Details of the Target

General Information of Target

Target ID LDTP13943
Target Name Thioredoxin-related transmembrane protein 2 (TMX2)
Gene Name TMX2
Gene ID 51075
Synonyms
TXNDC14; Thioredoxin-related transmembrane protein 2; Cell proliferation-inducing gene 26 protein; Thioredoxin domain-containing protein 14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAA
HAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFE
RMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADP
SNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYH
NTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH
Target Bioclass
Transporter and channel
Subcellular location
Endoplasmic reticulum membrane
Function
Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
Uniprot ID
Q9Y320
Ensemble ID
ENST00000278422.9
HGNC ID
HGNC:30739

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
J82 SNV: p.A281S DBIA    Probe Info 
JURKAT Deletion: p.L131YfsTer20 .
MFE319 Insertion: p.L131PfsTer6 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.48  LDD0318  [1]
CHEMBL5175495
 Probe Info  		7.87  LDD0196  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
TH211
 Probe Info  		Y199(20.00); Y261(20.00)  LDD0260  [4]
C-Sul
 Probe Info  		2.90  LDD0066  [5]
FBP2
 Probe Info  		2.20  LDD0317  [1]
STPyne
 Probe Info  		K193(9.60); K207(7.69)  LDD0277  [6]
IPM
 Probe Info  		N.A.  LDD0241  [7]
Probe 1
 Probe Info  		Y261(9.95)  LDD3495  [8]
BTD
 Probe Info  		C46(1.96)  LDD1700  [9]
DBIA
 Probe Info  		C186(0.99)  LDD0078  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
WYneO
 Probe Info  		N.A.  LDD0022  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
AOyne
 Probe Info  		14.00  LDD0443  [14]
NAIA_5
 Probe Info  		C59(0.00); C46(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		8.82  LDD1740  [16]
C055
 Probe Info  		11.96  LDD1752  [16]
C056
 Probe Info  		25.28  LDD1753  [16]
C091
 Probe Info  		12.13  LDD1782  [16]
C092
 Probe Info  		22.94  LDD1783  [16]
C094
 Probe Info  		36.25  LDD1785  [16]
C112
 Probe Info  		21.11  LDD1799  [16]
C134
 Probe Info  		24.42  LDD1816  [16]
C153
 Probe Info  		16.22  LDD1834  [16]
C218
 Probe Info  		13.83  LDD1892  [16]
C220
 Probe Info  		14.22  LDD1894  [16]
C228
 Probe Info  		18.64  LDD1901  [16]
C231
 Probe Info  		16.00  LDD1904  [16]
C235
 Probe Info  		21.41  LDD1908  [16]
C246
 Probe Info  		14.12  LDD1919  [16]
C285
 Probe Info  		21.56  LDD1955  [16]
C289
 Probe Info  		41.36  LDD1959  [16]
C349
 Probe Info  		10.41  LDD2010  [16]
C350
 Probe Info  		29.24  LDD2011  [16]
C362
 Probe Info  		29.45  LDD2023  [16]
C373
 Probe Info  		7.73  LDD2033  [16]
C388
 Probe Info  		53.08  LDD2047  [16]
C407
 Probe Info  		10.93  LDD2064  [16]
OEA-DA
 Probe Info  		14.06  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C46(0.93)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C46(0.93)  LDD2112  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C46(1.13)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C46(0.98)  LDD2103  [9]
 LDCM0214  AC1 HCT 116 C186(1.04); C46(1.39); C59(0.95)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C186(1.25); C46(1.10); C59(0.95)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C186(0.99); C46(0.84); C59(0.82)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C186(0.86); C46(0.82); C59(0.73)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C186(0.93); C46(0.76); C59(0.57)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C186(0.88); C46(0.86); C59(0.58)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C186(1.01); C46(1.12); C59(0.71)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C186(0.91); C46(0.77); C59(0.59)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C186(0.86); C46(0.70); C59(0.61)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C186(0.79); C46(0.80); C59(0.81)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C186(0.97); C46(0.94); C59(0.96)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C186(0.97); C46(0.96); C59(0.74)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C186(1.16); C46(1.05); C59(0.84)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C186(0.93); C46(0.80); C59(0.65)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C186(0.85); C46(0.69); C59(0.60)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C186(0.78); C46(0.84); C59(0.74)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C186(0.97); C46(1.02); C59(1.10)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C186(0.82); C46(1.47); C59(1.07)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C186(1.04); C46(1.04); C59(1.09)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C186(0.87); C46(1.14); C59(1.16)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C186(0.88); C46(1.06); C59(1.19)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C186(0.98); C46(1.22); C59(1.23)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C186(1.02); C46(1.18); C59(1.30)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C186(1.27); C46(1.21); C59(0.96)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C186(0.88); C46(1.41); C59(1.06)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C186(0.99); C46(1.05); C59(1.28)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C186(0.94); C46(1.43); C59(1.14)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C186(1.06); C46(1.00); C59(1.14)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C186(0.99); C46(1.19); C59(1.32)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C186(1.13); C46(1.23); C59(1.35)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C186(1.14); C46(1.26); C59(1.14)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C186(1.07); C46(1.18); C59(1.19)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C186(1.01); C59(1.07)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C186(0.75); C59(1.38)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C186(0.74