Details of the Target

General Information of Target

Target ID LDTP02061
Target Name Anion exchange protein 2 (SLC4A2)
Gene Name SLC4A2
Gene ID 6522
Synonyms
AE2; EPB3L1; HKB3; MPB3L; Anion exchange protein 2; AE 2; Anion exchanger 2; Non-erythroid band 3-like protein; BND3L; Solute carrier family 4 member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGE
EPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPT
IEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQ
EATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRR
IGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG
REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERW
GKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVL
RALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEV
ERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREA
VELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT
AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKAL
LQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAAL
SPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFS
FCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETF
YKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT
ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ
KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIIS
KKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDK
PKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLH
LLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR
MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
Target Bioclass
Transporter and channel
Family
Anion exchanger (TC 2.A.31) family
Subcellular location
Apical cell membrane
Function
Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. Plays an important role in osteoclast differentiation and function. Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH. Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses.
Uniprot ID
P04920
Ensemble ID
ENST00000392826.6
HGNC ID
HGNC:11028

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.E68Ter .
A204 SNV: p.R240C DBIA    Probe Info 
CCK81 Insertion: p.D705Ter .
DU145 SNV: p.L272P .
HCC1143 SNV: p.S609R .
HCC44 SNV: p.R301P .
HT115 SNV: p.A139T; p.A493T; p.E571K .
HUH7 Substitution: p.A250Ter .
JURKAT SNV: p.R895P .
KO52 SNV: p.L650P .
MCC13 SNV: p.E48K .
MOLT4 SNV: p.V281I .
NALM6 SNV: p.A909D .
NCIH1155 SNV: p.S3N .
NCIH2122 SNV: p.R359L .
NUGC3 SNV: p.G124E .
RKO SNV: p.A182T .
RL SNV: p.D462A .
SW1271 SNV: p.G792V .
UMUC3 SNV: p.G396R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.97  LDD0402  [1]
STPyne
 Probe Info  		K426(3.31); K434(7.44); K501(10.00); K893(0.22)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K975(2.29); K893(3.14)  LDD3494  [3]
DBIA
 Probe Info  		C16(1.96)  LDD3375  [4]
AHL-Pu-1
 Probe Info  		C16(2.13)  LDD0168  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C134
 Probe Info  		23.92  LDD1816  [8]
C153
 Probe Info  		16.34  LDD1834  [8]
C158
 Probe Info  		11.39  LDD1838  [8]
C187
 Probe Info  		16.80  LDD1865  [8]
C191
 Probe Info  		9.58  LDD1868  [8]
C193
 Probe Info  		5.70  LDD1869  [8]
C310
 Probe Info  		10.27  LDD1977  [8]
C413
 Probe Info  		11.88  LDD2069  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C16(2.13)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C16(10.10)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C1215(1.13)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C1215(1.11); C16(1.01)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C1215(0.92); C16(1.06)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C1215(1.08); C16(0.95)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C1215(0.87); C16(1.01)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C1215(1.03); C16(1.02)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C1215(1.05)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C1215(1.03); C16(1.05)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C1215(1.39); C16(0.96)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C1215(1.06); C16(1.22)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C1215(1.08); C16(0.88)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C1215(1.10); C16(1.01); C608(1.29)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C1215(0.82); C16(1.17)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C1215(1.05); C16(0.95)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C1215(0.98); C16(0.92); C523(1.06)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C1215(1.16)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C1215(1.04); C16(0.96)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C1215(1.09); C16(1.01)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C1215(0.98); C16(0.87)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C1215(0.96); C16(1.00); C608(1.29)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C1215(0.86); C16(0.98)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C1215(0.90); C16(1.06)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C1215(0.94); C16(0.98)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C1215(1.01); C16(0.71); C523(1.05)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C1215(0.97)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C1215(1.02); C16(1.01)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C1215(0.90); C16(0.92)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C1215(1.06); C16(0.97)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C1215(0.98); C16(0.94); C608(1.04)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C1215(0.87); C16(1.05)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C1215(1.05); C16(1.10)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C1215(1.03); C16(1.11)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C1215(0.98); C16(0.91); C523(1.03)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C1215(1.07)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C1215(1.10); C16(0.96)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C1215(1.11); C16(1.11)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C1215(1.02); C16(1.00)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C1215(1.00); C16(1.10); C608(0.99)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C1215(0.98); C16(1.23)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C1215(0.99); C16(1.05)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C1215(1.02); C16(1.00); C523(1.18)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C1215(1.07)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C1215(0.99); C16(1.06); C608(1.02)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C1215(1.11); C16(0.86)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C1215(1.00); C16(1.07)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C1215(0.99); C16(1.03)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C1215(1.00); C16(1.09); C608(1.15)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C1215(0.90); C16(1.06)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C1215(1.00); C16(1.00)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C1215(0.92); C16(0.93); C523(1.06)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C1215(1.06)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C1215(0.98); C16(0.97)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C1215(1.00); C16(0.98)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C1215(0.93); C16(1.00)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C1215(1.00); C16(0.94)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C1215(1.03); C16(0.99); C608(1.51)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C1215(0.95); C16(1.13)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C1215(1.04); C16(0.98)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C1215(0.96); C16(0.91); C523(1.06)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C1215(1.15); C16(0.95)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C1215(0.97); C16(0.97); C523(0.98)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C1215(1.01); C16(0.94); C608(1.18)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C1215(1.14)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C1215(0.92); C16(0.99); C523(0.97)  LDD1514  [9]
