Details of the Target

General Information of Target

Target ID LDTP13210
Target Name Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1)
Gene Name LRWD1
Gene ID 222229
Synonyms
CENP-33; ORCA; Leucine-rich repeat and WD repeat-containing protein 1; Centromere protein 33; CENP-33; Origin recognition complex-associated protein; ORC-associated protein; ORCA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRLNEQRLFQPDLCDVDLVLVPQRSVFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLE
ALAPGGLQQILNFIYTSKLLVNAANVHEVLSAASLLQMADIAASCQELLDARSLGPPGPG
TVALAQPAASCTPAAPPYYCDIKQEADTPGLPKIYAREGPDPYSVRVEDGAGTAGGTVPA
TIGPAQPFFKEEKEGGVEEAGGPPASLCKLEGGEELEEELGGSGTYSRREQSQIIVEVNL
NNQTLHVSTGPEGKPGAGPSPATVVLGREDGLQRHSDEEEEDDEEEEEEEEEEEGGGSGR
EEEEEEEGGSQGEEEEEEEDGHSEQEEEEEEEEEEGPSEQDQESSEEEEGEEGEAGGKQG
PRGSRSSRADPPPHSHMATRSRENARRRGTPEPEEAGRRGGKRPKPPPGVASASARGPPA
TDGLGAKVKLEEKQHHPCQKCPRVFNNRWYLEKHMNVTHSRMQICDQCGKRFLLESELLL
HRQTDCERNIQCVTCGKAFKKLWSLHEHNKIVHGYAEKKFSCEICEKKFYTMAHVRKHMV
AHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCNERFQYKYQLRSHMSIHIG
HKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPYICEICGKSFTSRPNMKRHRRTHTGEKPY
PCDVCGQRFRFSNMLKAHKEKCFRVSHTLAGDGVPAAPGLPPTQPQAHALPLLPGLPQTL
PPPPHLPPPPPLFPTTASPGGRMNANN
Target Bioclass
Other
Family
LRWD1 family
Subcellular location
Nucleus
Function
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Uniprot ID
Q9UFC0
Ensemble ID
ENST00000292616.10
HGNC ID
HGNC:21769

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.72  LDD0402  [1]
Probe 1
 Probe Info  		Y131(8.37)  LDD3495  [2]
AHL-Pu-1
 Probe Info  		C522(2.23)  LDD0168  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C522(1.12); C76(0.86); C88(0.86)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C522(0.00); C449(0.00); C454(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C522(0.00); C449(0.00); C454(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
1d-yne
 Probe Info  		N.A.  LDD0356  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
AOyne
 Probe Info  		14.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C159
 Probe Info  		10.20  LDD1839  [12]
C198
 Probe Info  		18.00  LDD1874  [12]
C212
 Probe Info  		5.98  LDD1886  [12]
FFF probe13
 Probe Info  		5.38  LDD0476  [13]
FFF probe3
 Probe Info  		6.55  LDD0465  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C522(2.23)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C454(3.86); C522(3.38)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C249(1.24); C281(1.15); C384(0.76); C385(0.87)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C249(1.35); C281(0.80); C384(0.95); C385(1.06)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C249(1.01); C281(0.40); C384(0.93); C385(0.88)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C249(1.21); C281(0.57); C384(0.90); C385(0.94)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C249(1.15); C281(0.96); C384(0.87); C385(0.90)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C249(1.54); C281(0.65); C384(0.81); C385(0.76)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C249(1.56); C281(0.75); C384(0.79); C385(0.77)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C249(1.59); C281(0.59); C384(0.87); C385(0.96)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C249(1.45); C281(0.42); C384(0.75); C385(0.90)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C249(2.01); C281(0.49); C384(0.83); C385(0.95)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C249(1.09); C281(0.33); C384(0.99); C385(1.08)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C249(1.05); C281(0.62); C384(0.85); C385(0.97)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C249(1.49); C281(0.72); C384(1.02); C385(1.08)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C249(1.10); C281(0.48); C384(0.92); C385(0.97)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C249(0.94); C281(0.46); C384(0.91); C385(0.97)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C249(1.43); C281(0.47); C384(0.88); C385(1.03)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C249(1.08); C281(0.99); C384(1.02); C385(1.03)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C249(1.08); C281(0.97); C384(0.95); C385(0.87)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C249(1.35); C281(0.84); C384(0.99); C385(0.91)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C249(1.47); C281(0.90); C384(0.92); C385(0.86)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C249(1.08); C281(0.89); C384(1.38); C385(1.34)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C249(1.44); C281(0.97); C384(1.17); C385(1.11)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C249(1.35); C281(0.81); C384(1.14); C385(1.07)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C249(1.32); C281(0.99); C384(0.98); C385(1.33)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C249(1.38); C281(1.50); C384(1.15); C385(1.08)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C249(1.23); C281(1.36); C384(0.82); C385(0.78)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C249(1.18); C281(0.77); C384(1.07); C385(1.04)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C249(1.21); C281(1.44); C384(1.15); C385(1.12)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C249(1.45); C281(1.10); C384(1.14); C385(1.10)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C249(1.13); C281(1.04); C384(0.83); C385(0.79)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