Details of the Target

General Information of Target

Target ID LDTP09671
Target Name U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31)
Gene Name PRPF31
Gene ID 26121
Synonyms
PRP31; U4/U6 small nuclear ribonucleoprotein Prp31; Pre-mRNA-processing factor 31; Serologically defined breast cancer antigen NY-BR-99; U4/U6 snRNP 61 kDa protein; Protein 61K; hPrp31
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKTIAKLWDSKMF
AEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSK
RFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLS
EEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTN
LSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCT
LAARVDSFHESTEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYR
KMKERLGLTEIRKQANRMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARI
SKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYF
SSMAEFLKVKGEKSGLMST
Target Bioclass
Other
Family
PRP31 family
Subcellular location
Nucleus
Function Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
Uniprot ID
Q8WWY3
Ensemble ID
ENST00000321030.9
HGNC ID
HGNC:15446

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO829 SNV: p.S482N DBIA    Probe Info 
HCC1187 SNV: p.R365W DBIA    Probe Info 
HUCCT1 SNV: p.Q332Ter DBIA    Probe Info 
LS180 SNV: p.A216T DBIA    Probe Info 
MDAMB468 SNV: p.E461Q DBIA    Probe Info 
MOLT4 SNV: p.I249T IA-alkyne    Probe Info 
NUGC3 SNV: p.P285S DBIA    Probe Info 
SNU308 SNV: p.T410I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.22  LDD0402  [1]
TH211
 Probe Info  		Y90(5.04)  LDD0257  [2]
Probe 1
 Probe Info  		Y90(9.02); Y205(18.43); Y435(54.40)  LDD3495  [3]
BTD
 Probe Info  		C149(1.46)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C247(2.19)  LDD0169  [5]
IPM
 Probe Info  		C247(5.24)  LDD1701  [4]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
DBIA
 Probe Info  		C247(0.97)  LDD0078  [7]
ATP probe
 Probe Info  		K430(0.00); K298(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C191(0.00); C247(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C149(0.00); C191(0.00); C247(0.00)  LDD0037  [9]
TFBX
 Probe Info  		C247(0.00); C299(0.00)  LDD0027  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
1c-yne
 Probe Info  		N.A.  LDD0228  [15]
W1
 Probe Info  		N.A.  LDD0236  [16]
AOyne
 Probe Info  		7.70  LDD0443  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
HHS-465
 Probe Info  		Y273(0.00); Y275(0.00)  LDD2240  [19]
HHS-482
 Probe Info  		Y275(0.89)  LDD2239  [20]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C244
 Probe Info  		14.22  LDD1917  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C149(0.79)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C149(1.00)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C299(0.57); C149(0.48)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C149(0.96)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C149(1.13)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C149(1.33)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C149(0.82)  LDD2103  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C149(0.67)  LDD2131  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C247(2.19)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C247(1.08)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C247(0.96)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C247(0.91)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C247(1.01)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C247(0.96)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C247(0.93)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C247(0.95)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C247(0.84)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C247(0.81)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C247(0.91)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C247(0.81)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C247(0.92)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C247(1.07)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C247(1.01)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C247(0.93)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C247(0.95)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C247(1.02)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C247(1.04)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C247(1.19)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C247(1.11)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C247(1.01)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C247(1.02)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C247(0.94)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C247(1.26)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C247(1.22)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C247(0.88)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C247(0.90)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C247(1.05)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C247(0.99)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C247(0.97)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C247(0.98)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C247(0.96)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C247(1.03)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C247(1.23)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C247(1.19)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C247(1.12)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C247(1.08)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C247(1.11)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C247(1.23)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C247(1.13)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C247(1.18)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C247(1.15)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C247(1.27)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C247(1.21)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C247(1.08)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C247(1.29)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C247(1.30)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C247(1.28)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C247(1.12)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C247(1.06)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C247(1.04)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C247(1.10)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C247(1.10)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C247(1.25)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C247(1.17)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C247(1.01)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C247(1.08)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C247(1.16)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C247(1.23)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C247(1.34)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C247(1.11)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C247(1.05)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C247(1.10)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C247(1.14)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C247(1.32)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C247(1.31)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C247(0.97)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C247(1.06)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C247(1.01)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C247(0.92)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C247(1.16)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C247(1.09)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C247(0.97)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C247(0.91)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C247(1.02)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C247(1.07)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C247(1.02)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C247(0.95)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C247(1.10)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C247(1.16)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C247(1.08)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C247(1.25)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C247(1.07)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C247(1.18)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C247(0.81)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C247(0.87)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C247(0.87)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C247(0.90)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C247(0.75)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C247(1.22)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C247(0.96)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C247(0.97)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C247(1.03)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C247(0.98)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C247(1.05)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C247(1.01)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C247(1.06)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C247(0.98)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C247(0.94)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C247(1.30)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C247(1.23)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C247(1.12)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C247(1.00)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C247(1.07)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C247(1.10)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C247(1.16)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C247(1.15)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C247(1.42)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