Details of the Target

General Information of Target

Target ID LDTP01163
Target Name Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9)
Gene Name COQ9
Gene ID 57017
Synonyms
C16orf49; Ubiquinone biosynthesis protein COQ9, mitochondrial
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAAAVSGALGRAGWRLLQLRCLPVARCRQALVPRAFHASAVGLRSSDEQKQQPPNSFSQ
QHSETQGAEKPDPESSHSPPRYTDQGGEEEEDYESEEQLQHRILTAALEFVPAHGWTAEA
IAEGAQSLGLSSAAASMFGKDGSELILHFVTQCNTRLTRVLEEEQKLVQLGQAEKRKTDQ
FLRDAVETRLRMLIPYIEHWPRALSILMLPHNIPSSLSLLTSMVDDMWHYAGDQSTDFNW
YTRRAMLAAIYNTTELVMMQDSSPDFEDTWRFLENRVNDAMNMGHTAKQVKSTGEALVQG
LMGAAVTLKNLTGLNQRR
Target Bioclass
Other
Family
COQ9 family
Subcellular location
Mitochondrion
Function
Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.
Uniprot ID
O75208
Ensemble ID
ENST00000262507.11
HGNC ID
HGNC:25302

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC70 SNV: p.M302R .
HT115 SNV: p.E69D .
KMCH1 SNV: p.A4V .
TOV21G SNV: p.G294V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y93(9,109.43)  LDD3495  [1]
DBIA
 Probe Info  		C153(3.33)  LDD3312  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
5E-2FA
 Probe Info  		H148(0.00); H285(0.00)  LDD2235  [4]
m-APA
 Probe Info  		H285(0.00); H148(0.00); H199(0.00); H62(0.00)  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
STPyne
 Probe Info  		N.A.  LDD0009  [7]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [3]
PAL-AfBPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		38.59  LDD1785  [8]
C106
 Probe Info  		19.56  LDD1793  [8]
C143
 Probe Info  		22.63  LDD1825  [8]
C178
 Probe Info  		17.03  LDD1857  [8]
C194
 Probe Info  		9.32  LDD1870  [8]
C201
 Probe Info  		59.71  LDD1877  [8]
C206
 Probe Info  		22.32  LDD1881  [8]
C220
 Probe Info  		13.18  LDD1894  [8]
C228
 Probe Info  		23.59  LDD1901  [8]
C243
 Probe Info  		11.39  LDD1916  [8]
C278
 Probe Info  		64.45  LDD1948  [8]
C282
 Probe Info  		14.93  LDD1952  [8]
C284
 Probe Info  		22.01  LDD1954  [8]
C285
 Probe Info  		26.91  LDD1955  [8]
C287
 Probe Info  		10.41  LDD1957  [8]
C288
 Probe Info  		6.41  LDD1958  [8]
C289
 Probe Info  		41.64  LDD1959  [8]
C348
 Probe Info  		11.31  LDD2009  [8]
C349
 Probe Info  		9.06  LDD2010  [8]
C350
 Probe Info  		77.17  LDD2011  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C153(0.98)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C153(1.27)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C153(1.10)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C153(1.01)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C153(0.93)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C153(0.97)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C153(1.05)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C153(1.31)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C153(0.93)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C153(1.06)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C153(1.14)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C153(0.88)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C153(1.04)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C153(1.18)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C153(1.18)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C153(1.01)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C153(1.07)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C153(1.20)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C153(1.09)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C153(0.99)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C153(1.03)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C153(1.08)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C153(1.01)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C153(1.01)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C153(1.00)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C153(1.19)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C153(1.10)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C153(1.19)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C153(1.01)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C153(1.31)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C153(1.16)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C153(0.94)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C153(1.12)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C153(1.02)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C153(1.20)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C153(1.21)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C153(1.17)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C153(1.08)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C153(1.19)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C153(1.20)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C153(1.08)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C153(0.96)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C153(1.09)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C153(1.03)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C153(1.06)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C153(1.04)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C153(1.03)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C153(1.02)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C153(1.04)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C153(1.20)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C153(1.29)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C153(1.19)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C153(1.17)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C153(0.89)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C153(1.10)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C153(0.91)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C153(1.32)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C153(1.00)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C153(1.03)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C153(1.07)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C153(1.01)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C153(0.95)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C153(0.90)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C153(1.02)  LDD1514  [10]
 LDCM0367  CL1 HEK-293T C153(0.88)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C153(0.85)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C153(0.93)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C153(1.02)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C153(0.91)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C153(1.00)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C153(1.00)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C153(0.97)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C153(1.01)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C153(1.02)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C153(1.24)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C153(0.92)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C153(0.91)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C153(1.07)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C153(0.95)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C153(0.94)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C153(1.17)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C153(1.05)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C153(1.15)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C153(0.96)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C153(1.27)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C153(1.07)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C153(1.16)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C153(0.76)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C153(1.09)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C153(1.10)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C153(1.12)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C153(1.08)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C153(1.21)