Details of the Target

General Information of Target

Target ID LDTP07626
Target Name Rapamycin-insensitive companion of mTOR (RICTOR)
Gene Name RICTOR
Gene ID 253260
Synonyms
KIAA1999; Rapamycin-insensitive companion of mTOR; AVO3 homolog; hAVO3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL
NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV
LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER
DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT
RQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIIN
LCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTEEFIEALLSVDPGRFQD
SWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHIS
VRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFH
EMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRVQKDIFILKDTEEALLINLRDSQVLQH
KENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQ
LTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWLNASSGMKPERSLQNNGLLTTLSQHYF
LFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKI
LTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACED
KANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYV
DLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQN
IITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCE
VLSIRGTCVYVLGLIAKTKQGCDILKCHNWDAVRHSRKHLWPVVPDDVEQLCNELSSIPS
TLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGPIK
DKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVD
FNHSDDFTPISTVQKTLQLETSFMGNKHIEDTGSTPSIGENDLKFTKNFGTENHRENTSR
ERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTVVS
TKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFS
YTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPSRF
MKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQVK
DIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDA
SLFLESTEDTGLQEHTDDNCLYCVCIEILGFQPSNQLSAICSHSDFQDIPYSDWCEQTIH
NPLEVVPSKFSGISGCSDGVSQEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLV
INLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDV
QFLQMHEEAEAVLATPPKQPIVDTSAES
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
RICTOR family
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
TTD ID
T78181
Uniprot ID
Q6R327
DrugMap ID
TT143WL
Ensemble ID
ENST00000296782.9
HGNC ID
HGNC:28611
ChEMBL ID
CHEMBL1795179

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL23 SNV: p.R32L DBIA    Probe Info 
HEC1 SNV: p.L1384S .
HS936T Insertion: p.L923TfsTer38 DBIA    Probe Info 
HT1080 Insertion: p.N1128QfsTer13 DBIA    Probe Info 
IGROV1 SNV: p.W917Ter DBIA    Probe Info 
KASUMI2 SNV: p.E829G DBIA    Probe Info 
KMRC20 SNV: p.A976D .
MCC26 SNV: p.Q1400Ter; p.Q1446K .
MFE319 SNV: p.S1470F .
NCIH1793 SNV: p.Q620E; p.Q620H DBIA    Probe Info 
OV56 SNV: p.N44Y DBIA    Probe Info 
SKMEL5 SNV: p.P1602L DBIA    Probe Info 
VCAP SNV: p.G407A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K1334(0.81); K477(6.67); K507(1.00); K826(4.46)  LDD0277  [2]
BTD
 Probe Info  		C218(1.29)  LDD2127  [3]
Johansson_61
 Probe Info  		_(20.00)  LDD1490  [4]
AHL-Pu-1
 Probe Info  		C1576(4.30); C1012(4.99)  LDD0171  [5]
DBIA
 Probe Info  		C218(5.80); C68(4.94)  LDD0209  [6]
CY4
 Probe Info  		N.A.  LDD0247  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		C987(0.00); C68(0.00); C728(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C1631(0.00); C987(0.00); C728(0.00)  LDD0037  [8]
IPM
 Probe Info  		C1608(0.00); C1317(0.00)  LDD0025  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		C1012(0.00); C1317(0.00); C1631(0.00)  LDD2226  [10]
TFBX
 Probe Info  		C1317(0.00); C132(0.00); C1576(0.00); C218(0.00)  LDD0027  [9]
WYneN
 Probe Info  		C1631(0.00); C1608(0.00); C728(0.00)  LDD0021  [11]
NPM
 Probe Info  		N.A.  LDD0016  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Methacrolein
 Probe Info  		C1576(0.00); C68(0.00)  LDD0218  [12]
AOyne
 Probe Info  		12.00  LDD0443  [13]
NAIA_5
 Probe Info  		C987(0.00); C968(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C1576(4.30); C1012(4.99)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C987(0.98); C218(1.12); C982(1.04); C68(1.04)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C987(1.03); C218(0.91); C68(0.99); C317(1.08)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C987(0.91); C218(0.88); C68(1.10); C1012(1.08)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C987(0.81); C218(0.87); C982(1.09); C1317(1.07)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C218(0.94); C982(1.02); C68(1.03); C1012(1.00)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C987(1.10); C218(0.97); C982(0.95); C1317(0.90)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C987(0.96); C218(1.07); C982(0.99); C68(0.98)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C987(0.94); C218(0.86); C68(1.08); C317(0.99)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C987(1.01); C218(0.99); C68(1.21); C1012(1.13)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C987(1.02); C218(0.95); C68(1.01); C317