Details of the Target

General Information of Target

Target ID LDTP11136
Target Name Sugar transporter SWEET1 (SLC50A1)
Gene Name SLC50A1
Gene ID 55974
Synonyms
RAG1AP1; SCP; Sugar transporter SWEET1; HsSWEET1; RAG1-activating protein 1; Solute carrier family 50 member 1; Stromal cell protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKITRQKHAKKHLGFFRNNFGVREPYQILLDGTFCQAALRGRIQLREQLPRYLMGETQLC
TTRCVLKELETLGKDLYGAKLIAQKCQVRNCPHFKNAVSGSECLLSMVEEGNPHHYFVAT
QDQNLSVKVKKKPGVPLMFIIQNTMVLDKPSPKTIAFVKAVESGQLVSVHEKESIKHLKE
EQGLVKNTEQSRRKKRKKISGPNPLSCLKKKKKAPDTQSSASEKKRKRKRIRNRSNPKVL
SEKQNAEGE
Target Bioclass
Transporter and channel
Family
SWEET sugar transporter family
Subcellular location
Golgi apparatus membrane
Function Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.
Uniprot ID
Q9BRV3
Ensemble ID
ENST00000303343.12
HGNC ID
HGNC:30657

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C133(0.00); C176(0.00); C159(0.00)  LDD2223  [1]
PAL-AfBPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C153
 Probe Info  		39.12  LDD1834  [2]
C156
 Probe Info  		15.03  LDD1836  [2]
C159
 Probe Info  		23.92  LDD1839  [2]
C160
 Probe Info  		21.71  LDD1840  [2]
C161
 Probe Info  		19.03  LDD1841  [2]
C176
 Probe Info  		4.99  LDD1855  [2]
C210
 Probe Info  		42.81  LDD1884  [2]
C215
 Probe Info  		7.16  LDD1889  [2]
C217
 Probe Info  		7.26  LDD1891  [2]
C218
 Probe Info  		20.97  LDD1892  [2]
C219
 Probe Info  		15.24  LDD1893  [2]
C220
 Probe Info  		14.32  LDD1894  [2]
C250
 Probe Info  		5.17  LDD1923  [2]
C264
 Probe Info  		16.68  LDD1935  [2]
C266
 Probe Info  		14.52  LDD1937  [2]
C268
 Probe Info  		9.00  LDD1938  [2]
C270
 Probe Info  		11.31  LDD1940  [2]
BD-F
 Probe Info  		K64(0.00); Y60(0.00)  LDD0024  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription termination factor 3, mitochondrial (MTERF3) MTERF family Q96E29
Nonsense-mediated mRNA decay factor SMG9 (SMG9) SMG9 family Q9H0W8

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652