Details of the Target

General Information of Target

Target ID LDTP13953
Target Name Endophilin-B1 (SH3GLB1)
Gene Name SH3GLB1
Gene ID 51100
Synonyms
KIAA0491; Endophilin-B1; Bax-interacting factor 1; Bif-1; SH3 domain-containing GRB2-like protein B1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKELRSTILFNAYKKEIFTTNNGYKSMQKKLRSNWKIQSLKDEITSEKLNGVKLWITAG
PREKFTAAEFEILKKYLDTGGDVFVMLGEGGESRFDTNINFLLEEYGIMVNNDAVVRNVY
HKYFHPKEALVSSGVLNREISRAAGKAVPGIIDEESSGNNAQALTFVYPFGATLSVMKPA
VAVLSTGSVCFPLNRPILAFYHSKNQGGKLAVLGSCHMFSDQYLDKEENSKIMDVVFQWL
TTGDIHLNQIDAEDPEISDYMMLPYTATLSKRNRECLQESDEIPRDFTTLFDLSIFQLDT
TSFHSVIEAHEQLNVKHEPLQLIQPQFETPLPTLQPAVFPPSFRELPPPPLELFDLDETF
SSEKARLAQITNKCTEEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHVFFQVVEFKKL
NQEHDIDTSETAFQNNF
Target Bioclass
Transporter and channel
Family
Endophilin family
Subcellular location
Cytoplasm
Function
May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2. Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability.
Uniprot ID
Q9Y371
Ensemble ID
ENST00000370558.8
HGNC ID
HGNC:10833

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.A239V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
FBPP2
 Probe Info  		2.75  LDD0318  [2]
TH211
 Probe Info  		Y80(9.42); Y155(5.54)  LDD0257  [3]
TH216
 Probe Info  		Y155(20.00); Y80(12.96)  LDD0259  [3]
STPyne
 Probe Info  		K10(0.21); K156(8.04); K160(5.24); K163(10.00)  LDD0277  [4]
DA-P3
 Probe Info  		45.31  LDD0179  [5]
DBIA
 Probe Info  		C304(4.08)  LDD0209  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C121(0.00); C304(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.13  LDD1740  [14]
C091
 Probe Info  		10.13  LDD1782  [14]
C092
 Probe Info  		28.84  LDD1783  [14]
C106
 Probe Info  		16.56  LDD1793  [14]
C112
 Probe Info  		22.78  LDD1799  [14]
C134
 Probe Info  		20.39  LDD1816  [14]
C201
 Probe Info  		70.52  LDD1877  [14]
C220
 Probe Info  		12.64  LDD1894  [14]
C228
 Probe Info  		23.59  LDD1901  [14]
C246
 Probe Info  		12.38  LDD1919  [14]
C285
 Probe Info  		21.56  LDD1955  [14]
C289
 Probe Info  		53.45  LDD1959  [14]
C350
 Probe Info  		22.47  LDD2011  [14]
C362
 Probe Info  		35.02  LDD2023  [14]
C367
 Probe Info  		5.35  LDD2028  [14]
C388
 Probe Info  		50.56  LDD2047  [14]
C390
 Probe Info  		22.01  LDD2049  [14]
C407
 Probe Info  		12.91  LDD2064  [14]
FFF probe11
 Probe Info  		16.14  LDD0471  [15]
FFF probe13
 Probe Info  		17.95  LDD0475  [15]
FFF probe14
 Probe Info  		19.86  LDD0477  [15]
FFF probe3
 Probe Info  		7.39  LDD0464  [15]
FFF probe4
 Probe Info  		7.42  LDD0466  [15]
JN0003
 Probe Info  		17.20  LDD0469  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]
OEA-DA
 Probe Info  		17.58  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C226(1.26)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C226(1.02)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C226(0.85)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C226(1.08)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C226(0.97)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C226(1.12)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C226(1.10)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C226(0.92)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C226(0.85)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C226(0.84)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C226(0.99)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C226(1.02)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C226(0.95)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C226(1.07)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C226(0.82)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C226(1.33)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C226(0.90)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C226(0.88)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C226(1.02)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C226(0.96)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C226(1.00)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C226(1.02)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C226(1.22)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C226(0.94)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C226(1.22)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C226(1.06)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C226(0.94)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C226(1.04)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C226(0.89)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C226(0.86)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C226(1.03)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C226(1.01)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C226(0.94)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C226(1.08)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C226(1.01)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C226(0.89)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C226(1.02)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C226(0.95)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C226(0.99)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C226(0.96)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C226(0.73)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C226(1.23)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C226(0.91)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C226(0.89)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C226(0.88)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C226(1.01)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C226(1.10)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C226(0.79)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C226(0.96)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C226(0.99)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