Details of the Target

General Information of Target

Target ID LDTP04849
Target Name CD81 antigen (CD81)
Gene Name CD81
Gene ID 975
Synonyms
TAPA1; TSPAN28; CD81 antigen; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD antigen CD81
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLELGDKPAPNTFYV
GIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIA
KDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNLCPSGSN
IISNLFKEDCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY
Target Bioclass
Transporter and channel
Family
Tetraspanin (TM4SF) family
Subcellular location
Cell membrane
Function
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype. Present in MHC class II compartments, may also play a role in antigen presentation. Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction. In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption. May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels. Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Association with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.; (Microbial infection) Involved in SAMHD1-dependent restriction of HIV-1 replication. May support early replication of both R5- and X4-tropic HIV-1 viruses in T cells, likely via proteasome-dependent degradation of SAMHD1.; (Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms.
Uniprot ID
P60033
Ensemble ID
ENST00000263645.10
HGNC ID
HGNC:1701
ChEMBL ID
CHEMBL1075180

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		3.24  LDD0197  [2]
FBPP2
 Probe Info  		8.50  LDD0318  [3]
CHEMBL5175495
 Probe Info  		10.00  LDD0196  [4]
BTD
 Probe Info  		C190(0.50)  LDD2091  [5]
Jackson_14
 Probe Info  		2.63  LDD0123  [6]
Johansson_61
 Probe Info  		_(4.63)  LDD1485  [7]
DBIA
 Probe Info  		C175(1.70)  LDD0531  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
IPM
 Probe Info  		C157(0.00); C156(0.00); C175(0.00)  LDD2156  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C383
 Probe Info  		12.55  LDD2042  [15]
C388
 Probe Info  		56.10  LDD2047  [15]
FFF probe11
 Probe Info  		5.40  LDD0471  [16]
FFF probe13
 Probe Info  		11.19  LDD0475  [16]
OEA-DA
 Probe Info  		3.08  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C190(0.73)  LDD2117  [5]
 LDCM0214  AC1 HCT 116 C175(1.70)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C175(1.20)  LDD0532  [8]
 LDCM0226  AC11 HCT 116 C175(0.99)  LDD0543  [8]
 LDCM0237  AC12 HCT 116 C175(0.94)  LDD0554  [8]
 LDCM0259  AC14 HCT 116 C175(1.11)  LDD0576  [8]
 LDCM0270  AC15 HCT 116 C175(1.04)  LDD0587  [8]
 LDCM0276  AC17 HEK-293T C6(1.14); C175(1.05); C157(0.91)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C6(1.17); C175(1.04); C157(1.06); C156(0.80)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C175(1.74); C156(0.93)  LDD1517  [18]
 LDCM0279  AC2 HCT 116 C175(1.55)  LDD0596  [8]
 LDCM0280  AC20 HEK-293T C175(1.02); C157(1.04)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C175(1.02); C157(0.95)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C6(1.05); C175(1.00); C157(1.24)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C175(1.03); C156(1.04)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C175(0.97); C157(1.05); C156(0.83)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C6(1.04); C175(0.97); C157(0.91)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C6(1.16); C175(1.09); C157(1.07); C156(1.03)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C175(1.11); C156(0.96)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C175(1.00); C157(0.97)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C175(1.05); C157(1.01)  LDD1528  [18]
 LDCM0290  AC3 HCT 116 C175(1.82)  LDD0607  [8]
 LDCM0291  AC30 HEK-293T C6(1.06); C175(1.17); C157(1.04)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C175(1.06); C156(0.98)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C175(1.10); C157(0.95); C156(0.83)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C6(1.27); C175(1.00); C157(1.07)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C6(1.13); C175(1.02); C157(1.00); C156(1.05)  LDD1534  [18]
 LDCM0296  AC35 HCT 116 C175(0.85)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C175(1.29)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C175(1.00)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C175(1.03)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C175(1.00)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C175(1.54)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C175(1.16)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C175(1.07)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C175(1.23)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C175(0.97)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C175(1.16)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C175(1.08)  LDD0624  [8]
 LDCM0308  AC46 HEK-293T C6(1.08); C175(1.15); C157(1.09)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C175(1.08); C156(0.97)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C175(1.03); C157(0.93); C156(0.86)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C6(1.04); C175(0.88); C157(0.82)  LDD1550  [18]
 LDCM0312  AC5 HCT 116 C175(1.66)  LDD0629  [8]
 LDCM0313  AC50 HEK-293T C6(1.09); C175(1.03); C157(1.06); C156(0.82)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C175(0.97); C156(1.05)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C175(1.07); C157(1.06)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C175(1.04); C157(0.97)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C6(1.08); C175(1.19); C157(0.82)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C175(1.15); C156(1.04)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C175(1.05); C157(0.94); C156(0.93)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C6(1.20); C175(0.99); C157(0.90)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C6(1.13); C175(1.00); C157(0.98); C156(0.92)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C175(0.99); C156(0.91)  LDD1561  [18]
