Details of the Target

General Information of Target

Target ID LDTP00298
Target Name Importin subunit alpha-4 (KPNA3)
Gene Name KPNA3
Gene ID 3839
Synonyms
QIP2; Importin subunit alpha-4; Importin alpha Q2; Qip2; Karyopherin subunit alpha-3; SRP1-gamma
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAENPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDS
DVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV
KCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWA
LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETV
QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKV
QTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQ
VQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLL
SVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEI
IDQYFSGDDIDEDPCLIPEATQGGTYNFDPTANLQTKEFNF
Target Bioclass
Transporter and channel
Family
Importin alpha family
Subcellular location
Cytoplasm
Function
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.
Uniprot ID
O00505
Ensemble ID
ENST00000261667.8
HGNC ID
HGNC:6396
ChEMBL ID
CHEMBL4523119

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
DBIA
 Probe Info  		C174(0.93); C191(0.93)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C325(0.00); C417(0.00); C456(0.00); C228(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C417(0.00); C456(0.00); C228(0.00); C325(0.00)  LDD0036  [5]
IPIAA_H
 Probe Info  		C417(0.00); C325(0.00)  LDD0030  [6]
IPIAA_L
 Probe Info  		C325(0.00); C174(0.00); C417(0.00)  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C325(0.00); C417(0.00); C456(0.00); C228(0.00)  LDD0037  [5]
1c-yne
 Probe Info  		K97(0.00); K386(0.00)  LDD0228  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]
AOyne
 Probe Info  		12.10  LDD0443  [9]
NAIA_5
 Probe Info  		C325(0.00); C228(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C220
 Probe Info  		15.78  LDD1894  [11]
C428
 Probe Info  		7.06  LDD2083  [11]
FFF probe13
 Probe Info  		17.13  LDD0475  [12]
FFF probe2
 Probe Info  		13.46  LDD0463  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C456(4.73)  LDD0372  [13]
 LDCM0214  AC1 HCT 116 C174(0.77); C191(0.77); C228(0.72); C417(0.47)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C174(0.78); C191(0.81); C228(0.83); C417(0.62)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C174(1.53); C191(1.53); C228(0.78)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C174(1.03); C191(1.03); C228(0.69)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C174(1.21); C191(1.21); C228(0.71)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C174(1.19); C191(1.19); C228(0.62)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C174(1.47); C191(1.47); C228(0.79)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C174(1.06); C191(1.06); C228(0.70)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C174(1.31); C191(1.31); C228(0.67)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C174(1.41); C191(1.41); C228(0.68)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C174(1.26); C191(1.26); C228(0.80)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C174(1.22); C191(1.22); C228(0.87)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C174(0.78); C191(0.84); C228(0.78); C417(0.56)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C174(1.26); C191(1.26); C228(0.79)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C174(1.08); C191(1.08); C228(0.90)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C174(1.04); C191(1.04); C228(0.66)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C174(0.96); C191(0.96); C228(1.01)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C174(0.88); C191(0.81); C228(0.97)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C174(0.89); C191(0.68); C228(0.96)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C174(0.91); C191(0.76); C228(0.86)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C174(0.77); C191(0.87); C228(0.84)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C174(1.00); C191(0.94); C228(0.97)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C174(0.91); C191(0.78); C228(0.93)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C174(0.98); C191(1.05); C228(0.85); C417(0.76)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C174(1.16); C191(1.01); C228(0.76)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C174(1.13); C191(1.05); C228(0.85)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C174(0.95); C191(0.85); C228(0.96)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C174(1.10); C191(1.01); C228(1.02)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C174(1.21); C191(1.01); C228(0.99)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C174(1.12); C191(0.88); C228(1.09)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C174(1.33); C191(1.13); C228(0.97)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C174(1.07); C191(1.03); C228(0.84)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C228(1.56); C417(0.94)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C228(1.44); C417(0.88)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C228(1.23); C417(1.09)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C228(1.39); C417(0.88)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C228(1.22); C417(0.63)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C228(1.35); C417(0.60)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C228(1.22); C417(0.89)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C228(1.26); C417(0.92)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C228(1.32); C417(0.74)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C228(1.12); C417(0.90)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C228(1.01); C417(0.63)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C228(1.06); C417(0.79)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C174(0.92); C191(1.12); C228(0.79); C417(0.59)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C228(1.07); C417(0.99)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C228(1.06); C417(0.67)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C228(1.12); C417(0.68)