Details of the Target

General Information of Target

Target ID LDTP18135
Target Name Protein phosphatase 1 regulatory subunit 14B (PPP1R14B)
Gene Name PPP1R14B
Gene ID 26472
Synonyms
PLCB3N; PNG; Protein phosphatase 1 regulatory subunit 14B; Phospholipase C-beta-3 neighbouring gene protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPSGTVSDSESSNSSSDAEELERCREAAMPAWGLEQRPHVAGKPRAGAANSQLSTSQP
SLRHKVNEHEQDGNELQTTPEFRAHVAKKLGALLDSFITISEAAKEPAKAKVQKVALEDD
GFRLFFTSVPGGREKEESPQPRRKRQPSSSSEDSDEEWRRCREAAVSASDILQESAIHSP
GTVEKEAKKKRKLKKKAKKVASVDSAVAATTPTSMATVQKQKSGELNGDQVSLGTKKKKK
AKKASETSPFPPAKSATAIPAN
Target Bioclass
Other
Family
PP1 inhibitor family
Subcellular location
Cytoplasm
Function Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated.
Uniprot ID
Q96C90
Ensemble ID
ENST00000309318.8
HGNC ID
HGNC:9057

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		6.50  LDD0066  [1]
STPyne
 Probe Info  		K140(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y29(6.04)  LDD3495  [3]
DBIA
 Probe Info  		C659(0.95)  LDD3331  [4]
HHS-475
 Probe Info  		Y29(1.38)  LDD0264  [5]
HHS-465
 Probe Info  		Y29(1.43)  LDD2237  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
SF
 Probe Info  		N.A.  LDD0028  [9]
1c-yne
 Probe Info  		N.A.  LDD0228  [10]
1d-yne
 Probe Info  		N.A.  LDD0357  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C420
 Probe Info  		12.82  LDD2075  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C120(0.90)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C85(0.95); C120(1.03)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C85(0.97); C120(0.97)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C85(0.81); C120(0.96)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C85(1.04); C120(1.03)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C85(1.11); C120(0.97)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C120(0.88)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C85(1.15); C120(1.00)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C85(0.75); C120(0.88)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C85(1.02); C120(1.15)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C85(0.78); C120(0.92)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C85(1.15); C120(1.11)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C85(1.09); C120(1.08)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C85(1.02); C120(1.16)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C85(1.06); C120(1.05)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C120(0.85)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C85(0.90); C120(0.97)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C85(0.81); C120(0.96)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C85(0.74); C120(0.91)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C85(1.18); C120(1.09)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C85(0.60); C120(0.97)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C85(1.02); C120(1.01)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C85(1.01); C120(0.90)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C85(1.15); C120(0.97)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C120(1.00)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C85(1.03); C120(1.01)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C85(0.98); C120(0.94)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C85(1.11); C120(0.98)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C85(1.42); C120(1.06)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C85(1.32); C120(1.10)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C85(1.05); C120(1.01)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C85(0.98); C120(0.96)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C85(1.26); C120(1.02)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C120(0.98)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C85(1.10); C120(0.95)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C85(0.86); C120(1.04)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C85(1.19); C120(0.89)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C85(1.07); C120(0.95)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C85(1.10); C120(1.02)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C85(0.94); C120(0.95)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C85(1.31); C120(1.11)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C120(0.89)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C85(0.81); C120(0.96)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C85(0.97); C120(1.03)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C85(1.00); C120(1.11)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C85(0.90); C120(1.06)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C85(1.39); C120(1.02)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C85(1.09); C120(1.14)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C85(0.95); C120(0.97)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C85(1.00); C120(0.98)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C120(0.90)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C85(1.01); C120(1.12)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C85(1.04); C120(1.06)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C85(1.02); C120(0.97)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C85(0.66); C120(0.94)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C85(1.05); C120(0.95)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C85(1.02); C120(1.04)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C85(1.00); C120(0.94)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C85(1.09); C120(1.01)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C85(0.93); C120(1.05)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C85(1.06); C120(0.96)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C85(1.60); C120(1.06)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C120(0.91)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C85(1.07); C120(1.01)  LDD1514  [13]
 LDCM0367  CL1 HEK-293T C120(0.98)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C85(0.86); C120(0.72)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C85(1.03); C120(1.00)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C120(1.02)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C85(1.11); C120(0.96)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C85(1.77); C120(1.09)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C85(1.03); C120(0.96)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C120(1.06)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C85(0.88); C120(1.01)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C85(1.37); C120(1.14)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C85(1.07); C120(0.91)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C120(0.96)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C85(1.21); C120(0.81)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C85(0.81); C120(0.90)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C85(1.24); C120(0.96)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C85(1.06); C120(1.00)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C120(1.09)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C85(0.96); C120(0.91)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C85(0.82); C120(1.06)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C85(1.08); C120(1.17)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C120(1.09)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C85(1.34); C120(1.16)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C85(1.11); C120(1.11)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C85(1.09); C120(0.87)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C85(1.21); C120(0.99)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C120(1.01)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