Details of the Target

General Information of Target

Target ID LDTP12729
Target Name Required for meiotic nuclear division protein 1 homolog (RMND1)
Gene Name RMND1
Gene ID 55005
Synonyms
C6orf96; Required for meiotic nuclear division protein 1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSVEKTTNRSEQKSRKFLKSLIRKQPQELLLVIGTGVSAAVAPGIPALCSWRSCIEAVI
EAAEQLEVLHPGDVAEFRRKVTKDRDLLVVAHDLIRKMSPRTGDAKPSFFQDCLMEVFDD
LEQHIRSPVVLQSILSLMDRGAMVLTTNYDNLLEAFGRRQNKPMESLDLKDKTKVLEWAR
GHMKYGVLHIHGLYTDPCGVVLDPSGYKDVTQDAEVMEVLQNLYRTKSFLFVGCGETLRD
QIFQALFLYSVPNKVDLEHYMLVLKENEDHFFKHQADMLLHGIKVVSYGDCFDHFPGYVQ
DLATQICKQQSPDADRVDSTTLLGNACQDCAKRKLEENGIEVSKKRTQSDTDDAGGS
Target Bioclass
Other
Family
RMD1/sif2 family
Subcellular location
Mitochondrion
Function Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.
Uniprot ID
Q9NWS8
Ensemble ID
ENST00000444024.3
HGNC ID
HGNC:21176