C249(1.43); C281(1.35); C384(1.08); C385(1.02)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C249(1.23); C281(1.05); C384(1.14); C385(1.12)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C249(1.26); C384(1.73); C385(1.73); C449(1.22)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C249(0.72); C384(1.76); C385(1.76); C449(1.14)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C249(0.79); C384(1.43); C385(1.43); C449(0.91)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C249(0.68); C384(1.46); C385(1.46); C449(1.21)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C249(0.78); C384(1.22); C385(1.22); C449(0.92)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C249(0.78); C384(1.44); C385(1.44); C449(1.08)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C249(1.29); C384(0.95); C385(0.95); C449(0.82)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C249(0.89); C384(1.18); C385(1.18); C449(0.96)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C249(0.98); C384(1.04); C385(1.04); C449(0.99)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C249(0.83); C384(0.96); C385(0.96); C449(1.07)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C249(0.91); C384(0.83); C385(0.83); C449(0.83)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C249(0.90); C384(1.02); C385(1.02); C449(1.06)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C249(1.37); C281(1.30); C384(1.07); C385(1.45)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C249(0.82); C384(0.99); C385(0.99); C449(0.85)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C249(0.97); C384(0.91); C385(0.91); C449(0.93)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C249(0.85); C384(1.21); C385(1.21); C449(1.12)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C384(0.64); C76(0.76); C88(0.87); C449(1.20)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C76(0.53); C88(0.54); C384(0.88); C454(0.88)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C76(0.65); C88(0.67); C384(0.75); C454(1.02)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C76(0.52); C88(0.59); C384(0.68); C454(0.83)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C76(0.55); C88(0.55); C384(0.72); C454(0.91)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C88(0.51); C76(0.56); C384(0.70); C454(0.79)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C88(0.50); C76(0.51); C454(0.73); C449(0.77)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C76(0.90); C449(1.02); C454(1.02); C384(1.06)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C384(0.65); C76(0.71); C88(0.75); C454(0.92)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C384(0.68); C76(0.71); C88(0.77); C454(0.93)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C76(0.48); C88(0.62); C384(0.76); C454(0.87)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C76(0.48); C88(0.53); C454(0.83); C384(0.87)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C249(1.30); C384(0.87); C449(0.95); C454(0.84)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C249(1.21); C384(0.71); C449(0.99); C454(0.87)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C249(1.21); C384(0.69); C449(0.99); C454(0.93)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C249(0.98); C384(0.77); C449(1.19); C454(1.06)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C454(0.65); C449(0.81); C88(0.85); C76(0.86)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C468(0.47); C76(0.59); C88(0.60); C454(0.69)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C454(0.67); C76(0.81); C449(0.81); C88(0.81)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C76(0.69); C384(0.71); C88(0.75); C385(0.84)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C454(0.76); C76(0.83); C88(0.85); C449(0.87)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C468(0.64); C469(0.74); C76(0.82); C88(0.82)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C454(0.79); C449(0.92); C281(0.92); C384(0.97)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C454(0.70); C463(0.75); C467(0.75); C449(0.76)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C449(0.87); C76(0.93); C249(0.97); C454(1.00)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C467(0.70); C469(0.70); C281(0.70); C522(0.76)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C281(0.46); C88(0.69); C76(0.70); C467(0.70)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C281(0.53); C88(0.66); C76(0.69); C449(0.80)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C281(0.41); C88(0.68); C76(0.73); C522(0.74)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C281(0.53); C76(0.69); C88(0.77); C449(0.77)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C522(0.54); C88(0.72); C76(0.76); C384(0.84)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C281(0.43); C76(0.56); C88(0.66); C385(0.68)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C281(0.53); C76(0.60); C467(0.62); C469(0.62)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C281(0.34); C76(0.48); C88(0.58); C449(0.65)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C76(0.57); C88(0.60); C467(0.72); C469(0.72)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C76(0.53); C88(0.55); C384(0.69); C467(0.72)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C249(0.80); C454(0.98); C384(0.99); C449(1.01)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C249