Details of the Target

General Information of Target

Target ID LDTP08766
Target Name Vacuolar protein sorting-associated protein 52 homolog (VPS52)
Gene Name VPS52
Gene ID 6293
Synonyms
SACM2L; Vacuolar protein sorting-associated protein 52 homolog; SAC2 suppressor of actin mutations 2-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAATMAAAARELVLRAGTSDMEEEEGPLAGGPGLQEPLQLGELDITSDEFILDEVDVH
IQANLEDELVKEALKTGVDLRHYSKQVELELQQIEQKSIRDYIQESENIASLHNQITACD
AVLERMEQMLGAFQSDLSSISSEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSA
LVTAILEAPVTEPRFLEQLQELDAKAAAVREQEARGTAACADVRGVLDRLRVKAVTKIRE
FILQKIYSFRKPMTNYQIPQTALLKYRFFYQFLLGNERATAKEIRDEYVETLSKIYLSYY
RSYLGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKPSLRSRNTIFTLGTRGSVISPTELE
APILVPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFVVSGPAAHDLFHAVMG
RTLSMTLKHLDSYLADCYDAIAVFLCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRF
ELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSINQTIPNERTMQLLGQLQ
VEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEF
IEELLSPPFGGLVAFVKEAEALIERGQAERLRGEEARVTQLIRGFGSSWKSSVESLSQDV
MRSFTNFRNGTSIIQGALTQLIQLYHRFHRVLSQPQLRALPARAELINIHHLMVELKKHK
PNF
Target Bioclass
Other
Family
VPS52 family
Subcellular location
Golgi apparatus, trans-Golgi network membrane
Function
Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
Uniprot ID
Q8N1B4
Ensemble ID
ENST00000383210.4
HGNC ID
HGNC:10518

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.S517P DBIA    Probe Info 
CMK SNV: p.P336T DBIA    Probe Info 
COLO679 SNV: p.I483M .
CORL88 SNV: p.Y270F DBIA    Probe Info 
HCC15 SNV: p.Q92K .
HGC27 SNV: p.L520V DBIA    Probe Info 
KASUMI2 SNV: p.R703Q DBIA    Probe Info 
LNCaP clone FGC SNV: p.L80F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K717(8.33)  LDD0277  [1]
BTD
 Probe Info  		C220(0.92)  LDD2107  [2]
DBIA
 Probe Info  		C220(135.22)  LDD0209  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C220(0.00); C394(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C220(0.00); C394(0.00)  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0147  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]
AOyne
 Probe Info  		10.60  LDD0443  [9]
MPP-AC
 Probe Info  		N.A.  LDD0428  [10]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		10.70  LDD1760  [11]
C064
 Probe Info  		7.94  LDD1761  [11]
C106
 Probe Info  		22.16  LDD1793  [11]
C216
 Probe Info  		4.92  LDD1890  [11]
C303
 Probe Info  		7.16  LDD1972  [11]
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C220(1.23)  LDD0812  [13]
 LDCM0215  AC10 HCT 116 C220(0.95)  LDD0532  [13]
 LDCM0226  AC11 HCT 116 C220(0.94)  LDD0543  [13]
 LDCM0230  AC113 HEK-293T C220(1.21)  LDD0828  [13]
 LDCM0231  AC114 HEK-293T C220(0.75)  LDD0829  [13]
 LDCM0232  AC115 HEK-293T C220(0.70)  LDD0830  [13]
 LDCM0233  AC116 HEK-293T C220(0.71)  LDD0831  [13]
 LDCM0234  AC117 HEK-293T C220(0.85)  LDD0832  [13]
 LDCM0235  AC118 HEK-293T C220(0.78)  LDD0833  [13]
 LDCM0236  AC119 HEK-293T C220(0.58)  LDD0834  [13]
 LDCM0237  AC12 HCT 116 C220(0.85)  LDD0554  [13]
 LDCM0238  AC120 HEK-293T C220(0.80)  LDD0836  [13]
 LDCM0239  AC121 HEK-293T C220(0.57)  LDD0837  [13]
 LDCM0240  AC122 HEK-293T C220(0.53)  LDD0838  [13]
 LDCM0241  AC123 HEK-293T C220(0.63)  LDD0839  [13]
 LDCM0242  AC124 HEK-293T C220(0.70)  LDD0840  [13]
 LDCM0243  AC125 HEK-293T C220(0.54)  LDD0841  [13]
 LDCM0244  AC126 HEK-293T C220(0.46)  LDD0842  [13]
 LDCM0245  AC127 HEK-293T C220(0.66)  LDD0843  [13]
 LDCM0259  AC14 HCT 116 C220(0.76)  LDD0576  [13]
 LDCM0263  AC143 HCT 116 C220(1.10)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C220(0.99)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C220(0.91)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C220(1.04)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C220(1.22)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C220(0.84)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C220(1.08)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C220(0.82)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C220(1.86)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C220(0.79)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C220(0.85)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C220(1.04)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C220(0.89)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C220(0.92)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C220(0.72)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C220(0.90)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C220(1.02)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C220(1.21)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C220(1.04)  LDD0595  [13]
