Details of the Target

General Information of Target

Target ID LDTP08456
Target Name Palmitoyltransferase ZDHHC17 (ZDHHC17)
Gene Name ZDHHC17
Gene ID 23390
Synonyms
HIP14; HIP3; HYPH; KIAA0946; Palmitoyltransferase ZDHHC17; EC 2.3.1.225; Acyltransferase ZDHHC17; EC 2.3.1.-; DHHC domain-containing cysteine-rich protein 17; DHHC17; Huntingtin yeast partner H; Huntingtin-interacting protein 14; HIP-14; Huntingtin-interacting protein 3; HIP-3; Huntingtin-interacting protein H; Putative MAPK-activating protein PM11; Putative NF-kappa-B-activating protein 205; Zinc finger DHHC domain-containing protein 17
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWD
IVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLG
GDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKG
QDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTV
ISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKE
FRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPL
GIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQK
KKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHR
YFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVF
HFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEF
RCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV
Target Bioclass
Enzyme
Family
DHHC palmitoyltransferase family, AKR/ZDHHC17 subfamily
Subcellular location
Golgi apparatus membrane
Function
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3. Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation.
Uniprot ID
Q8IUH5
Ensemble ID
ENST00000426126.7
HGNC ID
HGNC:18412

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.V448A .
HEC1 SNV: p.E4D .
HT SNV: p.Y18H .
KNS42 SNV: p.H352P .
REH SNV: p.A253V .
SNGM SNV: p.S436G .
TE11 SNV: p.P359A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K451(5.50)  LDD0277  [1]
Johansson_61
 Probe Info  		_(20.00)  LDD1490  [2]
HHS-482
 Probe Info  		Y286(1.34)  LDD0285  [3]
HHS-475
 Probe Info  		Y286(4.42)  LDD0264  [4]
DBIA
 Probe Info  		C453(1.02); C456(1.02)  LDD0531  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C453(1.02); C456(1.02)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C453(0.89); C456(0.85)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C453(0.74); C456(0.74)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C453(0.71); C456(0.71)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C453(0.72); C456(0.72)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C453(0.66); C456(0.66)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C453(0.67); C456(0.67)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C453(0.65); C456(0.65)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C453(0.68); C456(0.68)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C453(0.63); C456(0.66)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C453(0.62); C456(0.55)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C453(0.73); C456(0.62)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C453(0.82); C456(0.77)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C453(0.67); C456(0.68)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C453(0.65); C456(0.60)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C453(0.61); C456(0.61)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C453(0.99); C456(0.99)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C453(0.92); C456(0.92)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C453(0.94); C456(0.94)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C453(1.00); C456(1.00)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C453(1.01); C456(1.01)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C453(1.02); C456(1.02)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C453(1.02); C456(1.02)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C453(0.87); C456(0.84)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C453(0.89); C456(0.89)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C453(1.10); C456(1.10)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C453(1.00); C456(1.00)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C453(1.12); C456(1.12)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C453(1.02); C456(1.02)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C453(0.96); C456(0.96)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C453(0.93); C456(0.93)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C453(0.96); C456(0.96)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C453(1.22); C456(1.22)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C453(1.12); C456(1.12)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C453(1.05); C456(1.05)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C453(0.99); C456(0.99)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C453(1.13); C456(1.13)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C453(1.21); C456(1.21)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C453(1.06); C456(1.06)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C453(1.07); C456(1.07)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C453(0.99); C456(0.99)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C453(1.02); C456(1.02)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C453(1.09); C456(1.09)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C453(0.98); C456(0.98)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C453(1.01); C456(0.96)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C453(1.04); C456(1.04)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C453(0.99); C456(0.99)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C453(1.15); C456(1.15)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C453(0.90); C456(0.90)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C453(0.92); C456(0.92)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C453(1.04); C456(1.04)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C453(0.83); C456(0.83)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C453(0.79); C456(0.79)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C453(0.91); C456(0.91)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C453(0.80); C456(0.80)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C456(0.78); C453(0.81)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C453(0.91); C456(0.91)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C453(0.88); C456(0.88)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C453(0.84); C456(0.84)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C453(0.83); C456(0.83)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C453(0.85); C456(0.85)