Details of the Target

General Information of Target

Target ID LDTP12704
Target Name Anoctamin-10 (ANO10)
Gene Name ANO10
Gene ID 55129
Synonyms
TMEM16K; Anoctamin-10; Transmembrane protein 16K
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGLTLFVGRLPPSARSEQLEELFSQVGPVKQCFVVTEKGSKACRGFGYVTFSMLEDVQR
ALKEITTFEGCKINVTVAKKKLRNKTKEKGKNENSECPKKEPKAKKAKVADKKARLIIRN
LSFKCSEDDLKTVFAQFGAVLEVNIPRKPDGKMRGFGFVQFKNLLEAGKALKGMNMKEIK
GRTVAVDWAVAKDKYKDTQSVSAIGEEKSHESKHQESVKKKGREEEDMEEEENDDDDDDD
DEEDGVFDDEDEEEENIESKVTKPVQIQKRAVKRPAPAKSSDHSEEDSDLEESDSIDDGE
ELAQSDTSTEEQEDKAVQVSNKKKRKLPSDVNEGKTVFIRNLSFDSEEEELGELLQQFGE
LKYVRIVLHPDTEHSKGCAFAQFMTQEAAQKCLLAASPENEAGGLKLDGRQLKVDLAVTR
DEAAKLQTTKVKKPTGTRNLYLAREGLIRAGTKAAEGVSAADMAKRERFELLKHQKLKDQ
NIFVSRTRLCLHNLPKAVDDKQLRKLLLSATSGEKGVRIKECRVMRDLKGVHGNMKGQSL
GYAFAEFQEHEHALKALRLINNNPEIFGPLKRPIVEFSLEDRRKLKMKELRIQRSLQKMR
SKPATGEPQKGQPEPAKDQQQKAAQHHTEEQSKVPPEQKRKAGSTSWTGFQTKAEVEQVE
LPDGKKRRKVLALPSHRGPKIRLRDKGKVKPVHPKKPKPQINQWKQEKQQLSSEQVSRKK
AKGNKTETRFNQLVEQYKQKLLGPSKGAPLAKRSKWFDS
Target Bioclass
Transporter and channel
Family
Anoctamin family
Subcellular location
Cell membrane
Function Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
Uniprot ID
Q9NW15
Ensemble ID
ENST00000292246.8
HGNC ID
HGNC:25519

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.K466T .
Ishikawa (Heraklio) 02 ER SNV: p.Y515H DBIA    Probe Info 
JURKAT SNV: p.T274I .
KNS42 SNV: p.A558D .
KP4 SNV: p.L179V DBIA    Probe Info 
MFE319 SNV: p.I401T .
NCIH23 SNV: p.T644N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.60  LDD0318  [1]
STPyne
 Probe Info  		K155(10.00); K278(1.25); K623(6.10)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
BTD
 Probe Info  		C92(1.19)  LDD2099  [4]
Acrolein
 Probe Info  		N.A.  LDD0221  [5]
DBIA
 Probe Info  		C265(1.16)  LDD0531  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
YN-1
 Probe Info  		N.A.  LDD0447  [8]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		21.86  LDD1740  [9]
C063
 Probe Info  		14.22  LDD1760  [9]
C106
 Probe Info  		19.43  LDD1793  [9]
C112
 Probe Info  		26.35  LDD1799  [9]
C159
 Probe Info  		8.69  LDD1839  [9]
C161
 Probe Info  		14.93  LDD1841  [9]
C169
 Probe Info  		31.56  LDD1849  [9]
C201
 Probe Info  		29.86  LDD1877  [9]
C210
 Probe Info  		39.40  LDD1884  [9]
C218
 Probe Info  		11.31  LDD1892  [9]
C219
 Probe Info  		5.28  LDD1893  [9]
C220
 Probe Info  		18.38  LDD1894  [9]
C225
 Probe Info  		5.74  LDD1898  [9]
C228
 Probe Info  		26.17  LDD1901  [9]
C264
 Probe Info  		16.45  LDD1935  [9]
C285
 Probe Info  		25.28  LDD1955  [9]
C289
 Probe Info  		30.27  LDD1959  [9]
C348
 Probe Info  		10.93  LDD2009  [9]
C349
 Probe Info  		16.80  LDD2010  [9]
C350
 Probe Info  		42.81  LDD2011  [9]
C390
 Probe Info  		28.05  LDD2049  [9]
C403
 Probe Info  		17.51  LDD2061  [9]
FFF probe11
 Probe Info  		20.00  LDD0471  [10]
FFF probe13
 Probe Info  		14.53  LDD0476  [10]
FFF probe3
 Probe Info  		20.00  LDD0465  [10]
OEA-DA
 Probe Info  		20.00  LDD0046  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C265(1.27); C92(0.74)  LDD2112  [4]
 LDCM0214  AC1 HCT 116 C265(1.16)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C265(1.01)  LDD0813  [6]
 LDCM0216  AC100 HEK-293T C265(1.22)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C265(1.13)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C265(1.30)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C265(1.20)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C265(1.38)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C265(1.03)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C265(1.24)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C265(1.29)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C265(1.14)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C265(1.17)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C265(0.92)  LDD0824  [6]
 LDCM0227  AC110 HEK-293T C265(1.04)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C265(0.80)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C265(0.93)  LDD0827  [6]
 LDCM0230  AC113 HEK-293T C265(1.02)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C265(1.17)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C265(1.33)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C265(1.00)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C265(0.94)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C265(2.12)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C265(1.57)  LDD0834  [6]
 LDCM0237  AC12 HEK-293T C265(1.32)  LDD0835  [6]
 LDCM0238  AC120 HEK-293T C265(1.32)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C265(0.84)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C265(1.08)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C265(1.10)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C265(1.14)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C265(1.47)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C265(0.96)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C265(1.03)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C265(0.79)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C265(0.94)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C265(0.83)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C265(0.77)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C265(0.81)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C265(0.80)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C265(0.91)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C265(0.77)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C265(0.94)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C265(0.83)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C265(0.92)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C265(0.81)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C265(1.35)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C265(0.80)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C265(0.87)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C265(0.85)  LDD0860  [6]
 LDCM0263  AC143 HCT 116 C265(1.16)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C265(1.19)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C265(0.86)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C265(0.81)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C265(0.85)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C265(0.89)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C265(1.06)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C265(1.05)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C265(1.43)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C265(1.00)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C265(1.27)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C265(0.84)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C265(0.91)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C265(1.30)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C265(1.46)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C265(0.85)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C265(0.96)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C265(0.91)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C265(0.77)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C265(0.98)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C265(1.03)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C265(0.83)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C265(0.78)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C265(0.76)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C265(1.06)  LDD0601  [6]
