Details of the Target

General Information of Target

Target ID LDTP11525
Target Name Kinetochore protein Nuf2 (NUF2)
Gene Name NUF2
Gene ID 83540
Synonyms
CDCA1; NUF2R; Kinetochore protein Nuf2; hNuf2; hNuf2R; hsNuf2; Cell division cycle-associated protein 1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAVVSEDDFQHSSNSTYRTTSSSLRADQEALLEKLLDRPPPGLQRPEDRFCGTYIIFFSL
GIGSLLPWNFFITAKEYWMFKLRNSSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLV
ANFLLVNRVAVHIRVLASLTVILAIFMVITALVKVDTSSWTRGFFAVTIVCMVILSGAST
VFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATVF
LVLCMGLYLLLSRLEYARYYMRPVLAAHVFSGEEELPQDSLSAPSVASRFIDSHTPPLRP
ILKKTASLGFCVTYVFFITSLIYPAICTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADL
CGRQLTAWIQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSS
LLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI
Target Type
Literature-reported
Target Bioclass
Other
Family
NUF2 family
Subcellular location
Nucleus
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
TTD ID
T15126
Uniprot ID
Q9BZD4
DrugMap ID
TTIXBFP
Ensemble ID
ENST00000271452.8
HGNC ID
HGNC:14621

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K213(3.76); K348(10.00); K349(6.25); K367(10.00)  LDD0277  [3]
BTD
 Probe Info  		C377(0.79)  LDD2089  [4]
AHL-Pu-1
 Probe Info  		C377(8.33); C111(3.46)  LDD0168  [5]
DBIA
 Probe Info  		C377(0.86)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C111(0.00); C377(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
VSF
 Probe Info  		N.A.  LDD0007  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		C377(0.00); C111(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		8.57  LDD1779  [14]
C158
 Probe Info  		8.94  LDD1838  [14]
C201
 Probe Info  		24.59  LDD1877  [14]
C206
 Probe Info  		16.68  LDD1881  [14]
C284
 Probe Info  		22.16  LDD1954  [14]
C296
 Probe Info  		12.55  LDD1966  [14]
C310
 Probe Info  		7.57  LDD1977  [14]
C413
 Probe Info  		16.00  LDD2069  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C377(8.33); C111(3.46)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C377(3.61); C285(3.32); C111(2.06)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C377(0.89)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C285(1.03)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C377(0.74)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C377(0.90)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C377(0.82)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C377(1.08)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C377(1.01)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C377(0.86)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C377(0.95)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C377(0.99)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C377(0.98)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C377(0.85)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C285(0.90)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C377(1.22)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C377(0.86)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C377(1.01)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C377(1.16)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C377(1.27)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C377(1.27)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C377(1.25)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C377(1.14)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C377(1.37)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C377(1.61)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C285(0.99)  LDD0835  [6]
 LDCM0238  AC120 HCT 116 C377(1.46)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C377(1.16)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C377(1.09)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C377(0.94)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C377(1.12)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C377(1.04)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C377(0.94)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C377(1.15)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C285(1.21); C289(1.21)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C285(0.95); C289(0.95)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C285(1.14); C289(1.14)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C285(1.06); C289(1.06)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C285(0.84); C289(0.84)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C285(0.89); C289(0.89)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C285(0.99); C289(0.99)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C285(1.04); C289(1.04)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C285(0.97); C289(0.97)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C285(0.95); C289(0.95)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C285(0.90); C289(0.90)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C285(0.90); C289(0.90)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C285(1.11)  LDD0857  [6]
 LDCM0260  AC140 HCT 116 C285(0.85); C289(0.85)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C285(0.92); C289(0.92)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C285(0.83); C289(0.83)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C285(0.89); C289(0.89)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C285(1.15); C289(1.15)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C285(0.96); C289(0.96)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C285(1.21); C289(1.21)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C285(1.44); C289(1.44)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C285(1.72); C289(1.72)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C285(1.37); C289(1.37)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C285(1.40)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C285(0.89); C289(0.89)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C285(0.97); C289(0.97)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C285(1.43); C289(1.43)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C285(1.83); C289(1.83)