 LDCM0279  AC2 HEK-293T C220(1.40)  LDD0877  [13]
 LDCM0280  AC20 HCT 116 C220(1.07)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C220(1.04)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C220(0.87)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C220(1.06)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C220(1.11)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C220(0.86)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C220(0.85)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C220(0.71)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C220(0.72)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C220(0.83)  LDD0606  [13]
 LDCM0290  AC3 HEK-293T C220(1.26)  LDD0888  [13]
 LDCM0291  AC30 HCT 116 C220(1.05)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C220(0.91)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C220(0.70)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C220(0.81)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C220(0.96)  LDD0612  [13]
 LDCM0296  AC35 HEK-293T C220(1.02)  LDD0894  [13]
 LDCM0297  AC36 HEK-293T C220(0.97)  LDD0895  [13]
 LDCM0298  AC37 HEK-293T C220(1.03)  LDD0896  [13]
 LDCM0299  AC38 HEK-293T C220(1.00)  LDD0897  [13]
 LDCM0300  AC39 HEK-293T C220(0.82)  LDD0898  [13]
 LDCM0301  AC4 HEK-293T C220(0.82)  LDD0899  [13]
 LDCM0302  AC40 HEK-293T C220(1.04)  LDD0900  [13]
 LDCM0303  AC41 HEK-293T C220(1.05)  LDD0901  [13]
 LDCM0304  AC42 HEK-293T C220(0.92)  LDD0902  [13]
 LDCM0305  AC43 HEK-293T C220(0.84)  LDD0903  [13]
 LDCM0306  AC44 HEK-293T C220(0.87)  LDD0904  [13]
 LDCM0307  AC45 HEK-293T C220(1.07)  LDD0905  [13]
 LDCM0308  AC46 HEK-293T C119(1.16)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C220(1.07)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C394(0.99)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C220(1.19)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C220(1.03)  LDD0910  [13]
 LDCM0313  AC50 HEK-293T C220(1.05)  LDD1552  [14]
 LDCM0316  AC53 HEK-293T C119(1.05)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C119(0.84)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C220(1.12)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C394(1.00)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C220(1.06)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C220(1.10)  LDD1560  [14]
 LDCM0323  AC6 HCT 116 C220(0.80)  LDD0640  [13]
 LDCM0325  AC61 HEK-293T C119(1.02)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C119(0.95)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C220(0.97)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C394(1.05)  LDD1567  [14]
 LDCM0334  AC7 HCT 116 C220(0.82)  LDD0651  [13]
 LDCM0345  AC8 HCT 116 C220(0.88)  LDD0662  [13]
 LDCM0349  AC83 HEK-293T C220(1.04)  LDD0947  [13]
 LDCM0350  AC84 HEK-293T C220(0.70)  LDD0948  [13]
 LDCM0351  AC85 HEK-293T C220(0.68)  LDD0949  [13]
 LDCM0352  AC86 HEK-293T C220(0.67)  LDD0950  [13]
 LDCM0353  AC87 HEK-293T C220(0.71)  LDD0951  [13]
 LDCM0354  AC88 HEK-293T C220(0.72)  LDD0952  [13]
 LDCM0355  AC89 HEK-293T C220(0.70)  LDD0953  [13]
 LDCM0357  AC90 HEK-293T C220(0.61)  LDD0955  [13]
 LDCM0358  AC91 HEK-293T C220(0.87)  LDD0956  [13]
 LDCM0359  AC92 HEK-293T C220(0.79)  LDD0957  [13]
 LDCM0360  AC93 HEK-293T C220(0.55)  LDD0958  [13]
 LDCM0361  AC94 HEK-293T C220(0.68)  LDD0959  [13]
 LDCM0362  AC95 HEK-293T C220(0.64)  LDD0960  [13]
 LDCM0363  AC96 HEK-293T C220(0.44)  LDD0961  [13]
 LDCM0364  AC97 HEK-293T C220(0.65)  LDD0962  [13]
 LDCM0248  AKOS034007472 HCT 116 C220(0.95)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C220(0.96)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C220(0.85)  LDD0592  [13]
