Details of the Target

General Information of Target

Target ID LDTP07208
Target Name Alpha/beta hydrolase domain-containing protein 17B (ABHD17B)
Gene Name ABHD17B
Gene ID 51104
Synonyms
C9orf77; FAM108B1; Alpha/beta hydrolase domain-containing protein 17B; Abhydrolase domain-containing protein 17B; EC 3.1.2.22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNNLSFSELCCLFCCPPCPGKIASKLAFLPPDPTYTLMCDESGSRWTLHLSERADWQYSS
REKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGNAVDLGQMSSFYIGLGSRINC
NIFSYDYSGYGASSGKPTEKNLYADIEAAWLALRTRYGIRPENVIIYGQSIGTVPSVDLA
ARYESAAVILHSPLTSGMRVAFPDTKKTYCFDAFPNIDKISKITSPVLIIHGTEDEVIDF
SHGLALFERCQRPVEPLWVEGAGHNDVELYGQYLERLKQFVSQELVNL
Target Bioclass
Enzyme
Family
AB hydrolase superfamily, ABHD17 family
Subcellular location
Cell membrane
Function
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Has depalmitoylating activity towards GAP43. Has depalmitoylating activity towards MAP6. Has depalmitoylating activity towards NRAS.
Uniprot ID
Q5VST6
Ensemble ID
ENST00000333421.7
HGNC ID
HGNC:24278
ChEMBL ID
CHEMBL2189132

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.A245T .
RKO SNV: p.Q283H .
SW756 SNV: p.H49L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		3.26  LDD0197  [1]
TG42
 Probe Info  		4.41  LDD0043  [2]
STPyne
 Probe Info  		K206(0.83); K207(5.56)  LDD0277  [3]
DBIA
 Probe Info  		C39(0.97)  LDD3317  [4]
Johansson_61
 Probe Info  		_(4.04)  LDD1487  [5]
AHL-Pu-1
 Probe Info  		C39(4.59); C210(2.30)  LDD0171  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C120(0.00); C210(0.00); C39(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C81(0.00); C120(0.00); C68(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C250(0.00); C68(0.00); C120(0.00); C39(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
IPM
 Probe Info  		C210(0.00); C250(0.00)  LDD2156  [10]
TFBX
 Probe Info  		C86(0.00); C210(0.00)  LDD0148  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C39(4.59); C210(2.30)  LDD0171  [6]
 LDCM0214  AC1 HEK-293T C81(0.97); C250(1.02); C210(1.11); C39(0.91)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C81(0.91); C250(1.12); C210(1.03); C39(1.27)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C81(0.90); C250(1.01); C210(1.00); C39(1.24)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C250(0.99); C210(1.05); C39(0.89); C68(0.95)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C250(1.02); C210(1.04); C39(1.07); C68(0.94)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C81(0.68); C250(1.05); C210(1.13); C39(1.16)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C81(0.79); C250(0.99); C210(1.04); C39(1.06)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C81(1.04); C250(1.08); C210(1.04); C39(0.68)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C81(0.84); C250(1.17); C210(1.10); C39(0.92)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C81(1.04); C250(1.13); C210(0.95); C39(1.18)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C250(1.02); C210(1.04); C39(0.82); C68(0.89)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C81(0.85); C250(0.97); C210(1.10); C39(1.16)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C250(0.98); C210(0.98); C39(1.15); C68(0.92)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C81(0.95); C250(0.93); C210(1.02); C39(1.12)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C81(1.20); C250(0.88); C210(0.87); C39(0.90)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C81(0.59); C250(1.07); C210(1.10); C39(1.07)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C81(1.15); C250(1.18); C210(1.01); C39(0.89)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C81(0.78); C250(0.98); C210(1.02); C39(1.12)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C250(1.15); C210(1.05); C39(0.77); C68(0.96)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C81(0.82); C250(1.05); C210(1.11); C39(0.89)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C81(0.76); C250(1.03); C210(0.97); C39(1.17)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C250(0.99); C210(0.94); C39(1.02); C68(1.05)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C81(0.72); C250(0.92); C210(1.01); C39(1.02)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C81(0.96); C250(0.91); C210(0.91); C39(0.97)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C81(0.94); C250(0.99); C210(0.99); C39(1.06)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C81(1.12); C250(1.07); C210(1.01); C39(1.37)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C81(0.75); C250(1.01); C210(1.00); C39(1.05)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C250(1.02); C210(1.04); C39(0.80); C68(1.06)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C81(0.92); C250(0.96); C210(1.10); C39(1.29)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C250(0.98); C210(0.96); C39(1.02); C68(0.93)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C81(0.82); C250(1.05); C210(0.94); C39(0.99)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C250(0.97); C210(1.05); C39(0.98); C68(1.01)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C81(0.93); C250(0.91); C210(0.92); C39(0.96)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C81(0.58); C250(1.01); C210(1.02); C39(1.68)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C81(1.09); C250(1.18); C210(1.00); C39(0.89)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C81(0.74); C250(0.95); C210(1.04); C39(1.02)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C250(1.10); C210(1.04); C39(0.86); C68(