Details of the Target

General Information of Target

Target ID LDTP09255
Target Name Motile sperm domain-containing protein 2 (MOSPD2)
Gene Name MOSPD2
Gene ID 158747
Synonyms
Motile sperm domain-containing protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAENHAQNKAKLISETRRRFEAEYVTDKSDKYDARDVERLQQDDNWVESYLSWRHNIVDE
TLKMLDESFQWRKEISVNDLNESSIPRWLLEIGVIYLHGYDKEGNKLFWIRVKYHVKDQK
TILDKKKLIAFWLERYAKRENGKPVTVMFDLSETGINSIDMDFVRFIINCFKVYYPKYLS
KIVIFDMPWLMNAAFKIVKTWLGPEAVSLLKFTSKNEVQDYVSVEYLPPHMGGTDPFKYS
YPPLVDDDFQTPLCENGPITSEDETSSKEDIESDGKETLETISNEEQTPLLKKINPTEST
SKAEENEKVDSKVKAFKKPLSVFKGPLLHISPAEELYFGSTESGEKKTLIVLTNVTKNIV
AFKVRTTAPEKYRVKPSNSSCDPGASVDIVVSPHGGLTVSAQDRFLIMAAEMEQSSGTGP
AELTQFWKEVPRNKVMEHRLRCHTVESSKPNTLTLKDNAFNMSDKTSEDICLQLSRLLES
NRKLEDQVQRCIWFQQLLLSLTMLLLAFVTSFFYLLYS
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins. In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis. The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs. Promotes migration of primary monocytes and neutrophils, in response to various chemokines.
Uniprot ID
Q8NHP6
Ensemble ID
ENST00000380492.8
HGNC ID
HGNC:28381

