Details of the Target

General Information of Target

Target ID LDTP12073
Target Name Golgi reassembly-stacking protein 2 (GORASP2)
Gene Name GORASP2
Gene ID 26003
Synonyms
GOLPH6; Golgi reassembly-stacking protein 2; GRS2; Golgi phosphoprotein 6; GOLPH6; Golgi reassembly-stacking protein of 55 kDa; GRASP55; p59
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAPRTSCSGSGERESPERK
LLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSS
TGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRC
VLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRA
KRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPR
SGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLH
SPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVEL
TVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLG
PLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLH
AAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKA
QVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRAL
AAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQ
AGRPSS
Target Bioclass
Other
Family
GORASP family
Subcellular location
Golgi apparatus membrane
Function
Key structural protein of the Golgi apparatus. The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon. Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks. However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA. Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells. Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane.
Uniprot ID
Q9H8Y8
Ensemble ID
ENST00000234160.5
HGNC ID
HGNC:17500

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.V435L .
NUGC3 SNV: p.G92D DBIA    Probe Info 
PANC1 Deletion: p.L302YfsTer4 DBIA    Probe Info 
SUPT1 Deletion: p.F105LfsTer32 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
FBP2
 Probe Info  		2.43  LDD0323  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
Probe 1
 Probe Info  		Y72(25.66)  LDD3495  [4]
HHS-475
 Probe Info  		Y164(0.46)  LDD0264  [5]
HHS-465
 Probe Info  		Y196(0.75)  LDD2237  [6]
DBIA
 Probe Info  		C173(1.19)  LDD0080  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
m-APA
 Probe Info  		N.A.  LDD2231  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		C192(0.00); C173(0.00)  LDD0036  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C192(0.00); C173(0.00)  LDD0037  [10]
NAIA_5
 Probe Info  		N.A.  LDD2224  [12]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
NHS
 Probe Info  		N.A.  LDD0010  [13]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
TFBX
 Probe Info  		N.A.  LDD0148  [14]
1c-yne
 Probe Info  		N.A.  LDD0228  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [3]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		5.28  LDD1733  [17]
C214
 Probe Info  		5.39  LDD1888  [17]
VE-P
 Probe Info  		N.A.  LDD0396  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C173(1.11)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C173(0.79)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C173(0.65)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C173(0.62)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C173(0.60)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C173(0.51)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C173(0.63)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C173(0.51)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C173(0.59)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C173(0.61)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C173(0.81)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C173(0.71)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C173(0.76)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C173(0.66)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C173(0.60)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C173(0.56)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C173(1.03)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C173(0.66)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C173(0.63)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C173(0.57)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C173(0.72)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C173(0.78)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C173(0.71)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C173(1.09)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C173(0.84)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C173(0.79)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C173(0.72)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C173(0.98)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C173(0.84)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C173(0.76)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C173(0.65)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C173(0.66)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C173(0.98)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C173(1.31)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C173(0.97)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C173(1.10)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C173(1.21)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C173(1.02)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C173(0.86)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C173(0.94)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C173(1.07)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C173(1.30)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C173(0.91)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C173(0.89)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C173(0.95)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C173(0.93)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C173(0.95)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C173(1.23)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C173(0.95)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C173(0.54)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C173(0.69)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C173(0.48)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C173(0.58)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C173(0.42)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C173(0.43)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C173(0.85)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C173(0.68)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C173(0.78)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C173(0.59)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C173(0.44)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C173(0.66)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C173(0.55)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C173(1.16)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C173(1.11)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C173(0.92)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C173(0.90)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C173(0.91)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C173(1.01)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C173(0.89)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C173(0.82)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C173(1.07)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C173(0.90)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C173(0.97)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C173(0.73)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C173(0.61)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C173(0.58)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C173(0.72)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C173(0.58)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C173(1.16)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C173(0.56)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C173(0.61)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C173(0.52)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C173(0.56)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C173(0.56)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C173(1.48)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C173(1.28)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C173(1.27)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C173(1.20)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C173(1.04)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C173(1.01)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C173(0.82)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C173(1.12)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C173(0.95)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C173(0.99)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C173(0.95)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C173(0.98)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C173(0.89)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C173(0.85)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C173(0.93)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C173(0.78)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C173(1.05)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C173(0.83)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C173(1.14)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C173(0.98)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C173(0.86)