Details of the Target

General Information of Target

Target ID LDTP15712
Target Name RING finger and SPRY domain-containing protein 1 (RSPRY1)
Gene Name RSPRY1
Gene ID 89970
Synonyms
KIAA1972; RING finger and SPRY domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQPSGGRAPGTRIYSWSCPTVMSPGEKLDPIPDSFILQPPVFHPVVPYVTTIFGGLHAG
KMVMLQGVVPLDAHRFQVDFQCGCSLCPRPDIAFHFNPRFHTTKPHVICNTLHGGRWQRE
ARWPHLALRRGSSFLILFLFGNEEVKVSVNGQHFLHFRYRLPLSHVDTLGIFGDILVEAV
GFLNINPFVEGSREYPAGHPFLLMSPRLEVPCSHALPQGLSPGQVIIVRGLVLQEPKHFT
VSLRDQAAHAPVTLRASFADRTLAWISRWGQKKLISAPFLFYPQRFFEVLLLFQEGGLKL
ALNGQGLGATSMNQQALEQLRELRISGSVQLYCVHS
Target Bioclass
Other
Subcellular location
Secreted
Uniprot ID
Q96DX4
Ensemble ID
ENST00000394420.9
HGNC ID
HGNC:29420

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.V372I .
HCT15 SNV: p.Q17K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C167(4.68)  LDD3312  [1]
BTD
 Probe Info  		C208(0.91)  LDD2107  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C208(0.00); C167(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C167(0.00); C44(0.00); C46(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C208(0.00); C167(0.00); C190(0.00)  LDD0037  [3]
IPM
 Probe Info  		C208(0.00); C190(0.00)  LDD2156  [4]
AOyne
 Probe Info  		13.40  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		18.13  LDD1799  [6]
C218
 Probe Info  		22.32  LDD1892  [6]
C219
 Probe Info  		5.43  LDD1893  [6]
C220
 Probe Info  		22.94  LDD1894  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C208(0.90)  LDD2117  [2]
 LDCM0214  AC1 HEK-293T C421(1.10)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C421(1.06)  LDD0813  [8]
 LDCM0216  AC100 HEK-293T C208(0.57)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C208(0.64)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C208(0.48)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C208(0.78)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C208(0.69)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C208(0.51)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C208(0.54)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C208(0.54)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C208(0.49)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C208(0.36)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C421(0.88)  LDD0824  [8]
 LDCM0227  AC110 HEK-293T C208(0.63)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C208(0.68)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C208(0.75)  LDD0827  [8]
 LDCM0230  AC113 PaTu 8988t C208(1.24); C421(1.25); C404(1.18); C399(1.18)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C208(0.95); C421(1.23); C404(1.10); C399(1.10)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C208(1.26); C421(0.85); C404(1.01); C399(1.01)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C208(1.13); C421(1.04); C404(0.94); C399(0.94)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C208(1.19); C421(0.99); C404(0.91); C399(0.91)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C208(0.91); C421(0.98); C404(1.14); C399(1.14)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C208(1.08); C421(1.15); C404(1.13); C399(1.13)  LDD1115  [8]
 LDCM0237  AC12 HEK-293T C421(0.98)  LDD0835  [8]
 LDCM0238  AC120 PaTu 8988t C208(1.06); C421(1.40); C404(1.46); C399(1.46)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C208(1.08); C421(1.38); C404(1.53); C399(1.53)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C208(0.89); C421(1.22); C404(1.51); C399(1.51)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C208(0.97); C421(1.21); C404(1.20); C399(1.20)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C208(1.10); C421(1.04); C404(1.10); C399(1.10)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C208(0.95); C421(0.87); C404(0.81); C399(0.81)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C208(1.00); C421(1.08); C404(1.00); C399(1.00)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C208(0.93); C421(1.44); C404(1.35); C399(1.35)  LDD1124  [8]
 LDCM0246  AC128 PaTu 8988t C404(0.89); C399(0.89)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C404(0.73); C399(0.73)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C404(0.84); C399(0.84)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C404(1.17); C399(1.17)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C404(0.89); C399(0.89)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C404(0.92); C399(0.92)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C404(0.83); C399(0.83)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C404(0.91); C399(0.91)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C404(0.96); C399(0.96)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C404(0.78); C399(0.78)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C404(0.93); C399(0.93)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C404(2.24); C399(2.24)  LDD1137  [8]
