Details of the Target

General Information of Target

Target ID LDTP04375
Target Name Methionine aminopeptidase 2 (METAP2)
Gene Name METAP2
Gene ID 10988
Synonyms
MNPEP; P67EIF2; Methionine aminopeptidase 2; MAP 2; MetAP 2; EC 3.4.11.18; Initiation factor 2-associated 67 kDa glycoprotein; p67; p67eIF2; Peptidase M
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Peptidase M24A family, Methionine aminopeptidase eukaryotic type 2 subfamily
Subcellular location
Cytoplasm
Function
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
TTD ID
T75596
Uniprot ID
P50579
DrugMap ID
TTZL0OI
Ensemble ID
ENST00000261220.13
HGNC ID
HGNC:16672
ChEMBL ID
CHEMBL3922

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.A51S DBIA    Probe Info 
HDQP1 SNV: p.G94A DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.R259M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.01  LDD0402  [1]
P8
 Probe Info  		5.51  LDD0451  [2]
A-EBA
 Probe Info  		4.87  LDD0215  [3]
CY4
 Probe Info  		100.00  LDD0244  [4]
STPyne
 Probe Info  		K281(5.28); K427(8.33)  LDD0277  [5]
ONAyne
 Probe Info  		K281(7.69)  LDD0275  [5]
Probe 1
 Probe Info  		Y273(21.97); Y361(9.65)  LDD3495  [6]
BTD
 Probe Info  		C380(1.13)  LDD2099  [7]
AHL-Pu-1
 Probe Info  		C380(4.27)  LDD0168  [8]
DBIA
 Probe Info  		C436(4.84); C448(4.84); C121(1.68)  LDD0080  [9]
5E-2FA
 Probe Info  		H375(0.00); H391(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K46(0.00); K348(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C380(0.00); C416(0.00); C263(0.00); C298(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C468(0.00); C121(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C380(0.00); C416(0.00); C298(0.00); C121(0.00)  LDD0037  [12]
ATP probe
 Probe Info  		N.A.  LDD0035  [14]
NAIA_4
 Probe Info  		C121(0.00); C290(0.00)  LDD2226  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
IPM
 Probe Info  		C468(0.00); C416(0.00); C121(0.00); C135(0.00)  LDD0147  [16]
1c-yne
 Probe Info  		N.A.  LDD0228  [17]
Acrolein
 Probe Info  		C121(0.00); C135(0.00); C448(0.00)  LDD0217  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
W1
 Probe Info  		C121(0.00); C448(0.00)  LDD0236  [19]
AOyne
 Probe Info  		8.70  LDD0443  [20]
NAIA_5
 Probe Info  		C290(0.00); C468(0.00); C380(0.00); C416(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C173
 Probe Info  		12.73  LDD1853  [21]
C282
 Probe Info  		24.08  LDD1952  [21]
C353
 Probe Info  		18.00  LDD2014  [21]
C416
 Probe Info  		5.74  LDD2071  [21]
PARPYnD
 Probe Info  		2.29  LDD0375  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C380(1.60)  LDD2117  [7]
 LDCM0025  4SU-RNA HEK-293T C380(4.27)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C380(2.14)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C121(0.69); C135(0.99); C197(0.86); C263(0.65)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C121(0.86); C135(1.39); C197(1.06); C223(0.44)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C135(0.88); C223(0.76); C228(0.76); C263(0.79)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C135(0.89); C223(1.02); C228(1.02); C263(0.63)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C135(0.99); C223(0.91); C228(0.91); C263(0.68)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C135(0.90); C223(1.17); C228(1.17); C263(0.63)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C135(0.92); C223(0.86); C228(0.86); C263(0.69)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C135(0.98); C223(0.82); C228(0.82); C263(0.63)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C135(0.98); C223(0.72); C228(0.72); C263(0.65)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C135(0.85); C223(0.98); C228(0.98); C263(0.69)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C135(0.85); C223(0.68); C228(0.68); C263(0.84)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C135(0.94); C223(0.90); C228(0.90); C263(0.78)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C121(0.94); C135(1.40); C197(1.11); C223(0.36)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C135(1.03); C223(0.99); C228(0.99); C263(0.77)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C135(0.91); C223(0.66); C228(0.66); C263(0.75)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C135(0.97); C223(1.00); C228(1.00); C263(0.64)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C135(1.01); C197(0.86); C223(0.98); C228(0.98)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C135(0.93); C197(0.87); C223(1.07); C228(1.07)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C135(0.93); C197(0.97); C223(0.76); C228(0.76)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C135(0.82); C197(0.82); C223(0.77); C228(0.77)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C135(1.05); C197(0.93); C223(0.76); C228(0.76)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C135(1.09); C197(0.85); C223(0.78); C228(0.78)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C135(1.09); C197(0.82); C223(0.64); C228(0.64)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C121(0.97); C135(1.27); C197(0.91); C223(0.61)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C135(1.24); C197(0.82); C223(1.02); C228(1.02)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C135(1.15); C197(1.05); C223(1.29); C228(1.29)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C135