794  [18]
 LDCM0478  CL84 HCT 116 C110(1.08); C44(1.16); C45(1.07)  LDD0795  [18]
 LDCM0479  CL85 HCT 116 C110(1.05); C44(1.29); C45(1.06)  LDD0796  [18]
 LDCM0480  CL86 HCT 116 C110(1.01); C44(1.21); C45(1.09)  LDD0797  [18]
 LDCM0481  CL87 HCT 116 C110(1.25); C44(2.03); C45(1.42)  LDD0798  [18]
 LDCM0482  CL88 HCT 116 C110(1.23); C44(1.98); C45(1.43)  LDD0799  [18]
 LDCM0483  CL89 HCT 116 C110(0.93); C44(1.06); C45(1.03)  LDD0800  [18]
 LDCM0484  CL9 HCT 116 C365(1.25); C44(0.97); C45(0.97)  LDD0801  [18]
 LDCM0485  CL90 HCT 116 C110(1.33); C44(1.37); C45(1.04)  LDD0802  [18]
 LDCM0486  CL91 HCT 116 C110(0.84); C44(1.06); C45(1.06)  LDD0803  [18]
 LDCM0487  CL92 HCT 116 C110(0.92); C44(1.17); C45(1.17)  LDD0804  [18]
 LDCM0488  CL93 HCT 116 C110(0.87); C44(1.33); C45(1.33)  LDD0805  [18]
 LDCM0489  CL94 HCT 116 C110(0.82); C44(1.08); C45(1.08)  LDD0806  [18]
 LDCM0490  CL95 HCT 116 C110(0.78); C44(1.07); C45(1.07)  LDD0807  [18]
 LDCM0491  CL96 HCT 116 C110(0.85); C44(1.07); C45(1.07)  LDD0808  [18]
 LDCM0492  CL97 HCT 116 C110(0.78); C44(0.93); C45(0.93)  LDD0809  [18]
 LDCM0493  CL98 HCT 116 C110(0.74); C44(0.97); C45(0.97)  LDD0810  [18]
 LDCM0494  CL99 HCT 116 C110(0.82); C44(1.08); C45(1.08)  LDD0811  [18]
 LDCM0495  E2913 HEK-293T C365(0.96); C110(1.10); C353(0.97); C158(1.38)  LDD1698  [19]
 LDCM0625  F8 Ramos C110(0.59)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C110(0.77)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C110(0.59)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C110(0.65)  LDD2191  [20]
 LDCM0576  Fragment14 Ramos C110(0.72)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C110(0.77)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C110(1.17)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C110(0.61)  LDD2196  [20]
 LDCM0588  Fragment30 Ramos C110(0.80)  LDD2199  [20]
 LDCM0590  Fragment32 Ramos C110(0.67)  LDD2201  [20]
 LDCM0468  Fragment33 HCT 116 C44(0.80); C45(0.80)  LDD0785  [18]
 LDCM0566  Fragment4 Ramos C110(0.49)  LDD2184  [20]
 LDCM0427  Fragment51 HCT 116 C110(0.66); C44(1.01); C45(1.01)  LDD0744  [18]
 LDCM0614  Fragment56 Ramos C110(0.79)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C110(0.58)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C110(0.78)  LDD2188  [20]
 LDCM0022  KB02 HEK-293T C365(1.05); C158(0.87); C110(0.97)  LDD1492  [19]
 LDCM0023  KB03 Jurkat C45(51.43)  LDD0209  [5]
 LDCM0024  KB05 G361 C191(1.38)  LDD3311  [21]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C311(0.57)  LDD2109  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C311(0.80)  LDD2137  [3]
 LDCM0131  RA190 MM1.R C110(1.48)  LDD0304  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntaxin-11 (STX11) Syntaxin family O75558

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
22 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.