(0.79); C454(0.84); C449(0.86); C384(1.08)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C469(0.79); C249(0.88); C468(0.96); C88(1.04)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C249(0.82); C454(0.96); C449(0.97); C469(1.02)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C249(0.92); C88(0.98); C468(1.01); C454(1.06)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C88(0.62); C76(0.72); C522(0.73); C384(0.90)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C88(0.85); C76(0.88); C469(0.92); C468(0.92)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C76(0.92); C249(0.94); C449(0.99); C469(1.00)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C76(0.85); C249(0.85); C88(0.89); C449(0.92)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C76(0.88); C449(0.88); C454(0.91); C88(0.95)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C88(0.85); C76(0.87); C449(0.89); C249(0.91)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C88(0.82); C76(0.84); C469(0.87); C449(0.94)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C449(0.33); C454(0.33); C281(0.63); C463(0.92)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C449(0.43); C454(0.43); C281(0.72); C76(0.90)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C449(0.34); C454(0.34); C281(0.79); C463(0.87)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C449(0.25); C454(0.25); C281(0.62); C76(0.69)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C88(0.58); C76(0.64); C522(0.73); C384(0.96)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C449(0.27); C454(0.27); C76(0.73); C467(0.74)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C449(0.42); C454(0.42); C463(0.79); C281(0.84)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C449(0.30); C454(0.30); C281(0.66); C463(0.87)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C449(0.49); C454(0.49); C281(0.82); C76(0.87)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C449(0.39); C454(0.39); C463(0.82); C76(0.83)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C449(0.52); C454(0.52); C281(0.79); C463(0.81)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C449(0.36); C454(0.36); C463(0.69); C469(0.71)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C88(0.45); C76(0.49); C449(0.80); C454(0.80)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C76(0.48); C88(0.48); C468(0.63); C469(0.63)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C88(0.44); C76(0.45); C463(0.78); C281(0.83)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C76(0.71); C449(0.82); C454(0.82); C281(0.90)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C76(0.47); C88(0.50); C449(0.73); C454(0.73)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C88(0.51); C76(0.54); C468(0.68); C469(0.68)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C88(0.44); C76(0.46); C463(0.67); C467(0.69)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C88(0.46); C76(0.50); C463(0.69); C467(0.71)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C88(0.47); C76(0.51); C463(0.76); C467(0.81)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C76(0.40); C88(0.41); C385(0.89); C463(0.97)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C88(0.45); C76(0.45); C449(0.88); C454(0.88)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C76(0.38); C88(0.39); C468(0.63); C469(0.63)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C522(0.73); C76(0.83); C88(0.84); C385(0.86)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C249(0.72); C88(0.80); C385(0.81); C384(0.81)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C76(0.87); C281(0.90); C449(0.98); C454(0.98)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C522(0.64); C88(0.78); C249(0.82); C76(0.83)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C522(0.64); C249(0.85); C449(0.90); C454(0.90)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C249(0.76); C88(0.80); C76(0.81); C281(0.98)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C76(0.83); C88(0.83); C522(0.84); C449(0.85)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C249(0.77); C449(0.84); C454(0.84); C88(0.86)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C249(0.74); C449(0.78); C454(0.78); C88(0.91)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C522(0.84); C88(0.85); C249(0.98); C76(0.99)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C76(0.76); C385(0.77); C88(0.78); C249(0.85)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C385(0.73); C384(0.78); C249(0.83); C522(0.83)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C522(0.74); C249(0.78); C76(0.82); C88(0.84)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C76(0.76); C449(0.94); C454(0.94); C281(0.97)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C88(0.79); C76(0.86); C449(0.98); C454(0.98)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C385(0.63); C384(0.73); C522(0.79); C249(0.80)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C449(0.78); C454(0.78); C522(0.83); C249(0.86)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C76(0.52); C449(0.72); C454(0.72); C467(0.83)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C76(0.52); C449(0.68); C454(0.70); C467(0.80)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C76(0.55); C281(0.71); C449(0.74); C454(0.77)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C76(0.62); C88(0.78); C385(0.80); C384(0.82)