(1.04); C197(1.02); C223(1.00); C228(1.00)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C135(0.97); C197(1.00); C223(1.26); C228(1.26)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C135(1.19); C197(1.11); C223(0.83); C228(0.83)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C135(1.01); C197(0.88); C223(1.11); C228(1.11)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C135(0.94); C197(1.07); C223(0.97); C228(0.97)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C135(1.14); C197(0.93); C223(0.88); C228(0.88)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C121(1.07); C135(0.43); C223(1.22); C228(1.22)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C121(0.92); C135(0.43); C223(0.94); C228(0.94)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C121(0.93); C135(0.47); C223(0.81); C228(0.81)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C121(1.11); C135(0.43); C223(1.49); C228(1.49)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C121(0.89); C135(0.47); C223(0.97); C228(0.97)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C121(0.87); C135(0.49); C223(1.06); C228(1.06)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C121(0.91); C135(0.54); C223(1.36); C228(1.36)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C121(0.86); C135(0.52); C223(1.11); C228(1.11)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C121(0.87); C135(0.50); C223(1.23); C228(1.23)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C121(0.85); C135(0.47); C223(1.41); C228(1.41)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C121(0.84); C135(0.56); C223(2.05); C228(2.05)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C121(0.86); C135(0.52); C223(1.27); C228(1.27)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C121(0.86); C135(1.03); C197(0.87); C223(0.88)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C121(0.89); C135(0.56); C223(1.59); C228(1.59)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C121(0.95); C135(0.57); C223(1.51); C228(1.51)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C121(0.82); C135(0.49); C223(1.18); C228(1.18)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C121(0.73); C263(0.76); C468(0.82); C135(0.83)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C263(0.64); C436(0.64); C448(0.64); C223(0.65)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C436(0.60); C448(0.60); C263(0.74); C468(0.76)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C263(0.55); C436(0.60); C448(0.60); C121(0.68)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C436(0.57); C448(0.57); C263(0.63); C468(0.76)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C263(0.75); C290(0.76); C121(0.86); C436(0.87)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C263(0.57); C436(0.70); C448(0.70); C121(0.72)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C436(0.66); C448(0.66); C380(0.71); C263(0.76)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C263(0.72); C121(0.75); C290(0.76); C436(0.87)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C436(0.68); C448(0.68); C223(0.70); C228(0.70)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C436(0.59); C448(0.59); C121(0.59); C263(0.70)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C263(0.77); C436(0.79); C448(0.79); C290(0.86)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C121(0.72); C135(0.95); C197(1.24); C223(0.92)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C121(0.86); C135(1.03); C197(1.16); C223(0.83)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C121(0.84); C135(0.90); C197(1.09); C223(0.97)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C121(0.97); C135(1.05); C197(1.13); C223(1.06)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C436(0.81); C448(0.89); C197(0.91); C468(0.93)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C197(0.59); C121(0.70); C263(0.76); C436(0.80)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C436(0.82); C468(0.82); C448(0.89); C263(0.92)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C436(0.58); C448(0.69); C468(0.74); C121(0.75)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C436(0.83); C197(0.85); C448(0.90); C263(0.92)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C436(0.79); C197(0.80); C448(0.84); C263(0.88)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C468(0.85); C263(0.90); C448(0.93); C436(0.98)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C197(0.84); C436(0.84); C263(0.84); C468(0.87)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C436(0.88); C380(0.91); C468(0.94); C448(0.97)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C448(0.63); C416(0.66); C248(0.67); C263(0.69)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C248(0.42); C448(0.54); C223(0.61); C436(0.62)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C448(0.53); C436(0.65); C263(0.66); C248(0.69)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C448(0.57); C248(0.61); C223(0.63); C416(0.64)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C448(0.53); C416(0.68); C263(0.69); C436(0.71)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C436(0.60); C448(0.67); C121(0.73); C468(0.75)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C448(0.61); C436(0.67); C416(0.70); C121(0.71)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C448