Details of the Target

General Information of Target

Target ID LDTP11867
Target Name UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1)
Gene Name DPAGT1
Gene ID 1798
Synonyms
DPAGT2; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; EC 2.7.8.15; GlcNAc-1-P transferase; G1PT; GPT; N-acetylglucosamine-1-phosphate transferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAAAAVAGVGRGGGGAEPRQERSRARGWAGVERSEGRRMEPGEELEEEGSPGGREDG
FTAEHLAAEAMAADMDPWLVFDARTTPATELDAWLAKYPPSQVTRYGDPGSPNSEPVGWI
AVYGQGYSPNSGDVQGLQAAWEALQTSGRPITPGTLRQLAITHHVLSGKWLMHLAPGFKL
DHAWAGIARAVVEGQLQVAKVSPRAKEGGRQVICVYTDDFTDRLGVLEADSAIRAAGIKC
LLTYKPDVYTYLGIYRANRWHLCPTLYESRFQLGGSARGSRVLDRANNVELT
Target Bioclass
Enzyme
Family
Glycosyltransferase 4 family
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
Uniprot ID
Q9H3H5
Ensemble ID
ENST00000354202.9
HGNC ID
HGNC:2995
ChEMBL ID
CHEMBL4739704

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BXPC3 SNV: p.Q58K .
Ishikawa (Heraklio) 02 ER SNV: p.L118P DBIA    Probe Info 
LOXIMVI SNV: p.P298S DBIA    Probe Info 
MCAS SNV: p.E214K .
MOLT4 SNV: p.G145D IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K48(6.25)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
BTD
 Probe Info  		C42(2.06)  LDD1700  [3]
DBIA
 Probe Info  		C42(1.12)  LDD0563  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
ENE
 Probe Info  		N.A.  LDD0006  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		11.16  LDD1782  [10]
C092
 Probe Info  		33.59  LDD1783  [10]
C094
 Probe Info  		28.25  LDD1785  [10]
C112
 Probe Info  		34.30  LDD1799  [10]
C134
 Probe Info  		28.84  LDD1816  [10]
C153
 Probe Info  		32.90  LDD1834  [10]
C218
 Probe Info  		19.70  LDD1892  [10]
C219
 Probe Info  		5.03  LDD1893  [10]
C220
 Probe Info  		24.93  LDD1894  [10]
C225
 Probe Info  		9.00  LDD1898  [10]
C226
 Probe Info  		7.89  LDD1899  [10]
C228
 Probe Info  		33.59  LDD1901  [10]
C287
 Probe Info  		9.58  LDD1957  [10]
C289
 Probe Info  		26.54  LDD1959  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C42(0.91)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C42(0.94)  LDD2112  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C42(0.87)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C42(0.94)  LDD2117  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C42(0.54)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C42(0.86)  LDD2131  [3]
 LDCM0214  AC1 HEK-293T C42(1.05)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C42(1.07); C358(1.03)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C42(1.17)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C42(1.20)  LDD1510  [11]
 LDCM0246  AC128 HCT 116 C42(1.12)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C42(1.09)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C42(0.76)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C42(0.70)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C42(0.79)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C42(0.98)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C42(0.90)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C42(0.60)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C42(0.65)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C42(0.60)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C42(0.58)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C42(0.75)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C42(1.08); C358(1.01)  LDD1512  [11]
 LDCM0260  AC140 HCT 116 C42(0.58)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C42(0.62)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C42(0.64)  LDD0579  [4]
 LDCM0270  AC15 HEK-293T C42(1.05)  LDD1513  [11]
 LDCM0276  AC17 HCT 116 C42(0.87)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C42(0.86)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C42(0.94)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C42(1.08); C358(1.00)  LDD1518  [11]
 LDCM0280  AC20 HCT 116 C42(0.96)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C42(0.90)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C42(0.97)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C42(0.87)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C42(0.96)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C42(0.98)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C42(1.09); C358(0.91)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C42(1.05)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C42(1.07)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C42(1.00)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C42(1.07)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C42(0.90); C358(1.04)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C42(1.05)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C42(1.00)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C42(1.01)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C42(1.18); C358(1.03)  LDD1534  [11]
 LDCM0296  AC35 HCT 116 C42(0.93)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C42(0.93)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C42(1.14)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C42(1.15)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C42(0.97)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C42(1.20)  LDD1540  [11]
 LDCM0302  AC40 HCT 116 C42(1.05)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C42(1.00)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C42(1.02)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C42(1.01)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C42(1.11)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C42(1.15)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C42(1.12); C358(1.07)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C42(1.16)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C42(0.94)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C42(0.95)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C42(1.09)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C42(1.13); C358(1.02)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C42(1.14)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C42(1.14)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C42(1.01)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C42(1.11); C358(1.08)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C42(1.03)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C42(0.97)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C42(1.08)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C42(1.13); C358(1.02)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C42(1.00)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C42(1.10); C358(1.10)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C42(1.23)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C42(1.10)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C42(1.09); C358(1.14)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C42(1.13)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C42(0.98)  LDD1567  [11]
 LDCM0332  AC68 HCT 116 C42(1.48)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C42(1.28)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C42(1.09)  LDD1568  [11]
 LDCM0335  AC70 HCT 116 C42(1.46)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C42(2.41)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C42(1.01)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C42(1.72)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C42(1.77)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C42(1.63)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C42(1.05)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C42(0.91)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C42(1.14)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C42(1.03)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C42(0.98)  LDD1569  [11]
 LDCM0346  AC80 HCT 116 C42(1.59)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C42(1.38)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C42(1.23)  LDD0665  [4]
 LDCM0248  AKOS034007472 HEK-293T C42(1.05)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C42(1.02)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C42(0.96)  LDD1514  [11]
 LDCM0367  CL1 HEK-293T C42(1.34)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C42(1.71); C358(1.32)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C42(1.16)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C42(1.14)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C42(1.08)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C42(1.08)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C42(1.14)  LDD1577  [11]
 LDCM0374  CL105 HCT 116 C42(0.96)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C42(0.71)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C42(1.00)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C42(1.02)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C42(0.79)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C42(1.25)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C42(0.85)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C42(0.73)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C42(0.97)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C42(1.06)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C42(1.18)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C42(1.13)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C42(1.17)  LDD1590  [11]