); C59(1.27)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C186(0.81); C59(1.10)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C186(1.01); C59(1.33)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C186(0.79); C59(1.37)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C186(0.83); C59(1.24)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C186(0.68); C59(1.35)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C186(0.75); C59(1.09)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C186(1.00); C59(1.12)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C186(0.88); C59(1.15)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C186(0.74); C59(1.48)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C186(0.98); C46(1.02); C59(0.85)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C186(1.08); C59(1.24)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C186(0.76); C59(1.20)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C186(0.86); C59(1.62)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C46(0.77); C186(0.85); C59(0.91)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C46(0.71); C59(0.85); C186(1.03)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C46(0.79); C59(0.80); C186(1.03)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C59(0.69); C46(0.89); C186(0.91)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C46(0.67); C59(0.77); C186(0.85)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C59(0.70); C186(0.85); C46(0.88)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C59(0.84); C46(0.92); C186(1.09)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C59(0.84); C46(0.98); C186(1.12)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C59(0.84); C46(0.88); C186(1.11)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C46(0.76); C59(0.83); C186(1.15)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C59(0.68); C46(0.88); C186(0.99)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C59(0.66); C186(0.84); C46(1.12)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C186(0.85); C46(0.87); C59(0.66)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C186(1.06); C46(0.88); C59(0.60)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C186(0.98); C46(0.99); C59(0.99)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C186(1.10); C46(0.91); C59(0.90)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C186(0.86); C46(1.01); C59(1.05)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C59(0.56); C186(0.77); C46(1.26)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C59(0.76); C186(1.03); C46(1.19)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C186(0.87); C59(1.03); C46(1.11)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C59(0.50); C186(0.94); C46(1.05)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C59(0.57); C186(0.89); C46(1.20)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C59(0.76); C46(0.97); C186(1.01)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C59(0.68); C186(0.99); C46(1.23)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C59(0.55); C46(0.95); C186(1.44)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C46(0.89); C186(0.96); C59(1.14)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C46(0.77); C186(1.00); C59(1.16)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C46(0.90); C186(0.91); C59(1.01)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C186(0.92); C46(0.95); C59(1.71)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C59(0.80); C186(0.83); C46(0.93)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C59(0.93); C186(1.07); C46(1.43)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C59(0.96); C46(0.97); C186(1.04)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C46(0.84); C186(1.04); C59(1.06)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C46(0.84); C186(0.86); C59(1.28)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C59(0.87); C46(0.88); C186(0.91)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C59(0.67); C46(0.81); C186(0.94)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C46(0.95); C186(1.19); C59(1.20)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C46(0.80); C186(0.96); C59(1.02)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C46(0.68); C186(0.96); C59(1.49)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C186(0.84); C46(0.87); C59(1.03)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C59(0.92); C186(1.00); C46(1.02)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C59(0.92); C186(1.20); C46(1.81)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C46(0.83); C186(0.90); C59(1.33)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C46(0.71); C186(0.80); C59(1.47)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C46(0.77); C186(0.84); C59(1.47)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C46(0.71); C186(0.75); C59(3.00)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C46(0.56); C186(0.86); C59(1.46)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C46(0.63); C186(0.86); C59(1.48)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C186(1.07)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C186(1.38)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C186(1.80)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C186(1.09)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C186(1.03); C59(1.10); C46(2.03)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C186(0.89)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C186(1.10)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C186(0.83)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C186(1.10)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C186(1.01)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C186(1.00)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C186(1.14)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C59(0.65); C46(0.82); C186(0.85)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C46(0.71); C59(0.87); C186(1.13)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C59(0.72); C186(0.74); C46(0.92)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C46(0.96); C186(1.00); C59(1.03)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C186(0.70); C46(0.79); C59(0.90)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C59(0.60); C46(0.75); C186(1.14)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C186(0.79); C46(0.81); C59(0.86)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C186(0.77); C46(0.86); C59(0.89)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C59(0.71); C186(0.72); C46(1.08)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C59(1.04); C186(1.04); C46(1.25)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C186(0.91); C59(0.95); C46(1.12)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C59(0.79); C186(0.79); C46(0.80)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C186(0.87); C59(0.99)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C186(0.93); C59(1.02)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C59(0.96); C46(1.03); C186(1.10)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C186(1.66); C59(1.84)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C186(1.01); C59(1.22)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C186(0.81); C59(1.43)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C186(1.14); C59(1.17)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C186(0.93); C59(1.12)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C186(0.83); C59(1.12)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C186(1.17); C59(1.48)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C186(0.89); C59(0.96)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C59(0.95); C186(0.95)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C186(1.24); C59(1.38)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C59(0.91); C46(0.91); C186(0.99)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C59(1.31); C186(1.37)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C186(0.97); C59(1.37)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C59(1.16); C186(1.17)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C186(0.97); C59(1.09)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C59(0.89); C186(0.93)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C186(0.92); C59(1.03)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C186(0.89); C59(1.36)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C59(0.96); C186(1.04)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C186(0.86); C59(1.07)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C186(0.78); C59(1.17)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C186(0.93); C59(1.35)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C186(0.80); C59(0.99)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C186(0.80); C59(1.12)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C186(0.77); C59(1.01)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C59(0.95); C186(1.93)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C186(0.81); C59(0.91)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C59(1.05); C186(1.13)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C186(0.73); C59(0.96)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C59(0.64); C46(0.74); C186(0.81)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C59(0.67); C46(0.83); C186(0.87)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C46(0.86)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C186(1.22); C46(1.03); C59(1.23)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C59(0.98); C46(1.05); C186(1.07)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C59(0.92); C46(0.95); C186(1.11)  LDD0592  [10]
 LDCM0020  ARS-1620 HCC44 C186(0.99)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C46(0.79)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C186(0.92); C46(0.97)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C46(0.86); C186(0.97)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C59(0.99); C186(1.07); C46(1.39)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C46(0.91); C59(0.99); C186(1.03)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C46(1.05); C186(1.13); C59(1.14)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C59(0.94); C186(1.18); C46(1.23)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C59(1.02); C46(1.20); C186(1.21)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C59(0.79); C186(0.92); C46(1.24)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C59(0.83); C186(0.93); C46(1.37)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C59(0.77); C186(0.86); C46(1.21)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C186(0.97); C59(1.10); C46(1.11)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C59(0.84); C186(0.89); C46(1.11)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C46(0.88); C186(1.12)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C59(0.74); C186(1.02); C46(1.22)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C59(0.65); C186(0.87); C46(1.13)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C59(0.90); C46(0.99); C186(1.02)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C46(0.77); C59(0.78); C186(0.90)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C186(0.84); C59(0.98); C46(1.09)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C59(0.84); C46(0.93); C186(1.07)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C59(0.78); C46(0.88); C186(0.98)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C186(0.93); C46(1.11); C59(1.25)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C46(0.78); C186(0.86); C59(1.76)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C46(0.67); C186(0.86); C59(2.24)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C186(0.93