(0.47); C436(0.54); C416(0.58); C263(0.62)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C448(0.52); C416(0.62); C263(0.63); C436(0.69)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C448(0.49); C436(0.60); C416(0.62); C263(0.68)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C448(0.47); C436(0.59); C416(0.62); C263(0.67)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C121(0.86); C380(0.94); C290(0.95); C135(1.01)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C121(0.68); C468(0.91); C135(0.92); C380(0.96)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C121(0.65); C468(0.87); C380(0.90); C416(0.91)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C121(0.68); C468(0.87); C290(0.92); C135(0.98)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C416(0.89); C468(0.89); C121(0.89); C263(0.93)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C436(0.48); C448(0.59); C121(0.64); C263(0.72)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C121(0.78); C290(0.84); C468(0.94); C416(0.95)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C121(0.76); C468(0.90); C290(0.92); C380(0.94)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C121(0.76); C290(0.90); C380(0.90); C263(1.01)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C121(0.72); C468(0.86); C380(0.86); C290(0.88)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C121(0.68); C290(0.85); C468(0.85); C380(0.97)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C121(0.87); C290(0.87); C380(0.91); C468(0.92)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C223(0.68); C228(0.68); C263(0.90); C436(0.92)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C223(0.55); C228(0.55); C468(0.90); C436(0.91)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C223(0.54); C228(0.54); C263(0.74); C468(0.81)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C223(0.73); C228(0.73); C436(0.86); C448(0.92)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C436(0.51); C121(0.60); C448(0.63); C263(0.74)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C223(0.50); C228(0.50); C436(0.86); C197(0.87)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C223(0.73); C228(0.73); C468(0.95); C263(0.95)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C223(0.72); C228(0.72); C436(0.90); C197(0.94)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C223(0.50); C228(0.50); C290(0.89); C263(0.90)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C223(0.58); C228(0.58); C436(0.93); C197(0.95)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C223(0.46); C228(0.46); C436(0.93); C290(0.94)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C223(0.46); C228(0.46); C290(0.93); C197(1.00)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C436(0.40); C448(0.40); C263(0.54); C223(0.65)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C436(0.39); C448(0.39); C263(0.51); C468(0.77)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C436(0.52); C448(0.52); C223(0.62); C228(0.62)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C436(0.62); C448(0.62); C263(0.79); C468(0.82)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C436(0.41); C448(0.41); C263(0.49); C468(0.70)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C436(0.35); C448(0.35); C263(0.46); C468(0.69)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C436(0.51); C448(0.51); C263(0.65); C223(0.78)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C436(0.36); C448(0.36); C263(0.53); C468(0.80)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C436(0.46); C448(0.46); C263(0.60); C223(0.67)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C436(0.52); C448(0.52); C263(0.56); C223(0.59)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C436(0.41); C448(0.41); C223(0.48); C228(0.48)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C436(0.44); C448(0.44); C263(0.53); C223(0.70)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C263(0.83); C436(0.89); C448(0.89); C416(0.92)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C263(0.80); C436(0.89); C448(0.89); C468(0.96)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C223(0.69); C228(0.69); C436(0.72); C448(0.72)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C263(0.72); C436(0.74); C448(0.74); C416(0.86)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C263(0.83); C436(0.84); C448(0.84); C416(0.92)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C436(0.81); C448(0.81); C263(0.89); C468(1.01)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C436(0.84); C448(0.84); C263(0.90); C223(0.95)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C263(0.95); C436(0.98); C448(0.98); C290(1.04)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C223(0.82); C228(0.82); C197(1.00); C436(1.02)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C223(0.92); C228(0.92); C436(0.92); C448(0.92)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C263(0.82); C436(0.83); C448(0.83); C468(0.93)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C263(0.70); C436(0.82); C448(0.82); C380(0.87)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C436(0.79); C448(0.79); C263(0.87); C223(0.91)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C436(0.66); C448(0.66); C416(0.70); C223(0.76)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C263