C247(1.25)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C247(1.40)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C247(1.11)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C247(1.04)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C247(1.05)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C247(1.28)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C247(1.41)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C247(0.94)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C247(1.17)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C247(1.18)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C247(1.15)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C247(1.04)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C247(1.05)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C247(1.17)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C247(1.07)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C247(1.13)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C247(1.08)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C247(1.13)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C247(1.28)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C247(1.30)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C247(1.28)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C247(1.11)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C247(1.14)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C247(1.16)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C247(1.10)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C247(1.07)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C247(1.17)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C247(1.23)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C247(1.24)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C247(1.11)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C247(1.06)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C247(1.01)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C247(0.92)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C247(0.93)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C247(0.99)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C247(0.99)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C247(0.80)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C247(1.01)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C247(1.02)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C247(1.03)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C247(0.99)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C247(0.94)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C247(1.08)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C247(1.03)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C247(0.98)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C247(0.88)  LDD0683  [7]
 LDCM0545  Acetamide MDA-MB-231 C149(0.54)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C149(0.66)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C247(0.94)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C247(1.28)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C247(1.22)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C247(0.97)  LDD0078  [7]
 LDCM0498  BS-3668 MDA-MB-231 C149(0.37)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C247(1.23); C247(1.13)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C247(0.91)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C247(1.03)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C247(1.12)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C247(1.09)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C247(1.06)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C247(0.87)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C247(1.14)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C247(1.38)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C247(1.43)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C247(1.35)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C247(1.43)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C247(1.53)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C247(1.11)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C247(1.36)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C247(1.22)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C247(0.92)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C247(1.15)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C247(1.21)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C247(1.08)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C247(1.12)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C247(1.08)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C247(0.91)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C247(0.90)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C247(1.14)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C247(0.83)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C247(1.22)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C247(1.22)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C247(1.06)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C247(1.12)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C247(1.00)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C247(1.23)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C247(1.12)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C247(1.05)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C247(1.12)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C247(0.99)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C247(1.12)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C247(1.15)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C247(1.08)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C247(1.09)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C247(1.12)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C247(0.99)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C247(1.14)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C247(1.09)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C247(1.32)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C247(1.06)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C247(1.10)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C247(1.08)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C247(1.09)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C247(0.97)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C247(1.08)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C247(1.11)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C247(0.96)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C247(1.05)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C247(1.29)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C247(1.27)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C247(1.07)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C247(1.60)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C247(1.43)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C247(1.23)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C247(1.31)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C247(1.05)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C247(0.94)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C247(1.23)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C247(1.28)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C247(1.39)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C247(1.48)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C247(1.37)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C247(1.25)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C247(0.82)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C247(0.85)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C247(0.93)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C247(0.91)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C247(0.96)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C247(0.83)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C247(0.82)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C247(0.86)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C247(0.94)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C247(0.75)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C247(0.85)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C247(0.95)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C247(0.86)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C247(0.84)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C247(0.92)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C247(0.96)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C247(0.85)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C247(1.08)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C247(1.13)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C247(1.14)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C247(0.96)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C247(1.06)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C247(1.11)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C247(0.93)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C247(1.21)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C247(1.07)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C247(0.99)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C247(1.07)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C247(1.10)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C247(1.16)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C247(1.08)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C247(1.06)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C247(1.07)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C247(1.27)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C247(1.08)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C247(1.22)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C247(1.26)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C247(1.11)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C247(1.10)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C247(1.34)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C247(1.24)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C247(1.46)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C247(1.19)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C247(1.14)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C247(1.07)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C247(1.18)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C247(1.73)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C247(1.08)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C247(1.10)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C247(1.13)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C247(1.09)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C247(1.07)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C247(1.12)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C247(1.20)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C247(1.17)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C247(1.24)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C247(1.13)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C247(1.10)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C247(1.01); C191(1.45)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C247(2.32); C299(1.87)  LDD1702  [4]
