Details of the Target

General Information of Target

Target ID LDTP09578
Target Name Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1)
Gene Name PTPMT1
Gene ID 114971
Synonyms
MOSP; PLIP; Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; EC 3.1.3.27; PTEN-like phosphatase; Phosphoinositide lipid phosphatase; Protein-tyrosine phosphatase mitochondrial 1; EC 3.1.3.16, EC 3.1.3.48
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAATALLEAGLARVLFYPTLLYTLFRGKVPGRAHRDWYHRIDPTVLLGALPLRSLTRQLV
QDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALK
YQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLK
EFHKQITARATKDGTFVISKT
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Subcellular location
Mitochondrion inner membrane
Function
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity.
Uniprot ID
Q8WUK0
Ensemble ID
ENST00000326656.12
HGNC ID
HGNC:26965
ChEMBL ID
CHEMBL2052033

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.P30S .
LS513 SNV: p.V143M .
MOLT4 SNV: p.D42N .
SNU1079 Substitution: p.R57Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
HDSF-alk
 Probe Info  		2.44  LDD0197  [2]
STPyne
 Probe Info  		K28(3.28)  LDD0277  [3]
IPM
 Probe Info  		N.A.  LDD0241  [4]
DBIA
 Probe Info  		C81(1.77)  LDD3310  [5]
IA-alkyne
 Probe Info  		C81(1.37)  LDD2206  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [7]
AOyne
 Probe Info  		14.10  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
TER-AC
 Probe Info  		N.A.  LDD0426  [10]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		16.68  LDD1753  [11]
C091
 Probe Info  		9.99  LDD1782  [11]
C220
 Probe Info  		12.47  LDD1894  [11]
C228
 Probe Info  		17.63  LDD1901  [11]
C235
 Probe Info  		17.51  LDD1908  [11]
C285
 Probe Info  		21.11  LDD1955  [11]
C287
 Probe Info  		8.94  LDD1957  [11]
C288
 Probe Info  		6.45  LDD1958  [11]
C289
 Probe Info  		35.02  LDD1959  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C81(0.99)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C81(0.99); C127(0.96)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C81(0.93)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C81(0.90)  LDD1510  [12]
 LDCM0246  AC128 PaTu 8988t C81(1.00)  LDD1125  [13]
 LDCM0247  AC129 PaTu 8988t C81(0.95)  LDD1126  [13]
 LDCM0249  AC130 PaTu 8988t C81(1.02)  LDD1128  [13]
 LDCM0250  AC131 PaTu 8988t C81(0.98)  LDD1129  [13]
 LDCM0251  AC132 PaTu 8988t C81(0.90)  LDD1130  [13]
 LDCM0252  AC133 PaTu 8988t C81(0.90)  LDD1131  [13]
 LDCM0253  AC134 PaTu 8988t C81(0.86)  LDD1132  [13]
 LDCM0254  AC135 PaTu 8988t C81(0.91)  LDD1133  [13]
 LDCM0255  AC136 PaTu 8988t C81(1.05)  LDD1134  [13]
 LDCM0256  AC137 PaTu 8988t C81(0.96)  LDD1135  [13]
 LDCM0257  AC138 PaTu 8988t C81(0.88)  LDD1136  [13]
 LDCM0258  AC139 PaTu 8988t C81(1.12)  LDD1137  [13]
 LDCM0259  AC14 HEK-293T C81(0.93); C127(0.91)  LDD1512  [12]
 LDCM0260  AC140 PaTu 8988t C81(0.92)  LDD1139  [13]
 LDCM0261  AC141 PaTu 8988t C81(1.04)  LDD1140  [13]
 LDCM0262  AC142 PaTu 8988t C81(0.94)  LDD1141  [13]
 LDCM0263  AC143 PaTu 8988t C81(0.85)  LDD1142  [13]
 LDCM0264  AC144 PaTu 8988t C81(1.12)  LDD1143  [13]
 LDCM0265  AC145 PaTu 8988t C81(1.03)  LDD1144  [13]
 LDCM0266  AC146 PaTu 8988t C81(1.00)  LDD1145  [13]
 LDCM0267  AC147 PaTu 8988t C81(0.99)  LDD1146  [13]
 LDCM0268  AC148 PaTu 8988t C81(0.82)  LDD1147  [13]
 LDCM0269  AC149 PaTu 8988t C81(0.96)  LDD1148  [13]
 LDCM0270  AC15 HEK-293T C81(0.89)  LDD1513  [12]
 LDCM0271  AC150 PaTu 8988t C81(1.24)  LDD1150  [13]
 LDCM0272  AC151 PaTu 8988t C81(0.88)  LDD1151  [13]
 LDCM0273  AC152 PaTu 8988t C81(0.92)  LDD1152  [13]
 LDCM0274  AC153 PaTu 8988t C81(0.97)  LDD1153  [13]
 LDCM0621  AC154 PaTu 8988t C81(0.98)  LDD2166  [13]
 LDCM0622  AC155 PaTu 8988t C81(1.04)  LDD2167  [13]
 LDCM0623  AC156 PaTu 8988t C81(0.97)  LDD2168  [13]
 LDCM0624  AC157 PaTu 8988t C81(1.29)  LDD2169  [13]
 LDCM0276  AC17 HEK-293T C81(0.97)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C81(0.97); C127(0.90)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C81(1.01)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C81(1.01); C127(0.95)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C81(0.91)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C81(1.03); C127(0.77)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C81(0.94); C127(0.94)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C81(0.97)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C81(0.94)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C81(0.97)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C81(1.01); C127(0.86)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C81(0.96)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C81(0.95)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C81(0.97); C127(0.86)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C81(1.00)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C81(0.92); C127(0.96)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C81(0.94)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C81(1.01)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C81(0.94)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C81(0.92); C127(1.02)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C81(1.00)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C81(0.89)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C81(0.95); C127(0.93)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C81(0.84); C127(0.97)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C81(0.94)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C81(0.94)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C81(0.97)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C81(0.92)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C81(1.01); C127(0.94)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C81(0.93)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C81(0.88)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C81(0.96); C127(0.86)  LDD1546  [12]