 LDCM0367  CL1 HEK-293T C220(1.47); C394(1.39); C119(1.03)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C119(1.43)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C220(1.10)  LDD0967  [13]
 LDCM0370  CL101 HCT 116 C220(0.70)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C220(0.72)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C220(0.69)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C220(0.75)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C220(1.17)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C220(1.40)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C220(1.28)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C220(1.38)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C220(1.05)  LDD0695  [13]
 LDCM0379  CL11 HEK-293T C220(1.43)  LDD1583  [14]
 LDCM0380  CL110 HCT 116 C220(1.13)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C220(1.08)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C220(0.91)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C220(0.66)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C220(0.94)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C220(0.90)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C220(0.96)  LDD0703  [13]
 LDCM0387  CL117 HEK-293T C220(1.16)  LDD0985  [13]
 LDCM0388  CL118 HEK-293T C220(0.94)  LDD0986  [13]
 LDCM0389  CL119 HEK-293T C220(0.89)  LDD0987  [13]
 LDCM0390  CL12 HEK-293T C394(1.00)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C220(0.97)  LDD0989  [13]
 LDCM0392  CL121 HEK-293T C220(1.20); C394(1.29); C119(0.85)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C220(1.11); C119(0.80)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C119(1.41)  LDD1598  [14]
 LDCM0396  CL125 HEK-293T C220(0.98); C394(1.40); C119(0.75)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C220(1.20); C119(0.81)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C119(0.71)  LDD1602  [14]
 LDCM0400  CL13 HEK-293T C220(1.48); C394(1.40); C119(1.04)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C220(1.10); C119(1.19)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C119(1.09)  LDD1606  [14]
 LDCM0404  CL17 HEK-293T C220(1.03)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C220(0.97)  LDD1609  [14]
 LDCM0407  CL2 HEK-293T C220(1.46); C119(1.07)  LDD1611  [14]
 LDCM0409  CL21 HEK-293T C119(1.15)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C119(1.51)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C220(1.44)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C394(0.80)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C220(1.31); C394(1.22); C119(0.98)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C220(1.14); C119(0.84)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C119(0.83)  LDD1619  [14]
 LDCM0417  CL29 HEK-293T C220(1.07)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C119(0.97)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C220(0.98)  LDD1623  [14]
 LDCM0422  CL33 HEK-293T C119(1.07)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C119(1.31)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C220(1.06)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C394(0.91)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C220(1.01); C394(1.28); C119(0.72)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C119(1.06)  LDD1632  [14]
 LDCM0431  CL41 HEK-293T C220(1.04)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C220(0.97)  LDD1636  [14]
 LDCM0435  CL45 HEK-293T C119(0.93)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C220(0.93)  LDD1034  [13]
 LDCM0437  CL47 HEK-293T C220(0.76)  LDD1035  [13]
 LDCM0438  CL48 HEK-293T C220(0.99)  LDD1036  [13]
 LDCM0439  CL49 HEK-293T C220(1.02)  LDD1037  [13]
 LDCM0440  CL5 HEK-293T C220(1.01)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C220(0.81)  LDD1039  [13]
 LDCM0442  CL51 HEK-293T C220(0.97)  LDD1040  [13]
 LDCM0443  CL52 HEK-293T C220(0.95)  LDD1041  [13]
 LDCM0444  CL53 HEK-293T C220(0.85)  LDD1042  [13]
 LDCM0445  CL54 HEK-293T C220(0.82)  LDD1043  [13]
 LDCM0446  CL55 HEK-293T C220(0.78)  LDD1044  [13]
 LDCM0447  CL56 HEK-293T C220(0.85)  LDD1045  [13]
 LDCM0448  CL57 HEK-293T C220(0.81)  LDD1046  [13]
 LDCM0449  CL58 HEK-293T C220(1.05)  LDD1047  [13]