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C174(0.71); C417(0.74); C228(0.76); C191(0.80)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C417(0.46); C191(0.80); C228(0.81); C174(0.82)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C417(0.61); C191(0.74); C174(0.75); C228(0.95)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C417(0.46); C228(0.60); C174(0.62); C191(0.82)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C417(0.48); C191(0.91); C228(0.91); C174(1.04)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C417(0.57); C228(0.74); C174(0.76); C191(1.01)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C417(0.49); C228(0.66); C174(0.67); C191(0.82)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C417(0.57); C228(0.84); C174(0.96); C191(1.15)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C417(0.62); C174(0.69); C228(0.74); C191(0.88)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C417(0.61); C174(0.75); C228(0.82); C191(1.09)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C417(0.45); C228(0.64); C174(0.67); C191(0.76)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C174(0.33); C417(0.54); C191(0.73); C228(0.74)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C174(0.56); C191(0.66); C228(0.72); C417(0.52)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C174(0.52); C191(0.61); C228(0.60); C417(0.47)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C174(0.75); C191(0.76); C228(0.80); C417(0.72)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C174(0.68); C191(0.95); C228(0.94); C417(0.80)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C174(0.77); C191(0.77); C228(1.05)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C228(0.86); C174(1.04); C191(1.04)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C174(0.83); C191(0.83); C228(1.01)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C417(0.63); C174(0.72); C191(0.72); C228(0.84)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C174(0.90); C191(0.90); C228(1.06)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C174(0.91); C191(0.91); C228(0.97)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C228(1.00); C174(1.35); C191(1.35)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C174(0.86); C191(0.86); C228(1.03)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C174(1.12); C191(1.12); C228(1.23)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C417(0.59); C174(0.78); C191(0.78); C228(0.85)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C417(0.49); C174(0.59); C191(0.59); C228(0.73)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C417(0.51); C174(0.64); C191(0.64); C228(0.76)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C417(0.49); C174(0.69); C191(0.69); C228(0.78)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C417(0.48); C174(0.59); C191(0.59); C228(0.80)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C417(0.57); C174(0.70); C191(0.70); C228(0.85)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C417(0.55); C174(0.68); C191(0.68); C228(0.71)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C417(0.46); C174(0.63); C191(0.63); C228(0.80)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C417(0.41); C174(0.55); C191(0.55); C228(0.68)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C417(0.45); C174(0.68); C191(0.68); C228(0.69)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C417(0.46); C228(0.71); C174(1.00); C191(1.00)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C228(0.92); C417(1.20)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C417(0.76); C228(0.99)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C417(0.75); C228(1.14)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C228(1.15); C417(1.23)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C228(0.91); C417(1.50)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C417(0.42); C174(0.71); C191(0.71); C228(0.76)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C228(0.97); C417(1.01)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C228(1.06); C417(1.08)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C228(1.01); C417(1.13)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C228(0.92); C417(1.29)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C228(1.06); C417(1.14)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C417(0.92); C228(0.98)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C228(0.94); C174(1.00); C191(1.00)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C174(0.96); C191(0.96); C228(1.01)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C174(1.10); C191(1.10); C228(1.24)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C174(0.69); C191(0.69); C228(1.01)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C417(0.42); C174(0.68); C191(0.68); C228(0.76)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C174(0.98); C191(0.98); C228(0.99)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C174(1.04); C191(1.04); C228(1.04)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C174(0.89); C191(0.89); C228(0.99)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C228(0.95); C174(1.04); C191(1.04)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C228(0.99); C174(1.38); C191(1.38)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C174(0.95); C191(0.95); C228(1.09)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C174(1.09); C191(1.09); C228(1.16)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C174(0.54); C191(0.54); C228(0.84)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C174(0.78); C191(0.78); C228(0.87)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C174(0.44); C191(0.44); C228(0.87)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C417(0.58); C228(0.77); C174(0.79); C191(0.95)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C174(0.55); C191(0.55); C228(0.85)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C228(0.75); C174(0.89); C191(0.89)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C174(0.40); C191(0.40); C228(1.07)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C174(0.44); C191(0.44); C228(0.94)