Details of the Target

General Information of Target

Target ID LDTP03399
Target Name CD82 antigen (CD82)
Gene Name CD82
Gene ID 3732
Synonyms
KAI1; SAR2; ST6; TSPAN27; CD82 antigen; C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; CD antigen CD82
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSACIKVTKYFLFLFNLIFFILGAVILGFGVWILADKSSFISVLQTSSSSLRMGAYVFI
GVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGI
VTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTDNAELMNRPEVTYPCSCEVKG
EEDNSLSVRKGFCEAPGNRTQSGNHPEDWPVYQEGCMEKVQAWLQENLGIILGVGVGVAI
IELLGMVLSICLCRHVHSEDYSKVPKY
Target Bioclass
Other
Family
Tetraspanin (TM4SF) family
Subcellular location
Cell membrane
Function Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
Uniprot ID
P27701
Ensemble ID
ENST00000227155.9
HGNC ID
HGNC:6210

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.P206L .
NUGC3 Deletion: p.A64QfsTer31 .
SW1271 SNV: p.R167L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K114(0.98)  LDD3494  [1]
Jackson_14
 Probe Info  		2.22  LDD0123  [2]
Johansson_61
 Probe Info  		_(14.15)  LDD1485  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0615  Fragment63-R Jurkat _(19.39)  LDD1487  [3]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [3]
 LDCM0569  Fragment7 Jurkat _(14.15)  LDD1485  [3]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.22  LDD0123  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vang-like protein 1 (VANGL1) Vang family Q8TAA9
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metalloproteinase inhibitor 1 (TIMP1) Protease inhibitor I35 (TIMP) family P01033
NKG2-A/NKG2-B type II integral membrane protein (KLRC1) . P26715
Small integral membrane protein 3 (SMIM3) . Q9BZL3

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.