Details of the Target

General Information of Target

Target ID LDTP12188
Target Name Arsenite methyltransferase (AS3MT)
Gene Name AS3MT
Gene ID 57412
Synonyms
CYT19; Arsenite methyltransferase; EC 2.1.1.137; Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLWLLFFLVTAIHAELCQPGAENAFKVRLSIRTALGDKAYAWDTNEEYLFKAMVAFSMRK
VPNREATEISHVLLCNVTQRVSFWFVVTDPSKNHTLPAVEVQSAIRMNKNRINNAFFLND
QTLEFLKIPSTLAPPMDPSVPIWIIIFGVIFCIIIVAIALLILSGIWQRRRKNKEPSEVD
DAEDKCENMITIENGIPSDPLDMKGGHINDAFMTEDERLTPL
Target Bioclass
Enzyme
Family
Methyltransferase superfamily, Arsenite methyltransferase family
Subcellular location
Cytoplasm, cytosol
Function
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH.
Uniprot ID
Q9HBK9
Ensemble ID
ENST00000369880.8
HGNC ID
HGNC:17452
ChEMBL ID
CHEMBL4295950

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.L328S .
HT115 SNV: p.E191Ter .
KYM1 SNV: p.I9V DBIA    Probe Info 
SNU449 SNV: p.S79N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBP2
 Probe Info  		2.08  LDD0317  [1]
Johansson_61
 Probe Info  		_(4.65)  LDD1490  [2]
DBIA
 Probe Info  		C360(11.65); C369(11.65); C368(3.41); C32(2.27)  LDD0080  [3]
IA-alkyne
 Probe Info  		C226(0.00); C271(0.00); C334(0.00); C250(0.00)  LDD0165  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
WYneO
 Probe Info  		N.A.  LDD0022  [6]
IPM
 Probe Info  		N.A.  LDD0005  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
W1
 Probe Info  		C334(0.00); C32(0.00)  LDD0236  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C206(0.98); C226(1.34); C360(0.95); C368(0.95)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C206(1.02); C226(0.76); C32(0.94); C360(1.65)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C206(0.98); C226(1.33); C32(1.10); C360(0.73)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C206(1.05); C226(1.42); C32(1.48); C360(0.79)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C206(0.99); C226(1.30); C32(0.99); C360(0.81)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C206(0.98); C226(0.92); C32(1.18); C360(0.67)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C206(0.97); C226(0.96); C32(1.10); C360(0.76)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C206(1.00); C226(1.33); C32(0.94); C360(1.04)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C206(1.12); C226(1.46); C32(1.17); C360(1.08)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C206(0.95); C226(1.38); C32(1.20); C360(0.82)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C206(1.03); C226(1.25); C32(1.50); C360(1.06)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C206(1.01); C226(1.25); C32(1.13); C360(0.99)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C206(0.93); C226(0.82); C32(0.86); C360(1.51)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C206(0.78); C226(1.48); C32(0.87); C360(0.33)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C206(0.85); C226(1.39); C32(0.87); C360(0.42)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C206(0.76); C226(1.19); C32(0.97); C360(0.35)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C206(1.07); C32(1.24); C61(1.02); C85(0.98)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C206(1.04); C32(1.54); C61(0.86); C85(1.12)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C206(1.15); C32(1.34); C61(0.95); C85(1.17)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C206(1.02); C32(1.33); C61(1.22); C85(1.73)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C206(1.24); C32(1.35); C61(0.90); C85(1.07)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C206(1.15); C32(1.49); C61(1.01); C85(1.38)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C206(1.15); C32(1.73); C61(0.93); C85(1.25)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C206(0.95); C226(0.90); C32(0.85); C360(1.53)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C206(1.05); C32(1.50); C61(1.08); C85(0.94)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C206(0.96); C32(1.27); C61(0.84); C85(1.09)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C206(0.94); C32(1.41); C61(0.63); C85(0.93)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C206(1.08); C32(1.18); C61(0.56); C85(1.17)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C206(1.07); C32(1.66); C61(0.91); C85(0.90)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C206(1.03); C32(1.25); C61(0.60); C85(1.11)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C206(0.81); C32(1.26); C61(0.43); C85(1.11)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C206(0.93); C32(1.17); C61(0.36); C85(1.03)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C206(1.13); C226(0.84); C32(0.81); C360(1.10)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C206(0.99); C226(0.95); C32(1.08); C360(0.69)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C206(0.99); C226(0.96); C32(0.83); C360(0.86)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C206(0.99); C226(1.04); C32(0.89); C360(1.26)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C206(1.00); C226(0.75); C32(0.87); C360(1.01)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C206(1.00); C226(0.94); C32(1.10); C360(0.71)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C206(1.12); C226(0.75); C32(0.82); C360(0.75)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C206(0.79); C226(0.77); C32(0.91); C360(0.66)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C206(0.93); C226(0.90); C32(0.73); C360(0.56)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C206(0.95); C226(0.82); C32(0.84); C360(0.38)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C206(0.81); C226(0.76); C32(0.64); C360(0.28)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C206(0.93); C226(0.89); C32(1.06); C360(0.38)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C206(1.10); C226(0.84); C32(0.92); C360(2.33)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C206(0.90); C226(0.83); C32(0.83); C360(0.65)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C206(0.97); C226(0.84); C32(0.72); C360(0.41)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C206(0.96); C226(0.85); C32(0.91); C360(0.64)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C206(0.63); C226(0.90); C32(1.14); C61(0.73)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C206(0.87); C226(1.20); C32(1.46); C61(0.60)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C206(0.76); C226(1.09); C32(1.54); C61(0.57)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C206(0.72); C226(1.01); C32(1.46); C61(0.59)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C206(0.67); C226(1.05); C32(1.30); C61(0.48)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C206(0.74); C226(0.90); C32(1.18); C61(0.63)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C206(0.89); C226(1.02); C32(0.98); C61(1.18)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C206(1.10); C226(0.88); C32(1.08); C360(1.64)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C206(0.86); C226(0.95); C32(1.33); C61(0.92)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C206(0.79); C226(0.96); C32(1.33); C61(0.72)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C206(0.81); C226(1.08); C32(1.24); C61(0.76)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C206(0.78); C226(1.17); C32(1.57); C61(0.69)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C206(0.81); C226(1.21); C32(1.51); C61(0.87)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C206(0.85); C226(1.03); C32(1.19); C61(0.84)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C206(0.66); C226(1.02); C32(1.34); C61(0.48)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C206(0.68); C226(1.04); C32(1.23); C61(0.36)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C206(1.08); C271(1.33); C360(2.71); C368(3.03)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C206(0.81); C271(1.05); C360(2.23); C368(2.55)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C206(1.22); C271(1.14); C360(1.85); C368(2.34)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C206(0.95); C226(1.18); C360(1.91); C368(1.91)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C206(0.99); C271(1.62); C360(1.83); C368(2.23)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C206(1.21); C271(1.32); C360(1.83); C368(2.23)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C206(0.96); C271(1.46); C360(1.75); C368(2.04)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C206(0.90); C271(2.09); C360(1.70); C368(1.79)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C206(0.98); C271(0.97); C360(1.66); C368(1.81)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C206(0.75); C226(0.90); C32(0.90); C360(0.75)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C206(0.78); C226(0.99); C32(0.99); C360(0.80)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C206(1.04); C226(0.97); C32(0.97); C360(0.87)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C206(1.18); C226(1.28); C32(1.28); C360(1.12)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C206(0.84); C226(0.88); C32(0.88); C360(0.79)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C206(1.05); C226(0.97); C360(0.89); C368(0.89)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C206(0.94); C226(1.18); C32(1.18); C360(0.86)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C206(0.85); C226(1.31); C32(1.31); C360(0.82)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C206(0.97); C226(1.04); C32(1.04); C360(0.92)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C206(1.02); C226(1.15); C32(1.15); C360(0.89)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C206(0.93); C226(1.16); C32(1.16); C360(1.03)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C206(1.32); C226(1.14); C271(1.15); C32(0.82)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C206(1.38); C226(1.96); C271(1.24); C32(1.35)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C206(1.20); C226(1.44); C271(1.34); C32(1.03)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C206(1.18); C226(1.32); C271(1.04); C32(0.87)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C206(1.32); C226(1.18); C271(1.19); C32(0.90)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C206(1.13); C226(1.35); C360(1.08); C368(1.08)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C206(1.25); C226(1.21); C271(1.13); C32(0.78)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C206(1.19); C226(1.16); C271(1.26); C32(0.75)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C206(0.95); C226(0.99); C271(1.13); C32(0.77)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C206(1.30); C226(1.36); C271(1.23); C32(0.86)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C206(1.32); C226(1.20); C271(1.31); C32(0.79)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C206(1.38); C226(1.31); C271(1.27); C32(1.03)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C206(0.71); C271(1.30); C32(0.84); C360(0.93)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C206(0.75); C271(1.36); C32(0.82); C360(0.95)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C206(0.91); C271(1.50); C32(0.91); C360(0.89)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C206(0.97); C271(1.18); C32(1.04); C360(0.91)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C206(1.13); C226(0.89); C360(1.17); C368(1.17)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C206(1.03); C271(1.34); C32(1.06); C360(1.02)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