(1.19)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C987(1.01); C218(0.88); C982(1.05); C1317(1.11)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C987(1.09); C218(0.94); C982(1.05); C68(0.99)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C218(0.93); C982(0.92); C68(0.97); C1012(1.22)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C987(1.12); C218(0.98); C982(0.92); C1317(0.93)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C987(1.00); C218(0.99); C982(0.95); C68(1.02)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C987(0.81); C218(1.12); C982(1.08); C68(1.02)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C987(1.06); C218(0.89); C68(0.97); C317(0.97)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C987(1.00); C218(1.09); C68(0.98); C1012(1.30)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C987(0.88); C218(0.85); C982(1.15); C1317(1.28)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C987(1.04); C218(0.92); C982(0.91); C68(1.06)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C987(0.85); C218(1.15); C68(1.03); C1012(1.02)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C218(0.94); C982(1.03); C68(0.99); C1012(1.06)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C987(1.10); C218(0.97); C982(0.93); C1317(0.93)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C987(1.01); C218(0.97); C982(1.07); C68(1.01)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C987(0.89); C218(1.01); C982(1.03); C68(1.08)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C987(1.03); C218(0.99); C68(1.01); C317(0.97)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C987(0.95); C218(1.07); C68(1.02); C1012(0.99)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C987(0.99); C218(0.84); C982(1.14); C1317(1.20)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C987(1.11); C218(1.03); C982(1.06); C68(1.07)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C218(0.96); C982(1.09); C68(1.07); C1012(0.93)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C987(1.06); C218(0.94); C982(1.01); C1317(0.99)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C987(0.90); C218(0.93); C982(1.06); C1317(1.23)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C987(1.02); C218(0.98); C982(1.13); C68(1.07)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C987(0.97); C218(1.10); C982(0.97); C68(0.98)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C987(1.04); C218(0.92); C68(1.05); C317(1.06)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C987(0.98); C218(1.12); C68(1.00); C1012(1.05)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C987(0.91); C218(0.90); C982(1.13); C1317(1.19)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C987(1.07); C218(0.99); C982(1.01); C68(1.14)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C218(1.03); C982(1.03); C68(1.08); C1012(1.38)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C987(1.03); C218(1.04); C982(0.99); C1317(0.99)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C987(1.13); C218(0.93); C982(1.11); C68(1.10)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C987(1.10); C218(1.21); C982(0.96); C68(0.98)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C987(0.99); C218(0.90); C982(1.10); C68(1.07)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C987(1.12); C218(0.97); C68(1.07); C317(1.07)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C987(0.99); C218(1.06); C68(1.05); C1012(1.12)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C987(0.96); C218(0.82); C982(1.06); C1317(0.92)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C987(1.07); C218(0.98); C982(1.05); C68(1.04)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C218(0.95); C982(1.14); C68(1.08); C1012(1.28)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C987(1.13); C218(0.88); C982(0.96); C1317(1.00)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C987(1.03); C218(1.08); C982(1.13); C68(1.08)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C987(0.87); C218(1.19); C982(1.05); C68(1.04)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C987(0.99); C218(0.96); C68(0.96); C317(1.12)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C987(0.91); C218(1.15); C68(1.04); C1012(0.98)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C218(0.94); C982(1.08); C68(1.03); C1012(0.99)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C987(0.93); C218(0.90); C982(1.16); C1317(1.09)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C987(0.93); C218(0.96); C982(1.16); C68(1.08)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C218(0.96); C982(1.10); C68(1.07); C1012(1.03)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C987(0.99); C218(1.00); C982(1.05); C1317(1.00)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C987(1.08); C218(1.01); C982(1.03); C68(1.11)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C987(0.99); C218(0.95); C982(1.00); C1317(0.96)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C987(0.98); C218(0.86); C982(1.12); C68(1.02)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C987(0.95); C218(0.95); C982(0.97); C68(1.06)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C987(0.91); C218(1.07); C982(1.00); C68(1.03)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C987(1.10); C218(1.06); C982(1.20); C68(1.13)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H264(0.00); C68(0.00)  LDD0222  [12]