 LDCM0308  AC46 PaTu 8988t C81(1.07)  LDD1187  [13]
 LDCM0309  AC47 PaTu 8988t C81(0.86)  LDD1188  [13]
 LDCM0310  AC48 PaTu 8988t C81(0.66)  LDD1189  [13]
 LDCM0311  AC49 PaTu 8988t C81(0.78)  LDD1190  [13]
 LDCM0312  AC5 HEK-293T C81(0.98); C127(0.80)  LDD1551  [12]
 LDCM0313  AC50 PaTu 8988t C81(0.85)  LDD1192  [13]
 LDCM0314  AC51 PaTu 8988t C81(0.57)  LDD1193  [13]
 LDCM0315  AC52 PaTu 8988t C81(0.63)  LDD1194  [13]
 LDCM0316  AC53 PaTu 8988t C81(0.59)  LDD1195  [13]
 LDCM0317  AC54 PaTu 8988t C81(0.63)  LDD1196  [13]
 LDCM0318  AC55 PaTu 8988t C81(1.04)  LDD1197  [13]
 LDCM0319  AC56 PaTu 8988t C81(0.70)  LDD1198  [13]
 LDCM0320  AC57 PaTu 8988t C81(0.87)  LDD1199  [13]
 LDCM0321  AC58 PaTu 8988t C81(0.84)  LDD1200  [13]
 LDCM0322  AC59 PaTu 8988t C81(1.06)  LDD1201  [13]
 LDCM0323  AC6 HEK-293T C81(0.96); C127(1.04)  LDD1562  [12]
 LDCM0324  AC60 PaTu 8988t C81(0.85)  LDD1203  [13]
 LDCM0325  AC61 PaTu 8988t C81(1.09)  LDD1204  [13]
 LDCM0326  AC62 PaTu 8988t C81(1.12)  LDD1205  [13]
 LDCM0327  AC63 PaTu 8988t C81(1.00)  LDD1206  [13]
 LDCM0328  AC64 PaTu 8988t C81(1.31)  LDD1207  [13]
 LDCM0329  AC65 PaTu 8988t C81(1.15)  LDD1208  [13]
 LDCM0330  AC66 PaTu 8988t C81(1.06)  LDD1209  [13]
 LDCM0331  AC67 PaTu 8988t C81(1.19)  LDD1210  [13]
 LDCM0334  AC7 HEK-293T C81(0.97)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C81(0.96)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C81(0.98); C127(0.84)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C81(0.94)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C81(0.94)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C81(1.02)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C81(1.78); C127(1.39)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C81(1.01); C127(1.06)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C81(0.95)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C81(1.12); C127(1.07)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C81(0.93); C127(0.84)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C81(0.96); C127(0.99)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C81(0.98)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C81(0.99); C127(0.88)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C81(0.94); C127(0.77)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C81(1.00); C127(0.92)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C81(1.01)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C81(1.15)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C81(1.11); C127(0.93)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C81(0.99); C127(0.92)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C81(1.01); C127(0.91)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C81(0.93)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C81(1.24); C127(1.08)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C81(0.89); C127(0.94)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C81(0.99); C127(1.05)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C81(0.90)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C81(0.90); C127(0.89)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C81(0.95); C127(0.83)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C81(1.02)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C81(0.93); C127(0.99)  LDD1595  [12]
 LDCM0392  CL121 PaTu 8988t C81(0.99)  LDD1271  [13]
 LDCM0393  CL122 PaTu 8988t C81(0.70)  LDD1272  [13]
 LDCM0394  CL123 PaTu 8988t C81(0.76)  LDD1273  [13]
 LDCM0395  CL124 PaTu 8988t C81(1.07)  LDD1274  [13]
 LDCM0396  CL125 PaTu 8988t C81(1.00)  LDD1275  [13]
 LDCM0397  CL126 PaTu 8988t C81(1.10)  LDD1276  [13]
 LDCM0398  CL127 PaTu 8988t C81(1.08)  LDD1277  [13]
 LDCM0399  CL128 PaTu 8988t C81(0.99)  LDD1278  [13]
 LDCM0400  CL13 HEK-293T C81(1.01)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C81(1.01); C127(0.88)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C81(1.15); C127(1.17)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C81(0.98); C127(1.08)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C81(1.26)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C81(0.94); C127(1.02)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C81(0.97)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C81(1.02); C127(0.87)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C81(0.97)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C81(1.27); C127(1.11)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C81(1.21); C127(1.09)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C81(1.07)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C81(0.96)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C81(1.04)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C81(1.11); C127(0.85)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C81(0.91); C127(0.95)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C81(1.06); C127(1.02)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C81(0.88)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C81(0.98); C127(0.94)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C81(1.02); C127(1.00)