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.S75VfsTer17 DBIA    Probe Info 
KPL1 SNV: p.F369L .
MCF7 SNV: p.F369L .
RAMOS SNV: p.N381K IA-alkyne    Probe Info 
SNGM SNV: p.S81Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.21  LDD0318  [1]
DBIA
 Probe Info  		C390(1.07)  LDD0531  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
NAIA_5
 Probe Info  		C310(0.00); C409(0.00)  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		16.45  LDD1713  [6]
C004
 Probe Info  		6.82  LDD1714  [6]
C106
 Probe Info  		16.11  LDD1793  [6]
C112
 Probe Info  		18.13  LDD1799  [6]
C220
 Probe Info  		13.64  LDD1894  [6]
C228
 Probe Info  		19.84  LDD1901  [6]
C349
 Probe Info  		12.13  LDD2010  [6]
C350
 Probe Info  		41.64  LDD2011  [6]
C362
 Probe Info  		36.25  LDD2023  [6]
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe3
 Probe Info  		20.00  LDD0464  [7]
FFF probe4
 Probe Info  		17.90  LDD0466  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C390(1.07)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C409(0.96); C390(0.98); C310(0.97)  LDD1508  [8]
 LDCM0216  AC100 HCT 116 C390(0.98)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C390(0.87)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C390(0.83)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C390(0.84)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C390(1.18)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C390(0.96)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C390(0.92)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C390(0.95)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C390(0.91)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C390(1.02)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C409(0.99); C390(1.01); C310(0.98)  LDD1509  [8]
 LDCM0227  AC110 HCT 116 C390(0.94)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C390(1.04)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C390(1.16)  LDD0546  [2]
 LDCM0237  AC12 HEK-293T C409(0.96); C390(0.92); C310(0.97)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C409(0.94); C390(1.03); C310(0.96)  LDD1512  [8]
 LDCM0263  AC143 HCT 116 C390(0.93)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C390(1.14)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C390(0.98)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C390(0.97)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C390(1.16)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C390(1.48)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C390(0.97)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C409(0.95); C390(1.01); C310(0.96)  LDD1513  [8]
 LDCM0271  AC150 HCT 116 C390(0.89)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C390(0.85)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C390(1.07)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C390(1.14)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C390(1.43)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C390(1.32)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C390(1.02)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C390(1.11)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C390(1.31)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C390(1.11)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C390(1.05)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C390(0.89)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C390(0.74)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C390(0.84)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C390(0.80)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C390(0.93)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C390(1.31)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C390(0.96)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C390(1.14)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C390(0.91)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C390(0.74)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C390(0.83)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C390(1.16)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C390(0.76)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C390(0.73)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C390(0.74)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C390(0.70)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C390(0.96)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C390(1.28)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C390(1.15)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C390(1.13)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C390(1.59)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C390(1.32)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C390(1.14)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C390(0.91)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C390(1.14)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C390(1.22)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C390(0.98)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C390(1.08)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C390(1.25)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C390(0.94)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C390(0.77)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C390(0.99)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C390(0.99)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C390(1.13)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C390(1.03)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C390(0.95)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C390(0.67)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C390(0.85)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C390(1.18)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C390(1.07)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C390(0.99)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C390(1.03)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C390(0.94)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C390(0.99)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C409(0.95); C390(1.03); C310(0.95)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C390(0.75)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C390(1.17)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C390(1.21)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C390(1.06)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C390(1.07)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C390(1.25)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C390(1.06)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C390(1.31)  LDD0929  [2]
 LDCM0334  AC7 HEK-293T C409(0.97); C390(0.95); C310(0.97)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C409(0.91); C390(1.00); C310(1.01)  LDD1569  [8]
 LDCM0349  AC83 HCT 116 C390(0.88)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C390(0.86)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C390(0.87)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C390(0.65)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C390(0.70)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C390(0.83)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C390(0.86)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C390(0.70)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C390(1.16)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C390(0.73)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C390(0.76)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C390(0.78)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C390(0.67)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C390(1.12)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C390(0.61)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C390(1.04)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C390(0.92)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C409(0.96); C390(0.98); C310(0.87)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C409(1.00); C390(1.12); C310(0.99)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C409(1.03); C390(0.98); C310(0.96)  LDD1514  [8]
 LDCM0367  CL1 HCT 116 C390(0.81)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C390(0.98)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C390(1.24)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C409(0.96); C390(0.99); C310(0.89)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C409(0.89); C390(0.99); C310(0.97)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C409(1.00); C390(1.04); C310(0.90)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C409(1.04); C390(1.02); C310(0.88)  LDD1577  [8]
 LDCM0374  CL105 HCT 116 C390(0.73)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C390(0.99)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C390(1.04)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C390(1.08)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C390(0.94)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C390(1.13)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C390(0.94)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C390(0.92)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C390(0.86)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C390(0.78)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C390(0.89)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C390(0.91)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C390(0.71)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C390(1.33)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C390(1.42)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C390(1.03)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C390(1.47)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C390(0.97)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C390(0.78)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C390(0.74)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C390(0.58)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C390(0.83)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C390(0.90)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C390(0.84)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C390(0.90)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C390(0.69)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C390(1.40)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C390(1.26)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C390(1.37)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C409(1.03); C390(1.18); C310(0.92)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C409(1.09); C390(1.15); C310(0.95)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C409(1.04); C390(0.96); C310(0.86)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C409(1.02); C390(1.02); C310(0.98)  LDD1610  [8]
 LDCM0407  CL2 HCT 116 C390(0.95)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C409(0.92); C390(0.91); C310(0.93)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C409(1.02); C390(1.07); C310(0.94)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C409(0.97); C390(1.05); C310(0.96)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C409(0.93); C390(1.11); C310(1.00)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C409(0.99); C390(1.08); C310(1.02)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C409(1.00); C390(1.03); C310(1.01)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C409(0.98); C390(0.94); C310(1.01)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C409(1.05); C390(1.03); C310(1.06)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C409(1.00); C390(1.02); C310(0.96)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C409(0.97); C390(1.01); C310(0.91)  LDD1621  [8]
 LDCM0418  CL3 HCT 116 C390(0.98)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C409(1.00); C390(0.90); C310(0.93)  LDD1623  [8]
 LDCM0420  CL31 HCT 116 C390(1.28)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C390(0.72)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C390(0.89)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C390(1.21)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C390(0.85)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C390(1.07)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C390(0.93)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C390(0.88)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C390(0.99)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C390(1.20)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C390(0.78)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C390(1.10)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C390(1.36)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C390(1.12)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C390(1.40)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C390(1.11)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C390(1.46)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C390(0.88)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C390(1.02)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C390(1.28)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C390(1.54)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C390(1.18)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C390(1.11)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C390(1.07)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C390(1.03)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C390(1.21)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C390(0.98)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C390(0.96)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C390(1.04)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C390(1.46)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C390(1.35)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C390(1.94)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C390(1.00)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C390(1.22)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C390(1.26)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C390(0.94)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C390(1.39)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C390(0.99)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C390(1.30)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C390(1.27)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C390(1.28)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C390(1.74)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C390(1.22)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C390(1.52)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C390(1.13)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C390(1.48)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C390(1.89)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C390(0.95)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C390(0.93)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C390(0.74)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C390(1.05)  LDD1070  [2]
 LDCM0473  CL8 HCT 116 C390(0.83)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C390(1.00)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C390(0.92)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C390(1.37)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C390(1.27)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C390(0.82)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C390(0.96)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C390(1.03)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C390(0.91)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C390(1.16)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C390(1.14)  LDD1081  [2]
 LDCM0484  CL9 HCT 116 C390(1.14)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C390(1.00)  LDD1083  [2]
 LDCM0486  CL91 HCT 116 C390(0.88)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C390(0.97)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C390(1.09)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C390(1.15)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C390(0.82)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C390(1.05)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C390(1.08)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C390(1.03)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C390(1.13)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C409(1.05); C390(1.04); C310(1.03)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C390(4.26)  LDD1702  [9]
 LDCM0625  F8 Ramos C409(0.93)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C409(0.54)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C409(0.75)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C409(1.21)  LDD2191  [10]
 LDCM0580  Fragment21 Ramos C409(0.78)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C409(1.00)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C409(0.77)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C409(1.44)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C409(0.93)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C409(1.37)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C409(0.92)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C390(1.71)  LDD1066  [2]
 LDCM0596  Fragment38 Ramos C409(0.82)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C409(1.07)  LDD2184  [10]
 LDCM0427  Fragment51 HCT 116 C390(1.03)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C409(0.82)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C409(0.84)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C409(1.18)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C409(0.65)  LDD2188  [10]
 LDCM0022  KB02 HEK-293T C409(0.96); C390(0.85); C310(0.96)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C409(1.01); C390(0.99); C310(1.00)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C390(2.13)  LDD3310  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase B (PPIB) Cyclophilin-type PPIase family P23284
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840