(0.91); C135(0.92); C436(0.93); C448(0.93)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C263(0.84); C436(0.90); C448(0.90); C121(0.93)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C121(0.87); C416(1.01); C436(1.01); C448(1.01)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C223(0.75); C436(0.79); C448(0.79); C228(0.82)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C436(0.78); C448(0.78); C416(0.78); C248(0.79)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C436(0.67); C448(0.67); C416(0.68); C248(0.84)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C223(0.66); C228(0.79); C436(0.86); C448(0.86)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C223(0.68); C436(0.86); C448(0.86); C416(0.90)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C436(0.78); C448(0.78); C416(0.90); C223(0.92)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C223(0.75); C416(0.76); C436(0.78); C448(0.78)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C223(0.72); C416(0.83); C228(0.84); C248(0.96)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C223(0.70); C228(0.76); C436(0.79); C448(0.79)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C223(0.57); C228(0.64); C248(0.71); C416(0.76)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C416(0.68); C248(0.71); C228(0.79); C436(0.81)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C416(0.64); C436(0.75); C448(0.75); C223(0.78)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C436(0.55); C448(0.55); C380(0.62); C416(0.72)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C416(0.63); C436(0.77); C448(0.77); C380(0.80)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C248(0.61); C416(0.63); C228(0.67); C223(0.73)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C436(0.33); C448(0.33); C263(0.61); C380(0.72)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C436(0.45); C448(0.45); C263(0.70); C135(0.75)  LDD0683  [9]
 LDCM0545  Acetamide MDA-MB-231 C380(0.79)  LDD2138  [7]
 LDCM0248  AKOS034007472 HCT 116 C121(0.95); C135(1.29); C197(1.09); C223(0.39)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C223(0.54); C228(0.54); C436(0.61); C448(0.61)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C436(0.66); C448(0.66); C223(0.77); C228(0.77)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.69  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C135(1.14)  LDD2171  [9]
 LDCM0146  AZ9482 MDA-MB-468 2.29  LDD0375  [22]
 LDCM0108  Chloroacetamide HeLa H391(0.00); C448(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C380(20.00); C121(1.73); C468(1.57)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C248(0.78); C448(0.82); C380(0.83); C416(0.83)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C468(0.61); C248(0.78); C436(0.78); C263(0.80)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C436(0.55); C448(0.67); C468(0.69); C263(0.75)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C436(0.64); C448(0.64); C223(0.70); C228(0.70)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C223(0.64); C228(0.64); C416(0.68); C468(0.70)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C223(0.58); C228(0.58); C416(0.63); C436(0.78)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C223(0.58); C228(0.58); C416(0.67); C436(0.71)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C436(0.69); C448(0.75); C468(0.81); C263(0.84)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C436(0.61); C263(0.65); C448(0.75); C197(0.82)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C197(0.68); C436(0.68); C263(0.69); C448(0.91)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C197(0.66); C436(0.72); C263(0.81); C121(0.90)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C436(0.67); C263(0.76); C448(0.77); C197(0.80)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C468(0.74); C380(0.81); C416(0.84); C248(0.85)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C263(0.75); C436(0.76); C448(0.82); C197(0.85)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C436(0.73); C197(0.73); C263(0.76); C448(0.80)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C416(0.68); C121(0.70); C436(0.79); C263(0.79)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C448(0.52); C263(0.63); C436(0.64); C416(0.66)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C448(0.52); C436(0.70); C121(0.71); C263(0.71)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C448(0.52); C416(0.60); C263(0.66); C436(0.68)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C416(0.62); C448(0.62); C263(0.71); C121(0.75)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C290(0.89); C416(1.09); C121(1.09); C380(1.12)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C121(0.72); C468(0.88); C416(0.95); C197(0.97)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C416(0.85); C121(0.89); C380(0.91); C468(0.99)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C416(0.83); C248(0.84); C380(0.91); C468(0.92)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C121(0.65); C468(0.77); C380(0.89); C416(0.94)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C468(0.76); C223(0.84); C228(0.84); C380(0.89)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C197(0.88); C263(0.91); C436(0.96); C468(0.97)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C223(0.69); C228(0.69); C263