 LDCM0259  AC14 HEK-293T C421(1.19)  LDD0857  [8]
 LDCM0260  AC140 PaTu 8988t C404(0.72); C399(0.72)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C404(0.73); C399(0.73)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C404(0.69); C399(0.69)  LDD1141  [8]
 LDCM0263  AC143 HEK-293T C421(1.28)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C421(1.35)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C421(1.43)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C421(1.29)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C421(1.57)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C421(1.45)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C421(1.22)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C421(1.30)  LDD0868  [8]
 LDCM0271  AC150 HEK-293T C421(1.53)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C421(1.26)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C421(1.23)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C421(1.24)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C421(1.19)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C421(1.37)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C421(1.43)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C421(1.90)  LDD2165  [8]
 LDCM0276  AC17 HEK-293T C421(1.39)  LDD0874  [8]
 LDCM0277  AC18 HEK-293T C421(1.17)  LDD0875  [8]
 LDCM0278  AC19 HEK-293T C421(1.16)  LDD0876  [8]
 LDCM0279  AC2 HEK-293T C208(1.12); C190(1.07)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C421(1.46)  LDD0878  [8]
 LDCM0281  AC21 HEK-293T C421(1.28)  LDD0879  [8]
 LDCM0282  AC22 HEK-293T C421(1.39)  LDD0880  [8]
 LDCM0283  AC23 HEK-293T C421(1.53)  LDD0881  [8]
 LDCM0284  AC24 HEK-293T C421(1.11)  LDD0882  [8]
 LDCM0285  AC25 HEK-293T C208(0.92); C421(1.17)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C208(0.92); C421(1.15)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C208(0.90); C421(1.09)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C208(0.61); C421(0.98)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C208(0.83); C421(1.27)  LDD0887  [8]
 LDCM0290  AC3 HEK-293T C208(1.01)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C208(0.95); C421(1.20)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C208(0.89); C421(1.03)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C208(0.97); C421(1.13)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C208(0.86); C421(1.22)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C208(0.90); C421(1.10)  LDD0893  [8]
 LDCM0296  AC35 HEK-293T C421(0.99)  LDD0894  [8]
 LDCM0297  AC36 HEK-293T C421(1.12)  LDD0895  [8]
 LDCM0298  AC37 HEK-293T C421(1.00)  LDD0896  [8]
 LDCM0299  AC38 HEK-293T C421(0.89)  LDD0897  [8]
 LDCM0300  AC39 HEK-293T C421(0.97)  LDD0898  [8]
 LDCM0301  AC4 HEK-293T C208(0.94); C421(1.03)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C421(1.03)  LDD0900  [8]
 LDCM0303  AC41 HEK-293T C421(1.08)  LDD0901  [8]
 LDCM0304  AC42 HEK-293T C421(0.93)  LDD0902  [8]
 LDCM0305  AC43 HEK-293T C421(1.00)  LDD0903  [8]
 LDCM0306  AC44 HEK-293T C421(1.12)  LDD0904  [8]
 LDCM0307  AC45 HEK-293T C421(1.11)  LDD0905  [8]
 LDCM0308  AC46 HEK-293T C208(0.91); C421(1.02)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C208(0.90); C421(1.11)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C208(0.84); C421(1.11)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C208(1.00); C421(1.10)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C208(1.04); C190(1.20); C421(1.10)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C208(0.90); C421(1.38)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C208(0.83); C421(1.31)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C208(0.78); C421(1.23)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C208(0.87); C421(1.01)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C208(0.86); C421(1.28)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C208(0.88); C421(1.13)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C208(0.86); C421(1.13)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C421(1.04)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C208(1.17); C190(1.03)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C208(1.11)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C421(0.87)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C208(1.16); C421(0.89)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C208(0.99); C190(0.99); C421(0.97)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C208(1.06); C190(1.01); C421(1.02)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C208(1.12); C190(1.00)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C208(1.03); C190(1.02); C292(1.16)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C421(1.07)  LDD0932  [8]