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C153(1.05)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C153(1.15)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C153(1.28)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C153(1.21)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C153(1.01)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C153(1.04)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C153(1.00)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C153(0.88)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C153(0.97)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C153(0.79)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C153(1.02)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C153(1.08)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C153(0.96)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C153(0.78)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C153(1.09)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C153(1.08)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C153(0.77)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C153(1.13)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C153(1.05)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C153(1.04)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C153(0.99)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C153(1.12)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C153(1.01)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C153(0.91)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C153(0.97)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C153(0.90)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C153(0.75)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C153(1.08)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C153(1.00)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C153(0.72)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C153(1.05)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C153(0.99)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C153(0.90)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C153(1.05)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C153(0.95)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C153(1.03)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C153(1.10)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C153(0.99)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C153(0.86)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C153(1.20)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C153(1.05)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C153(0.83)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C153(1.13)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C153(0.96)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C153(1.13)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C153(1.03)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C153(0.90)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C153(0.83)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C153(1.21)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C153(0.89)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C153(0.84)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C153(0.91)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C153(1.11)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C153(0.85)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C153(0.73)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C153(1.22)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C153(1.21)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C153(1.10)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C153(0.99)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C153(1.16)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C153(0.90)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C153(1.31)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C153(0.95)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C153(0.96)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C153(1.12)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C153(0.98)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C153(1.06)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C153(0.78)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C153(0.92)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C153(1.09)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C153(0.95)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C153(0.88)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C153(1.00)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C153(1.06)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C153(0.69)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C153(1.00)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C153(0.81)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C153(0.93)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C153(1.03)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C153(0.85)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C153(0.97)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C153(1.19)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C153(1.22)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C153(1.14)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C153(0.96)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C153(0.88)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C153(0.93)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C153(0.99)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C153(1.15)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C153(0.95)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C153(1.01)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C153(1.19)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C153(1.08)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C153(0.91)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C153(1.03)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C153(1.04)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C153(1.05)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C153(1.00)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C153(1.02)  LDD1631  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HEK-293T C153(1.14)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C153(1.04)  LDD1497  [10]
 LDCM0024  KB05 HMCB C153(3.33)  LDD3312  [2]
 LDCM0109  NEM HeLa H101(0.00); H199(0.00)  LDD0223  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) ATP-dependent AMP-binding enzyme family Q96CM8
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5) MenG/UbiE family Q5HYK3
5-demethoxyubiquinone hydroxylase, mitochondrial (COQ7) COQ7 family Q99807
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) Glutamate 5-kinase family; Gamma-glutamyl phosphate reductase family P54886
Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) Glycosyltransferase 2 family Q10471
Heme oxygenase 1 (HMOX1) Heme oxygenase family P09601
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Lysoplasmalogenase TMEM86A (TMEM86A) TMEM86 family Q8N2M4
Transmembrane reductase CYB561D2 (CYB561D2) . O14569
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid scramblase 2 (PLSCR2) Phospholipid scramblase family Q9NRY7
Syntaxin-3 (STX3) Syntaxin family Q13277
Tetraspanin-33 (TSPAN33) Tetraspanin (TM4SF) family Q86UF1
Transmembrane protein 14C (TMEM14C) TMEM14 family Q9P0S9
Adiponectin (ADIPOQ) . Q15848
Transmembrane protein 79 (TMEM79) . Q9BSE2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) . O14798
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cortexin-3 (CTXN3) Cortexin family Q4LDR2
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
ORM1-like protein 1 (ORMDL1) ORM family Q9P0S3
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Scavenger receptor class F member 1 (SCARF1) . Q14162
Testis-expressed protein 264 (TEX264) . Q9Y6I9
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228
WAP four-disulfide core domain protein 2 (WFDC2) . Q14508

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402