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C173(1.05)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C173(0.88)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C173(0.85)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C173(0.59)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C173(0.62)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C173(0.59)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C173(0.73)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C173(0.58)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C173(0.73)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C173(0.70)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C173(0.68)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C173(0.54)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C173(0.67)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C173(0.77)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C173(0.53)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C173(0.79)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C173(0.97)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C173(0.86)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C173(0.69)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C173(0.91)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C173(0.76)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C173(0.76)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C173(0.77)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C173(0.75)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C173(0.78)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C173(0.84)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C173(0.93)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C173(1.12)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C173(0.85)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C173(0.83)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C173(1.11)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C173(0.82)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C173(0.51)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C173(0.57)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C173(0.63)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C173(0.58)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C173(0.74)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C173(0.66)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C173(0.59)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C173(0.93)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C173(0.62)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C173(0.63)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C173(0.79)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C173(0.71)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C173(0.72)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C173(0.74)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C173(0.62)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C173(0.37)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C173(0.79)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C173(1.22)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C173(1.02)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C173(0.70)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C173(1.19)  LDD2171  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0367  CL1 HCT 116 C173(1.02)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C173(0.84)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C173(0.98)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C173(0.75)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C173(0.84)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C173(0.97)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C173(0.97)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C173(0.83)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C173(0.93)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C173(0.89)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C173(0.88)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C173(0.80)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C173(0.84)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C173(0.81)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C173(0.88)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C173(0.91)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C173(0.56)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C173(0.61)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C173(0.61)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C173(0.64)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C173(0.86)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C173(1.04)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C173(1.04)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C173(0.75)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C173(1.13)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C173(1.17)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C173(0.89)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C173(0.76)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C173(0.94)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C173(0.79)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C173(0.85)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C173(0.71)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C173(0.62)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C173(0.77)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C173(0.96)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C173(0.97)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C173(0.88)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C173(0.85)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C173(0.90)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C173(0.84)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C173(1.26)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C173(0.71)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C173(0.65)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C173(0.96)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C173(0.87)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C173(0.76)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C173(0.71)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C173(0.78)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C173(0.83)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C173(0.77)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C173(0.77)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C173(1.17)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C173(0.92)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C173(0.83)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C173(0.63)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C173(0.60)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C173(0.51)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C173(0.55)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C173(0.58)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C173(0.59)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C173(0.58)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C173(1.06)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C173(0.64)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C173(0.63)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C173(0.60)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C173(0.59)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C173(0.65)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C173(0.65)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C173(1.27)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C173(1.21)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C173(1.54)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C173(1.03)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C173(0.97)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C173(1.07)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C173(1.44)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C173(1.12)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C173(1.01)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C173(1.15)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C173(1.20)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C173(1.08)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C173(1.39)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C173(1.21)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C173(1.22)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C173(0.90)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C173(1.01)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C173(0.94)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C173(0.89)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C173(0.78)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C173(0.73)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C173(0.93)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C173(0.73)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C173(0.85)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C173(0.84)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C173(0.97)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C173(0.82)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