Details of the Target

General Information of Target

Target ID LDTP06855
Target Name Anoctamin-6 (ANO6)
Gene Name ANO6
Gene ID 196527
Synonyms
TMEM16F; Anoctamin-6; Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL
FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK
LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE
FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI
YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA
WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL
NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP
EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV
FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP
RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC
LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK
LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD
IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL
SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV
MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA
VDNNLRPKSE
Target Bioclass
Transporter and channel
Family
Anoctamin family
Subcellular location
Cell membrane
Function
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.; (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.
Uniprot ID
Q4KMQ2
Ensemble ID
ENST00000320560.13
HGNC ID
HGNC:25240

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.R208K DBIA    Probe Info 
COLO678 SNV: p.E820Ter DBIA    Probe Info 
COLO792 SNV: p.Y405N DBIA    Probe Info 
DU145 SNV: p.M12I; p.Q505Ter .
JHH7 SNV: p.D258Y .
MCC26 SNV: p.A740V .
NB1 SNV: p.D748E .
NCIH1299 SNV: p.W628Ter .
RL952 SNV: p.T646A DBIA    Probe Info 
SNGM SNV: p.I482N .
TOV21G Deletion: p.F62LfsTer12 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K188(10.00); K220(10.00); K251(6.02); K644(0.73)  LDD0277  [1]
DBIA
 Probe Info  		C271(1.66)  LDD3311  [2]
BTD
 Probe Info  		C250(1.12)  LDD2093  [3]
AHL-Pu-1
 Probe Info  		C105(4.27)  LDD0169  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C337(0.00); C134(0.00); C105(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C250(0.00); C337(0.00); C261(0.00); C105(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C250(0.00); C134(0.00); C105(0.00)  LDD0037  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		C250(0.00); C426(0.00)  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		7.11  LDD1714  [9]
C040
 Probe Info  		13.00  LDD1740  [9]
C091
 Probe Info  		12.04  LDD1782  [9]
C092
 Probe Info  		20.68  LDD1783  [9]
C094
 Probe Info  		32.67  LDD1785  [9]
C100
 Probe Info  		5.21  LDD1789  [9]
C158
 Probe Info  		9.71  LDD1838  [9]
C160
 Probe Info  		6.96  LDD1840  [9]
C161
 Probe Info  		10.48  LDD1841  [9]
C186
 Probe Info  		8.00  LDD1864  [9]
C187
 Probe Info  		22.47  LDD1865  [9]
C218
 Probe Info  		23.43  LDD1892  [9]
C219
 Probe Info  		6.41  LDD1893  [9]
C220
 Probe Info  		13.55  LDD1894  [9]
C264
 Probe Info  		17.39  LDD1935  [9]
C287
 Probe Info  		9.00  LDD1957  [9]
C289
 Probe Info  		25.28  LDD1959  [9]
C310
 Probe Info  		11.63  LDD1977  [9]
C350
 Probe Info  		24.25  LDD2011  [9]
VE-P
 Probe Info  		N.A.  LDD0396  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C337(0.47)  LDD2112  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C337(1.26)  LDD2152  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C337(0.56)  LDD2132  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C105(4.27)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C426(1.07); C250(0.94); C105(0.95); C134(1.26)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C426(0.94); C250(0.92); C105(0.98); C134(1.09)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C426(1.06); C250(1.07); C105(1.09); C134(1.03)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C426(1.03); C250(1.01); C105(1.07)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C250(1.08); C105(1.01); C134(1.02); C261(1.05)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C250(1.06); C105(0.95); C134(0.82)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C426(1.09); C250(0.98); C105(0.97); C134(0.84)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C426(0.90); C250(0.99); C105(1.00); C134(0.90)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C426(1.01); C250(1.10); C105(1.11); C134(0.75)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C426(0.97); C250(1.01); C105(0.86); C134(1.13)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C426(1.04); C250(1.09); C105(1.01)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C426(0.98); C250(1.03); C105(1.05); C134(1.11)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C250(1.07); C105(0.96); C134(1.14); C261(0.87)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C250(1.09); C105(1.04); C134(0.97)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C250(1.14); C105(0.91); C134(1.00); C261(1.62)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C426(1.09); C250(0.95); C105(0.89); C134(1.01)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C426(0.95); C250(0.96); C105(0.97); C134(0.80)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C426(1.10); C250(1.03); C105(1.13); C134(0.94)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C426(0.95); C250(1.06); C105(1.02)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C426(1.09); C250(1.04); C105(1.05); C134(0.93)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C426(0.91); C250(1.06); C105(1.03); C134(1.06)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C250(1.09); C105(1.11); C134(0.87); C261(1.00)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C250(1.10); C105(1.00); C134(0.99)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C250(1.12); C105(0.89); C134(1.14); C261(1.06)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C426(1.16); C250(0.94); C105(0.98); C134(0.88)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C426(0.96); C250