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C453(0.85); C456(0.85)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C453(0.89); C456(0.89)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C453(0.96); C456(0.96)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C453(1.05); C456(1.05)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C453(0.90); C456(0.90)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C453(0.93); C456(0.93)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C453(1.02); C456(1.02)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C453(0.99); C456(0.99)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C453(0.97); C456(0.97)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C453(1.00); C456(1.00)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C453(0.95); C456(0.95)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C453(1.00); C456(1.00)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C453(0.89); C456(0.89)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C453(0.89); C456(0.89)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C453(0.85); C456(0.85)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C453(0.87); C456(0.87)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C453(0.89); C456(0.89)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C453(1.15); C456(1.15)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C453(0.79); C456(0.79)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C453(0.92); C456(0.92)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C453(0.73); C456(0.73)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C453(0.81); C456(0.81)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C453(0.81); C456(0.81)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C453(1.14); C456(1.14)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C453(1.04); C456(1.04)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C453(1.16); C456(1.16)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C453(0.99); C456(0.99)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C453(1.04); C456(1.04)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C453(1.06); C456(1.06)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C453(1.04); C456(1.04)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C453(0.92); C456(0.92)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C453(0.92); C456(0.92)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C453(0.95); C456(0.95)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C453(1.04); C456(1.04)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C453(1.01); C456(1.01)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C453(0.78); C456(0.82)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C456(0.85); C453(0.89)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C453(0.88); C456(0.89)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C453(0.73); C456(0.80)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C453(1.19); C456(1.19)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C453(0.70); C456(0.84)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C453(0.74); C456(0.78)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C453(0.75); C456(0.78)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C453(0.63); C456(0.67)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C453(0.64); C456(0.68)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C453(0.69); C456(0.72)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C453(0.72); C456(0.79)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C453(0.88); C456(0.88)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C453(0.79); C456(0.79)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C453(0.80); C456(0.80)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C453(0.94); C456(0.97)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C453(0.80); C456(0.80)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C453(0.81); C456(0.81)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C453(0.78); C456(0.78)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C453(0.80); C456(0.80)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C453(0.76); C456(0.76)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C453(0.88); C456(0.88)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C453(0.85); C456(0.85)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C453(0.78); C456(0.78)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C453(0.99); C456(0.99)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C453(1.07); C456(1.07)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C453(1.04); C456(1.09)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C453(0.93); C456(0.93)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C453(1.08); C456(1.08)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C453(0.86); C456(0.86)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C453(0.87); C456(0.87)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C453(1.02); C456(1.02)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C453(0.80); C456(0.80)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C453(0.80); C456(0.80)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C453(0.76); C456(0.76)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C453(0.64); C456(0.64)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C453(0.73); C456(0.73)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C456(1.10); C453(1.18)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C453(0.73); C456(0.73)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C453(0.84); C456(0.84)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C453(0.76); C456(0.76)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C453(0.73); C456(0.73)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C453(0.78); C456(0.78)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C453(0.79); C456(0.79)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C453(0.86); C456(0.86)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C453(0.99); C456(0.99)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C453(0.91); C456(0.91)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C453(0.87); C456(0.87)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C453(1.17); C456(1.17)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C453(0.87); C456(0.87)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C453(0.80); C456(0.80)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C453(0.92); C456(0.92)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C453(0.78); C456(0.78)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C453(0.98); C456(0.98)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C453(0.79); C456(0.79)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C453(0.80); C456(0.80)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C453(0.65); C456(0.65)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C453(0.79); C456(0.79)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C453(0.90); C456(0.86)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C456(0.95); C453(1.06)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C453(0.90); C456(0.90)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C453(0.94); C456(0.94)  LDD2171  [5]