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C174(0.58); C191(0.58); C228(1.01)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C174(0.50); C191(0.50); C228(0.93)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C228(0.90); C174(1.24); C191(1.24)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C174(0.52); C191(0.52); C228(0.95)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C417(0.66); C228(0.97); C174(0.99); C191(0.99)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C417(0.81); C174(1.04); C191(1.04); C228(1.05)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C417(0.67); C174(0.80); C228(0.85); C191(0.90)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C174(0.73); C191(0.73); C417(1.07); C228(1.09)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C174(0.96); C191(0.96); C228(1.13); C417(1.31)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C417(0.70); C174(0.98); C191(0.98); C228(0.99)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C174(0.73); C191(0.73); C417(0.98); C228(1.07)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C417(0.74); C174(0.98); C191(0.98); C228(1.05)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C417(0.98); C174(0.99); C191(0.99); C228(1.18)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C174(0.86); C191(0.86); C417(0.90); C228(1.23)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C417(0.72); C174(0.73); C191(0.73); C228(1.06)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C417(0.59); C174(0.88); C191(0.88); C228(1.01)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C174(0.87); C191(0.87); C228(1.10); C417(1.50)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C417(0.65); C228(0.72); C174(1.02); C191(1.13)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C174(0.76); C191(0.76); C417(0.87); C228(1.01)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C417(0.31); C228(1.07); C174(1.50); C191(1.50)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C417(0.84); C174(1.09); C191(1.09); C228(1.21)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C174(0.70); C191(0.70); C228(0.74)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C174(0.68); C191(0.68); C228(0.71)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C228(0.69); C174(0.72); C191(0.72)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C228(0.85); C174(0.86); C191(0.86)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C228(0.84); C174(0.93); C191(0.93)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C228(0.88); C174(0.96); C191(0.96)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C174(0.80); C191(0.80); C228(0.82)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C174(0.82); C191(0.82); C228(1.29)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C174(0.76); C191(0.76); C228(0.85)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C228(0.86); C174(0.87); C191(0.87)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C174(0.68); C191(0.68); C228(0.74)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C174(0.51); C191(0.51); C228(0.75)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C174(0.71); C191(0.71); C228(0.80)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C174(0.65); C191(0.65); C228(0.83)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C174(0.62); C191(0.62); C228(0.67)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C228(0.62); C174(0.89); C191(0.89)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C228(0.70); C174(1.04); C191(1.04)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C174(0.87); C191(0.91); C228(0.99); C417(0.80)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C417(0.63); C174(0.83); C228(0.83); C191(0.87)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C417(0.51); C228(0.78); C174(0.85); C191(0.98)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 13.60  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C174(0.93); C191(0.93)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HCT 116 C174(0.97); C191(0.97); C228(1.10); C417(1.13)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C174(0.65); C191(0.65); C417(0.83); C228(0.96)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C417(0.50); C174(0.70); C191(0.70); C228(0.73)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C417(0.54); C228(0.84); C191(0.93); C174(0.98)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C417(0.73); C174(0.74); C191(0.85); C228(0.93)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C417(0.76); C174(0.86); C228(0.97); C191(1.01)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C417(0.69); C174(0.90); C228(1.01); C191(1.11)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C174(0.83); C191(0.83); C228(0.87)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C174(0.85); C191(0.85); C228(1.02)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C174(0.78); C191(0.78); C228(0.90)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C174(0.88); C191(0.88); C228(0.94)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C174(0.76); C191(0.76); C228(0.93)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C174(0.71); C191(0.71); C417(0.85); C228(0.95)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C174(0.83); C191(0.83); C228(0.95)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C174(0.95); C191(0.95); C228(0.96)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C417(0.83); C228(0.86); C174(0.87); C191(0.87)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C417(0.48); C174(0.71); C191(0.71); C228(0.71)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C417(0.55); C174(0.75); C191(0.75); C228(0.78)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C417(0.57); C228(0.70); C174(0.75); C191(0.75)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C417(0.53); C228(0.75); C174(0.79); C191(0.79)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C228(0.94); C417(1.11)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C417(0.92); C228(0.94)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C417(0.80); C228(0.86)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C174(0.65); C191(0.65); C417(0.80); C228(1