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C81(1.05)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C81(0.97)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C81(1.57); C127(1.05)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C81(1.20); C127(1.13)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C81(1.08)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C81(0.98)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C81(0.91)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C81(1.00); C127(0.79)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C81(1.09); C127(1.16)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C81(1.01); C127(1.00)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C81(1.06)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C81(0.97); C127(1.12)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C81(0.93)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C81(1.01)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C81(1.21); C127(1.15)  LDD1639  [12]
 LDCM0436  CL46 PaTu 8988t C81(1.03)  LDD1315  [13]
 LDCM0437  CL47 PaTu 8988t C81(1.15)  LDD1316  [13]
 LDCM0438  CL48 PaTu 8988t C81(1.19)  LDD1317  [13]
 LDCM0439  CL49 PaTu 8988t C81(1.30)  LDD1318  [13]
 LDCM0440  CL5 HEK-293T C81(1.05)  LDD1644  [12]
 LDCM0441  CL50 PaTu 8988t C81(1.11)  LDD1320  [13]
 LDCM0442  CL51 PaTu 8988t C81(1.38)  LDD1321  [13]
 LDCM0443  CL52 PaTu 8988t C81(1.42)  LDD1322  [13]
 LDCM0444  CL53 PaTu 8988t C81(1.35)  LDD1323  [13]
 LDCM0445  CL54 PaTu 8988t C81(1.59)  LDD1324  [13]
 LDCM0446  CL55 PaTu 8988t C81(1.94)  LDD1325  [13]
 LDCM0447  CL56 PaTu 8988t C81(0.35)  LDD1326  [13]
 LDCM0448  CL57 PaTu 8988t C81(1.40)  LDD1327  [13]
 LDCM0449  CL58 PaTu 8988t C81(1.48)  LDD1328  [13]
 LDCM0450  CL59 PaTu 8988t C81(1.33)  LDD1329  [13]
 LDCM0451  CL6 HEK-293T C81(1.26); C127(1.19)  LDD1654  [12]
 LDCM0452  CL60 PaTu 8988t C81(1.40)  LDD1331  [13]
 LDCM0453  CL61 HEK-293T C81(0.93)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C81(0.97); C127(0.72)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C81(0.88); C127(0.86)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C81(1.13); C127(1.10)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C81(0.97)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C81(1.02); C127(0.95)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C81(0.92)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C81(1.04)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C81(1.07); C127(0.84)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C81(1.03)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C81(1.08); C127(1.11)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C81(1.07)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C81(0.94)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C81(0.99)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C81(0.92); C127(0.92)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C81(0.93); C127(0.97)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C81(1.22)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C81(0.99); C127(1.11)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C81(0.89)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C81(1.83)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C81(0.94)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C81(1.00); C127(0.94)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C81(1.00); C127(1.13)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C81(1.06)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C81(1.16)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C81(0.87)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C81(0.99); C127(0.85)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C81(0.77); C127(0.78)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C81(0.96); C127(0.95)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C81(0.90)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C81(1.07); C127(1.03)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C81(1.63); C127(1.19)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C81(0.93)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C81(1.02)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C81(1.14); C127(1.06)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C81(1.05); C127(1.06)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C81(1.46)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C81(1.17)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C81(1.03)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C81(0.95); C127(0.84)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C81(0.93); C127(0.84)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C81(0.92); C127(0.74)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C81(0.91); C127(0.81)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C81(0.93); C127(0.84)  LDD1631  [12]
 LDCM0022  KB02 HEK-293T C81(0.91)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C81(1.00)  LDD1497  [12]
 LDCM0024  KB05 COLO792 C81(1.77)  LDD3310  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C81(1.37)  LDD2206  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C81(1.29)  LDD2207  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Progranulin (GRN) Granulin family P28799
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 2-3 (KRTAP2-3) KRTAP type 2 family P0C7H8
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Keratin-associated protein 5-7 (KRTAP5-7) KRTAP type 5 family Q6L8G8
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.