1.13)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C81(0.64); C250(0.99); C210(0.99); C39(1.02)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C250(1.12); C210(1.04); C39(0.99); C68(0.90)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C81(0.81); C250(1.09); C210(1.02); C39(1.10)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C81(0.81); C250(0.94); C210(0.87); C39(1.05)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C81(0.78); C250(1.11); C210(1.05); C39(1.05)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C81(0.69); C250(0.96); C210(1.11); C39(0.88)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C81(1.00); C250(1.02); C210(1.04); C39(0.98)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C81(1.10); C250(1.00); C210(0.99); C39(1.15)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C250(1.01); C210(1.01); C39(0.98); C68(1.03)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C81(0.79); C250(1.04); C210(1.11); C39(1.08)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C250(1.07); C210(1.04); C39(1.17); C68(0.96)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C81(0.89); C250(1.07); C210(1.09); C39(0.97)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C81(1.26); C250(0.99); C210(0.90); C39(1.01)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C81(0.79); C250(0.97); C210(1.04); C39(1.21)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C81(1.31); C250(1.09); C210(1.01); C39(1.03)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C81(1.07); C250(0.98); C210(1.00); C39(1.12)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C250(1.03); C210(1.03); C39(1.04); C68(0.99)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C250(0.98); C210(1.04); C39(0.97); C68(0.97)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C81(1.03); C250(1.08); C210(1.12); C39(1.05)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C250(0.95); C210(0.96); C39(1.04); C68(0.98)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C81(1.55); C250(0.96); C210(1.06); C39(1.06)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C81(0.98); C250(0.99); C210(0.90); C39(1.12)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C81(1.06); C250(1.00); C210(1.03); C39(1.01)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C81(0.97); C250(0.97); C210(0.94); C39(1.11)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C81(0.72); C250(1.01); C210(1.11); C39(0.96)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C81(0.66); C250(0.97); C210(1.02); C39(1.07)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C81(0.93); C250(0.94); C210(0.96); C39(1.01)  LDD1514  [12]
 LDCM0367  CL1 HEK-293T C81(0.76); C250(1.21); C210(1.30); C39(0.94)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C250(1.27); C210(1.51); C39(1.14); C68(1.05)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C81(0.97); C250(1.00); C210(1.18); C39(0.91)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C81(0.87); C250(0.97); C210(1.17); C39(1.52)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C250(1.19); C210(1.36); C39(1.08); C68(1.01)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C81(0.80); C250(1.19); C210(1.06); C39(1.17)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C81(0.72); C250(1.05); C210(1.12); C39(0.76)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C81(0.79); C250(0.85); C210(0.99); C39(1.22)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C250(1.23); C210(1.11); C39(1.23); C68(1.01)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C81(0.82); C250(1.08); C210(0.91); C39(0.97)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C81(0.74); C250(1.03); C210(1.07); C39(0.84)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C81(1.05); C250(1.04); C210(1.10); C39(0.88)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C81(0.88); C250(1.02); C210(1.24); C39(1.00)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C250(1.23); C210(1.35); C39(1.11); C68(1.00)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C81(0.65); C250(1.08); C210(1.27); C39(0.94)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C81(0.63); C250(1.11); C210(1.09); C39(1.12)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C81(1.43); C250(1.01); C210(0.92); C39(1.21)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C250(1.20); C210(1.41); C39(0.66); C68(1.03)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C81(0.76); C250(1.09); C210(1.01); C39(0.97)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C81(0.58); C250(1.16); C210(1.01); C39(0.84)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C81(0.82); C250(1.02); C210(0.92); C39(1.25)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C250(1.13); C210(1.00); C39(0.86); C68(1.01)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C81(0.93); C250(1.07); C210(1.01); C39(1.06)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C81(0.81); C250(0.92); C210(1.08); C39(0.94)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C81(0.65); C250(0.99); C210(1.02); C39(1.28)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C81(0.83); C250(1.08); C210(0.99); C39(1.16)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C250(1.12); C210(1.11); C39(1.11); C68(1.00)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C81(1.01); C250(1.37); C210(1.54); C39(0.99)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C81(0.58); C250(1.07); C210(1.26); C39(0.91)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C81(0.93); C250(0.98); C210(0.96); C39(1.24)