 LDCM0367  CL1 HCT 116 C456(1.02); C453(1.04)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C453(0.87); C456(0.88)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C453(0.96); C456(0.96)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C456(1.10); C453(1.11)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C456(0.93); C453(1.02)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C456(1.14); C453(1.27)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C456(0.97); C453(1.05)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C453(0.91); C456(0.91)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C453(0.87); C456(0.87)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C453(0.91); C456(0.91)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C453(0.94); C456(0.94)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C453(0.94); C456(0.94)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C453(1.12); C456(1.22)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C453(0.90); C456(0.90)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C453(0.79); C456(0.79)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C453(0.88); C456(0.88)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C453(0.77); C456(0.77)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C453(0.78); C456(0.78)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C453(0.74); C456(0.74)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C453(0.80); C456(0.80)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C453(0.90); C456(0.90)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C453(0.99); C456(0.99)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C453(1.00); C456(1.00)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C453(1.13); C456(1.17)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C453(0.89); C456(0.89)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C456(1.30); C453(1.33)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C456(0.78); C453(0.82)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C456(0.77); C453(0.83)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C453(0.78); C456(0.94)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C453(1.04); C456(1.04)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C453(0.94); C456(0.94)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C453(0.93); C456(0.93)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C453(0.90); C456(0.90)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C453(1.00); C456(1.01)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C453(1.11); C456(1.13)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C453(1.18); C456(1.18)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C453(0.86); C456(0.86)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C453(0.98); C456(0.98)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C453(0.94); C456(0.94)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C453(1.03); C456(1.03)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C456(1.15); C453(1.16)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C453(1.07); C456(1.07)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C453(1.09); C456(1.09)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C453(1.12); C456(1.12)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C453(0.99); C456(0.99)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C453(1.05); C456(1.05)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C453(0.89); C456(0.89)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C453(0.87); C456(0.87)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C453(1.07); C456(1.07)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C453(0.95); C456(0.95)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C453(1.07); C456(1.07)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C453(1.20); C456(1.13)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C453(1.06); C456(1.06)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C453(0.84); C456(0.84)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C453(0.73); C456(0.73)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C453(0.79); C456(0.79)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C453(0.81); C456(0.81)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C453(0.67); C456(0.67)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C453(0.85); C456(0.85)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C453(0.76); C456(0.76)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C453(0.73); C456(0.73)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C453(1.12); C456(1.14)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C453(0.74); C456(0.74)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C453(0.73); C456(0.73)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C453(0.71); C456(0.71)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C453(0.65); C456(0.65)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C453(0.69); C456(0.69)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C453(0.65); C456(0.65)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C453(0.96); C456(0.96)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C453(0.91); C456(0.91)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C453(0.98); C456(0.98)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C453(0.98); C456(0.98)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C453(1.11); C456(1.12)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C453(0.89); C456(0.89)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C453(1.00); C456(1.00)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C453(0.96); C456(0.96)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C453(0.99); C456(0.99)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C453(0.95); C456(0.95)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C453(1.05); C456(1.05)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