Details of the Target

General Information of Target

Target ID LDTP15434
Target Name ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL6IP6)
Gene Name ARL6IP6
Gene ID 151188
Synonyms
PFAAP1; ADP-ribosylation factor-like protein 6-interacting protein 6; ARL-6-interacting protein 6; Aip-6; Phosphonoformate immuno-associated protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MCRMSFKKETPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHID
CVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAAS
QYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTA
PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL
KNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLLRSKEGPRK
S
Target Bioclass
Other
Family
ARL6IP6 family
Subcellular location
Nucleus inner membrane
Uniprot ID
Q8N6S5
Ensemble ID
ENST00000326446.10
HGNC ID
HGNC:24048

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.88  LDD0402  [1]
IA-alkyne
 Probe Info  		C48(1.67)  LDD0304  [2]
AHL-Pu-1
 Probe Info  		C48(7.33)  LDD0168  [3]
DBIA
 Probe Info  		C48(1.08)  LDD1514  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
AOyne
 Probe Info  		14.80  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		7.52  LDD1725  [7]
C055
 Probe Info  		12.82  LDD1752  [7]
C056
 Probe Info  		24.76  LDD1753  [7]
C218
 Probe Info  		16.91  LDD1892  [7]
C220
 Probe Info  		13.64  LDD1894  [7]
C225
 Probe Info  		5.70  LDD1898  [7]
C226
 Probe Info  		6.11  LDD1899  [7]
C228
 Probe Info  		29.86  LDD1901  [7]
C388
 Probe Info  		54.19  LDD2047  [7]
FFF probe11
 Probe Info  		20.00  LDD0471  [8]
OEA-DA
 Probe Info  		20.00  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C48(7.33)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C48(8.61)  LDD0169  [3]
 LDCM0284  AC24 HEK-293T C48(1.08)  LDD1523  [4]
 LDCM0293  AC32 HEK-293T C48(1.25)  LDD1532  [4]
 LDCM0302  AC40 HEK-293T C48(1.20)  LDD1541  [4]
 LDCM0310  AC48 HEK-293T C48(1.46)  LDD1549  [4]
 LDCM0319  AC56 HEK-293T C48(1.27)  LDD1558  [4]
 LDCM0328  AC64 HEK-293T C48(1.36)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C48(1.17)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C48(1.08)  LDD1514  [4]
 LDCM0156  Aniline NCI-H1299 13.04  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C48(1.07)  LDD2214  [10]
 LDCM0390  CL12 HEK-293T C48(1.19)  LDD1594  [4]
 LDCM0412  CL24 HEK-293T C48(1.09)  LDD1616  [4]
 LDCM0425  CL36 HEK-293T C48(1.11)  LDD1629  [4]
 LDCM0438  CL48 HEK-293T C48(1.19)  LDD1642  [4]
 LDCM0452  CL60 HEK-293T C48(1.19)  LDD1655  [4]
 LDCM0465  CL72 HEK-293T C48(1.27)  LDD1668  [4]
 LDCM0478  CL84 HEK-293T C48(1.05)  LDD1681  [4]
 LDCM0491  CL96 HEK-293T C48(1.28)  LDD1694  [4]
 LDCM0131  RA190 MM1.R C48(1.67)  LDD0304  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Clarin-2 (CLRN2) Clarin family A0PK11
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 205 (TMEM205) TMEM205 family Q6UW68
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 61 (GPR61) G-protein coupled receptor 1 family Q9BZJ8
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 2 (CMTM2) Chemokine-like factor family Q8TAZ6
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
10 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.