Details of the Target

General Information of Target

Target ID LDTP04425
Target Name Translocon-associated protein subunit delta (SSR4)
Gene Name SSR4
Gene ID 6748
Synonyms
TRAPD; Translocon-associated protein subunit delta; TRAP-delta; Signal sequence receptor subunit delta; SSR-delta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAMASLGALALLLLSSLSRCSAEACLEPQITPSYYTTSDAVISTETVFIVEISLTCKNR
VQNMALYADVGGKQFPVTRGQDVGRYQVSWSLDHKSAHAGTYEVRFFDEESYSLLRKAQR
NNEDISIIPPLFTVSVDHRGTWNGPWVSTEVLAAAIGLVIYYLAFSAKSHIQA
Target Bioclass
Other
Family
TRAP-delta family
Subcellular location
Endoplasmic reticulum membrane
Function TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Uniprot ID
P51571
Ensemble ID
ENST00000320857.7
HGNC ID
HGNC:11326
ChEMBL ID
CHEMBL4295777

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y102(20.00)  LDD0260  [1]
C-Sul
 Probe Info  		3.40  LDD0066  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
m-APA
 Probe Info  		H138(0.00); H98(0.00)  LDD2231  [3]
SF
 Probe Info  		Y67(0.00); Y102(0.00); Y112(0.00)  LDD0028  [4]
Ox-W18
 Probe Info  		N.A.  LDD2175  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
AOyne
 Probe Info  		9.30  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		6.50  LDD1740  [8]
C056
 Probe Info  		18.25  LDD1753  [8]
C091
 Probe Info  		10.20  LDD1782  [8]
C094
 Probe Info  		26.17  LDD1785  [8]
C106
 Probe Info  		19.56  LDD1793  [8]
C112
 Probe Info  		18.38  LDD1799  [8]
C134
 Probe Info  		22.32  LDD1816  [8]
C161
 Probe Info  		11.00  LDD1841  [8]
C169
 Probe Info  		20.68  LDD1849  [8]
C201
 Probe Info  		58.08  LDD1877  [8]
C206
 Probe Info  		26.17  LDD1881  [8]
C207
 Probe Info  		20.11  LDD1882  [8]
C210
 Probe Info  		49.18  LDD1884  [8]
C220
 Probe Info  		13.18  LDD1894  [8]
C228
 Probe Info  		19.03  LDD1901  [8]
C231
 Probe Info  		19.43  LDD1904  [8]
C234
 Probe Info  		5.58  LDD1907  [8]
C235
 Probe Info  		23.26  LDD1908  [8]
C289
 Probe Info  		39.95  LDD1959  [8]
C293
 Probe Info  		17.63  LDD1963  [8]
C349
 Probe Info  		8.94  LDD2010  [8]
C350
 Probe Info  		30.06  LDD2011  [8]
C362
 Probe Info  		35.02  LDD2023  [8]
C388
 Probe Info  		42.52  LDD2047  [8]
C390
 Probe Info  		26.91  LDD2049  [8]
FFF probe11
 Probe Info  		13.29  LDD0471  [9]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
FFF probe3
 Probe Info  		11.56  LDD0465  [9]
JN0003
 Probe Info  		20.00  LDD0469  [9]
STS-2
 Probe Info  		N.A.  LDD0138  [10]
OEA-DA
 Probe Info  		17.87  LDD0046  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H98(0.00); H138(0.00)  LDD0222  [6]
 LDCM0107  IAA HeLa H138(0.00); H98(0.00)  LDD0221  [6]
 LDCM0109  NEM HeLa H98(0.00); H138(0.00)  LDD0223  [6]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
5 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
11 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570