(0.86); C436(0.87)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C223(0.57); C228(0.57); C436(0.84); C448(0.89)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C436(0.58); C448(0.58); C223(0.65); C228(0.65)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C436(0.50); C448(0.50); C263(0.63); C223(0.75)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C436(0.48); C448(0.48); C223(0.64); C228(0.64)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C436(0.41); C448(0.41); C263(0.63); C468(0.71)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C248(0.61); C223(0.72); C416(0.77); C448(0.81)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C248(0.64); C223(0.79); C436(0.81); C416(0.85)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C263(0.65); C228(0.75); C448(0.75); C197(0.78)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C223(0.53); C228(0.53); C468(0.78); C448(0.79)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C121(0.69); C436(0.72); C448(0.72); C468(0.80)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C448(0.60); C436(0.62); C263(0.66); C223(0.69)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C436(0.73); C448(0.75); C263(0.75); C416(0.84)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C248(0.63); C223(0.69); C228(0.75); C380(0.76)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C223(0.76); C228(0.76); C468(0.81); C436(0.83)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C448(0.74); C436(0.75); C416(0.79); C223(0.79)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C135(0.76); C416(0.89); C468(0.93); C223(0.95)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C223(0.60); C228(0.60); C436(0.75); C448(0.76)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C223(0.44); C228(0.44); C448(0.76); C436(0.76)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C121(1.16); C135(0.89); C197(1.16); C223(0.48)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C121(1.17); C135(0.89); C197(1.00); C223(0.90)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C121(1.00); C135(0.86); C197(1.04); C223(0.52)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C121(1.09); C135(0.90); C197(1.03); C223(0.68)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C121(0.98); C135(0.86); C197(0.99); C223(0.60)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C121(0.94); C135(1.11); C197(0.90); C223(1.29)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C121(0.95); C135(0.75); C197(1.12); C223(0.67)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C121(0.97); C135(0.67); C197(1.09); C223(1.09)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C121(0.88); C135(0.79); C197(1.15); C223(0.79)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C121(0.90); C135(0.71); C197(1.18); C223(0.63)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C121(1.13); C135(0.95); C197(1.06); C223(0.71)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C121(1.10); C135(1.08); C197(1.12); C223(1.09)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C121(1.03); C135(0.80); C197(1.11); C223(0.96)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C121(1.41); C135(1.11); C197(1.15); C223(1.41)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C121(1.15); C135(0.88); C197(1.06); C223(1.08)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C121(0.93); C135(1.09); C197(1.05); C223(0.74)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C121(0.95); C135(0.81); C197(1.07); C223(1.00)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C121(1.34); C135(0.93); C197(1.10); C223(0.95)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C121(1.27); C135(1.04); C197(1.17); C223(1.08)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C121(1.29); C135(1.09); C197(1.11); C223(0.84)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C121(1.23); C135(1.01); C197(1.24); C223(0.71)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C121(1.24); C135(0.88); C197(1.18); C223(0.71)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C121(1.30); C135(0.86); C197(1.02); C223(0.42)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C121(1.27); C135(0.90); C197(1.21); C223(0.66)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C121(1.17); C135(0.78); C197(1.01); C223(0.53)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C121(1.40); C135(0.91); C197(0.97); C223(0.61)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C121(0.92); C135(1.06); C197(1.07); C223(0.63)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C121(1.26); C135(0.93); C197(0.99); C223(0.72)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C121(1.29); C135(0.89); C197(1.19); C223(0.57)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C121(1.18); C135(0.91); C197(0.93); C223(0.54)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C121(1.26); C135(0.92); C197(0.98); C223(2.31)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C121(1.30); C135(0.81); C197(0.95); C223(0.63)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C121(1.32); C135(0.82); C197(1.04); C223(0.80)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C121(1.20); C135(0.92); C197(1.05); C223(0.67)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C121(1.29); C135(0.94); C197(1.08); C223(0.74)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C121(1.53); C135(0.88); C197