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C285(1.16); C289(1.16)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C285(1.42); C289(1.42)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C285(1.00); C289(1.00)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C285(1.00); C289(1.00)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C285(0.84); C289(0.84)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C285(2.22); C289(2.22)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C285(1.28); C289(1.28)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C377(1.18)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C285(2.07); C289(2.07)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C285(1.25); C289(1.25)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C285(0.93); C289(0.93)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C285(0.97); C289(0.97)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C285(0.81); C289(0.81)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C285(0.77); C289(0.77)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C285(0.86); C289(0.86)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C285(1.05); C289(1.05)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C285(0.93); C289(0.93)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C285(1.33); C289(1.33)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C377(1.07)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C285(1.31); C289(1.31)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C285(1.11); C289(1.11)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C285(1.23); C289(1.23)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C285(0.91); C289(0.91)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C285(1.18); C289(1.18)  LDD0612  [6]
 LDCM0296  AC35 HEK-293T C285(0.90)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C285(1.14)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C285(0.87)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C285(0.99)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C285(1.11)  LDD0898  [6]
 LDCM0301  AC4 HCT 116 C377(0.98)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C285(1.22)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C285(0.84)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C285(1.40)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C285(1.13)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C285(0.97)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C285(0.93)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C285(0.96); C111(0.75); C289(1.55)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C285(0.99); C111(0.61); C289(1.88)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C285(1.13); C111(0.56); C289(1.45)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C285(1.29); C111(0.88); C289(1.61)  LDD0909  [6]
 LDCM0312  AC5 HCT 116 C377(0.91)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C285(1.35); C111(0.93); C289(1.59)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C285(1.39); C111(0.70); C289(2.13)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C285(1.26); C111(0.75); C289(1.73)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C285(1.18); C111(0.93); C289(1.55)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C285(1.20); C111(0.91); C289(2.11)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C285(1.06); C111(0.83); C289(1.83)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C285(0.90); C111(0.77); C289(1.48)  LDD0917  [6]
 LDCM0320  AC57 HEK-293T C111(1.31)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C111(1.43)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C111(1.40)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C285(1.01)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C111(0.62)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C111(0.97)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C111(1.03)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C111(0.92)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C111(1.42)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C111(1.05)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C111(1.17)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C111(0.96)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C111(0.99); C289(1.09)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C111(1.15); C289(1.30)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C285(1.14)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C111(0.92); C289(1.61)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C111(1.00); C289(0.96)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C111(1.01); C289(0.98)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C111(0.79); C289(2.22)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C111(0.79); C289(1.26)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C111(0.79); C289(1.07)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C111(0.83); C289(1.20)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C111(0.91); C289(1.23)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C111(0.81); C289(1.52)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C111(0.93); C289(0.98)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C285(1.39)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C111(0.78); C289(1.41)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C111(0.80); C289(1.28)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C111(0.66); C289(1.86)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C285(1.08); C111(1.23); C289(0.66)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C285(1.19); C111(1.13); C289(0.86)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C285(1.10); C111(1.18); C289(0.94)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C285(0.97); C111(1.07); C289(0.63)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C285(1.31); C111(1.40); C289(0.82)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C285(1.12); C111(1.03); C289(0.99)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C285(1.01); C111(1.06); C289(1.11)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C285(1.32); C111(1.02); C289(0.89)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C285(1.61); C111(1.28); C289(0.70)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C285(1.38); C111(0.99); C289(0.94)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C285(1.73); C111(0.72); C289(1.23)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C285(1.38); C111(0.85); C289(1.49)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C285(1.07); C111(1.20); C289(0.75)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C285(1.32); C111(1.26); C289(0.88)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C285(2.06); C111(0.42); C289(1.97)  LDD0962  [6]