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C76(0.72); C88(0.83); C384(0.85); C522(0.92)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C76(0.68); C467(0.77); C469(0.77); C88(0.81)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C76(0.49); C88(0.70); C467(0.75); C469(0.75)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C88(0.73); C249(0.77); C281(0.82); C76(0.84)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C76(0.58); C281(0.74); C88(0.79); C449(0.88)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C76(0.50); C88(0.71); C281(0.77); C384(0.82)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C76(0.54); C88(0.64); C384(0.75); C281(0.87)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C281(0.67); C467(0.71); C469(0.71); C76(0.78)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C76(0.69); C88(0.88); C467(0.90); C469(0.90)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C76(0.62); C467(0.64); C469(0.64); C281(0.69)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C76(0.45); C281(0.68); C449(0.71); C454(0.72)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C76(0.43); C88(0.47); C467(0.48); C469(0.48)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C281(0.59); C88(0.63); C76(0.64); C522(0.70)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C249(1.08); C281(0.91); C384(1.16); C385(1.24)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C281(0.92); C76(0.93); C449(1.01); C454(1.01)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C76(0.66); C449(0.88); C454(0.88); C281(0.95)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C522(1.12); C76(0.86); C88(0.86)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HCT 116 C463(0.45); C467(0.45); C384(0.70); C88(0.84)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C463(0.29); C467(0.29); C281(0.67); C76(0.97)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C88(0.64); C76(0.69); C384(0.79); C522(0.89)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C76(0.77); C281(0.81); C449(0.87); C454(0.87)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C281(0.93); C76(0.98); C249(1.08); C449(1.10)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C281(0.74); C249(1.03); C384(1.09); C88(1.13)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C384(0.97); C76(1.00); C281(1.10); C88(1.10)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C454(0.63); C88(0.63); C76(0.65); C449(0.78)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C468(0.54); C88(0.58); C454(0.61); C76(0.64)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C88(0.55); C76(0.55); C454(0.63); C449(0.78)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C88(0.51); C76(0.54); C454(0.60); C449(0.72)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C76(0.66); C88(0.67); C454(0.77); C449(0.85)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C463(0.53); C467(0.53); C384(0.90); C281(0.91)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C76(0.65); C468(0.68); C454(0.69); C88(0.72)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C76(0.67); C454(0.72); C468(0.76); C281(0.77)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C281(0.75); C385(0.78); C384(0.79); C522(0.80)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C76(0.52); C88(0.58); C384(0.61); C385(0.61)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C76(0.70); C88(0.82); C449(0.84); C281(0.86)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C76(0.64); C384(0.69); C88(0.71); C385(0.71)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C88(0.65); C76(0.66); C384(0.72); C385(0.76)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C469(0.73); C88(0.89); C454(0.89); C449(0.91)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C88(0.84); C76(0.87); C469(0.87); C249(0.92)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C469(0.83); C76(0.85); C449(0.89); C88(0.90)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C463(0.63); C467(0.63); C281(0.82); C384(0.92)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C469(0.86); C249(0.90); C384(0.96); C76(0.99)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C463(0.40); C469(0.56); C467(0.72); C449(0.79)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C449(0.29); C454(0.29); C463(0.72); C469(0.85)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C449(0.59); C454(0.59); C385(0.69); C88(0.83)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C449(0.28); C454(0.28); C281(0.70); C76(0.78)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C449(0.68); C454(0.68); C76(0.69); C88(0.70)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C76(0.58); C88(0.61); C468(0.89); C469(0.89)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C76(0.61); C88(0.63); C449(0.77); C454(0.77)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C88(0.47); C76(0.49); C281(0.76); C384(0.82)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C463(0.48); C467(0.48); C384(0.81); C76(1.01)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C463(0.45); C467(0.45); C384(0.85); C281(0.88)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C463(0.35); C467(0.35); C384(0.72); C76(1.03)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C76(0.72); C88(0.74); C449(0.77); C454(0.77)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C88(0.63); C76(0.67); C281(0.75); C469(0.82)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C88(