 LDCM0387  CL117 HCT 116 C42(1.05)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C42(1.06)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C42(0.98)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C42(1.26)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C42(1.10)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C42(1.09)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C42(1.05)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C42(1.23)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C42(1.19)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C42(1.20)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C42(1.08)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C42(1.06)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C42(1.09)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C42(1.22)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C42(0.98)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C42(1.49)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C42(1.15)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C42(1.28)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C42(1.20); C358(1.29)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C42(1.22)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C42(1.02)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C42(1.29)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C42(1.37)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C42(1.25); C358(1.11)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C42(1.10)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C42(1.19)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C42(1.41)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C42(0.96)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C42(1.02)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C42(1.04)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C42(0.95)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C42(1.18)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C42(1.02); C358(1.30)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C42(1.18)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C42(1.13)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C42(1.94)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C42(1.14); C358(1.28)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C42(1.15)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C42(1.17)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C42(1.16)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C42(1.04)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C42(1.28)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C42(1.04)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C42(1.04)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C42(0.99); C358(1.05)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C42(1.14)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C42(1.25)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C42(1.24)  LDD1639  [11]
 LDCM0436  CL46 HCT 116 C42(1.23)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C42(1.12)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C42(1.09)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C42(0.92)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C42(0.99)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C42(1.11)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C42(1.14)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C42(1.19)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C42(1.17)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C42(1.23)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C42(0.88)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C42(1.13)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C42(0.99)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C42(1.19)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C42(1.13)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C42(1.45); C358(1.04)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C42(1.05)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C42(1.02)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C42(0.74)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C42(0.73)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C42(1.00)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C42(0.94)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C42(0.92)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C42(1.07)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C42(1.43)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C42(0.79)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C42(1.28)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C42(1.03)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C42(1.02)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C42(1.14)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C42(1.09)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C42(1.00)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C42(1.02)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C42(1.20)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C42(1.12); C358(1.04)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C42(1.18)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C42(2.87)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C42(1.24)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C42(1.12)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C42(1.17); C358(1.00)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C42(1.21)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C42(1.22)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C42(1.33)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C42(1.09)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C42(1.24)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C42(1.18)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C42(0.99)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C42(1.21)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C42(2.42); C358(1.27)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C42(1.19)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C42(1.51)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C42(1.36)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C42(1.27); C358(1.25)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C42(2.19)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C42(1.17)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C42(1.18)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C42(1.06)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C42(1.07)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C42(1.20)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C42(7.87)  LDD1702  [3]
 LDCM0573  Fragment11 Ramos C42(0.21)  LDD2190  [12]
 LDCM0576  Fragment14 Ramos C42(3.49)  LDD2193  [12]
 LDCM0468  Fragment33 HCT 116 C42(1.16)  LDD0785  [4]
 LDCM0427  Fragment51 HEK-293T C42(0.97)  LDD1631  [11]
 LDCM0569  Fragment7 Ramos C42(0.09)  LDD2186  [12]
 LDCM0022  KB02 HEK-293T C42(0.93)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C42(0.96)  LDD1497  [11]
 LDCM0024  KB05 MEWO C42(1.45)  LDD3319  [13]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C42(0.87)  LDD2089  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C42(0.97)  LDD2093  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C42(1.13)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C42(1.65)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C42(0.90)  LDD2100  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C42(1.61)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C42(0.96)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C42(0.72)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C42(0.70)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C42(1.05)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C42(0.63)  LDD2114  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C42(1.68)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C42(0.82)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C42(0.88)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C42(1.37)  LDD2127  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C42(0.65)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C42(1.19)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C42(1.32)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C42(0.75)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C42(2.06)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C42(0.90)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C42(0.82)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C42(2.83)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C42(1.21)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C42(0.81)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C42(0.54)  LDD2150  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C42(0.75)  LDD2207  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.