); C46(0.93)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C46(0.58); C186(0.84); C59(1.85)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C186(1.17)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C186(0.74)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C186(0.99)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C186(1.64)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C186(0.93); C46(1.15); C59(1.45)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C46(0.86); C186(0.92); C59(1.04)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C59(0.74); C186(0.78); C46(0.94)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C186(0.95); C59(0.98); C46(1.16)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C186(0.95); C46(1.02)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C46(0.92); C186(0.99)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C186(1.12); C46(1.19)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C186(0.85); C59(0.86); C46(0.88)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C59(0.91); C46(0.97); C186(1.12)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C59(0.74); C46(0.80); C186(0.95)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C59(0.68); C46(0.81); C186(1.03)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C186(0.89); C46(1.05)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C186(0.80); C46(0.85); C59(0.92)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C59(0.70); C186(0.94); C46(1.02)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C59(0.82); C46(0.88); C186(0.91)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C59(0.72); C46(0.87); C186(0.90)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C186(0.86); C46(0.90); C59(0.67)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C186(1.00); C46(0.93); C59(0.85)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C186(0.86); C46(0.89); C59(0.89)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C186(0.97); C46(0.92); C59(1.30)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C186(0.81); C46(0.85); C59(0.73)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C186(0.85); C46(0.87); C59(0.66)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C186(0.94); C46(0.99)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C186(1.09); C46(0.87); C59(0.77)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C186(1.12); C59(0.45)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C186(0.88); C59(0.61)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C186(0.84); C59(0.79)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C186(1.00); C59(0.73)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C186(0.91); C59(0.59)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C186(0.96); C59(0.67)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C186(1.01); C59(0.74)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C186(0.93); C59(0.56)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C186(0.96); C46(1.05)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C186(0.98); C59(0.57)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C186(0.95); C59(0.60)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C186(0.99); C59(0.75)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C186(0.94); C59(0.61)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C186(1.02); C59(0.63)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C186(1.01); C59(0.48)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C186(0.94); C46(1.00); C59(1.71)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C186(0.99); C46(1.05); C59(1.23)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C186(0.89); C46(0.91); C59(1.13)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C186(0.82); C46(0.98); C59(1.23)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C186(1.04); C46(1.15)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C186(0.80); C46(0.91); C59(1.36)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C186(0.91); C46(1.21); C59(1.28)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C186(0.87); C46(0.95); C59(1.23)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C186(0.69); C46(1.16); C59(1.20)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C186(0.69); C46(0.96); C59(1.15)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C186(0.85); C46(0.84); C59(1.27)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C186(0.73); C46(0.83); C59(0.92)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C186(0.77); C46(0.94); C59(1.12)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C186(0.82); C46(0.84); C59(1.21)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C186(0.86); C46(0.93); C59(1.15)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C186(0.90); C46(1.09)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C186(0.77); C46(1.02); C59(1.25)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C59(1.04)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C59(1.01)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C59(0.98)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C59(0.83)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C59(0.95)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C59(0.69)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C59(0.76)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C59(0.78)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C59(0.79)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C186(1.06); C46(1.24)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C59(0.84)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C59(0.79)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C59(1.15)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C59(0.88)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C59(0.83)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C46(0.93); C59(0.73)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