Details of the Target

General Information of Target

Target ID LDTP08279
Target Name Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42)
Gene Name SLC25A42
Gene ID 284439
Synonyms
Mitochondrial coenzyme A transporter SLC25A42; Solute carrier family 25 member 42
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNGVKEGPVRLHEDAEAVLSSSVSSKRDHRQVLSSLLSGALAGALAKTAVAPLDRTKII
FQVSSKRFSAKEAFRVLYYTYLNEGFLSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGS
YYGFRGEALPPWPRLFAGALAGTTAASLTYPLDLVRARMAVTPKEMYSNIFHVFIRISRE
EGLKTLYHGFMPTVLGVIPYAGLSFFTYETLKSLHREYSGRRQPYPFERMIFGACAGLIG
QSASYPLDVVRRRMQTAGVTGYPRASIARTLRTIVREEGAVRGLYKGLSMNWVKGPIAVG
ISFTTFDLMQILLRHLQS
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.
Uniprot ID
Q86VD7
Ensemble ID
ENST00000318596.8
HGNC ID
HGNC:28380

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
DBIA
 Probe Info  		C235(1.29)  LDD1507  [2]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		22.32  LDD1752  [3]
C056
 Probe Info  		64.00  LDD1753  [3]
C063
 Probe Info  		17.15  LDD1760  [3]
C070
 Probe Info  		12.73  LDD1766  [3]
C072
 Probe Info  		8.51  LDD1768  [3]
C091
 Probe Info  		29.45  LDD1782  [3]
C092
 Probe Info  		53.08  LDD1783  [3]
C094
 Probe Info  		48.84  LDD1785  [3]
C178
 Probe Info  		15.67  LDD1857  [3]
C198
 Probe Info  		9.71  LDD1874  [3]
C210
 Probe Info  		58.49  LDD1884  [3]
C218
 Probe Info  		13.09  LDD1892  [3]
C220
 Probe Info  		13.36  LDD1894  [3]
C225
 Probe Info  		9.32  LDD1898  [3]
C226
 Probe Info  		9.19  LDD1899  [3]
C228
 Probe Info  		53.82  LDD1901  [3]
C246
 Probe Info  		14.52  LDD1919  [3]
C399
 Probe Info  		7.73  LDD2058  [3]
C403
 Probe Info  		31.12  LDD2061  [3]
DA-2
 Probe Info  		N.A.  LDD0072  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C235(1.29)  LDD1507  [2]
 LDCM0237  AC12 HEK-293T C235(0.98)  LDD1510  [2]
 LDCM0276  AC17 HEK-293T C235(0.83)  LDD1515  [2]
 LDCM0280  AC20 HEK-293T C235(0.90)  LDD1519  [2]
 LDCM0284  AC24 HEK-293T C235(0.89)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C235(0.90)  LDD1524  [2]
 LDCM0288  AC28 HEK-293T C235(0.98)  LDD1527  [2]
 LDCM0293  AC32 HEK-293T C235(0.89)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C235(0.96)  LDD1533  [2]
 LDCM0297  AC36 HEK-293T C235(0.91)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C235(0.99)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C235(0.99)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C235(1.07)  LDD1542  [2]
 LDCM0306  AC44 HEK-293T C235(0.95)  LDD1545  [2]
 LDCM0310  AC48 HEK-293T C235(1.12)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C235(1.10)  LDD1550  [2]
 LDCM0315  AC52 HEK-293T C235(1.01)  LDD1554  [2]
 LDCM0319  AC56 HEK-293T C235(0.94)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C235(1.05)  LDD1559  [2]
 LDCM0324  AC60 HEK-293T C235(1.03)  LDD1563  [2]
 LDCM0328  AC64 HEK-293T C235(1.03)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C235(0.99)  LDD1569  [2]
 LDCM0356  AKOS034007680 HEK-293T C235(1.13)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C235(0.88)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C235(1.13)  LDD1571  [2]
 LDCM0369  CL100 HEK-293T C235(1.42)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C235(1.18)  LDD1574  [2]
 LDCM0373  CL104 HEK-293T C235(0.93)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C235(0.93)  LDD1578  [2]
 LDCM0377  CL108 HEK-293T C235(0.98)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C235(1.02)  LDD1582  [2]
 LDCM0382  CL112 HEK-293T C235(0.90)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C235(1.14)  LDD1587  [2]
 LDCM0386  CL116 HEK-293T C235(0.92)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C235(1.13)  LDD1591  [2]
 LDCM0390  CL12 HEK-293T C235(1.10)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C235(1.00)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C235(0.95)  LDD1596  [2]
 LDCM0395  CL124 HEK-293T C235(0.81)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C235(1.19)  LDD1600  [2]
 LDCM0399  CL128 HEK-293T C235(0.93)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C235(1.36)  LDD1604  [2]
 LDCM0403  CL16 HEK-293T C235(0.87)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C235(0.90)  LDD1608  [2]
 LDCM0408  CL20 HEK-293T C235(1.10)  LDD1612  [2]
 LDCM0412  CL24 HEK-293T C235(1.02)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C235(1.15)  LDD1617  [2]
 LDCM0416  CL28 HEK-293T C235(0.86)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C235(0.87)  LDD1621  [2]
 LDCM0421  CL32 HEK-293T C235(1.01)  LDD1625  [2]
 LDCM0425  CL36 HEK-293T C235(1.02)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C235(1.22)  LDD1630  [2]
 LDCM0429  CL4 HEK-293T C235(1.20)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C235(0.95)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C235(1.01)  LDD1635  [2]
 LDCM0434  CL44 HEK-293T C235(1.01)  LDD1638  [2]
 LDCM0438  CL48 HEK-293T C235(1.21)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C235(1.13)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C235(1.23)  LDD1644  [2]
 LDCM0443  CL52 HEK-293T C235(0.88)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C235(1.22)  LDD1647  [2]
 LDCM0447  CL56 HEK-293T C235(1.05)  LDD1650  [2]
 LDCM0452  CL60 HEK-293T C235(1.06)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C235(1.34)  LDD1656  [2]
 LDCM0456  CL64 HEK-293T C235(1.14)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C235(1.10)  LDD1660  [2]
 LDCM0460  CL68 HEK-293T C235(1.01)  LDD1663  [2]
 LDCM0465  CL72 HEK-293T C235(1.06)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C235(1.02)  LDD1669  [2]
 LDCM0469  CL76 HEK-293T C235(0.89)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C235(0.94)  LDD1673  [2]
 LDCM0473  CL8 HEK-293T C235(0.85)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C235(1.12)  LDD1677  [2]
 LDCM0478  CL84 HEK-293T C235(0.99)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C235(1.01)  LDD1682  [2]
 LDCM0482  CL88 HEK-293T C235(1.12)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C235(0.87)  LDD1686  [2]
 LDCM0487  CL92 HEK-293T C235(1.02)  LDD1690  [2]
 LDCM0491  CL96 HEK-293T C235(1.17)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C235(1.04)  LDD1695  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
4 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.