Details of the Target
General Information of Target
Target ID | LDTP12331 | |||||
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Target Name | Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) | |||||
Gene Name | EMC7 | |||||
Gene ID | 56851 | |||||
Synonyms |
C11orf3; C15orf24; Endoplasmic reticulum membrane protein complex subunit 7; ER membrane protein complex subunit 7 |
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3D Structure | ||||||
Sequence |
MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRD
GEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPK EPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKST ADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP |
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Target Bioclass |
Transporter and channel
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Family |
EMC7 family
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Subcellular location |
Endoplasmic reticulum membrane
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Function |
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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Jackson_1 Probe Info |
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20.00 | LDD0122 | [1] | |
STPyne Probe Info |
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K141(3.45); K221(5.28); K225(10.00); K232(1.22) | LDD0277 | [2] | |
Jackson_14 Probe Info |
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2.63 | LDD0123 | [1] | |
HPAP Probe Info |
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3.86 | LDD0063 | [3] | |
Acrolein Probe Info |
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H87(0.00); H74(0.00) | LDD0227 | [4] | |
m-APA Probe Info |
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N.A. | LDD2231 | [5] |
PAL-AfBPP Probe
Competitor(s) Related to This Target
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Other
References