0.62); C76(0.64); C522(0.78); C281(0.91)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C88(0.65); C76(0.65); C281(0.86); C467(0.86)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C463(0.40); C467(0.40); C88(0.88); C384(0.98)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C76(0.51); C88(0.51); C281(0.65); C449(0.81)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C88(0.54); C76(0.56); C281(0.80); C467(0.91)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C76(0.53); C88(0.58); C522(0.84); C449(0.85)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C76(0.55); C88(0.55); C522(0.63); C467(0.79)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C88(0.49); C76(0.52); C449(0.86); C281(0.88)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C249(1.10); C281(0.83); C384(1.12); C385(1.08)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C249(1.15); C281(0.84); C384(1.11); C385(0.94)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C249(1.52); C281(0.91); C384(1.13); C385(0.98)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C249(1.27); C281(0.70); C384(1.27); C385(1.09)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C249(1.29); C281(0.89); C384(1.16); C385(1.05)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C249(1.02); C281(1.02); C384(0.85); C449(1.84)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C249(1.22); C281(0.98); C384(1.20); C385(1.10)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C249(1.12); C281(0.98); C384(0.84); C449(0.80)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C249(1.29); C281(0.80); C384(1.06); C449(0.72)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C249(1.27); C281(0.60); C384(1.08); C449(0.80)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C249(1.41); C281(0.59); C384(0.96); C449(0.78)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C249(1.58); C281(1.24); C384(0.70); C449(1.04)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C249(1.23); C281(0.88); C384(1.17); C449(0.76)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C249(1.69); C281(1.28); C384(0.94); C449(0.80)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C249(1.67); C281(0.97); C384(0.88); C449(0.97)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C249(0.93); C281(1.24); C384(0.73); C449(3.04)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C249(1.08); C281(0.82); C384(0.67); C449(0.92)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C249(1.21); C281(0.97); C384(1.00); C449(0.77)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C249(1.73); C281(1.03); C384(0.84); C449(0.74)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C249(1.35); C281(0.63); C384(0.87); C449(0.69)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C249(1.46); C281(0.75); C384(0.89); C449(0.88)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C249(1.85); C281(0.66); C384(0.96); C449(0.88)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C249(0.78); C281(0.51); C384(0.95); C385(1.14)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C249(0.96); C281(0.83); C384(0.99); C385(1.04)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C249(0.69); C281(0.66); C384(0.74); C385(0.92)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C249(0.84); C281(0.60); C384(0.94); C385(1.11)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C249(1.14); C281(1.05); C384(0.67); C449(1.13)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C249(0.86); C281(0.64); C384(0.82); C385(0.94)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C249(0.80); C281(0.53); C384(0.77); C385(1.08)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C249(0.97); C281(0.48); C384(0.78); C385(0.83)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C249(0.94); C281(1.50); C384(0.63); C385(0.83)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C249(0.61); C281(0.59); C384(0.71); C385(1.03)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C249(0.84); C281(0.66); C384(0.70); C385(1.08)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C249(0.97); C281(0.86); C384(0.73); C385(1.03)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C249(1.02); C281(0.92); C384(0.76); C385(1.15)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C249(0.90); C281(0.57); C384(0.78); C385(1.08)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C249(0.82); C281(0.74); C384(0.80); C385(1.03)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C249(1.48); C281(0.94); C384(0.84); C449(1.15)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C249(0.79); C281(0.54); C384(0.81); C385(0.96)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C249(1.04); C281(0.82); C384(0.91); C385(1.04)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C249(1.14); C281(0.78); C384(0.82); C385(1.04)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C249(1.20); C281(0.92); C384(0.84); C385(0.96)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C249(1.36); C281(0.91); C384(0.83); C385(0.95)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C249(1.04); C281(1.03); C384(0.92); C385(1.01)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C249(1.59); C281(0.76); C384(0.98); C385(1.18)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C249(1.44); C281(1.08); C384(0.95); C385(1.00)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C249(1.27); C281(1.16); C384(0.90); C385(0.90)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