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C250(1.11); C210(1.04); C39(1.64); C68(0.91)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C81(0.98); C250(1.06); C210(1.13); C39(1.03)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C81(0.72); C250(1.03); C210(1.06); C39(0.95)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C81(0.85); C250(0.96); C210(1.14); C39(0.93)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C250(1.05); C210(0.94); C39(1.08); C68(0.84)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C81(0.90); C250(1.39); C210(1.93); C39(1.13)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C81(0.79); C250(1.07); C210(1.01); C39(0.97)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C81(0.70); C250(1.20); C210(1.69); C39(1.05)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C81(0.85); C250(0.93); C210(1.01); C39(1.20)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C81(0.67); C250(1.06); C210(1.08); C39(1.16)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C250(0.95); C210(0.94); C39(1.62); C68(0.95)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C250(0.89); C210(1.14); C39(0.96); C68(1.02)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C81(0.93); C250(1.10); C210(1.97); C39(1.52)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C250(0.95); C210(1.15); C39(1.09); C68(0.99)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C81(0.93); C250(1.08); C210(1.06); C39(0.99)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C81(0.97); C250(0.91); C210(0.96); C39(1.10)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C81(0.85); C250(1.13); C210(1.70); C39(1.21)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C250(1.04); C210(1.00); C39(1.29); C68(0.84)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C81(0.73); C250(1.00); C210(1.01); C39(1.12)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C81(0.71); C250(1.07); C210(1.07); C39(0.83)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C81(0.78); C250(1.10); C210(1.02); C39(1.26)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C81(0.69); C250(1.32); C210(1.14); C39(1.20)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C81(0.87); C250(1.09); C210(0.96); C39(1.29)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C81(0.80); C250(1.06); C210(1.15); C39(1.04)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C250(0.91); C210(1.17); C39(0.78); C68(0.91)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C81(1.02); C250(1.35); C210(1.92); C39(1.01)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C250(1.01); C210(1.17); C39(0.98); C68(0.96)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C81(0.96); C250(0.85); C210(1.12); C39(1.07)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C81(1.14); C250(0.84); C210(1.08); C39(1.11)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C81(1.21); C250(1.01); C210(0.98); C39(0.97)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C81(0.72); C250(1.05); C210(1.11); C39(1.10)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C81(0.66); C250(1.08); C210(1.21); C39(1.13)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C81(0.61); C250(0.90); C210(0.97); C39(0.91)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C81(0.86); C250(1.01); C210(1.21); C39(0.83)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C81(1.06); C250(1.18); C210(0.96); C39(1.07)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C81(1.07); C250(0.99); C210(1.11); C39(1.05)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C250(0.92); C210(1.11); C39(0.81); C68(0.99)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C81(0.67); C250(0.97); C210(1.49); C39(0.98)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C250(0.84); C210(1.07); C39(1.19); C68(1.04)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C81(0.81); C250(0.91); C210(1.04); C39(1.29)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C81(1.19); C250(0.85); C210(1.14); C39(1.06)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C81(0.97); C250(1.15); C210(0.96); C39(0.81)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C81(0.79); C250(0.98); C210(1.04); C39(1.08)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C250(1.12); C210(1.19); C39(0.83); C68(1.05)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C81(0.70); C250(1.13); C210(1.07); C39(0.86)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C81(0.96); C250(1.03); C210(1.55); C39(1.05)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C81(0.81); C250(1.33); C210(1.55); C39(0.88)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C81(0.80); C250(0.94); C210(1.04); C39(1.18)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C250(0.98); C210(1.08); C39(1.12); C68(1.05)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C81(0.94); C250(1.05); C210(1.37); C39(0.92)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C250(1.02); C210(1.17); C39(0.97); C68(0.96)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C81(0.85); C250(1.09); C210(1.11); C39(0.94)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C81(0.80); C250(1.49); C210(1.44); C39(1.17)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C81(0.99); C250(0.88); C210(0.95); C39(1.11)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C81(0.88); C250(1.06); C210(0.97); C39(1.00)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C250(1.07); C210(1.00); C39(1.29); C68(0.90)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C81(0.86); C250(1.01); C210(0.98); C39(1.06)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