 LDCM0323  AC6 HCT 116 C175(1.17)  LDD0640  [8]
 LDCM0324  AC60 HEK-293T C175(0.99); C157(1.08)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C175(0.98); C157(0.92)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C6(1.04); C175(1.15); C157(0.92)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C175(1.06); C156(0.93)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C175(1.06); C157(1.00); C156(0.81)  LDD1567  [18]
 LDCM0334  AC7 HCT 116 C175(1.22)  LDD0651  [8]
 LDCM0345  AC8 HCT 116 C175(0.99)  LDD0662  [8]
 LDCM0248  AKOS034007472 HCT 116 C175(1.00)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C175(1.09)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C175(1.34)  LDD0592  [8]
 LDCM0498  BS-3668 MDA-MB-231 C190(0.50)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0367  CL1 HEK-293T C6(1.54); C175(1.00); C157(1.21)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C6(2.82); C175(1.90); C157(1.26)  LDD1572  [18]
 LDCM0369  CL100 HCT 116 C175(2.10)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C175(1.32)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C175(1.27)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C175(1.56)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C175(1.28)  LDD0690  [8]
 LDCM0374  CL105 HEK-293T C6(1.05); C175(1.05); C157(1.02)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C175(1.22); C157(1.05); C156(1.12)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C175(1.12)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C6(1.12); C175(1.04); C157(0.93)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C6(1.23); C175(1.00); C157(1.05)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C175(1.51); C156(1.52)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C175(1.21); C157(1.25); C156(1.13)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C175(1.10)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C6(1.18); C175(0.99); C157(0.94)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C6(1.01); C175(0.93); C157(1.03)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C175(1.08); C157(0.98); C156(1.06)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C175(0.95)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C6(1.08); C175(0.90); C157(0.98)  LDD1590  [18]
 LDCM0387  CL117 HCT 116 C175(1.09)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C175(1.39)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C175(1.13)  LDD0706  [8]
 LDCM0390  CL12 HEK-293T C175(1.35); C157(1.09); C156(1.03)  LDD1594  [18]
 LDCM0391  CL120 HCT 116 C175(1.16)  LDD0708  [8]
 LDCM0392  CL121 HEK-293T C6(1.09); C175(1.00); C157(0.91)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C175(1.17); C157(0.92); C156(1.00)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C175(1.60)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C6(1.30); C175(1.10); C157(0.83)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C6(1.15); C175(1.02); C157(0.92)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C175(1.00); C157(0.86); C156(0.69)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C175(0.99)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C6(1.12); C175(0.92); C157(0.92)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C6(1.03); C175(1.04); C157(1.05)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C175(1.01); C157(0.86); C156(1.19)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C175(1.31)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C6(1.12); C175(0.93); C157(0.83)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C6(2.26); C175(1.43); C157(1.02)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C6(1.07); C175(1.18); C157(1.08); C156(0.92)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C175(1.13); C156(1.10)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C175(0.98); C157(0.98); C156(1.17)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C175(1.09); C157(1.17)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C175(1.24); C157(1.00)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C6(1.19); C175(1.49); C157(1.05)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C175(1.46); C156(1.01)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C175(1.35); C157(1.10); C156(0.95)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C6(1.34); C175(1.10); C157(0.83)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C175(0.97); C157(1.19); C156(0.84)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C175(1.03)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C6(1.23); C175(0.91); C157(0.86)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C6(1.17); C175(0.91); C157(0.92)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C175(1.07)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C6(1.10); C175(1.06); C157(1.09); C156(0.91)  LDD1623  [18]
 LDCM0420  CL31 HCT 116 C175(1.93)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C175(1.32)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C175(2.05)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C175(1.73)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C175(1.66)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C175(2.22)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C175(1.92)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C175(2.19)  LDD0745  [8]
 LDCM0429  CL4 HEK-293T C6(1.31); C175(0.98); C157(0.87)  LDD1633  [18]
