Details of the Target

General Information of Target

Target ID LDTP09644
Target Name m-AAA protease-interacting protein 1, mitochondrial (MAIP1)
Gene Name MAIP1
Gene ID 79568
Synonyms
C2orf47; m-AAA protease-interacting protein 1, mitochondrial; Matrix AAA peptidase-interacting protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALAARLLPQFLHSRSLPCGAVRLRTPAVAEVRLPSATLCYFCRCRLGLGAALFPRSARA
LAASALPAQGSRWPVLSSPGLPAAFASFPACPQRSYSTEEKPQQHQKTKMIVLGFSNPIN
WVRTRIKAFLIWAYFDKEFSITEFSEGAKQAFAHVSKLLSQCKFDLLEELVAKEVLHALK
EKVTSLPDNHKNALAANIDEIVFTSTGDISIYYDEKGRKFVNILMCFWYLTSANIPSETL
RGASVFQVKLGNQNVETKQLLSASYEFQREFTQGVKPDWTIARIEHSKLLE
Target Bioclass
Other
Subcellular location
Mitochondrion matrix
Function
Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB).
Uniprot ID
Q8WWC4
Ensemble ID
ENST00000295079.6
HGNC ID
HGNC:26198

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.68  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
STPyne
 Probe Info  		K288(10.00)  LDD0277  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.99  LDD1740  [10]
C091
 Probe Info  		12.38  LDD1782  [10]
C092
 Probe Info  		22.94  LDD1783  [10]
C094
 Probe Info  		32.22  LDD1785  [10]
C218
 Probe Info  		12.38  LDD1892  [10]
C220
 Probe Info  		12.04  LDD1894  [10]
C228
 Probe Info  		16.22  LDD1901  [10]
C231
 Probe Info  		12.55  LDD1904  [10]
C285
 Probe Info  		23.75  LDD1955  [10]
C289
 Probe Info  		29.65  LDD1959  [10]
C376
 Probe Info  		6.63  LDD2036  [10]
C380
 Probe Info  		5.21  LDD2039  [10]
C382
 Probe Info  		9.51  LDD2041  [10]
C388
 Probe Info  		41.93  LDD2047  [10]
C429
 Probe Info  		12.91  LDD2084  [10]
C431
 Probe Info  		19.03  LDD2086  [10]
FFF probe11
 Probe Info  		17.48  LDD0471  [11]
FFF probe2
 Probe Info  		20.00  LDD0463  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 11.70  LDD0403  [1]
 LDCM0625  F8 Ramos C162(0.59)  LDD2187  [12]
 LDCM0573  Fragment11 Ramos C162(3.31)  LDD2190  [12]
 LDCM0576  Fragment14 Ramos C162(1.31)  LDD2193  [12]
 LDCM0586  Fragment28 Ramos C162(0.72)  LDD2198  [12]
 LDCM0566  Fragment4 Ramos C162(0.48)  LDD2184  [12]
 LDCM0569  Fragment7 Ramos C162(2.49)  LDD2186  [12]
 LDCM0022  KB02 Ramos C162(1.36)  LDD2182  [12]
 LDCM0023  KB03 Ramos C162(0.61)  LDD2183  [12]
 LDCM0024  KB05 Ramos C162(1.22)  LDD2185  [12]
 LDCM0627  NUDT7-COV-1 HEK-293T C162(0.34)  LDD2206  [13]
 LDCM0628  OTUB2-COV-1 HEK-293T C162(0.69)  LDD2207  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-I (APOC1) Apolipoprotein C1 family P02654
Apolipoprotein C-IV (APOC4) Apolipoprotein C4 family P55056
Histone H4-like protein type G (H4C7) Histone H4 family Q99525

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.