 LDCM0367  CL1 HEK-293T C987(0.91); C218(1.18); C982(1.08); C68(1.01)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C218(1.67); C982(1.31); C68(1.10); C1012(1.11)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C987(0.88); C218(1.08); C982(1.07); C68(0.97)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C987(0.92); C218(0.97); C982(1.01); C68(1.02)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C987(0.94); C1012(0.79); C1317(1.01); C317(0.88)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C987(1.03); C218(1.19); C982(0.97); C68(1.03)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C987(0.91); C218(1.13); C982(1.06); C68(1.01)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C987(0.99); C218(1.13); C982(0.99); C68(1.01)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C987(0.97); C1012(0.91); C1317(0.77); C317(1.00)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C987(1.11); C218(1.09); C982(1.01); C68(1.01)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C987(0.91); C218(0.93); C982(1.02); C68(0.95)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C987(0.95); C218(1.08); C982(1.09); C68(0.99)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C987(1.03); C218(1.21); C982(1.06); C1317(0.90)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C987(0.98); C1012(0.85); C1317(0.93); C317(1.20)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C987(1.04); C218(1.31); C982(1.00); C68(1.01)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C987(0.94); C218(1.02); C982(1.02); C68(0.98)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C987(0.98); C218(0.92); C982(0.97); C68(1.06)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C987(0.96); C1012(1.05); C1317(0.67); C317(0.77)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C987(1.03); C218(0.94); C982(1.14); C68(1.07)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C987(0.99); C218(1.04); C982(1.08); C68(1.07)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C987(1.03); C218(1.05); C982(1.09); C68(1.05)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C987(1.11); C1012(0.87); C1317(0.86); C317(1.05)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C987(1.03); C218(1.01); C982(0.96); C68(1.02)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C987(1.08); C218(1.07); C982(1.25); C68(1.10)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C987(1.04); C218(0.98); C982(1.22); C68(1.01)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C987(0.99); C218(1.06); C982(1.03); C68(1.02)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C987(0.96); C1012(1.10); C1317(0.66); C317(1.15)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C987(1.04); C218(1.67); C982(1.06); C68(1.09)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C987(1.07); C218(1.10); C982(1.13); C68(0.98)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C987(0.94); C218(1.02); C982(1.05); C68(1.11)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C987(0.91); C1012(0.92); C1317(0.81); C317(0.89)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C987(0.99); C218(1.06); C982(0.98); C68(1.06)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C987(0.95); C218(0.95); C982(1.10); C68(1.06)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C987(0.98); C218(1.08); C982(1.07); C68(1.00)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C987(0.96); C1012(0.92); C1317(0.95); C317(1.22)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C987(1.05); C218(1.44); C982(1.10); C68(0.98)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C987(1.10); C218(0.93); C982(1.05); C68(1.05)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C987(1.09); C218(1.46); C982(0.97); C68(1.05)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C987(1.08); C218(0.90); C68(1.04); C317(1.20)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C987(0.97); C218(0.84); C68(1.12); C1012(1.39)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C987(0.96); C1012(0.99); C1317(0.85); C317(1.41)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C987(0.91); C218(0.87); C982(1.04); C1317(1.18)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C987(1.13); C218(1.45); C982(1.27); C68(1.01)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C218(1.08); C982(1.01); C68(1.06); C1012(1.00)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C987(0.93); C218(1.12); C982(1.02); C1317(0.94)