Details of the Target

General Information of Target

Target ID LDTP11113
Target Name Receptor expression-enhancing protein 2 (REEP2)
Gene Name REEP2
Gene ID 51308
Synonyms
C5orf19; SGC32445; Receptor expression-enhancing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQPLCPPLSESWMLSAAWGPTRRPPPSDKDCGRSLVSSPDSWGSTPADSPVASPARPGT
LRDPRAPSVGRRGARSSRLGSGQRQSASEREKLRMRTLARALHELRRFLPPSVAPAGQSL
TKIETLRLAIRYIGHLSAVLGLSEESLQRRCRQRGDAGSPRGCPLCPDDCPAQMQTRTQA
EGQGQGRGLGLVSAVRAGASWGSPPACPGARAAPEPRDPPALFAEAACPEGQAMEPSPPS
PLLPGDVLALLETWMPLSPLEWLPEEPK
Target Bioclass
Other
Family
DP1 family
Subcellular location
Membrane
Function Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors.
Uniprot ID
Q9BRK0
Ensemble ID
ENST00000254901.9
HGNC ID
HGNC:17975

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		5.94  LDD1725  [1]
C055
 Probe Info  		16.91  LDD1752  [1]
C056
 Probe Info  		30.27  LDD1753  [1]
C091
 Probe Info  		16.00  LDD1782  [1]
C092
 Probe Info  		30.27  LDD1783  [1]
C094
 Probe Info  		52.35  LDD1785  [1]
C106
 Probe Info  		20.82  LDD1793  [1]
C178
 Probe Info  		17.27  LDD1857  [1]
C228
 Probe Info  		21.41  LDD1901  [1]
C244
 Probe Info  		15.78  LDD1917  [1]
C246
 Probe Info  		12.73  LDD1919  [1]
C285
 Probe Info  		25.63  LDD1955  [1]
C287
 Probe Info  		8.63  LDD1957  [1]
C289
 Probe Info  		60.55  LDD1959  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-acetyltransferase 8 (NAT8) Camello family Q9UHE5
Cytochrome P450 4F2 (CYP4F2) Cytochrome P450 family P78329
Ultra-long-chain fatty acid omega-hydroxylase (CYP4F22) Cytochrome P450 family Q6NT55
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) . Q969V5
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bax inhibitor 1 (TMBIM6) BI1 family P55061
Mitochondrial outer membrane protein SLC25A46 (SLC25A46) Mitochondrial carrier (TC 2.A.29) family Q96AG3
B-lymphocyte antigen CD20 (MS4A1) MS4A family P11836
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Transmembrane protein 208 (TMEM208) TMEM208 family Q9BTX3
Phospholipid transfer protein C2CD2L (C2CD2L) . O14523
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 60 (TMEM60) . Q9H2L4
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrin alpha-M (ITGAM) Integrin alpha chain family P11215
ORM1-like protein 3 (ORMDL3) ORM family Q8N138
Vesicle transport protein SFT2B (SFT2D2) SFT2 family O95562
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Protein YIF1A (YIF1A) YIF1 family O95070
Alpha-tocopherol transfer protein (TTPA) . P49638
Transmembrane protein 42 (TMEM42) . Q69YG0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587