(1.09); C105(0.88); C134(0.98)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C426(1.01); C250(1.03); C105(1.05); C134(1.01)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C426(0.93); C250(1.02); C105(1.05)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C426(0.97); C250(1.01); C105(1.08); C134(1.04)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C250(0.97); C105(1.08); C134(0.89); C261(0.98)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C250(1.04); C105(1.01); C134(1.05)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C426(0.94); C250(0.99); C105(1.08)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C250(1.12); C105(1.03); C134(1.13); C261(1.25)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C426(1.23); C250(0.93); C105(0.98); C134(1.10)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C426(0.87); C250(1.10); C105(0.97); C134(1.02)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C426(1.08); C250(1.00); C105(0.99); C134(1.00)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C426(0.99); C250(0.98); C105(1.02)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C426(0.97); C250(0.98); C105(1.13); C134(0.91)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C250(1.07); C105(1.05); C134(0.94); C261(1.20)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C250(1.02); C105(1.05); C134(0.99)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C250(1.20); C105(1.07); C134(1.06); C261(1.52)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C426(1.06); C250(0.94); C105(0.95); C134(0.88)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C426(1.01); C250(1.04); C105(1.12); C134(1.03)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C426(0.99); C250(1.12); C105(0.95); C134(1.08)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C426(1.05); C250(1.02); C105(1.04); C134(1.01)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C426(1.04); C250(1.03); C105(1.09)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C426(0.95); C250(0.99); C105(1.03); C134(1.02)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C250(1.06); C105(0.97); C134(1.01); C261(1.04)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C250(1.08); C105(1.02); C134(1.04)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C250(1.11); C105(0.94); C134(1.14); C261(1.04)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C426(1.11); C250(1.02); C105(0.95); C134(0.85)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C426(0.95); C250(1.03); C105(1.02); C134(0.99)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C426(1.17); C250(1.02); C105(1.04); C134(0.96)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C250(0.98); C105(1.09); C134(0.99); C261(0.84)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C426(1.03); C250(1.01); C105(1.08)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C426(0.96); C250(1.03); C105(1.06); C134(1.07)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C250(1.02); C105(0.98); C134(0.94); C261(1.35)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C250(1.13); C105(0.95); C134(1.01)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C250(1.23); C105(0.98); C134(0.90); C261(1.64)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C250(1.15); C105(1.10); C134(0.99)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C250(1.12); C105(1.03); C134(1.20); C261(0.89)  LDD1569  [11]
 LDCM0545  Acetamide MDA-MB-231 C337(0.51)  LDD2138  [3]
 LDCM0248  AKOS034007472 HEK-293T C426(0.96); C250(0.98); C105(1.10); C134(1.02)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C426(1.14); C250(0.93); C105(1.00); C134(1.09)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C250(1.11); C105(0.95); C134(0.99); C261(1.27)  LDD1514  [11]
 LDCM0367  CL1 HEK-293T C426(1.11); C250(1.09); C364(0.98); C105(0.92)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C250(1.08); C105(1.09); C134(0.84); C261(0.92)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C426(0.98); C250(1.03); C105(0.96); C134(1.08)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C426(0.82); C250(0.99); C364(1.03); C105(0.97)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C426(1.01); C250(1.00); C105(1.04); C134(0.99)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C426(1.08); C250(1.00); C105(0.93); C134(0.99)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C426(1.04); C250(1.10); C105(0.89); C134(0.97)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C426(0.92); C250(0.98); C364(1.07); C105(0.95)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C426(1.09); C250(1.03); C105(0.99); C134(0.76)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C426(1.02); C250(1.09); C105(0.97); C134(1.18)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C426(1.21); C250(1.09); C105(1.05); C134(0.84)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C426(1.05); C250(1.00); C364(1.02); C105(1.05)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C250(1.10); C105(1.04); C134(0.92)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C426(1.06); C250(1.02); C105(1.17); C134(0.77)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C426(1.10); C250(1.09); C105(1.00); C134(1.19)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C426(1.07); C250(1.07); C105(1.00); C134(0.93)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C426(1.01); C250(1.05); C364(0.99); C105(1.05)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C426(1.00); C250(1.09); C105(0.99); C134(0.64)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C426(1.01); C250(1.04); C105(0.98); C134(1.03)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C426(0.94); C250(1.02); C105(1.04); C134(1.13)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C426(0.96); C250(1.07); C364(0.99); C105(1.13)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C426(1.05); C250(0.94); C105(0.97); C134(0.97)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C426(1.13); C250(1.01); C105(0.97); C134(1.07)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C250(1.33); C105(0.94); C134(1.03); C261(1.15)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C426(0.97); C250(1.06); C105(1.04); C134(0.90)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C426(0.97); C250(1.00); C364(1.03); C105(0.93)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C426(1.09); C250(0.96); C105(1.10); C134(0.90)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C426(1.13); C250(0.99); C105(0.89); C134(1.06)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C426(1.04); C250(1.04); C105(0.92); C134(0.90)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C426(0.60); C250(1.05); C364(1.04); C105(1.01)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C426(1.01); C250(1.02); C105(1.10); C134(0.84)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C426(1.06); C250(1.06); C105(0.94); C134(1.28)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C426(1.02); C250(1.06); C105(1.01); C134(1.00)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C426(0.82); C250(1.02); C364(0.96); C105(0.93)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C426(1.10); C250(1.07); C105(1.03); C134(1.01)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C426(1.26); C250(0.94); C105(0.98); C134(1.19)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C426(1.22); C250(1.10); C105(1.00); C134(1.02)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C426(1.14); C250(0.86); C105(0.93); C134(0.99)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C426(1.20); C250(1.18); C105(0.96); C134(1.00)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C426(1.23); C250(1.05); C105(0.98); C134(0.96)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C426(1.19); C250(0.93); C105(1.11); C134(1.15)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C426(1.27); C250(0.94); C105(1.03)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C426(1.53); C250(1.11); C105(0.96); C134(0.87)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C250(0.94); C105(0.94); C134(1.11); C261(1.02)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C250(1.10); C105(0.99); C134(0.92)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C250(1.16); C105(0.92); C134(1.05); C261(1.01)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C426(0.80); C250(1.04); C364(0.95); C105(0.96)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C426(1.12); C250(1.01); C105(1.03); C134(0.99)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C426(1.08); C250(1.05); C105(0.99); C134(1.22)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C426(1.08); C250(1.05); C105(0.99); C134(1.06)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C426(1.23); C250(1.03); C105(0.99); C134(1.07)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C426(1.28); C250(0.93); C105(1.02); C134(1.07)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C426(1.09); C250(0.95); C105(1.09); C134(0.98)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C426(1.33); C250(1.06); C105(1.05); C134(0.78)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C426(1.13); C250(0.98); C105(1.01)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C426(1.23); C250(1.05); C105(0.88); C134(0.92)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C250(1.03); C105(0.89); C134(1.02); C261(0.98)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C250(1.17); C105(0.98); C134(1.03)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C250(1.19); C105(0.93); C134(0.94); C261(1.07)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C426(0.90); C250(1.05); C364(1.09); C105(1.10)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C426(1.01); C250(1.09); C105(0.87); C134(1.27)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C426(1.14); C250(1.01); C105(0.98); C134(0.99)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C426(1.00); C250(1.00); C105(1.04); C134(1.08)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C426(1.06); C250(0.89); C105(1.05); C134(0.93)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C426(1.12); C250(0.98); C105(0.95); C134(0.98)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C426(1.43); C250(1.13); C105(1.03); C134(0.98)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C426(1.04); C250(1.04); C105(1.06)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C426(1.11); C250(1.07); C105(0.96); C134(0.84)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C250(1.19); C105(1.03); C134(1.07); C261(1.25)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C250(1.13); C105(0.93); C134(1.00)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C250(1.21); C105(0.88); C134(1.30); C261(1.03)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C426(0.83); C250(1.08); C364(1.06); C105(0.97)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C426(1.29); C250(0.84); C105(0.96); C134(0.97)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C426(1.03); C250(1.02); C105(1.01); C134(0.97)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C426(1.19); C250(1.02); C105(1.14); C134(0.90)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C426(1.25); C250(0.94); C105(1.01); C134(0.82)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C426(1.04); C250(0.98); C105(1.00); C134(0.89)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C426(1.47); C250(1.13); C105(1.03); C134(1.00)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C426(1.18); C250(1.04); C105(1.05)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C426(1.19); C250(1.10); C105(1.06); C134(0.89)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C250(1.10); C105(0.98); C134(0.82); C261(1.13)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C250(1.06); C105(0.98); C