 LDCM0285  AC25 HEK-293T C265(0.89)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C265(0.91)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C265(0.99)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C265(2.18)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C265(1.01)  LDD0887  [6]
 LDCM0290  AC3 HCT 116 C265(1.19)  LDD0607  [6]
 LDCM0291  AC30 HEK-293T C265(0.99)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C265(1.00)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C265(0.96)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C265(1.04)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C265(1.05)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C265(0.74)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C265(0.82)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C265(0.97)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C265(0.86)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C265(0.85)  LDD0898  [6]
 LDCM0301  AC4 HCT 116 C265(1.08)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C265(0.97)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C265(1.09)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C265(0.98)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C265(0.96)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C265(0.90)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C265(0.76)  LDD0905  [6]
 LDCM0308  AC46 HCT 116 C265(0.76)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C265(0.66)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C265(0.77)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C265(0.75)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C265(1.10)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C265(0.73)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C265(0.99)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C265(0.86)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C265(0.83)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C265(0.96)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C265(0.82)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C265(0.70)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C265(1.19)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C265(0.97)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C265(0.91)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C265(1.26)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C265(1.05)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C265(1.03)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C265(0.79)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C265(0.97)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C265(0.99)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C265(1.06)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C265(1.06)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C265(0.95)  LDD0929  [6]
 LDCM0332  AC68 HCT 116 C265(1.11)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C265(0.95)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C265(0.93)  LDD0932  [6]
 LDCM0335  AC70 HCT 116 C265(1.05)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C265(1.08)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C265(0.98)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C265(1.28)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C265(1.03)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C265(1.17)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C265(1.13)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C265(1.19)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C265(0.93)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C265(1.05)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C265(1.26)  LDD0943  [6]
 LDCM0346  AC80 HCT 116 C265(1.18)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C265(1.09)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C265(1.00)  LDD0665  [6]
 LDCM0349  AC83 HEK-293T C265(1.04)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C265(1.16)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C265(1.13)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C265(1.19)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C265(1.13)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C265(1.25)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C265(1.30)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C265(1.13)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C265(1.10)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C265(1.04)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C265(1.37)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C265(1.11)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C265(1.16)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C265(1.03)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C265(0.96)  LDD0962  [6]
 LDCM0365  AC98 HEK-293T C265(1.37)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C265(1.43)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C265(1.22)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C265(1.09)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C265(1.19)  LDD0873  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HCT 116 C265(1.23)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C265(0.78)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C265(1.12)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C265(1.06)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C265(0.98)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C265(1.07)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C265(1.43)  LDD0971  [6]
 LDCM0374  CL105 HCT 116 C265(0.91)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C265(0.77)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C265(0.75)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C265(0.75)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C265(0.77)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C265(0.86)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C265(0.84)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C265(0.69)  LDD0698  [6]
 LDCM0382  CL112 HEK-293T C265(0.94)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C265(1.04)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C265(0.95)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C265(1.18)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C265(1.01)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C265(0.88)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C265(0.94)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C265(1.11)  LDD0987  [6]
 LDCM0390  CL12 HCT 116 C265(0.96)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C265(0.87)  LDD0989  [6]