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C987(1.03); C218(1.00); C982(1.09); C68(1.23)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C987(0.86); C218(1.37); C982(1.06); C68(0.96)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C987(0.88); C1012(0.79); C1317(0.79); C317(1.13)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C987(1.03); C218(1.12); C982(1.01); C68(0.94)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C987(0.89); C218(1.15); C982(1.03); C68(1.10)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C987(0.96); C218(1.25); C982(1.01); C68(0.90)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C987(1.03); C218(1.05); C982(0.99); C68(1.08)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C987(0.97); C218(0.92); C68(1.02); C317(0.84)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C987(0.94); C218(1.34); C68(0.92); C1012(0.85)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C987(0.83); C218(0.95); C982(1.03); C1317(1.49)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C987(1.05); C218(1.67); C982(1.12); C68(1.06)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C218(1.24); C982(1.00); C68(0.99); C1012(0.92)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C987(0.86); C218(1.17); C982(1.04); C1317(0.84)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C987(1.04); C218(1.22); C982(1.13); C68(1.06)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C987(0.88); C218(1.04); C982(0.99); C68(0.97)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C987(0.99); C218(1.10); C982(1.11); C68(0.98)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C987(0.96); C218(1.06); C982(1.09); C68(1.00)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C987(0.87); C218(1.01); C982(1.01); C68(0.99)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C987(0.84); C218(1.31); C982(0.95); C68(0.99)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C987(0.90); C218(1.08); C68(1.07); C317(0.97)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C987(0.92); C218(0.98); C68(1.02); C1012(1.08)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C987(0.83); C218(0.86); C982(1.20); C1317(1.13)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C987(0.93); C218(1.50); C982(1.09); C68(1.08)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C218(1.11); C982(1.05); C68(1.01); C1012(0.90)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C987(0.93); C218(1.09); C982(1.03); C1317(0.80)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C987(1.05); C218(1.30); C982(1.12); C68(1.22)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C987(0.80); C218(1.02); C982(1.02); C68(1.06)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C987(1.03); C218(1.20); C982(1.05); C68(1.05)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C987(0.90); C1012(0.87); C1317(0.68); C317(1.14)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C987(0.82); C218(1.01); C982(1.10); C68(1.07)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C987(0.77); C218(1.33); C982(1.06); C68(1.04)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C987(1.00); C218(1.59); C68(1.11); C317(0.94)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C987(0.95); C218(1.07); C68(1.08); C1012(1.38)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C987(0.74); C218(0.88); C982(1.39); C1317(1.20)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C987(0.98); C218(1.40); C982(1.31); C68(1.08)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C218(1.10); C982(1.05); C68(1.09); C1012(0.83)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C987(0.79); C218(1.12); C982(1.05); C1317(0.84)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C987(0.99); C218(1.27); C68(1.02); C317(0.92)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C987(1.04); C218(1.27); C982(1.27); C68(1.28)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C987(0.88); C218(0.81); C982(1.08); C68(1.02)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C987(0.94); C1012(1.01); C1317(0.71); C317(1.16)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C987(0.99); C218(1.13); C982(1.01); C68(0.99)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C987(0.90); C218(1.07); C982(1.12); C68(1.01)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C987(0.96); C218(1.08); C982(1.06); C68(1.11)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C987(1.06); C218(1.10); C68(1.04); C317(0.98)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C987(0.97); C218(1.32); C68(0.95); C1012(1.29)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C987(0.80); C218(0.94); C982(1.11); C1317(1.13)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C987(1.00); C218(1.24); C982(1.05); C68(1.04)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C987(0.93); C218(1.10); C68(1.04); C1012(1.50)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C218(1.06); C982(1.13); C68(1.05); C1012(0.88)