 LDCM0430  CL40 HCT 116 C175(1.84)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C175(1.81)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C175(1.73)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C175(1.59)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C175(1.39)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C175(1.21)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C175(1.44)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C175(1.86)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C175(1.64)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C175(1.75)  LDD0756  [8]
 LDCM0440  CL5 HEK-293T C6(1.21); C175(0.86); C157(0.82)  LDD1644  [18]
 LDCM0441  CL50 HCT 116 C175(1.76)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C175(1.14)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C175(1.23)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C175(1.75)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C175(1.79)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C175(1.32)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C175(1.66)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C175(1.81)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C175(1.18)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C175(1.62)  LDD0767  [8]
 LDCM0451  CL6 HEK-293T C6(1.69); C175(1.14); C157(1.01); C156(0.86)  LDD1654  [18]
 LDCM0452  CL60 HCT 116 C175(1.82)  LDD0769  [8]
 LDCM0453  CL61 PaTu 8988t C175(0.96)  LDD1332  [8]
 LDCM0454  CL62 PaTu 8988t C175(0.95)  LDD1333  [8]
 LDCM0455  CL63 PaTu 8988t C175(1.40)  LDD1334  [8]
 LDCM0456  CL64 PaTu 8988t C175(1.34)  LDD1335  [8]
 LDCM0457  CL65 PaTu 8988t C175(1.86)  LDD1336  [8]
 LDCM0458  CL66 PaTu 8988t C175(1.47)  LDD1337  [8]
 LDCM0459  CL67 PaTu 8988t C175(1.32)  LDD1338  [8]
 LDCM0460  CL68 PaTu 8988t C175(1.32)  LDD1339  [8]
 LDCM0461  CL69 PaTu 8988t C175(1.78)  LDD1340  [8]
 LDCM0462  CL7 HEK-293T C175(1.00); C156(0.97)  LDD1665  [18]
 LDCM0463  CL70 PaTu 8988t C175(1.18)  LDD1342  [8]
 LDCM0464  CL71 PaTu 8988t C175(1.23)  LDD1343  [8]
 LDCM0465  CL72 PaTu 8988t C175(1.29)  LDD1344  [8]
 LDCM0466  CL73 PaTu 8988t C175(1.08)  LDD1345  [8]
 LDCM0467  CL74 PaTu 8988t C175(1.47)  LDD1346  [8]
 LDCM0469  CL76 PaTu 8988t C175(0.98)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C175(0.93)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C175(1.01)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C175(1.14)  LDD1351  [8]
 LDCM0473  CL8 HEK-293T C175(1.74); C157(1.13)  LDD1676  [18]
 LDCM0474  CL80 PaTu 8988t C175(0.94)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C175(1.15)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C175(1.13)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C175(0.93)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C175(1.19)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C175(1.10)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C175(1.08)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C175(1.05)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C175(1.12)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C175(0.98)  LDD1362  [8]
 LDCM0484  CL9 HEK-293T C175(1.17); C157(0.98)  LDD1687  [18]
 LDCM0485  CL90 PaTu 8988t C175(1.18)  LDD1364  [8]
 LDCM0486  CL91 HCT 116 C175(1.75)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C175(1.85)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C175(1.96)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C175(1.70)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C175(1.80)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C175(1.52)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C175(2.47)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C175(2.61)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C175(2.20)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C175(0.87)  LDD1698  [18]
 LDCM0468  Fragment33 PaTu 8988t C175(1.36)  LDD1347  [8]
 LDCM0427  Fragment51 HCT 116 C175(1.59)  LDD0744  [8]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [7]
 LDCM0569  Fragment7 Jurkat _(4.63)  LDD1485  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C157(0.90)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C157(0.82)  LDD1497  [18]
 LDCM0024  KB05 NALM-6 C175(1.39)  LDD3339  [19]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C190(0.95)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C190(0.73)  LDD2115  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C190(0.93)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C190(0.22)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C190(0.59)  LDD2136  [5]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.63  LDD0123  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Delta(14)-sterol reductase LBR (LBR) ERG4/ERG24 family Q14739
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Methylmalonyl-CoA epimerase, mitochondrial (MCEE) Methylmalonyl-CoA epimerase family Q96PE7
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) . O14672
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Scavenger receptor class B member 1 (SCARB1) CD36 family Q8WTV0
Gap junction alpha-4 protein (GJA4) Connexin family P35212
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Syntaxin-1A (STX1A) Syntaxin family Q16623
Bone marrow stromal antigen 2 (BST2) Tetherin family Q10589
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein mS40 (MRPS18B) Bacterial ribosomal protein bS18 family Q9Y676
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Succinate dehydrogenase assembly factor 4, mitochondrial (SDHAF4) SDHAF4 family Q5VUM1
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840