C226(1.18)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C226(0.97)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C226(0.98)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C226(1.00)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C226(1.09)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C226(1.10)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C226(1.09)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C226(1.04)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C226(0.87)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C226(0.97)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C226(0.95)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C226(1.02)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C226(1.10)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C226(1.06)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 12.00  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C121(1.03)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C226(1.18)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C226(0.50)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C226(1.08)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C226(1.01)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C226(1.13)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C226(0.81)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C226(1.02)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C226(1.05)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C226(0.91)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C226(1.12)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C226(0.95)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C226(1.17)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C226(0.95)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C226(1.20)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C226(0.84)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C226(0.98)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C226(0.98)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C226(1.35)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C226(0.91)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C226(1.05)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C226(1.02)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C226(0.91)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C226(1.04)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C226(0.81)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C226(0.90)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C226(1.01)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C226(1.00)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C226(1.15)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C226(0.91)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C226(1.12)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C226(1.15)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C226(0.96)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C226(1.13)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C226(1.11)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C226(0.85)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C226(1.08)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C226(0.83)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C226(1.13)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C226(0.83)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C226(0.67)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C226(1.07)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C226(0.85)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C226(0.80)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C226(0.62)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C226(1.14)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C226(0.55)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C226(1.22)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C226(1.13)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C226(0.86)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C226(0.84)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C226(0.93)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C226(0.89)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C226(0.79)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C226(0.73)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C226(0.87)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C226(1.19)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C226(0.62)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C226(1.06)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C226(0.64)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C226(0.93)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C226(0.85)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C226(1.00)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C226(0.87)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C226(0.88)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C226(0.88)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C226(0.70)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C226(0.80)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C226(0.73)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C226(0.65)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C226(0.87)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C226(0.74)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C226(1.06)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C226(1.12)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C226(0.99)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C226(0.91)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C226(1.02)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C226(1.25)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