C85(0.99); C120(1.02)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C85(0.97); C120(0.97)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C85(1.12); C120(0.84)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C120(1.12)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C85(1.03); C120(1.05)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C85(1.13); C120(0.95)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C85(0.95); C120(0.95)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C120(1.03)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C85(1.37); C120(1.01)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C85(0.97); C120(1.04)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C85(1.09); C120(0.94)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C120(0.76)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C85(0.96); C120(0.95)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C85(0.89); C120(0.90)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C85(1.02); C120(0.97)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C85(0.75); C120(0.95)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C85(1.20); C120(0.84)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C85(0.98); C120(0.91)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C85(1.04); C120(0.89)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C85(1.25); C120(0.89)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C120(1.01)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C85(1.05); C120(1.07)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C85(1.09); C120(1.11)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C85(1.24); C120(1.08)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C120(0.90)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C85(1.14); C120(0.98)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C85(0.98); C120(0.93)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C85(0.81); C120(0.90)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C85(0.75); C120(0.86)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C85(1.25); C120(0.70)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C85(0.90); C120(0.87)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C85(1.36); C120(0.87)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C85(1.11); C120(0.97)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C120(1.14)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C85(0.87); C120(1.07)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C85(0.99); C120(0.98)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C85(1.42); C120(1.18)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C120(0.86)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C85(1.02); C120(0.99)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C85(1.32); C120(0.91)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C85(0.70); C120(0.94)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C85(1.19); C120(0.83)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C85(1.11); C120(0.89)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C85(0.97); C120(0.82)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C85(1.04); C120(1.02)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C120(1.18)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C120(0.90)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C85(0.87); C120(1.04)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C85(1.08); C120(0.99)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C120(0.84)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C85(0.96); C120(0.85)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C85(0.72); C120(1.00)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C85(0.79); C120(0.86)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C85(0.84); C120(0.80)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C85(0.89); C120(0.93)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C85(1.04); C120(0.89)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C85(0.97); C120(0.79)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C85(1.05); C120(0.97)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C120(1.21)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C85(1.09); C120(1.13)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C85(1.61); C120(1.12)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C85(0.83); C120(0.86)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C120(0.94)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C85(1.12); C120(1.05)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C85(0.87); C120(1.03)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C85(0.97); C120(0.92)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C85(1.16); C120(0.98)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C85(0.96); C120(0.92)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C85(0.89); C120(0.95)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C85(0.93); C120(0.91)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C85(1.16); C120(0.92)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C120(0.98)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C85(1.07); C120(1.06)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C85(1.29); C120(0.95)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C120(0.77)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C85(1.01); C120(0.98)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C85(1.01); C120(1.02)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C85(0.78); C120(0.72)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C85(1.09); C120(0.85)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C85(1.43); C120(0.94)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C85(1.27); C120(0.90)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C85(1.05); C120(0.82)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C85(1.03); C120(0.88)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C120(1.21)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C85(1.01); C120(1.16)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C85(1.17); C120(0.95)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C85(0.89); C120(0.91)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C120(1.04)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C85(1.50); C120(0.88)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C85(0.81); C120(0.82)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C85(0.73); C120(1.11)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C85(0.90); C120(1.00)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C85(1.16); C120(0.86)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C85(1.12); C120(0.96)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C85(0.91); C120(0.65)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C85(0.97); C120(0.93)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C120(1.03)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C85(1.01); C120(0.99)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C85(1.11); C120(1.00)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C85(1.16); C120(1.05)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C85(0.94); C120(1.10)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C85(0.85); C120(1.06)  LDD1631  [13]
 LDCM0116  HHS-0101 DM93 Y29(1.38)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y29(1.99)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y29(2.28)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y29(1.32)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y29(2.72)  LDD0268  [5]
 LDCM0022  KB02 42-MG-BA C659(1.18)  LDD2244  [4]
 LDCM0023  KB03 42-MG-BA C659(0.98)  LDD2661  [4]
 LDCM0024  KB05 MKN-1 C659(0.95)  LDD3331  [4]

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD029500 , PXD031647
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402