 LDCM0450  CL59 HEK-293T C220(0.74)  LDD1048  [13]
 LDCM0451  CL6 HEK-293T C220(1.23)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C220(0.86)  LDD1050  [13]
 LDCM0453  CL61 HCT 116 C220(0.69)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C220(0.85)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C220(0.87)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C220(0.89)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C220(0.74)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C220(0.84)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C220(0.86)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C220(0.88)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C220(0.86)  LDD0778  [13]
 LDCM0463  CL70 HCT 116 C220(1.13)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C220(0.92)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C220(0.77)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C220(0.70)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C220(0.81)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C220(1.15)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C220(1.03)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C220(1.24)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C220(1.06)  LDD0789  [13]
 LDCM0474  CL80 HCT 116 C220(0.95)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C220(0.98)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C220(0.90)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C220(1.04)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C220(1.02)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C220(0.87)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C220(1.04)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C220(1.00)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C220(1.11)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C220(0.88)  LDD0800  [13]
 LDCM0484  CL9 HEK-293T C119(0.89)  LDD1687  [14]
 LDCM0485  CL90 HCT 116 C220(1.32)  LDD0802  [13]
 LDCM0486  CL91 HEK-293T C220(0.91)  LDD1084  [13]
 LDCM0487  CL92 HEK-293T C220(0.99)  LDD1085  [13]
 LDCM0488  CL93 HEK-293T C220(1.49)  LDD1086  [13]
 LDCM0489  CL94 HEK-293T C220(1.21)  LDD1087  [13]
 LDCM0490  CL95 HEK-293T C220(0.90)  LDD1088  [13]
 LDCM0491  CL96 HEK-293T C220(1.11)  LDD1089  [13]
 LDCM0492  CL97 HEK-293T C220(1.02)  LDD1090  [13]
 LDCM0493  CL98 HEK-293T C220(0.93)  LDD1091  [13]
 LDCM0494  CL99 HEK-293T C220(1.18)  LDD1092  [13]
 LDCM0495  E2913 HEK-293T C119(0.93)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C220(1.14)  LDD1702  [2]
 LDCM0625  F8 Ramos C220(1.44); C394(1.94)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C220(1.29); C394(0.60)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C220(3.34); C394(1.30)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C220(2.28); C394(0.84)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C220(1.10); C394(2.00)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C220(0.82); C394(0.89)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C220(1.37)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C220(0.93); C394(0.81)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C220(1.34); C394(0.78)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C220(0.95)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C220(0.95); C394(0.60)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C220(1.48); C394(1.11)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C220(1.43); C394(0.86)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C220(2.97); C394(1.04)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C220(0.88)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C220(1.57); C394(0.66)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C220(1.13); C394(1.29)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C220(1.14); C119(0.98)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C220(1.53); C394(0.41)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C220(3.11); C394(0.82)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C220(1.23); C394(1.42)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C220(1.73)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C119(1.04)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C220(135.22)  LDD0209  [3]