 LDCM0345  AC8 HEK-293T C421(1.04)  LDD0943  [8]
 LDCM0365  AC98 HEK-293T C208(0.93)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C208(0.39)  LDD0964  [8]
 LDCM0248  AKOS034007472 HEK-293T C421(0.99)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C421(1.30)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C421(1.08)  LDD0873  [8]
 LDCM0367  CL1 PaTu 8988t C404(0.94); C399(0.80)  LDD1246  [8]
 LDCM0368  CL10 PaTu 8988t C404(1.03); C399(0.99)  LDD1247  [8]
 LDCM0369  CL100 HEK-293T C208(1.15); C190(0.91); C421(1.04)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C421(1.22)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C421(1.50)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C421(1.21)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C421(1.13)  LDD0971  [8]
 LDCM0374  CL105 HEK-293T C421(1.07)  LDD0972  [8]
 LDCM0375  CL106 HEK-293T C421(1.19)  LDD0973  [8]
 LDCM0376  CL107 HEK-293T C421(1.08)  LDD0974  [8]
 LDCM0377  CL108 HEK-293T C421(1.15)  LDD0975  [8]
 LDCM0378  CL109 HEK-293T C421(1.28)  LDD0976  [8]
 LDCM0379  CL11 PaTu 8988t C404(0.92); C399(0.71)  LDD1258  [8]
 LDCM0380  CL110 HEK-293T C421(1.29)  LDD0978  [8]
 LDCM0381  CL111 HEK-293T C421(1.00)  LDD0979  [8]
 LDCM0382  CL112 HEK-293T C208(0.79); C421(1.15)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C208(0.87); C421(1.19)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C208(0.93); C421(1.56)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C208(0.87); C421(1.26)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C208(0.92); C421(1.25)  LDD0984  [8]
 LDCM0387  CL117 HEK-293T C421(1.10)  LDD0985  [8]
 LDCM0388  CL118 HEK-293T C421(0.94)  LDD0986  [8]
 LDCM0389  CL119 HEK-293T C421(1.01)  LDD0987  [8]
 LDCM0390  CL12 PaTu 8988t C404(1.09); C399(0.93)  LDD1269  [8]
 LDCM0391  CL120 HEK-293T C421(1.10)  LDD0989  [8]
 LDCM0392  CL121 HEK-293T C208(0.88); C421(1.15)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C208(0.93); C421(1.20)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C208(1.01); C421(1.32)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C208(1.06); C421(1.21)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C208(0.97); C190(1.04); C167(1.08)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C208(0.98); C421(0.86)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C190(0.96)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C208(1.06); C190(0.92); C421(1.04)  LDD1603  [7]
 LDCM0400  CL13 PaTu 8988t C404(1.07); C399(0.81)  LDD1279  [8]
 LDCM0401  CL14 PaTu 8988t C404(1.13); C399(0.84)  LDD1280  [8]
 LDCM0402  CL15 PaTu 8988t C404(0.77); C399(0.64)  LDD1281  [8]
 LDCM0403  CL16 HEK-293T C208(1.02)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C208(0.98)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C208(0.93)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C208(1.09)  LDD1004  [8]
 LDCM0407  CL2 PaTu 8988t C404(0.99); C399(0.66)  LDD1286  [8]
 LDCM0408  CL20 HEK-293T C208(0.89)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C208(1.17)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C208(0.95)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C208(0.94)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C208(0.86)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C208(1.03)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C208(0.79)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C208(0.97)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C208(0.96)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C208(0.94)  LDD1015  [8]
 LDCM0418  CL3 PaTu 8988t C404(0.71); C399(0.77)  LDD1297  [8]
 LDCM0419  CL30 HEK-293T C208(0.88)  LDD1017  [8]
 LDCM0420  CL31 HEK-293T C421(0.97)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C421(1.20)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C421(1.12)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C421(1.29)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C421(1.21)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C421(1.17)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C421(1.08)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C421(1.56)  LDD1026  [8]
 LDCM0429  CL4 PaTu 8988t C404(0.69); C399(0.65)  LDD1308  [8]