 LDCM0392  CL121 HCT 116 C265(0.77)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C265(0.76)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C265(0.80)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C265(0.76)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C265(0.78)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C265(0.85)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C265(1.17)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C265(0.93)  LDD0997  [6]
 LDCM0400  CL13 HCT 116 C265(0.95)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C265(1.01)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C265(1.12)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C265(0.95)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C265(1.18)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C265(0.94)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C265(0.95)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C265(1.03)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C265(0.83)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C265(1.20)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C265(1.24)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C265(1.12)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C265(1.27)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C265(0.80)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C265(0.97)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C265(1.09)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C265(1.06)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C265(0.90)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C265(1.06)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C265(0.84)  LDD0736  [6]
 LDCM0420  CL31 PaTu 8988t C265(0.74)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C265(0.35)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C265(0.44)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C265(0.33)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C265(0.55)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C265(0.14)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C265(0.48)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C265(0.31)  LDD1307  [6]
 LDCM0429  CL4 HCT 116 C265(1.30)  LDD0746  [6]
 LDCM0430  CL40 PaTu 8988t C265(0.39)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C265(0.32)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C265(0.45)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C265(0.40)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C265(0.27)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C265(0.37)  LDD1314  [6]
 LDCM0436  CL46 HEK-293T C265(1.35)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C265(1.02)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C265(0.95)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C265(1.00)  LDD1037  [6]
 LDCM0440  CL5 HCT 116 C265(0.89)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C265(0.68)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C265(0.68)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C265(0.73)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C265(0.76)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C265(0.71)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C265(1.03)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C265(0.83)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C265(0.77)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C265(0.91)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C265(1.06)  LDD1048  [6]
 LDCM0451  CL6 HCT 116 C265(1.07)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C265(1.00)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C265(0.83)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C265(0.82)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C265(1.21)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C265(0.90)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C265(1.19)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C265(0.87)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C265(1.11)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C265(1.05)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C265(1.19)  LDD1059  [6]
 LDCM0462  CL7 HCT 116 C265(0.96)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C265(1.07)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C265(1.03)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C265(1.17)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C265(0.98)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C265(0.95)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C265(1.21)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C265(0.91)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C265(0.88)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C265(1.06)  LDD1070  [6]
 LDCM0473  CL8 HCT 116 C265(0.86)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C265(0.91)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C265(0.96)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C265(1.57)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C265(1.65)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C265(0.98)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C265(0.87)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C265(0.78)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C265(1.24)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C265(1.17)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C265(1.13)  LDD1081  [6]
 LDCM0484  CL9 HCT 116 C265(1.62)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C265(0.66)  LDD1083  [6]
 LDCM0486  CL91 HCT 116 C265(1.42)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C265(1.05)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C265(0.95)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C265(1.02)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C265(1.37)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C265(0.95)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C265(1.28)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C265(1.04)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C265(1.10)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C265(1.00); C92(1.03); C124(1.06)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C265(0.98)  LDD1066  [6]
 LDCM0427  Fragment51 PaTu 8988t C265(0.36)  LDD1306  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C92(0.98); C265(0.85)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C92(0.92); C265(1.01)  LDD1497  [12]
 LDCM0024  KB05 SKMEL24 C92(1.01)  LDD3323  [13]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C92(1.19)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C265(0.59)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C92(0.76)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C265(0.37)  LDD2109  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C265(0.67); C92(1.07)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C265(0.53)  LDD2127  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C265(0.18)  LDD2134  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C92(1.61)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C265(0.53)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C92(0.97)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C265(0.47); C92(0.61)  LDD2141  [4]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840