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C987(0.93); C218(1.13); C982(1.05); C1317(0.82)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C987(1.10); C218(1.14); C982(1.12); C68(1.13)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C987(0.99); C218(1.15); C982(1.05); C68(0.93)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C987(0.93); C1012(0.88); C1317(0.74); C317(1.18)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C987(1.03); C218(0.90); C982(1.00); C68(1.03)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C987(0.94); C218(1.25); C982(0.94); C68(0.88)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C987(1.09); C218(0.95); C68(1.01); C317(0.82)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C987(1.02); C218(1.03); C68(1.02); C1012(1.16)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C987(0.87); C218(1.23); C982(1.69); C1317(1.32)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C987(0.93); C218(0.90); C982(1.13); C1317(0.98)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C987(1.07); C218(1.10); C982(1.11); C68(1.11)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C218(1.00); C982(1.07); C68(1.05); C1012(1.11)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C987(1.09); C218(1.15); C982(1.09); C1317(0.90)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C987(1.12); C218(1.29); C982(1.16); C68(0.98)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C987(0.89); C218(1.05); C982(1.04); C68(1.10)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C987(0.97); C1012(0.96); C1317(0.89); C317(1.02)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C987(0.98); C218(1.08); C982(1.01); C68(1.07)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C987(0.96); C218(0.96); C982(1.12); C68(1.13)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C987(0.93); C218(1.12); C982(1.08); C68(1.23)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C987(1.09); C218(1.38); C982(1.15); C68(1.04)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C987(1.04); C218(1.83); C68(1.08); C317(0.97)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C987(0.93); C218(1.29); C68(1.13); C1012(1.31)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C987(0.91); C218(0.99); C982(1.20); C1317(1.32)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C987(1.06); C218(1.11); C982(1.16); C68(1.16)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C218(1.03); C982(1.06); C68(1.05); C1012(0.94)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C987(0.92); C218(1.59); C982(1.20); C1317(0.95)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C987(1.02); C218(1.55); C982(1.29); C68(1.19)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C987(0.97); C218(1.00); C982(1.03); C68(1.02)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C987(0.97); C1012(1.00); C1317(0.72); C317(1.14)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C987(1.03); C218(1.20); C982(0.96); C68(1.02)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C987(0.88); C218(1.15); C982(1.11); C68(1.05)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C987(0.74)  LDD1702  [3]
 LDCM0204  EV-97 T cell C1608(6.40)  LDD0525  [15]
 LDCM0625  F8 Ramos C1608(1.75); C1317(0.69)  LDD2187  [16]
 LDCM0574  Fragment12 Ramos C1317(1.28)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C1317(1.01)  LDD2192  [16]
 LDCM0580  Fragment21 Ramos C1317(0.88)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C1317(1.17)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C1317(1.26)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C1317(0.83)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C1317(1.14)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C1317(1.15)  LDD2200  [16]
 LDCM0468  Fragment33 HEK-293T C987(1.08); C218(1.08); C982(1.04); C68(1.00)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C1317(0.62)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C1608(3.33)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C987(0.86); C1012(0.99); C1317(0.70); C317(1.23)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C1317(1.32)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C1317(1.21)  LDD2205  [16]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [4]
 LDCM0022  KB02 HEK-293T C218(0.82); C1608(1.03); C87(1.06); C1317(0.95)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C218(5.80); C68(4.94)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C959(2.77)  LDD3310  [17]
 LDCM0109  NEM HeLa N.A.  LDD0225  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C218(1.29)  LDD2127  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C475(0.85)  LDD2136  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase mTOR (MTOR) PI3/PI4-kinase family P42345
Integrin-linked protein kinase (ILK) TKL Ser/Thr protein kinase family Q13418
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) . Q8TCU6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840