C46(0.96); C59(0.65)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C46(1.06); C59(0.73)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C46(0.97); C59(0.68)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C186(0.94); C46(0.99)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C46(0.83); C59(0.57)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C46(1.02); C59(0.71)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C46(0.98); C59(0.62)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C46(1.02); C59(0.76)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C46(0.96); C59(0.66)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C46(0.85); C59(0.81)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C46(1.09); C59(0.77)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C46(1.19); C59(0.71)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C46(0.93); C59(0.66)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C46(0.95); C59(0.56)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C186(0.86); C46(0.97)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C46(1.11); C59(0.81)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C186(1.10); C46(1.13); C59(0.93)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C186(1.02); C46(0.84); C59(0.68)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C186(1.45); C46(0.86); C59(0.87)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C186(1.12); C46(0.88); C59(0.96)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C186(1.19); C46(1.05); C59(0.86)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C186(1.07); C46(1.17); C59(0.81)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C186(0.91); C46(1.26); C59(0.85)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C186(0.96); C46(1.39); C59(0.97)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C186(0.98); C46(1.57); C59(0.77)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C186(1.05); C46(1.01)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C46(15.72); C186(1.86)  LDD1702  [9]
 LDCM0468  Fragment33 HCT 116 C59(0.79)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C186(1.19); C59(0.54)  LDD0744  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C186(0.99)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C186(0.95)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C186(2.60)  LDD3310  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C46(1.08)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C46(0.61)  LDD2121  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C46(1.38)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C46(0.98)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C46(1.02)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C46(1.14)  LDD2094  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C46(0.98)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C46(1.14); C186(0.80)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C46(1.09)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C46(0.82)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C46(1.08)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C46(0.63)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C46(0.99)  LDD2105  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C46(0.80)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C46(0.93)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C46(1.36); C186(1.13)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C46(1.00)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C46(1.03)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C46(0.58)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C46(0.55); C186(0.64)  LDD2115  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C46(1.31); C186(1.41)  LDD2119  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C46(1.03)  LDD2123  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C46(0.85); C186(1.13)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C46(1.00); C186(1.14)  LDD2127  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C46(1.00)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C46(0.70); C186(0.64)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C46(0.64)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C46(1.07); C186(1.26)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C46(0.98)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C46(1.00)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C46(1.96)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C46(0.94)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C46(1.33)  LDD2141  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C46(2.08); C186(2.86)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C46(0.97); C186(1.12)  LDD2146  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C46(1.20); C186(0.58)  LDD2148  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C46(2.41)  LDD2153  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ5
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NUQ2
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ7
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) 3-beta-HSD family Q9H2F3
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 3-beta-HSD family Q15738
Inactive pancreatic lipase-related protein 1 (PNLIPRP1) Lipase family P54315
N-acetyltransferase 8 (NAT8) Camello family Q9UHE5
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) Complex I NDUFA3 subunit family O95167
Cytochrome P450 4F2 (CYP4F2) Cytochrome P450 family P78329
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Lecithin retinol acyltransferase (LRAT) H-rev107 family O95237
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL) Membrane-bound acyltransferase family Q9HCP6
Inactive ubiquitin thioesterase OTULINL (OTULINL) Peptidase C65 family Q9NUU6
Squalene synthase (FDFT1) Phytoene/squalene synthase family P37268