.08)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C417(0.80); C228(1.03)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C228(0.81); C174(0.94); C191(0.94)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C228(0.94); C174(0.99); C191(0.99)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C228(0.91); C174(1.26); C191(1.26)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C228(0.86); C174(1.00); C191(1.00)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C174(0.46); C191(0.46); C228(0.90)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C174(0.57); C191(0.57); C228(0.87)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C174(0.50); C191(0.50); C228(1.04)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C174(0.68); C191(0.68); C228(0.84)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C417(0.77); C174(0.80); C191(0.80); C228(1.00)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C174(0.68); C191(0.68); C417(0.85); C228(1.08)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C417(0.82); C174(0.83); C191(0.83); C228(0.99)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C417(0.75); C228(0.83)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C174(0.69); C191(0.69); C417(0.71); C228(0.97)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C417(0.61); C174(0.70); C191(0.70); C228(0.97)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C417(0.68); C174(0.82); C191(0.82); C228(0.94)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C174(1.01); C191(1.01); C417(1.01); C228(1.11)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C174(0.63); C191(0.63); C417(0.64); C228(1.01)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C417(0.64); C174(0.65); C191(0.65); C228(0.95)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C417(0.75); C174(0.93); C191(0.93); C228(0.99)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C417(0.66); C228(0.97); C174(1.05); C191(1.05)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C417(0.69); C174(0.93); C191(0.93); C228(1.00)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C174(1.07); C191(1.07); C228(0.90); C417(0.62)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C174(0.82); C191(0.82); C228(0.88); C417(0.68)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C174(0.90); C191(0.90); C228(1.07); C417(0.67)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C174(0.75); C191(0.75); C228(1.04); C417(0.64)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C174(0.83); C191(0.83); C228(1.00); C417(0.63)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C174(0.87); C191(0.87); C228(1.04); C417(1.10)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C174(1.04); C191(1.04); C228(1.02); C417(0.68)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C174(1.01); C191(1.01); C228(0.84)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C174(1.02); C191(1.05); C228(0.84)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C174(0.85); C191(0.90); C228(0.82)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C174(1.00); C191(1.07); C228(0.89)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C174(1.00); C191(1.02); C228(0.91)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C174(1.01); C191(1.03); C228(0.95)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C174(1.12); C191(1.16); C228(1.01)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C174(1.01); C191(1.03); C228(0.89)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C174(0.98); C191(0.98); C228(1.01); C417(1.04)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C174(1.14); C191(1.17); C228(0.89)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C174(1.06); C191(1.05); C228(0.94)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C174(1.08); C191(1.10); C228(0.93)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C174(1.04); C191(1.07); C228(1.00)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C174(1.04); C191(1.07); C228(0.85)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C174(0.84); C191(0.84); C228(0.88)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C174(0.53); C191(0.53); C228(0.86)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C174(0.62); C191(0.62); C228(0.90)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C174(0.58); C191(0.58); C228(0.83)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C174(0.68); C191(0.68); C228(1.13)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C174(0.88); C191(0.88); C228(1.14); C417(0.78)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C174(0.67); C191(0.67); C228(0.92)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C174(0.54); C191(0.54); C228(0.98)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C174(0.56); C191(0.56); C228(0.85)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C174(1.40); C191(1.40); C228(0.87)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C174(0.77); C191(0.77); C228(0.93)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C174(0.96); C191(0.96); C228(1.06)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C174(0.91); C191(0.91); C228(1.02)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C174(0.88); C191(0.88); C228(1.01)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C174(0.64); C191(0.64); C228(1.01)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C174(0.70); C191(0.70); C228(1.23)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C174(0.78); C191(0.78); C228(0.91); C417(0.83)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C174(0.53); C191(0.53); C228(1.01)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C174(0.78); C191(0.87); C228(0.94); C417(1.01)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C174(0.72); C191(0.80); C228(0.81); C417(0.68)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C174(0.72); C191(0.86); C228(0.76); C417(1.07)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C174(0.75); C191(0.86); C228(0.80); C417(1.03)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C174(0.82); C191(0.91); C228(0.86); C417(0.71)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C174(0.74); C191(0.89); C228(0.79); C417(0.77)