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.T288A .
FTC133 SNV: p.H394R .
Ishikawa (Heraklio) 02 ER SNV: p.T26I DBIA    Probe Info 
MFE319 SNV: p.I95V DBIA    Probe Info 
NCIH2291 SNV: p.D263Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.05  LDD0402  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C471(0.95)  LDD0531  [3]
CY4
 Probe Info  		N.A.  LDD0247  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C442(0.00); C471(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
ENE
 Probe Info  		N.A.  LDD0006  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
STPyne
 Probe Info  		N.A.  LDD0009  [7]
TFBX
 Probe Info  		C471(0.00); C170(0.00)  LDD0148  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]
AOyne
 Probe Info  		14.60  LDD0443  [9]
NAIA_5
 Probe Info  		C442(0.00); C381(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		6.68  LDD1728  [11]
C107
 Probe Info  		6.28  LDD1794  [11]
C220
 Probe Info  		24.25  LDD1894  [11]
C349
 Probe Info  		9.45  LDD2010  [11]
STS-1
 Probe Info  		N.A.  LDD0137  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C471(0.95)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C471(1.35)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C471(1.12)  LDD0543  [3]
 LDCM0230  AC113 HCT 116 C471(1.10)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C471(1.10)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C471(1.24)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C471(1.24)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C471(1.24)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C471(1.03)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C471(1.17)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C471(0.94)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C471(1.20)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C471(1.05)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C471(1.13)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C471(0.99)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C471(0.93)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C471(1.04)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C471(1.17)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C471(1.16)  LDD0562  [3]
 LDCM0246  AC128 PaTu 8988t C471(1.01)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C471(1.20)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C471(1.09)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C471(1.23)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C471(1.58)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C471(1.68)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C471(1.37)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C471(1.53)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C471(1.42)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C471(1.08)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C471(1.46)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C471(1.05)  LDD1137  [3]
 LDCM0259  AC14 HCT 116 C471(1.27)  LDD0576  [3]
 LDCM0260  AC140 PaTu 8988t C471(1.20)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C471(0.93)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C471(1.37)  LDD1141  [3]
 LDCM0263  AC143 HCT 116 C471(1.10)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C471(1.38)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C471(1.23)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C471(1.59)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C471(1.49)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C471(2.11)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C471(1.86)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C471(1.24)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C471(1.11)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C471(1.06)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C471(1.50)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C471(2.04)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C471(1.36)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C471(1.38)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C471(1.12)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C471(0.95)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C471(0.97)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C471(0.94)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C471(1.11)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C471(1.08)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C471(0.90)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C471(0.95)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C471(1.03)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C471(0.91)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C471(0.98)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C471(0.97)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C471(1.14)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C471(1.03)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C471(1.09)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C471(1.44)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C471(1.02)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C471(1.46)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C471(1.20)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C471(1.34)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C471(0.94)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C471(0.92)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C471(0.80)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C471(0.85)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C471(0.85)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C471(0.97)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C471(1.03)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C471(0.96)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C471(0.93)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C471(0.92)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C471(0.96)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C471(0.96)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C471(0.88)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C471(0.96)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C471(1.39)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C471(1.31)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C471(1.36)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C471(1.29)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C471(0.96)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C471(1.56)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C471(1.42)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C471(1.48)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C471(1.21)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C471(1.32)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C471(1.13)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C471(1.37)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C471(1.16)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C471(0.94)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C471(1.25)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C471(1.21)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C471(1.21)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C471(1.10)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C471(1.13)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C471(1.05)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C471(1.21)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C471(1.29)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C471(0.96)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C471(1.30)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C471(0.86)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C471(0.81)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C471(1.12)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C471(1.07)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C471(0.79)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C471(0.93)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C471(1.08)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C471(0.90)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C471(1.07)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C471(0.76)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C471(0.92)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C471(0.87)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C471(0.92)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C471(1.06)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C471(0.72)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C471(0.93)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C471(0.81)  LDD0665  [3]
 LDCM0349  AC83 PaTu 8988t C471(0.82)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C471(0.71)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C471(1.02)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C471(1.10)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C471(1.16)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C471(1.02)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C471(0.76)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C471(1.00)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C471(0.86)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C471(0.94)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C471(0.87)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C471(1.01)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C471(0.94)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C471(0.80)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C471(0.77)  LDD1243  [3]
 LDCM0248  AKOS034007472 HCT 116 C471(1.12)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C471(1.29)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C471(1.64)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 14.14  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C471(0.00); C170(0.00)  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C471(1.11)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C471(1.24)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C471(0.93)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C471(1.31)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C471(1.06)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C471(1.07)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C471(1.07)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C471(1.04)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C471(1.03)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C471(1.11)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C471(1.18)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C471(1.02)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C471(1.14)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C471(0.96)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C471(1.05)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C471(1.02)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C471(1.38)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C471(1.25)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C471(1.29)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C471(0.98)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C471(1.29)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C471(1.01)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C471(0.94)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C471(1.25)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C471(1.05)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C471(1.40)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C471(1.42)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C471(1.66)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C471(1.39)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C471(1.06)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C471(1.13)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C471(1.01)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C471(0.96)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C471(1.27)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C471(1.22)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C471(1.22)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C471(0.87)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C471(1.16); C170(0.93)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C471(0.97)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C471(0.99)  LDD1610  [13]
 LDCM0407  CL2 HCT 116 C471(1.24)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C471(1.02)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C471(1.08)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C471(0.90)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C471(1.02)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C471(1.09)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C471(0.99)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C471(0.91); C170(0.93)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C471(0.93)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C471(0.84)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C471(1.12); C170(0.98)  LDD1621  [13]
 LDCM0418  CL3 HCT 116 C471(1.19)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C471(0.98)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C471(0.93)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C471(0.96)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C471(1.31)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C471(1.04)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C471(0.92)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C471(0.91)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C471(0.92)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C471(0.82)  LDD1632  [13]
 LDCM0429  CL4 HCT 116 C471(1.25)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C471(0.95)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C471(1.00); C170(0.95)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C471(0.92)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C471(0.89)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C471(1.13)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C471(0.92)  LDD1639  [13]
 LDCM0436  CL46 HCT 116 C471(1.08)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C471(1.01)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C471(1.12)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C471(1.17)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C471(1.13)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C471(1.06)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C471(1.12)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C471(1.17)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C471(1.05)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C471(1.40)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C471(1.01)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C471(1.03)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C471(1.02)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C471(1.07)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C471(0.96)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C471(1.52)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C471(1.13)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C471(1.00)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C471(0.95)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C471(0.90)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C471(0.95)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C471(0.94)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C471(0.94)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C471(0.81)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C471(0.87)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C471(1.00)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C471(1.32)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C471(0.98)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C471(0.94)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C471(1.09)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C471(0.92)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C471(0.92)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C471(1.06)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C471(0.92)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C471(0.94)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C471(0.95)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C471(1.22)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C471(0.91)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C471(0.96)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C471(1.03)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C471(0.99)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C471(1.01)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C471(1.00)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C471(0.89)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C471(0.91)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C471(0.81)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C471(1.11)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C471(1.38)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C471(1.08)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C471(1.00)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C471(0.93)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C471(0.93)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C471(0.94)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C471(1.08)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C471(0.94)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C471(1.03)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C471(1.07)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C471(1.02)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C471(0.82)  LDD1698  [13]
 LDCM0468  Fragment33 HCT 116 C471(1.01)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C471(0.94); C170(0.92)  LDD1631  [13]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 HEK-293T C471(1.06)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C471(0.99)  LDD1497  [13]
 LDCM0024  KB05 HMCB C471(2.40)  LDD3312  [14]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
StAR-related lipid transfer protein 3 (STARD3) STARD3 family Q14849
STARD3 N-terminal-like protein (STARD3NL) STARD3 family O95772
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 1 member A1 (BTN1A1) BTN/MOG family Q13410
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxysterol-binding protein-related protein 1 (OSBPL1A) OSBP family Q9BXW6
Regulator of microtubule dynamics protein 3 (RMDN3) RMDN family Q96TC7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840