 LDCM0365  AC98 HCT 116 C377(0.92)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C377(0.93)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C377(0.72)  LDD2138  [4]
 LDCM0248  AKOS034007472 HEK-293T C285(1.19)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C285(1.19)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C285(1.25)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 12.18  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C377(0.86)  LDD0078  [6]
 LDCM0498  BS-3668 MDA-MB-231 C377(0.81)  LDD2091  [4]
 LDCM0632  CL-Sc Hep-G2 C111(0.92)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C285(0.94); C289(0.94); C377(1.21)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C377(1.06); C285(1.47); C289(1.47)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C377(1.01)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C285(1.48)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C285(2.22)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C285(1.32)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C285(1.26)  LDD0971  [6]
 LDCM0374  CL105 HCT 116 C285(1.22); C289(1.22)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C285(1.13); C289(1.13)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C285(1.03); C289(1.03)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C285(1.57); C289(1.57)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C285(1.31); C289(1.31)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C377(1.04); C285(1.53); C289(1.53)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C285(1.99); C289(1.99)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C285(1.27); C289(1.27)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C285(0.85); C289(0.85)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C285(1.18); C289(1.18)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C285(1.13); C289(1.13)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C285(1.24); C289(1.24)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C285(1.12); C289(1.12)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C285(0.91)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C285(0.97)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C285(0.95)  LDD0987  [6]
 LDCM0390  CL12 HCT 116 C377(1.22); C285(1.62); C289(1.62)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C285(0.95)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C285(1.33); C111(0.69); C289(1.78)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C285(1.01); C111(0.71); C289(1.49)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C285(1.55); C111(0.82); C289(3.02)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C285(1.31); C111(0.90); C289(1.57)  LDD0993  [6]
 LDCM0396  CL125 HEK-293T C111(1.01)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C111(0.87)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C111(1.18)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C111(1.15)  LDD0997  [6]
 LDCM0400  CL13 HCT 116 C377(0.92); C285(1.33); C289(1.33)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C377(1.05); C285(1.16); C289(1.16)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C377(0.86); C285(1.42); C289(1.42)  LDD0719  [6]
 LDCM0403  CL16 HEK-293T C285(0.94); C111(0.92); C289(0.91)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C285(2.38); C111(0.79); C289(1.11)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C285(1.08); C111(1.00); C289(0.96)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C285(1.08); C111(0.81); C289(1.38)  LDD1004  [6]
 LDCM0407  CL2 HCT 116 C285(0.85); C289(0.85); C377(1.01)  LDD0724  [6]
 LDCM0408  CL20 HEK-293T C285(1.10); C111(1.26); C289(0.98)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C285(2.13); C111(0.58); C289(2.75)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C285(1.09); C111(0.85); C289(1.47)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C285(1.17); C111(1.04); C289(0.93)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C285(0.91); C111(1.55); C289(0.88)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C285(1.64); C111(0.79); C289(1.22)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C285(1.04); C111(1.25); C289(0.99)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C285(1.14); C111(1.25); C289(1.11)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C285(1.17); C111(0.80); C289(1.18)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C285(1.07); C111(0.90); C289(0.89)  LDD1015  [6]
 LDCM0418  CL3 HCT 116 C285(0.94); C289(0.94); C377(1.07)  LDD0735  [6]
 LDCM0419  CL30 HEK-293T C285(1.35); C111(0.66); C289(1.74)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C285(2.14); C289(1.11)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C285(1.51); C289(1.45)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C285(2.98); C289(2.56)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C285(1.33); C289(1.49)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C285(1.47); C289(1.37)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C285(1.47); C289(1.57)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C285(1.55); C289(1.47)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C285(3.10); C289(2.96)  LDD1026  [6]