C249(1.05); C281(0.75); C384(0.80); C385(0.95)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C249(1.56); C281(0.87); C384(0.99); C449(1.01)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C249(1.28); C281(0.82); C384(0.88); C385(0.91)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C249(1.28); C281(0.90); C384(1.02); C385(1.07)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C249(1.09); C281(0.83); C384(0.90); C385(1.19)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C249(1.16); C281(0.93); C384(0.86); C385(1.03)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C249(1.40); C281(0.97); C384(0.85); C385(0.94)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C249(1.03); C384(0.92); C449(1.33); C454(1.33)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C249(1.13); C384(0.62); C449(1.31); C454(1.31)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C249(1.03); C384(0.86); C449(1.22); C454(1.22)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C249(1.20); C384(0.97); C449(1.24); C454(1.24)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C249(1.41); C281(1.12); C384(0.93); C449(1.05)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C249(1.02); C384(0.86); C449(1.25); C454(1.25)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C249(1.45); C384(0.96); C449(1.29); C454(1.29)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C249(1.42); C384(0.81); C449(1.45); C454(1.45)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C249(1.41); C384(0.77); C449(1.34); C454(1.34)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C249(1.58); C384(0.74); C449(1.19); C454(1.19)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C249(1.09); C384(0.87); C449(1.21); C454(1.21)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C249(1.05); C384(0.86); C449(1.25); C454(1.25)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C249(1.32); C384(0.76); C449(1.24); C454(1.24)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C249(1.23); C384(0.74); C449(1.39); C454(1.39)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C249(1.83); C384(0.73); C449(1.14); C454(1.14)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C249(1.18); C281(1.03); C384(0.79); C449(1.58)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C249(1.09); C384(0.88); C449(1.68); C454(1.68)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C249(1.29); C281(0.79); C384(0.66); C385(0.63)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C249(1.19); C281(0.85); C384(0.61); C385(0.69)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C249(0.99); C281(0.86); C384(0.77); C385(1.05)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C249(1.54); C281(0.86); C384(0.71); C385(0.81)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C249(1.57); C281(0.96); C384(0.76); C385(0.88)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C249(1.24); C281(0.87); C384(0.70); C385(0.80)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C249(1.47); C281(0.89); C384(0.71); C385(0.79)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C249(1.22); C281(0.94); C384(0.77); C385(0.84)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C249(1.24); C281(0.92); C384(0.79); C385(0.90)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C249(1.00); C483(1.04); C522(1.14); C88(1.06)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C384(0.96)  LDD1702  [15]
 LDCM0625  F8 Ramos C249(1.67); C522(0.95)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C249(1.94)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C249(1.15); C522(0.78)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C249(0.73)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C249(0.91)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C249(0.69); C522(2.27)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C249(0.73)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C249(1.00)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C249(1.10)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C249(0.96); C522(2.49)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C249(1.39)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C249(1.10); C522(1.14)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C249(0.84)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C249(1.39); C522(1.40)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C249(1.14); C281(0.84); C384(0.93); C385(1.06)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C249(1.02)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C249(1.02)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C249(1.52); C281(1.09); C384(0.87); C449(0.87)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C249(1.36); C522(0.74)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C249(1.37); C522(0.70)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C249(1.35)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C249(1.26); C522(0.74)  LDD2188  [16]
 LDCM0022  KB02 HCT 116 C449(14.89); C454(14.89); C384(1.36)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C449(20.00); C454(20.00); C384(1.21)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C449(2.30); C454(2.30); C384(1.21)  LDD0082  [5]
 LDCM0131  RA190 MM1.R C249(1.32)  LDD0304  [17]
 LDCM0021  THZ1 HCT 116 C522(0.90)  LDD2173  [5]

References

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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.