 LDCM0430  CL40 HEK-293T C421(1.09)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C421(1.47)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C421(1.35)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C421(1.59)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C421(1.05)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C421(1.28)  LDD1033  [8]
 LDCM0436  CL46 HEK-293T C208(1.08)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C208(1.06)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C208(1.00)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C208(1.02)  LDD1037  [8]
 LDCM0440  CL5 PaTu 8988t C404(0.86); C399(0.79)  LDD1319  [8]
 LDCM0441  CL50 HEK-293T C208(1.26)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C208(1.25)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C208(1.17)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C208(1.13)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C208(1.15)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C208(1.04)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C208(1.03)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C208(1.36)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C208(1.05)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C208(1.11)  LDD1048  [8]
 LDCM0451  CL6 PaTu 8988t C404(1.22); C399(0.89)  LDD1330  [8]
 LDCM0452  CL60 HEK-293T C208(1.06)  LDD1050  [8]
 LDCM0453  CL61 HEK-293T C208(0.81)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C208(0.89)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C208(0.94)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C208(1.06)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C208(0.89)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C208(0.91)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C208(0.97)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C208(0.74)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C208(0.83)  LDD1059  [8]
 LDCM0462  CL7 PaTu 8988t C404(1.07); C399(0.78)  LDD1341  [8]
 LDCM0463  CL70 HEK-293T C208(0.83)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C208(0.74)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C208(0.82)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C208(0.94)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C208(0.82)  LDD1065  [8]
 LDCM0469  CL76 PaTu 8988t C208(0.86); C421(0.91)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C208(0.77); C421(0.74)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C208(0.76); C421(0.67)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C208(0.82); C421(0.73)  LDD1351  [8]
 LDCM0473  CL8 PaTu 8988t C404(0.86); C399(0.74)  LDD1352  [8]
 LDCM0474  CL80 PaTu 8988t C208(0.76); C421(0.78)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C208(0.68); C421(0.65)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C208(0.77); C421(0.74)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C208(0.68); C421(0.57)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C208(0.81); C421(0.84)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C208(0.82); C421(0.69)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C208(0.73); C421(0.73)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C208(0.74); C421(0.70)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C208(0.70); C421(0.76)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C208(0.83); C421(0.83)  LDD1362  [8]
 LDCM0484  CL9 PaTu 8988t C404(1.08); C399(0.89)  LDD1363  [8]
 LDCM0485  CL90 PaTu 8988t C208(0.78); C421(0.71)  LDD1364  [8]
 LDCM0486  CL91 HEK-293T C208(1.11)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C208(1.04); C421(0.81)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C208(1.20); C190(0.85); C421(1.16)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C208(0.94); C190(0.94); C421(1.06)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C208(1.55); C190(0.91)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C208(1.14); C190(0.95); C292(0.47)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C208(1.07); C190(0.92); C167(1.07)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C208(1.03); C421(0.91)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C190(0.93)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C190(1.03)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C208(0.72)  LDD1066  [8]
 LDCM0427  Fragment51 HEK-293T C421(1.05)  LDD1025  [8]
 LDCM0022  KB02 HEK-293T C208(0.85); C190(1.10); C421(1.05)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C208(0.99); C190(0.96); C421(0.90)  LDD1497  [7]
 LDCM0024  KB05 HMCB C167(4.68)  LDD3312  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C208(0.91)  LDD2107  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C208(0.81)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C208(1.08)  LDD2136  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.