134(0.89)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C426(1.06); C250(1.14); C105(0.85); C134(1.03)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C250(1.18); C105(0.95); C134(0.96); C261(1.38)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C426(0.90); C250(1.04); C364(0.97); C105(1.00)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C426(1.06); C250(1.00); C105(0.96); C134(1.11)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C426(1.23); C250(1.03); C105(1.09); C134(1.02)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C426(1.02); C250(1.02); C105(0.99); C134(0.80)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C426(1.07); C250(0.90); C105(0.93); C134(0.95)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C426(1.12); C250(0.99); C105(0.95); C134(0.99)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C426(1.12); C250(1.01); C105(1.06); C134(0.87)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C426(1.08); C250(1.08); C105(1.01)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C426(1.31); C250(0.97); C105(1.01); C134(0.91)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C426(1.35); C250(1.06); C105(1.02); C134(0.93)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C250(1.03); C105(1.00); C134(0.94); C261(1.00)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C250(1.10); C105(0.94); C134(0.86)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C250(1.24); C105(0.96); C134(0.90); C261(1.14)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C426(0.80); C250(1.09); C364(1.01); C105(1.03)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C426(1.09); C250(1.07); C105(1.14); C134(0.97)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C426(1.16); C250(1.03); C105(0.99); C134(0.99)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C426(1.19); C250(0.98); C105(0.92); C134(0.85)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C426(1.00); C250(1.03); C105(1.01); C134(1.02)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C426(1.25); C250(1.10); C105(1.06); C134(0.92)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C426(1.20); C250(1.05); C105(0.88)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C426(1.07); C250(1.09); C105(0.98)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C426(1.16); C250(1.00); C105(0.98); C134(0.95)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C250(1.14); C105(0.93); C134(0.93); C261(0.84)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C250(1.17); C105(1.02); C134(0.89)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C250(1.14); C105(0.87); C134(1.06); C261(1.21)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C426(0.81); C250(1.08); C364(1.04); C105(1.01)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C426(0.92); C250(1.01); C105(1.30); C134(1.13)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C426(1.03); C250(1.01); C105(1.04); C134(1.17)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C426(1.07); C250(1.05); C105(0.98); C134(1.14)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C426(1.04); C250(0.95); C105(0.96); C134(1.04)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C426(1.29); C250(0.98); C105(1.10); C134(0.89)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C426(0.85); C250(0.97); C105(0.83); C134(0.89)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C426(1.37); C250(1.16); C105(1.00); C134(0.87)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C426(1.06); C250(0.98); C105(1.00)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C426(1.13); C250(1.04); C105(0.92); C134(0.91)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C250(1.00); C105(0.95); C134(0.74); C261(1.14)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C250(1.01); C105(0.85); C134(0.80)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C250(1.20); C105(0.85); C134(0.99); C261(0.94)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C426(0.83); C250(0.99); C364(0.95); C105(0.91)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C426(0.93); C250(1.01); C105(1.06); C134(0.87)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C426(0.93); C250(1.01); C105(1.06); C134(1.10)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C426(1.24); C250(1.03); C105(0.97); C134(1.17)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C355(2.88)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C426(1.14); C250(0.93); C105(0.93); C134(1.17)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C426(0.89); C250(1.03); C105(0.98); C134(0.86)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C261(0.95); C250(0.98); C105(1.05); C134(0.98)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C261(1.00); C250(0.91); C105(0.99); C134(1.04)  LDD1497  [11]
 LDCM0024  KB05 G361 C271(1.66)  LDD3311  [2]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C337(1.13)  LDD2102  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C250(1.12)  LDD2093  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C337(0.81)  LDD2098  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C337(2.15)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C337(0.34)  LDD2104  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C337(1.17)  LDD2107  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C337(0.25)  LDD2114  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C250(0.79)  LDD2123  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C337(1.34)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C250(1.26)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C250(0.72)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C337(1.00); C250(1.19)  LDD2137  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C250(0.56)  LDD2150  [3]

References

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Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402