 LDCM0625  F8 Ramos C247(0.82)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C247(0.76)  LDD2189  [23]
 LDCM0574  Fragment12 Ramos C247(0.79)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C247(1.07)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C247(0.83)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C247(0.81)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C247(0.70)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C247(0.48)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C247(0.82)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C247(0.54)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C247(0.90)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C247(1.01)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C247(0.69)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C247(1.12)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C247(0.75)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C247(0.73)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C247(1.48)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C247(1.01)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C247(0.75)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C247(0.59)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C247(0.63)  LDD2188  [23]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HCT 116 C247(1.47)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C247(1.40)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C247(1.78)  LDD0082  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C149(0.87)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C149(0.45)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C149(0.55)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C149(1.21)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C149(0.79)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C149(1.32)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C149(1.29)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C149(0.20)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C149(0.64)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C149(1.12)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C149(0.97)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C149(0.73)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C149(0.82)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C149(1.42)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C149(0.73)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C149(0.92)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C149(0.76)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C299(0.81); C149(0.62)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C149(0.91)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C149(1.14)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C149(0.72)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C149(0.72)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C149(0.35)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C149(0.41)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C149(2.61)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C149(0.86)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C149(0.27)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C149(0.78)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C149(0.83)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C149(0.35)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C149(1.04)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C149(0.99)  LDD2128  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C149(0.61)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C149(0.40)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C149(0.91)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C149(1.03)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C149(1.07)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C149(1.46)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C149(0.69)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C299(0.89); C149(0.86)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C149(1.10)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C149(3.28)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C149(0.79)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C149(2.92)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C149(1.02)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C149(0.29)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C149(0.33); C247(1.28)  LDD2150  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Fas-activated serine/threonine kinase (FASTK) FAST protein kinase family Q14296
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Serine/threonine-protein kinase PAK 5 (PAK5) STE Ser/Thr protein kinase family Q9P286
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Tripartite motif-containing protein 14 (TRIM14) TRIM/RBCC family Q14142
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
pre-mRNA splicing regulator USH1G (USH1G) . Q495M9
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (PPP2R3C) . Q969Q6
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
Endothelial zinc finger protein induced by tumor necrosis factor alpha (ZNF71) Krueppel C2H2-type zinc-finger protein family Q9NQZ8
RB-associated KRAB zinc finger protein (RBAK) Krueppel C2H2-type zinc-finger protein family Q9NYW8
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger protein 24 (ZNF24) Krueppel C2H2-type zinc-finger protein family P17028
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 473 (ZNF473) Krueppel C2H2-type zinc-finger protein family Q8WTR7
Zinc finger protein 48 (ZNF48) Krueppel C2H2-type zinc-finger protein family Q96MX3
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 64 (ZFP64) Krueppel C2H2-type zinc-finger protein family Q9NTW7
Zinc finger protein 69 homolog B (ZFP69B) Krueppel C2H2-type zinc-finger protein family Q9UJL9
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
LIM/homeobox protein Lhx8 (LHX8) . Q68G74
Transcription factor HES-7 (HES7) . Q9BYE0
Transcription factor LBX1 (LBX1) . P52954
Transcriptional adapter 2-alpha (TADA2A) . O75478
Zinc finger protein 408 (ZNF408) . Q9H9D4
Other
Click To Hide/Show 67 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Ankyrin repeat and SOCS box protein 15 (ASB15) Ankyrin SOCS box (ASB) family Q8WXK1
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Condensin-2 complex subunit H2 (NCAPH2) CND2 H2 (condensin-2 subunit 2) family Q6IBW4
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Janus kinase and microtubule-interacting protein 2 (JAKMIP2) JAKMIP family Q96AA8
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) KHDRBS family O75525
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 4-11 (KRTAP4-11) KRTAP type 4 family Q9BYQ6
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
Paraneoplastic antigen Ma3 (PNMA3) PNMA family Q9UL41
Prickle-like protein 1 (PRICKLE1) Prickle / espinas / testin family Q96MT3
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
Serine/arginine-rich splicing factor 3 (SRSF3) Splicing factor SR family P84103
Syntaxin-11 (STX11) Syntaxin family O75558
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Brorin (VWC2) . Q2TAL6
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
Calpain small subunit 2 (CAPNS2) . Q96L46
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 106 (CCDC106) . Q9BWC9
Coiled-coil domain-containing protein 33 (CCDC33) . Q8N5R6
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
Coiled-coil domain-containing protein 70 (CCDC70) . Q6NSX1
Complement C1q tumor necrosis factor-related protein 1 (C1QTNF1) . Q9BXJ1
Ecotropic viral integration site 5 protein homolog (EVI5) . O60447
Heat shock factor 2-binding protein (HSF2BP) . O75031
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Huntingtin-associated protein 1 (HAP1) . P54257
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Leucine rich adaptor protein 1 (LURAP1) . Q96LR2
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
Myomegalin (PDE4DIP) . Q5VU43
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
Pre-mRNA-processing factor 6 (PRPF6) . O94906
PRKCA-binding protein (PICK1) . Q9NRD5
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Puratrophin-1 (PLEKHG4) . Q58EX7
RNA-binding motif protein, X chromosome (RBMX) . P38159
RNA-binding motif protein, Y chromosome, family 1 member A1 (RBMY1A1) . P0DJD3
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
20 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578