C173(0.79)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C173(0.89)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C173(0.93)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C173(0.77)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C173(0.77)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C173(0.81)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C173(0.79)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C173(0.86)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C173(0.73)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C173(0.67)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C173(0.85)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C173(0.86)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C173(0.76)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C173(0.74)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C173(0.71)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C173(0.84)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C173(1.00)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C173(0.87)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C173(0.77)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C173(0.82)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C173(0.80)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C173(1.00)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C173(1.04)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C173(1.09)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C173(1.03)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C173(0.87)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C173(0.83)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C173(0.93)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C173(1.01)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C173(0.89)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C173(0.86)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C173(0.67)  LDD2228  [12]
 LDCM0495  E2913 HEK-293T C173(0.93); C103(1.02)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C173(0.52)  LDD1702  [20]
 LDCM0468  Fragment33 HCT 116 C173(0.91)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C173(0.51)  LDD0744  [7]
 LDCM0116  HHS-0101 DM93 Y164(0.46)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y164(0.80)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y164(0.80)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y164(0.98)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y164(0.52)  LDD0268  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C173(1.19)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C173(1.10)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C173(1.31)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0227  [16]
 LDCM0131  RA190 MM1.R C173(1.14)  LDD0304  [21]
 LDCM0021  THZ1 HCT 116 C173(1.19)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 47 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Cystic fibrosis transmembrane conductance regulator (CFTR) ABCC family P13569
Methylthioribulose-1-phosphate dehydratase (APIP) Aldolase class II family Q96GX9
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (ALKBH4) AlkB family Q9NXW9
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (ACY3) AspA/AstE family Q96HD9
Tryptophan 5-hydroxylase 1 (TPH1) Biopterin-dependent aromatic amino acid hydroxylase family P17752
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A) Cyclic nucleotide phosphodiesterase family O76083
Cytidine deaminase (CDA) Cytidine and deoxycytidylate deaminase family P32320
Deoxycytidylate deaminase (DCTD) Cytidine and deoxycytidylate deaminase family P32321
Ecto-NOX disulfide-thiol exchanger 1 (ENOX1) ENOX family Q8TC92
Ethylmalonyl-CoA decarboxylase (ECHDC1) Enoyl-CoA hydratase/isomerase family Q9NTX5
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) Eukaryotic NMN adenylyltransferase family Q9HAN9
Maleylacetoacetate isomerase (GSTZ1) Zeta family O43708
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) Maf family O95671
Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) Glyoxalase II family O95571
Ribosyldihydronicotinamide dehydrogenase [quinone] (NQO2) NAD(P)H dehydrogenase (quinone) family P16083
ADP-sugar pyrophosphatase (NUDT5) Nudix hydrolase family Q9UKK9
Ornithine decarboxylase (ODC1) Orn/Lys/Arg decarboxylase class-II family P11926
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) Peroxiredoxin family P30048
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) Proteasome subunit S2 family Q13200
EKC/KEOPS complex subunit TP53RK (TP53RK) BUD32 family Q96S44
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Dual specificity protein phosphatase 21 (DUSP21) Protein-tyrosine phosphatase family Q9H596
Dual specificity protein phosphatase 4 (DUSP4) Protein-tyrosine phosphatase family Q13115
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) Pterin-4-alpha-carbinolamine dehydratase family P61457
Ribose-5-phosphate isomerase (RPIA) Ribose 5-phosphate isomerase family P49247
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Serine hydroxymethyltransferase, cytosolic (SHMT1) SHMT family P34896
Ras-related protein Rab-27B (RAB27B) Rab family O00194
Ras-related protein Rab-39A (RAB39A) Rab family Q14964
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Septin-1 (SEPTIN1) Septin GTPase family Q8WYJ6
Septin-14 (SEPTIN14) Septin GTPase family Q6ZU15
Translin (TSN) Translin family Q15631
Ubiquitin-conjugating enzyme E2 Z (UBE2Z) Ubiquitin-conjugating enzyme family Q9H832
Ataxin-3 (ATXN3) . P54252
BTB/POZ domain-containing protein 3 (BTBD3) . Q9Y2F9
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
E3 ubiquitin-protein ligase TRIM38 (TRIM38) . O00635
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Polyphosphoinositide phosphatase (FIG4) . Q92562
Ubiquitin-like protein 3 (UBL3) . O95164
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydropyrimidinase-related protein 2 (DPYSL2) Hydantoinase/dihydropyrimidinase family Q16555
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Alpha-crystallin B chain (CRYAB) Small heat shock protein (HSP20) family P02511
V-type proton ATPase subunit G 1 (ATP6V1G1) V-ATPase G subunit family O75348
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C5 (HOXC5) Antp homeobox family Q00444
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 148 (ZNF148) Krueppel C2H2-type zinc-finger protein family Q9UQR1
General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) TFII-I family Q9UHL9
Musculin (MSC) . O60682
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 50 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mth938 domain-containing protein (AAMDC) AAMDC family Q9H7C9
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Ataxin-1 (ATXN1) ATXN1 family P54253
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13) BACURD family Q8WZ19
Transgelin (TAGLN) Calponin family Q01995
Coiled-coil domain-containing protein 90B, mitochondrial (CCDC90B) CCDC90 family Q9GZT6
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Protein chibby homolog 1 (CBY1) Chibby family Q9Y3M2
Translation initiation factor eIF2B subunit alpha (EIF2B1) EIF-2B alpha/beta/delta subunits family Q14232
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (GNG7) G protein gamma family O60262
Guanine nucleotide-binding protein G(T) subunit gamma-T1 (GNGT1) G protein gamma family P63211
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Heat shock factor-binding protein 1 (HSBP1) HSBP1 family O75506
Intraflagellar transport protein 25 homolog (IFT25) IFT25 family Q9Y547
Keratin-associated protein 5-11 (KRTAP5-11) KRTAP type 5 family Q6L8G4
Contactin-associated protein-like 2 (CNTNAP2) Neurexin family Q9UHC6
NHS-like protein 2 (NHSL2) NHS family Q5HYW2
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
26S proteasome non-ATPase regulatory subunit 6 (PSMD6) Proteasome subunit S10 family Q15008
Meiotic recombination protein DMC1/LIM15 homolog (DMC1) RecA family Q14565
Migration and invasion enhancer 1 (MIEN1) SelWTH family Q9BRT3
tRNA-splicing endonuclease subunit Sen15 (TSEN15) SEN15 family Q8WW01
Charged multivesicular body protein 1a (CHMP1A) SNF7 family Q9HD42
Alpha-taxilin (TXLNA) Taxilin family P40222
Tektin-3 (TEKT3) Tektin family Q9BXF9
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) TTC19 family Q6DKK2
Coiled-coil domain-containing protein 153 (CCDC153) UPF0610 family Q494R4
Vacuolar protein sorting-associated protein 37B (VPS37B) VPS37 family Q9H9H4
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
BEN domain-containing protein 5 (BEND5) . Q7L4P6
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Calcium-regulated heat-stable protein 1 (CARHSP1) . Q9Y2V2
CGG triplet repeat-binding protein 1 (CGGBP1) . Q9UFW8
DnaJ homolog subfamily B member 13 (DNAJB13) . P59910
EMILIN-3 (EMILIN3) . Q9NT22
GA-binding protein subunit beta-2 (GABPB2) . Q8TAK5
M-phase-specific PLK1-interacting protein (MPLKIP) . Q8TAP9
MORN repeat-containing protein 2 (MORN2) . Q502X0
Probable RNA-binding protein 46 (RBM46) . Q8TBY0
Ral guanine nucleotide dissociation stimulator-like 2 (RGL2) . O15211
Rho guanine nucleotide exchange factor 15 (ARHGEF15) . O94989
SCAN domain-containing protein 1 (SCAND1) . P57086
Storkhead-box protein 1 (STOX1) . Q6ZVD7
TNF receptor-associated factor 1 (TRAF1) . Q13077
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.