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C174(0.78); C191(0.88); C228(0.73); C417(0.83)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C174(0.85); C191(0.86); C228(0.73); C417(0.70)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C174(0.65); C191(0.76); C228(0.75); C417(0.91)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C174(0.75); C191(0.75); C228(1.00); C417(0.82)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C174(0.76); C191(0.81); C228(0.82); C417(0.70)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C174(0.76); C191(0.85); C228(0.72); C417(1.01)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C174(0.83); C191(0.95); C228(0.77); C417(2.75)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C174(0.86); C191(0.94); C228(0.74); C417(0.99)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C174(0.80); C191(0.90); C228(0.81); C417(0.84)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C174(0.72); C191(0.72); C228(0.89); C417(0.75)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C174(0.79); C191(0.79); C228(0.90); C417(0.90)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C174(0.72); C191(0.72); C228(0.92); C417(0.74)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C174(0.68); C191(0.68); C228(0.85); C417(0.73)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C174(0.86); C191(0.86); C228(0.85); C417(0.83)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C174(0.93); C191(0.93); C228(0.94); C417(0.64)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C174(0.72); C191(0.72); C228(0.93); C417(0.57)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C174(0.86); C191(0.86); C228(0.97); C417(0.69)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C174(0.78); C191(0.78); C228(0.89); C417(0.59)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C174(0.82); C191(0.82); C228(0.92); C417(0.79)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C174(0.78); C191(0.78); C228(0.95); C417(0.73)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C174(0.74); C191(0.74); C228(0.96); C417(0.75)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C174(0.70); C191(0.70); C228(0.89); C417(0.68)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C174(0.61); C191(0.61); C228(0.88); C417(0.61)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C174(0.94); C191(0.94); C228(1.03); C417(0.76)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C174(0.81); C191(0.81); C228(0.96); C417(0.84)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C174(0.77); C191(0.77); C228(1.23); C417(0.67)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C174(0.95); C191(0.95); C228(0.83); C417(0.53)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C174(0.77); C191(0.77); C228(0.82); C417(0.56)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C174(0.80); C191(0.80); C228(0.91); C417(0.46)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C174(0.77); C191(0.77); C228(0.78); C417(0.43)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C174(0.68); C191(0.68); C228(0.77); C417(0.53)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C174(0.72); C191(0.72); C228(0.78); C417(0.53)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C174(0.66); C191(0.66); C228(0.78); C417(0.73)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C174(0.72); C191(0.72); C228(0.75); C417(0.48)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C174(0.86); C191(0.86); C228(0.74); C417(0.52)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C417(1.03); C228(1.02); C191(1.03); C174(1.22)  LDD1698  [14]
 LDCM0468  Fragment33 HCT 116 C174(0.83); C191(0.97); C228(0.71); C417(1.12)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C174(1.15); C191(1.09); C228(0.97)  LDD0744  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HCT 116 C228(1.61)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C228(3.28)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C228(2.84)  LDD0082  [4]
 LDCM0109  NEM HeLa H468(0.00); H28(0.00)  LDD0223  [3]
 LDCM0021  THZ1 HCT 116 C228(1.07)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Single-stranded DNA cytosine deaminase (AICDA) Cytidine and deoxycytidylate deaminase family Q9GZX7
Nucleolar RNA helicase 2 (DDX21) DEAD box helicase family Q9NR30
Methionine adenosyltransferase 2 subunit beta (MAT2B) DTDP-4-dehydrorhamnose reductase family Q9NZL9
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) Eukaryotic NMN adenylyltransferase family Q9HAN9
DNA-directed RNA polymerase III subunit RPC3 (POLR3C) Eukaryotic RPC3/POLR3C RNA polymerase subunit family Q9BUI4
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) Helicase family P19447
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Mitogen-activated protein kinase 9 (MAPK9) CMGC Ser/Thr protein kinase family P45984
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Importin subunit beta-1 (KPNB1) Importin beta family Q14974
Sodium/myo-inositol cotransporter 2 (SLC5A11) Sodium:solute symporter (SSF) (TC 2.A.21) family Q8WWX8
Nuclear pore complex protein Nup50 (NUP50) . Q9UKX7
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Zinc finger protein 764 (ZNF764) Krueppel C2H2-type zinc-finger protein family Q96H86
Metastasis-associated protein MTA1 (MTA1) . Q13330
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Cyclin-dependent kinase inhibitor 1B (CDKN1B) CDI family P46527
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Ferritin light chain (FTL) Ferritin family P02792
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
DNA repair protein RAD52 homolog (RAD52) RAD52 family P43351
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
U5 small nuclear ribonucleoprotein TSSC4 (TSSC4) TSSC4 family Q9Y5U2
Regulation of nuclear pre-mRNA domain-containing protein 1A (RPRD1A) UPF0400 (RTT103) family Q96P16
UV-stimulated scaffold protein A (UVSSA) UVSSA family Q2YD98
Zinc finger CCHC domain-containing protein 12 (ZCCHC12) ZCCHC12 family Q6PEW1
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Protein SPMIP9 (SPMIP9) . Q96LM6
TNFAIP3-interacting protein 3 (TNIP3) . Q96KP6
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402