C453(0.95); C456(0.95)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C453(0.93); C456(0.93)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C453(0.89); C456(0.89)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C453(0.94); C456(0.94)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C453(1.10); C456(1.17)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C453(0.85); C456(0.85)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C453(0.94); C456(0.94)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C453(0.95); C456(0.95)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C453(0.89); C456(0.89)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C453(0.94); C456(0.94)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C453(0.96); C456(0.96)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C453(0.89); C456(0.89)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C453(0.89); C456(0.89)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C453(0.96); C456(0.96)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C453(0.93); C456(0.93)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C453(1.27); C456(1.24)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C453(0.89); C456(0.89)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C453(0.82); C456(0.82)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C453(0.96); C456(0.96)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C453(0.85); C456(0.85)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C453(0.89); C456(0.89)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C453(0.99); C456(1.03)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C453(0.88); C456(0.92)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C453(0.93); C456(0.93)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C453(0.92); C456(0.95)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C453(0.93); C456(1.02)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C453(0.97); C456(0.96)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C453(0.95); C456(0.96)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C453(1.02); C456(1.05)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C453(0.95); C456(0.98)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C453(1.03); C456(1.06)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C453(0.87); C456(0.87)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C453(0.92); C456(0.93)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C453(0.90); C456(0.90)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C453(1.05); C456(1.05)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C453(1.05); C456(1.02)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C453(1.18); C456(1.28)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C453(0.98); C456(1.01)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C453(0.95); C456(0.95)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C453(0.91); C456(0.91)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C453(0.99); C456(0.99)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C453(0.98); C456(0.98)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C453(0.95); C456(0.95)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C453(1.07); C456(1.07)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C453(1.09); C456(1.09)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C453(1.00); C456(1.00)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C453(1.04); C456(1.04)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C453(1.02)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C453(1.12); C456(1.12)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C453(0.84); C456(0.84)  LDD0744  [5]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [2]
 LDCM0116  HHS-0101 DM93 Y286(4.42)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y286(0.06)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y286(4.35)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y286(1.17)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y286(1.27)  LDD0268  [4]
 LDCM0123  JWB131 DM93 Y286(1.34)  LDD0285  [3]
 LDCM0124  JWB142 DM93 Y286(0.31)  LDD0286  [3]
 LDCM0125  JWB146 DM93 Y286(0.44)  LDD0287  [3]
 LDCM0126  JWB150 DM93 Y286(0.05)  LDD0288  [3]
 LDCM0127  JWB152 DM93 Y286(1.01)  LDD0289  [3]
 LDCM0128  JWB198 DM93 Y286(0.42)  LDD0290  [3]
 LDCM0129  JWB202 DM93 Y286(0.96)  LDD0291  [3]
 LDCM0130  JWB211 DM93 Y286(0.26)  LDD0292  [3]
 LDCM0022  KB02 HEK-293T C456(0.93)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C456(1.00)  LDD1497  [7]
 LDCM0024  KB05 SNU-245 C453(2.21)  LDD3440  [8]
 LDCM0021  THZ1 HCT 116 C453(0.94); C456(0.94)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
Ubiquitin carboxyl-terminal hydrolase 32 (USP32) Peptidase C19 family Q8NFA0
Calpain-2 catalytic subunit (CAPN2) Peptidase C2 family P17655
Kallikrein-8 (KLK8) Peptidase S1 family O60259
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E) Phosphatase 2A regulatory subunit B56 family Q16537
Glycogen synthase kinase-3 alpha (GSK3A) CMGC Ser/Thr protein kinase family P49840
Ras-related protein Rab-39B (RAB39B) Rab family Q96DA2
Elongation factor 1-alpha 1 (EEF1A1) Classic translation factor GTPase family P68104
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Sodium/hydrogen exchanger 9 (SLC9A9) Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family Q8IVB4
Synaptosomal-associated protein 23 (SNAP23) SNAP-25 family O00161
Synaptosomal-associated protein 25 (SNAP25) SNAP-25 family P60880
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc fingers and homeoboxes protein 1, isoform 2 (ZHX1-C8orf76) . Q96EF9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 3 subunit E (EIF3E) EIF-3 subunit E family P60228
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgi phosphoprotein 3-like (GOLPH3L) GOLPH3/VPS74 family Q9H4A5
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Intraflagellar transport protein 57 homolog (IFT57) IFT57 family Q9NWB7
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP) MRL family Q7Z5R6
Neuronal membrane glycoprotein M6-a (GPM6A) Myelin proteolipid protein family P51674
Actin-binding protein WASF2 (WASF2) SCAR/WAVE family Q9Y6W5
Protein sprouty homolog 2 (SPRY2) Sprouty family O43597
Protein sprouty homolog 3 (SPRY3) Sprouty family O43610
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
Fasciculation and elongation protein zeta-2 (FEZ2) Zygin family Q9UHY8
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
DnaJ homolog subfamily C member 5 (DNAJC5) . Q9H3Z4
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840