C226(0.68)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C226(0.84)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C226(0.74)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C226(0.62)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C226(1.06)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C226(1.03)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C226(0.71)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C226(1.10)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C226(0.95)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C226(0.97)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C226(0.95)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C226(0.95)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C226(0.90)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C226(0.76)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C226(0.83)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C226(0.75)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C226(0.81)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C226(0.70)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C226(0.94)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C226(0.55)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C226(1.20)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C226(1.17)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C226(0.94)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C226(0.96)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C226(0.90)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C226(0.75)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C226(1.19)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C226(0.84)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C226(0.74)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C226(0.62)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C226(1.04)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C226(0.89)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C226(1.13)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C226(1.26)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C226(1.04)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C226(0.93)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C226(1.10)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C226(0.76)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C226(1.58)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C226(0.74)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C226(1.01)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C226(0.80)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C226(0.70)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C226(0.94)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C226(0.94)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C226(1.08)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C226(1.07)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C226(0.85)  LDD1697  [18]
 LDCM0027  Dopamine HEK-293T 45.31  LDD0179  [5]
 LDCM0495  E2913 HEK-293T C226(0.85)  LDD1698  [18]
 LDCM0031  Epigallocatechin gallate HEK-293T 33.22  LDD0183  [5]
 LDCM0625  F8 Ramos C121(0.54)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C121(1.36)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C121(0.03)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C121(3.06)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C121(0.80)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C121(1.38)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C121(2.85)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C121(0.91)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C121(2.38)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C121(1.00)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C121(0.47)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C121(1.50)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C121(0.84)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C121(1.68)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C226(0.94)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C121(1.20)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C121(1.76)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C226(1.10)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C121(1.55)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C121(1.24)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C121(1.25)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C121(7.34)  LDD2188  [19]
 LDCM0022  KB02 A2780 C21(2.24)  LDD2254  [20]
 LDCM0023  KB03 Jurkat C304(4.08)  LDD0209  [6]
 LDCM0024  KB05 G361 C21(5.12)  LDD3311  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C121(0.80)  LDD2207  [21]
 LDCM0029  Quercetin HEK-293T 6.70  LDD0181  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 28 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 60 (NAA60) Acetyltransferase family Q9H7X0
Adenylate kinase 8 (AK8) Adenylate kinase family Q96MA6
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Putative aldo-keto reductase family 1 member C8 (AKR1C8) Aldo/keto reductase family Q5T2L2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) ATP-dependent AMP-binding enzyme family Q96CM8
Bile acid-CoA:amino acid N-acyltransferase (BAAT) C/M/P thioester hydrolase family Q14032
Prostaglandin-H2 D-isomerase (PTGDS) Lipocalin family P41222
Holocytochrome c-type synthase (HCCS) Cytochrome c-type heme lyase family P53701
Cytochrome P450 2C8 (CYP2C8) Cytochrome P450 family P10632
Deubiquitinase DESI2 (DESI2) DeSI family Q9BSY9
DNA polymerase alpha subunit B (POLA2) DNA polymerase alpha subunit B family Q14181
Methylthioribose-1-phosphate isomerase (MRI1) EIF-2B alpha/beta/delta subunits family Q9BV20
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
FAST kinase domain-containing protein 2, mitochondrial (FASTKD2) FAST kinase family Q9NYY8