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) Protein-tyrosine phosphatase family P43378
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2) Sterol desaturase family Q96IV6
Fatty acid 2-hydroxylase (FA2H) Sterol desaturase family Q7L5A8
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Ubiquitin-conjugating enzyme family Q9Y385
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) Very long-chain fatty acids dehydratase HACD family Q6Y1H2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) . Q12982
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) . Q9NTJ5
Transporter and channel
Click To Hide/Show 42 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein ARV1 (ARV1) ARV1 family Q9H2C2
Bax inhibitor 1 (TMBIM6) BI1 family P55061
Gap junction beta-2 protein (GJB2) Connexin family P29033
Cytochrome c oxidase assembly protein COX20, mitochondrial (COX20) COX20 family Q5RI15
Derlin-1 (DERL1) Derlin family Q9BUN8
Statherin (STATH) Histatin/statherin family P02808
Insulin-induced gene 2 protein (INSIG2) INSIG family Q9Y5U4
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Solute carrier family 22 member 18 (SLC22A18) Organic cation transporter (TC 2.A.1.19) family Q96BI1
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
B-lymphocyte antigen CD20 (MS4A1) MS4A family P11836
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
CMP-sialic acid transporter (SLC35A1) Nucleotide-sugar transporter family P78382
Peroxisomal membrane protein PEX16 (PEX16) Peroxin-16 family Q9Y5Y5
PRA1 family protein 2 (PRAF2) PRA1 family O60831
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Protein RFT1 homolog (RFT1) RFT1 family Q96AA3
Secretory carrier-associated membrane protein 5 (SCAMP5) SCAMP family Q8TAC9
Sideroflexin-1 (SFXN1) Sideroflexin family Q9H9B4
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Syntaxin-3 (STX3) Syntaxin family Q13277
CD81 antigen (CD81) Tetraspanin (TM4SF) family P60033
Ion channel TACAN (TMEM120A) TMEM120 family Q9BXJ8
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 14C (TMEM14C) TMEM14 family Q9P0S9
Transmembrane protein 176A (TMEM176A) TMEM176 family Q96HP8
Transmembrane protein 208 (TMEM208) TMEM208 family Q9BTX3
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Translocating chain-associated membrane protein 1-like 1 (TRAM1L1) TRAM family Q8N609
Transmembrane protein 50B (TMEM50B) UPF0220 family P56557
Vesicle-associated membrane protein-associated protein A (VAPA) VAMP-associated protein (VAP) (TC 9.B.17) family Q9P0L0
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Protein YIPF1 (YIPF1) YIP1 family Q9Y548
Protein YIPF2 (YIPF2) YIP1 family Q9BWQ6
Phospholipid transfer protein C2CD2L (C2CD2L) . O14523
Proteolipid protein 2 (PLP2) . Q04941
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 203 (TMEM203) . Q969S6
Transmembrane protein 65 (TMEM65) . Q6PI78
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) Chemokine-like factor family Q96FZ5
C-C motif chemokine 2 (CCL2) Intercrine beta (chemokine CC) family P13500
Other
Click To Hide/Show 55 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BET1 homolog (BET1) BET1 family O15155
Glycodelin (PAEP) Lipocalin family P09466
Cortexin-3 (CTXN3) Cortexin family Q4LDR2
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Receptor expression-enhancing protein 2 (REEP2) DP1 family Q9BRK0
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Protein FAM3C (FAM3C) FAM3 family Q92520
FUN14 domain-containing protein 2 (FUNDC2) FUN14 family Q9BWH2
Radiation-inducible immediate-early gene IEX-1 (IER3) IER3 family P46695
Integrin alpha-M (ITGAM) Integrin alpha chain family P11215
MAL-like protein (MALL) MAL family Q13021
Promotilin (MLN) Motilin family P12872
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
Neuronal vesicle trafficking-associated protein 1 (NSG1) NSG family P42857
Nurim (NRM) Nurim family Q8IXM6
Leptin receptor gene-related protein (LEPROT) OB-RGRP/VPS55 family O15243
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
ORM1-like protein 2 (ORMDL2) ORM family Q53FV1
Epithelial membrane protein 3 (EMP3) PMP-22/EMP/MP20 family P54852
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Vesicle transport protein SEC20 (BNIP1) SEC20 family Q12981
Selenoprotein K (SELENOK) Selenoprotein K family Q9Y6D0
Small EDRK-rich factor 1 (SERF1A; SERF1B) SERF family O75920
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Sideroflexin-3 (SFXN3) Sideroflexin family Q9BWM7
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Syntaxin-7 (STX7) Syntaxin family O15400
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Transmembrane protein 115 (TMEM115) TMEM115 family Q12893
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Transmembrane protein 121 (TMEM121) TMEM121 family Q9BTD3
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Tumor protein p63-regulated gene 1 protein (TPRG1) TPRG1 family Q6ZUI0
Golgi apparatus membrane protein TVP23 homolog B (TVP23B) TVP23 family Q9NYZ1
Protein YIF1A (YIF1A) YIF1 family O95070
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Immediate early response 3-interacting protein 1 (IER3IP1) YOS1 family Q9Y5U9
Asialoglycoprotein receptor 1 (ASGR1) . P07306
Coiled-coil domain-containing protein 167 (CCDC167) . Q9P0B6
Emerin (EMD) . P50402
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Thrombomodulin (THBD) . P07204
Thrombospondin type-1 domain-containing protein 7B (THSD7B) . Q9C0I4
TPA-induced transmembrane protein (TTMP) . Q5BVD1
Transmembrane protein 140 (TMEM140) . Q9NV12
Transmembrane protein 222 (TMEM222) . Q9H0R3
Transmembrane protein 254 (TMEM254) . Q8TBM7
Transmembrane protein 51 (TMEM51) . Q9NW97
Uncharacterized protein CXorf66 (CXorf66) . Q5JRM2
WAP four-disulfide core domain protein 2 (WFDC2) . Q14508

References

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Mass spectrometry data entry: PXD018580
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840