 LDCM0367  CL1 HEK-293T C1215(0.94); C16(0.99)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C1215(1.07); C16(0.77)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C1215(1.07); C16(0.82)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C1215(1.06); C16(0.79)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C1215(1.07); C16(0.97); C608(0.82)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C1215(0.98); C16(1.02)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C1215(0.98); C16(0.89)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C1215(0.96); C16(0.61)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C1215(0.98); C16(1.17); C608(0.91)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C1215(1.05); C16(1.08)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C1215(0.99); C16(0.94)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C1215(0.98); C16(0.88)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C1215(1.09); C16(0.95)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C1215(1.05); C16(0.97); C608(0.92)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C1215(1.03); C16(1.09)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C1215(0.96); C16(0.90)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C1215(0.87); C16(0.79)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C1215(0.99); C16(1.05); C608(0.80)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C1215(0.94); C16(0.99)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C1215(0.99); C16(0.94)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C1215(0.90); C16(0.92)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C1215(0.98); C16(0.97); C608(1.00)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C1215(0.95); C16(1.01)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C1215(1.18); C16(0.96); C523(1.10)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C1215(1.04); C16(0.88)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C1215(0.89); C16(0.74)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C1215(1.05); C16(0.93); C608(0.88)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C1215(1.08); C16(1.01)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C1215(0.93); C16(0.95)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C1215(1.01); C16(0.83)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C1215(1.14); C16(1.15); C608(0.87)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C1215(1.00); C16(1.00)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C1215(0.95); C16(0.79)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C1215(0.97); C16(0.77)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C1215(1.14); C16(1.20); C608(1.27)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C1215(0.92); C16(0.94)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C1215(1.06); C16(0.96)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C1215(1.09)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C1215(1.11); C16(0.95)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C1215(1.13); C16(1.04)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C1215(1.07); C16(1.07); C608(0.92)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C1215(1.04); C16(1.04)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C1215(1.16); C16(1.19); C608(0.83)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C1215(1.15); C16(1.15)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C1215(0.99); C16(1.00)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C1215(1.25); C16(0.97); C523(1.11)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C1215(0.92); C16(0.71)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C1215(0.97); C16(1.06); C608(0.81)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C1215(0.93); C16(0.94)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C1215(0.99); C16(0.73)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C1215(1.16)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C1215(1.01); C16(1.27)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C1215(1.12); C16(1.08)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C1215(1.03); C16(0.93)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C1215(0.95); C16(0.88)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C1215(1.57); C16(1.15); C608(1.05)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C1215(1.13); C16(1.31)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C1215(0.94); C16(1.09)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C1215(1.17); C16(0.81); C523(0.97)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C1215(0.88); C16(0.73)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C1215(1.04); C16(0.95)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C1215(1.20); C16(0.79)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C1215(0.93); C16(0.82)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C1215(1.13)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C1215(1.04); C16(0.86)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C1215(1.22); C16(1.04)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C1215(1.09); C16(1.02)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C1215(1.24); C16(1.12); C608(1.11)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C1215(1.19); C16(1.08)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C1215(1.04); C16(1.05)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C1215(1.16); C16(0.75); C523(1.05)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C1215(0.87); C16(0.82)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C1215(1.06)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C1215(1.05); C16(1.12); C608(0.94)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C1215(0.99); C16(0.91)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C1215(1.20)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C1215(1.01); C16(0.89)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C1215(1.15); C16(1.11)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C1215(1.10); C16(1.30)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C1215(1.23); C16(1.08); C608(0.90)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C1215(1.10); C16(1.11)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C1215(1.00); C16(0.95)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C1215(1.09); C16(0.92)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C1215(1.21); C16(0.95); C523(1.00)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C1215(0.92); C16(0.69)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C1215(0.87); C16(1.24); C608(0.79)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C1215(0.90); C16(1.16)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C1215(0.96); C16(0.93)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C1215(1.02)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C1215(0.98); C16(0.94)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C1215(0.98); C16(1.01)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C1215(1.09); C16(1.09)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C1215(1.15); C16(1.08); C608(0.90)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C1215(1.02); C16(1.09)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C1215(0.99); C16(1.12)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C1215(1.00); C16(1.09)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C1215(1.12); C16(1.11); C523(1.13)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C1215(1.15); C16(0.67)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C1215(0.96); C16(1.04); C608(0.79)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C1215(0.93); C16(0.92)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C1215(1.07)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C1215(1.12); C16(0.85)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C1215(1.04); C16(0.77)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C1215(1.18); C16(0.97)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C1215(1.07); C16(1.10)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C1215(1.03); C16(1.05); C608(1.08)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C1215(1.02); C16(0.92)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C1215(1.04); C16(1.02)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C1215(1.06); C16(0.84); C523(1.04)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C1215(0.85); C16(0.59)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C1215(0.96); C16(1.31); C608(1.12)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C1215(0.98); C16(1.06)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C1215(1.05); C16(1.01)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C1215(1.03)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C1215(1.24); C16(1.16); C608(0.85)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C1215(1.20); C16(0.83)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C1215(0.93); C16(1.27)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C1215(1.04); C16(1.03)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C1215(1.12); C16(0.96); C608(1.27)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C1215(0.96); C16(1.22)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C1215(1.01); C16(1.02)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C1215(0.91); C16(0.79); C523(1.17)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C1215(0.97); C16(0.73)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C1215(1.00); C16(1.03); C608(1.05)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C1215(0.88); C16(0.87)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C1215(0.95); C16(0.96)  LDD1698  [9]
 LDCM0576  Fragment14 Ramos C16(0.63)  LDD2193  [10]
 LDCM0586  Fragment28 Ramos C16(0.53)  LDD2198  [10]
 LDCM0468  Fragment33 HEK-293T C1215(0.93); C16(1.05)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C1215(0.97); C16(1.19); C608(1.16)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C1215(0.79); C16(0.95)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C1215(0.91); C16(1.15)  LDD1497  [9]
 LDCM0024  KB05 OE33 C16(1.96)  LDD3375  [4]

References

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Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578