Plasmanylethanolamine desaturase 1 (PEDS1) Fatty acid desaturase CarF family A5PLL7
Amine oxidase [flavin-containing] B (MAOB) Flavin monoamine oxidase family P27338
Sphingomyelin phosphodiesterase 2 (SMPD2) Neutral sphingomyelinase family O60906
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) Peptidase S33 family Q8WTS1
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Fructose-2,6-bisphosphatase TIGAR (TIGAR) Phosphoglycerate mutase family Q9NQ88
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Dehydrogenase/reductase SDR family member 1 (DHRS1) Short-chain dehydrogenases/reductases (SDR) family Q96LJ7
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
Protein-glutamine gamma-glutamyltransferase K (TGM1) Transglutaminase family P22735
Tubulin alpha-1C chain (TUBA1C) Tubulin family Q9BQE3
Ubiquitin-conjugating enzyme E2 G1 (UBE2G1) Ubiquitin-conjugating enzyme family P62253
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 (JMJD7) . P0C870
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Transporter and channel
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase subunit g, mitochondrial (ATP5MG) ATPase g subunit family O75964
Apoptosis regulator BAX (BAX) Bcl-2 family Q07812
Growth hormone-inducible transmembrane protein (GHITM) BI1 family Q9H3K2
Calcium channel flower homolog (CACFD1) Calcium channel flower family Q9UGQ2
45 kDa calcium-binding protein (SDF4) CREC family Q9BRK5
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Peripherin-2 (PRPH2) PRPH2/ROM1 family P23942
Phosphatidylinositol transfer protein alpha isoform (PITPNA) PtdIns transfer protein family Q00169
Phosphatidylinositol transfer protein beta isoform (PITPNB) PtdIns transfer protein family P48739
Secretory carrier-associated membrane protein 1 (SCAMP1) SCAMP family O15126
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Sorting nexin-4 (SNX4) Sorting nexin family O95219
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) Tim17/Tim22/Tim23 family O14925
Barttin (BSND) . Q8WZ55
Multiple coagulation factor deficiency protein 2 (MCFD2) . Q8NI22
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 576 (ZNF576) Krueppel C2H2-type zinc-finger protein family Q9H609
Nuclear transcription factor Y subunit beta (NFYB) NFYB/HAP3 subunit family P25208
DnaJ homolog subfamily C member 1 (DNAJC1) . Q96KC8
Myc proto-oncogene protein (MYC) . P01106
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Succinate receptor 1 (SUCNR1) G-protein coupled receptor 1 family Q9BXA5
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-cell surface glycoprotein CD4 (CD4) . P01730
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
Platelet basic protein (PPBP) Intercrine alpha (chemokine CxC) family P02775
Other
Click To Hide/Show 54 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein A-I (APOA1) Apolipoprotein A1/A4/E family P02647
Apolipoprotein A-IV (APOA4) Apolipoprotein A1/A4/E family P06727
Nuclear nucleic acid-binding protein C1D (C1D) C1D family Q13901
Centrin-3 (CETN3) Centrin family O15182
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Cyclin-C (CCNC) Cyclin family P24863
Dedicator of cytokinesis protein 10 (DOCK10) DOCK family Q96BY6
RNA polymerase II elongation factor ELL2 (ELL2) ELL/occludin family O00472
Endophilin-B2 (SH3GLB2) Endophilin family Q9NR46
Small ribosomal subunit protein eS4, X isoform (RPS4X) Eukaryotic ribosomal protein eS4 family P62701
Protein FAM114A2 (FAM114A2) FAM114 family Q9NRY5
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
FUN14 domain-containing protein 1 (FUNDC1) FUN14 family Q8IVP5
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) GADD45 family P24522
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Histone H3.3C (H3-5) Histone H3 family Q6NXT2
Jupiter microtubule associated homolog 1 (JPT1) JUPITER family Q9UK76
Protein MAL2 (MAL2) MAL family Q969L2
Perilipin-3 (PLIN3) Perilipin family O60664
Alpha-1-antichymotrypsin (SERPINA3) Serpin family P01011
SH3 domain-binding protein 5-like (SH3BP5L) SH3BP5 family Q7L8J4
Sideroflexin-3 (SFXN3) Sideroflexin family Q9BWM7
Small integral membrane protein 12 (SMIM12) SMIM12 family Q96EX1
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Spindlin-2B (SPIN2B) SPIN/STSY family Q9BPZ2
Synaptogyrin-3 (SYNGR3) Synaptogyrin family O43761
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
General transcription factor IIH subunit 1 (GTF2H1) TFB1 family P32780
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Transmembrane protein 115 (TMEM115) TMEM115 family Q12893
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) Tom22 family Q9NS69
Tumor protein D54 (TPD52L2) TPD52 family O43399
UPF0462 protein C4orf33 (C4orf33) UPF0462 family Q8N1A6
Guanine nucleotide-binding protein subunit beta-4 (GNB4) WD repeat G protein beta family Q9HAV0
Histone-binding protein RBBP4 (RBBP4) WD repeat RBAP46/RBAP48/MSI1 family Q09028
Protein YIF1A (YIF1A) YIF1 family O95070
Alpha-tocopherol transfer protein (TTPA) . P49638
Ankyrin repeat and EF-hand domain-containing protein 1 (ANKEF1) . Q9NU02
Arfaptin-2 (ARFIP2) . P53365
Beta-2-glycoprotein 1 (APOH) . P02749
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Cysteine-rich C-terminal protein 1 (CRCT1) . Q9UGL9
Galectin-9C (LGALS9C) . Q6DKI2
Huntingtin-interacting protein M (H2AP) . O75409
Melanoma-associated antigen 8 (MAGEA8) . P43361
Melanoma-associated antigen B18 (MAGEB18) . Q96M61
Mucin-15 (MUC15) . Q8N387
Protein C12orf4 (C12orf4) . Q9NQ89
Protein NCBP2AS2 (NCBP2AS2) . Q69YL0
Regulator of hemoglobinization and erythroid cell expansion protein (RHEX) . Q6ZWK4
Small integral membrane protein 5 (SMIM5) . Q71RC9
Spartin (SPART) . Q8N0X7
Testicular spindle-associated protein SHCBP1L (SHCBP1L) . Q9BZQ2
UV radiation resistance-associated gene protein (UVRAG) . Q9P2Y5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.