 LDCM0429  CL4 HCT 116 C285(0.94); C289(0.94); C377(0.95)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C285(1.52); C289(1.30)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C285(2.87); C289(2.97)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C285(1.45); C289(2.38)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C285(1.72); C289(2.38)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C285(1.37); C289(1.53)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C285(2.75); C289(2.30)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C289(1.17)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C289(1.18)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C289(0.96)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C289(1.08)  LDD1037  [6]
 LDCM0440  CL5 HCT 116 C285(1.07); C289(1.07); C377(0.86)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C289(1.74)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C289(1.55)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C289(0.84)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C289(1.41)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C289(1.52)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C289(1.26)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C289(1.17)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C289(1.87)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C289(1.22)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C289(1.44)  LDD1048  [6]
 LDCM0451  CL6 HCT 116 C285(1.19); C289(1.19); C377(1.00)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C289(2.07)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C285(1.42); C111(0.82)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C285(1.12); C111(0.86)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C285(1.45); C111(0.75)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C285(1.79); C111(0.71)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C285(1.39); C111(0.73)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C285(1.52); C111(0.82)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C285(1.16); C111(0.77)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C285(1.34); C111(0.46)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C285(1.56); C111(0.78)  LDD1059  [6]
 LDCM0462  CL7 HCT 116 C285(1.24); C289(1.24); C377(1.12)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C285(1.32); C111(0.78)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C285(1.21); C111(0.67)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C285(1.11); C111(0.88)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C285(1.80); C111(0.55)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C285(1.59); C111(0.20)  LDD1065  [6]
 LDCM0469  CL76 HCT 116 C285(0.95); C289(0.95)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C285(1.39); C289(1.39)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C285(0.80); C289(0.80)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C285(0.85); C289(0.85)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C285(2.65); C289(2.65); C377(1.21)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C285(0.87); C289(0.87)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C285(0.85); C289(0.85)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C285(0.93); C289(0.93)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C285(1.04); C289(1.04)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C285(0.98); C289(0.98)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C285(1.11); C289(1.11)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C285(1.17); C289(1.17)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C285(1.11); C289(1.11)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C285(1.07); C289(1.07)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C285(0.97); C289(0.97)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C285(1.21); C289(1.21); C377(1.13)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C285(1.28); C289(1.28)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C377(1.15)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C377(1.01)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C377(0.91)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C377(0.91)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C377(0.99)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C377(1.14)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C377(1.05)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C377(1.08)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C377(1.05)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C111(1.11)  LDD1698  [15]
 LDCM0625  F8 Ramos C111(1.07)  LDD2187  [16]
 LDCM0573  Fragment11 Ramos C377(1.48); C111(9.84)  LDD2190  [16]
 LDCM0575  Fragment13 Ramos C111(0.92)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C377(0.43)  LDD2193  [16]
 LDCM0580  Fragment21 Ramos C111(3.82)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C111(0.53)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C111(0.70)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C377(0.90); C111(1.51)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C111(1.85)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C111(1.08)  LDD2200  [16]
 LDCM0468  Fragment33 HEK-293T C285(1.45); C111(0.27)  LDD1066  [6]
 LDCM0596  Fragment38 Ramos C111(0.73)  LDD2203  [16]
 LDCM0427  Fragment51 HEK-293T C285(1.28); C289(1.22)  LDD1025  [6]
 LDCM0610  Fragment52 Ramos C111(6.21)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C111(0.99)  LDD2205  [16]
 LDCM0022  KB02 HCT 116 C285(3.62); C289(3.62); C111(2.54); C377(1.25)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C285(3.26); C289(3.26); C111(1.37); C377(1.06)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C285(5.95); C289(5.95); C111(1.61); C377(1.27)  LDD0082  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C377(1.17)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C377(0.79)  LDD2089  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C377(1.08)  LDD2128  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C377(0.81)  LDD2150  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C111(1.52)  LDD2206  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C111(0.34)  LDD2207  [17]
 LDCM0021  THZ1 HCT 116 C285(1.20); C289(1.20)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere-associated protein E (CENPE) Kinesin family Q02224
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.