(0.84); C223(0.48)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C121(1.33); C135(0.92); C197(1.16); C223(0.60)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C121(0.86); C135(1.08); C197(0.89); C223(0.47)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C121(1.30); C135(1.06); C197(0.96); C223(0.47)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C121(1.03); C135(1.15); C197(0.86); C223(0.73)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C121(0.88); C135(2.22); C197(0.89); C223(0.62)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C121(0.91); C135(1.46); C197(0.77); C223(0.80)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C121(0.93); C135(1.74); C197(0.81); C223(0.64)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C121(0.98); C135(1.21); C197(0.83); C223(1.02)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C121(0.97); C135(1.55); C197(0.85); C223(0.62)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C121(1.00); C135(1.65); C197(0.87); C223(0.89)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C121(0.99); C135(1.94); C197(0.77); C223(1.48)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C121(0.90); C135(1.48); C197(0.66); C223(0.65)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C121(0.99); C135(1.35); C197(1.00); C223(0.51)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C121(0.96); C135(1.33); C197(0.77); C223(0.84)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C121(1.14); C135(1.43); C197(0.80); C223(0.88)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C121(1.10); C135(1.38); C197(0.77); C223(0.81)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C121(1.19); C135(1.52); C197(0.80); C223(0.80)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C121(1.14); C135(1.30); C197(0.95); C223(0.98)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C121(0.90); C135(0.94); C223(1.67); C228(1.67)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C121(0.92); C135(0.92); C223(2.40); C228(2.40)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C121(1.06); C135(0.97); C223(1.45); C228(1.45)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C121(1.09); C135(0.98); C223(1.46); C228(1.46)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C121(1.06); C135(1.57); C197(0.91); C223(0.88)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C121(0.97); C135(0.97); C223(1.43); C228(1.43)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C121(1.07); C135(0.97); C223(1.04); C228(1.04)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C121(0.72); C135(0.81); C223(1.35); C228(1.35)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C121(1.03); C135(0.96); C223(1.19); C228(1.19)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C121(1.05); C135(0.95); C223(1.01); C228(1.01)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C121(0.83); C135(1.15); C223(1.52); C228(1.52)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C121(0.97); C135(1.06); C223(1.43); C228(1.43)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C121(1.01); C135(1.11); C223(1.25); C228(1.25)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C121(0.95); C135(0.99); C223(1.75); C228(1.75)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C121(1.06); C135(0.77); C223(1.47); C228(1.47)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C121(1.01); C135(1.18); C197(1.10); C223(0.45)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C121(0.89); C135(0.75); C223(1.53); C228(1.53)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C121(0.84); C135(1.09); C197(1.02); C263(0.77)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C121(0.83); C135(1.11); C197(1.27); C263(0.83)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C121(0.87); C135(1.06); C197(1.10); C263(0.81)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C121(0.78); C135(1.08); C197(0.98); C263(0.81)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C121(0.76); C135(1.21); C197(1.10); C263(0.81)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C121(0.83); C135(1.21); C197(0.95); C263(0.79)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C121(0.69); C135(1.02); C197(0.93); C263(0.86)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C121(0.72); C135(1.08); C197(1.13); C263(0.77)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C121(0.76); C135(1.10); C197(1.09); C263(0.70)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C121(0.91); C263(1.00); C380(1.00); C468(1.09)  LDD1698  [23]
 LDCM0625  F8 Ramos C121(1.27)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C121(0.71)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C416(1.57); C121(1.05)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C121(0.71)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C121(1.24)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C416(1.11); C121(0.75)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C121(0.51)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C121(1.03)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C121(1.12)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C121(2.19)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C121(1.03)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C121(1.03)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C121(2.24)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C121(0.86)  LDD2201  [24]