 LDCM0024  KB05 G361 C95(7.85)  LDD3311  [16]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C220(0.92)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C220(0.92)  LDD2109  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C220(1.09)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C220(1.15)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C220(1.16)  LDD2136  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C220(0.86)  LDD2140  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (NOP2) RsmB/NOP family P46087
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
eEF1A lysine and N-terminal methyltransferase (METTL13) Methyltransferase superfamily Q8N6R0
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Serine/threonine-protein kinase N3 (PKN3) AGC Ser/Thr protein kinase family Q6P5Z2
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) CAMK Ser/Thr protein kinase family Q13131
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Ras-related protein Rab-4A (RAB4A) Rab family P20338
Ras-related protein Rab-4B (RAB4B) Rab family P61018
GTP-binding protein GEM (GEM) RGK family P55040
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Ribosome-releasing factor 2, mitochondrial (GFM2) Classic translation factor GTPase family Q969S9
V-type proton ATPase subunit D (ATP6V1D) V-ATPase D subunit family Q9Y5K8
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase NRDP1 (RNF41) . Q9H4P4
OTU domain-containing protein 6A (OTUD6A) . Q7L8S5
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (TSTD2) . Q5T7W7
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Sodium channel modifier 1 (SCNM1) . Q9BWG6
TBC1 domain family member 1 (TBC1D1) . Q86TI0
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
NF-kappa-B inhibitor beta (NFKBIB) NF-kappa-B inhibitor family Q15653
THAP domain-containing protein 11 (THAP11) THAP11 family Q96EK4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Transcriptional enhancer factor TEF-3 (TEAD4) . Q15561
Other
Click To Hide/Show 49 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Bystin (BYSL) Bystin family Q13895
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
DnaJ homolog subfamily C member 11 (DNAJC11) DNAJC11 family Q9NVH1
Protein FAM110A (FAM110A) FAM110 family Q9BQ89
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Pre-mRNA-splicing regulator WTAP (WTAP) Fl(2)d family Q15007
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Janus kinase and microtubule-interacting protein 2 (JAKMIP2) JAKMIP family Q96AA8
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Nuclear receptor 2C2-associated protein (NR2C2AP) NR2C2AP family Q86WQ0
Syndetin (VPS50) Syndetin family Q96JG6
Syntaxin-11 (STX11) Syntaxin family O75558
Alpha-taxilin (TXLNA) Taxilin family P40222
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
T-complex protein 11-like protein 1 (TCP11L1) TCP11 family Q9NUJ3
Tropomyosin alpha-3 chain (TPM3) Tropomyosin family P06753
Large ribosomal subunit protein uL1m (MRPL1) Universal ribosomal protein uL1 family Q9BYD6
Large ribosomal subunit protein uL11m (MRPL11) Universal ribosomal protein uL11 family Q9Y3B7
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Vacuolar protein sorting-associated protein 28 homolog (VPS28) VPS28 family Q9UK41
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Calcium-binding protein 5 (CABP5) . Q9NP86
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Coiled-coil domain-containing protein 146 (CCDC146) . Q8IYE0
Coiled-coil domain-containing protein 185 (CCDC185) . Q8N715
EPM2A-interacting protein 1 (EPM2AIP1) . Q7L775
Golgin subfamily A member 1 (GOLGA1) . Q92805
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Kelch-like protein 42 (KLHL42) . Q9P2K6
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
LIM domain transcription factor LMO4 (LMO4) . P61968
Phostensin (PPP1R18) . Q6NYC8
Protein PIMREG (PIMREG) . Q9BSJ6
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) . Q9NYJ8
Transcription elongation factor A N-terminal and central domain-containing protein (TCEANC) . Q8N8B7
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840