C81(0.65); C250(1.13); C210(1.48); C39(0.74)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C81(0.76); C250(0.99); C210(1.06); C39(1.62)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C81(0.93); C250(0.99); C210(1.02); C39(1.10)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C81(1.27); C250(0.98); C210(1.03); C39(1.41)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C250(0.86); C210(1.12); C39(1.07); C68(1.05)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C81(0.73); C250(1.00); C210(1.30); C39(1.04)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C81(0.85); C250(1.00); C210(1.14); C39(1.22)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C250(0.89); C210(1.03); C39(1.17); C68(0.99)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C81(0.75); C250(0.94); C210(1.04); C39(0.93)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C81(0.93); C250(0.89); C210(0.98); C39(1.12)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C81(0.96); C250(1.12); C210(1.02); C39(0.86)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C250(1.15); C210(0.96); C39(1.33); C68(1.03)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C81(0.79); C250(1.01); C210(0.99); C39(0.80)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C81(0.90); C250(1.13); C210(1.40); C39(0.39)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C81(1.04); C250(1.17); C210(0.95); C39(0.93)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C81(0.84); C250(1.01); C210(1.08); C39(0.98)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C250(1.71); C210(1.74); C39(0.67); C68(1.18)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C250(0.95); C210(1.01); C39(0.87); C68(0.93)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C81(0.99); C250(1.17); C210(1.15); C39(1.09)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C250(0.96); C210(1.04); C39(0.93); C68(1.09)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C81(0.82); C250(1.07); C210(1.17); C39(1.18)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C81(1.03); C250(0.96); C210(1.20); C39(0.97)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C81(0.94); C250(1.02); C210(0.87); C39(1.13)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C250(1.13); C210(1.06); C39(1.38); C68(1.09)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C81(0.74); C250(1.11); C210(1.11); C39(1.18)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C81(0.63); C250(1.03); C210(1.03); C39(0.94)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C81(0.96); C250(0.99); C210(1.09); C39(0.93)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C81(0.75); C250(1.05); C210(1.38); C39(1.10)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C81(0.97); C250(1.95); C210(1.90); C39(0.74)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C81(0.83); C250(0.98); C210(1.01); C39(1.10)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C250(1.05); C210(1.28); C39(0.69); C68(1.10)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C81(0.88); C250(1.17); C210(1.55); C39(1.01)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C250(1.04); C210(1.10); C39(1.03); C68(0.99)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C81(1.00); C250(1.60); C210(1.58); C39(0.80)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C81(1.02); C250(0.98); C210(1.36); C39(1.06)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C81(0.97); C250(1.27); C210(1.21); C39(0.87)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C250(1.14); C210(1.12); C39(1.63); C68(0.94)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C81(0.92); C250(1.00); C210(1.04); C39(1.27)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C81(0.79); C250(1.01); C210(1.06); C39(1.31)  LDD1698  [12]
 LDCM0625  F8 Ramos C210(0.74)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C210(0.24); C250(0.22)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C39(1.29)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C210(0.52); C39(0.80)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C210(0.75); C250(1.77)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C250(0.16)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C210(1.05); C39(1.12)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C210(0.91); C39(0.92); C250(0.48)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C210(0.71)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C210(0.79); C250(1.17)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C210(0.73)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C210(0.85); C250(0.24)  LDD2200  [13]
 LDCM0468  Fragment33 HEK-293T C81(0.89); C250(1.18); C210(1.07); C39(1.04)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C210(0.90); C39(0.97); C250(0.61)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C210(0.32); C250(1.22)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C250(0.97); C210(0.96); C39(0.85); C68(0.93)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C210(0.68); C250(0.30)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C210(0.52); C250(0.27)  LDD2205  [13]
 LDCM0615  Fragment63-R Jurkat _(4.04)  LDD1487  [5]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [5]
 LDCM0022  KB02 HEK-293T C68(0.94); C250(0.98); C120(1.00); C210(0.83)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C68(0.92); C250(1.06); C120(0.97); C210(0.93)  LDD1497  [12]
 LDCM0024  KB05 MEL182 C39(0.97)  LDD3317  [4]

References

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2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578