 LDCM0468  Fragment33 HCT 116 C121(1.03); C135(2.22); C197(0.85); C223(0.74)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C121(0.50)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C416(2.75); C121(0.66)  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C121(1.37); C135(1.85); C197(1.15); C223(1.86)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C121(1.68)  LDD2204  [24]
 LDCM0569  Fragment7 Ramos C416(0.43); C121(0.50)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C121(0.86)  LDD2188  [24]
 LDCM0107  IAA HeLa H391(0.00); C448(0.00)  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C436(4.84); C448(4.84); C121(1.68)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C436(10.01); C448(10.01); C121(1.50)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C436(9.40); C448(9.40); C121(1.58)  LDD0082  [9]
 LDCM0109  NEM HeLa N.A.  LDD0224  [18]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C380(1.13)  LDD2099  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C380(0.58)  LDD2104  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C380(1.20)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C380(0.96)  LDD2109  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C203(0.26)  LDD2118  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C203(0.98)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C203(0.15)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C380(1.45)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C380(1.32)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C290(0.39)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C380(1.98)  LDD2127  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C380(1.93)  LDD2136  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C380(1.62)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C203(0.55)  LDD2143  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C290(0.35)  LDD2145  [7]
 LDCM0021  THZ1 HCT 116 C135(1.14)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
D(4) dopamine receptor (DRD4) G-protein coupled receptor 1 family P21917

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Methionine Small molecular drug DB00134
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Beloranib Small molecular drug D0E4VQ
D-methionine Small molecular drug D0N0KW
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zgn-1061 Small molecular drug DA3GL5
Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sdx-7320 Polymer drug conjugate D07DWC
Ppi-2458 Small molecular drug D0KR1N
M8891 . D02SHI
Investigative
Click To Hide/Show 36 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-(4-fluorophenylsulfonamido)-1-naphthoic Acid Small molecular drug D0R4KE
2-(Phenylsulfonamido)-1-naphthoic Acid Small molecular drug D0I6RL
2-(Phenylsulfonamido)-5-propylbenzoic Acid Small molecular drug D00MUJ
2-(Pyridin-2-yl)-1h-benzo[D]Imidazol-5-amine Small molecular drug D0L6ZY
2-(Pyridin-2-yl)-1h-benzo[D]Imidazole Small molecular drug D0L4YF
2-(Pyridin-2-yl)-1h-imidazo[4,5-c]Pyridine Small molecular drug D08AXA
2-(Thiazol-4-yl)-1h-benzo[D]Imidazol-5-amine Small molecular drug D0B1LR
2-methyl-2-propanol Small molecular drug D0Q7LD
3,5,6,8-tetramethyl-n-methyl Phenanthrolinium Small molecular drug D05YKW
3,5-dimethyl-2-(Phenylsulfonamido)Benzoic Acid Small molecular drug D0K5UM
3-anilino-5-benzylthio-1,2,4-triazole Small molecular drug D05DCQ
3568-tetramethyl-n-methyl Phenanthrolinium Small molecular drug DB02310
5-bromo-2-(4-chlorophenylsulfonamido)Benzoic Acid Small molecular drug D0K7PS
5-bromo-2-{[(4-chlorophenyl)Sulfonyl]Amino}Benzoic Acid Small molecular drug DB07309
5-butyl-2-(Phenylsulfonamido)Benzoic Acid Small molecular drug D09KTF
5-chloro-2-(Pyridin-2-yl)-1h-benzo[D]Imidazole Small molecular drug D04MIY
5-ethyl-2-(Phenylsulfonamido)Benzoic Acid Small molecular drug D0S5GM
5-fluoro-2-(Pyridin-2-yl)-1h-benzo[D]Imidazole Small molecular drug D07PXR
5-methyl-2-(Phenylsulfonamido)Benzoic Acid Small molecular drug D07CWJ
5-methyl-2-(Pyridin-2-yl)-1h-benzo[D]Imidazole Small molecular drug D0C0UB
5-methyl-2-[(Phenylsulfonyl)Amino]Benzoic Acid Small molecular drug DB07313
5-p-tolyl-1h-[1,2,3]Triazole Small molecular drug D02ADV
A-357300 Small molecular drug D02APY
Fumagillin Small molecular drug D08CFL
N'-((2s3r)-3-amino-2-hydroxy-5-(Isopropylsulfanyl)Pentanoyl)-n-3-chlorobenzoyl Hydrazide Small molecular drug DB07377
Nitroxoline Small molecular drug DB01422
Ovalicin Small molecular drug D04SLM
Oxyquinoline Small molecular drug D0FO2B
Tert-butanol Small molecular drug DB03900
Xmt-1191 Small molecular drug D0MT5K
(2r3r4s5r6e)-345-trihydroxy-n-[(3s6r)-6-hydroxy-2-oxo-3-azepanyl]-2-methoxy-88-dimethyl-6-nonenamide . DB03396
(2s3r)-3-amino-2-hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-naphthyl)Ethyl)Amide . DB04108
2-[(Phenylsulfonyl)Amino]-5678-tetrahydronaphthalene-1-carboxylic Acid . DB07322
2-[({2-[(1z)-3-(Dimethylamino)Prop-1-enyl]-4-fluorophenyl}Sulfonyl)Amino]-5678-tetrahydronaphthalene-1-carboxylic Acid . DB07323
3-ethyl-6-{[(4-fluorophenyl)Sulfonyl]Amino}-2-methylbenzoic Acid . DB07746
N'-(2s3r)-3-amino-4-cyclohexyl-2-hydroxy-butano-n-(4-methylphenyl)Hydrazide . DB03086
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tnp-470 Small molecular drug D09OAQ

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578