C206(0.89); C271(1.50); C32(1.28); C360(0.96)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C206(0.89); C271(1.58); C32(1.13); C360(0.96)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C206(0.60); C271(1.13); C32(1.05); C360(1.34)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C206(0.74); C271(1.42); C32(1.10); C360(0.98)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C206(0.90); C271(1.26); C32(0.96); C360(1.15)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C206(0.90); C271(1.27); C32(1.13); C360(0.81)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C226(1.34); C271(1.06); C32(1.13); C360(0.87)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C226(1.21); C271(1.09); C32(1.14); C360(0.99)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C226(1.25); C271(0.99); C32(1.07); C360(0.99)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C206(1.10); C226(0.99); C32(0.94); C360(1.17)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C226(1.54); C271(0.93); C32(1.11); C360(0.88)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C226(1.18); C271(1.38); C32(1.16); C360(0.53)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C226(1.23); C271(1.23); C32(1.25); C360(0.68)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C226(1.29); C271(1.34); C32(1.22); C360(0.66)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C226(1.40); C271(1.16); C32(1.26); C360(0.79)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C226(1.27); C271(1.34); C32(1.19); C360(0.61)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C226(1.21); C271(1.06); C32(1.17); C360(0.57)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C226(1.23); C271(1.22); C32(1.24); C360(0.72)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C206(0.98); C226(0.77); C32(1.04); C360(0.83)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C206(0.86); C226(0.94); C32(0.84); C360(0.86)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C206(0.86); C226(0.95); C32(1.04); C360(0.81)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C206(0.97); C226(0.90); C32(0.81); C360(0.73)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C206(1.02); C226(0.75); C32(0.86); C360(0.84)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C206(1.17); C226(0.78); C32(0.88); C360(0.92)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C206(1.14); C226(0.66); C32(0.96); C360(0.87)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C206(1.09); C226(0.85); C32(0.89); C360(0.89)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C206(0.99); C226(0.72); C32(1.11); C360(0.85)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C206(1.00); C226(0.68); C32(0.97); C360(0.89)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C206(1.05); C226(0.82); C32(0.83); C360(0.80)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C206(0.98); C226(0.85); C32(0.97); C360(0.77)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C206(1.10); C226(0.64); C32(0.99); C360(0.96)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C206(1.01); C226(1.06); C32(1.18); C360(1.03)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C206(1.09); C226(0.70); C32(1.30); C360(0.74)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C206(1.04); C226(1.01); C32(1.20); C360(0.96)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C206(1.00); C226(1.04); C32(0.97); C360(0.75)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C206(0.98); C226(0.86); C271(0.84); C32(0.95)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C206(0.98); C226(0.85); C271(1.39); C32(0.98)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C206(0.90); C226(0.93); C271(1.11); C32(1.02)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C206(0.99); C226(0.78); C271(1.27); C32(0.96)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C206(0.92); C226(0.79); C271(1.10); C32(0.89)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C206(1.12); C226(0.85); C271(1.31); C32(1.05)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C206(1.03); C226(0.81); C271(1.38); C32(0.91)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C206(0.98); C226(0.89); C271(1.05); C32(1.00)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C206(0.86); C226(0.88); C271(1.23); C32(0.96)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C206(1.06); C226(0.88); C271(0.95); C32(1.00)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C206(0.90); C226(1.01); C271(0.92); C32(0.95)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C206(1.02); C226(0.80); C271(1.43); C32(0.82)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C206(1.05); C226(1.00); C271(1.14); C32(0.80)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C206(0.79); C226(0.75); C271(1.27); C32(0.80)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C206(0.69); C226(0.75); C271(1.97); C32(0.68)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C206(1.09); C226(1.07); C32(1.06); C360(1.08)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C206(1.00); C226(1.22); C32(1.30); C360(1.01)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C206(1.03); C226(0.90); C32(1.22); C360(1.91)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C206(0.98); C226(0.86); C32(0.80); C360(1.57)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C206(1.08); C226(0.87); C32(0.94); C360(3.21)  LDD0873  [3]
 LDCM0367  CL1 HEK-293T C206(1.26); C226(0.80); C271(0.93); C32(0.91)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C206(0.62); C226(0.35); C271(2.33); C32(0.41)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C206(1.57); C226(1.16); C360(1.04); C368(1.04)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C206(1.98); C226(1.25); C32(1.27); C360(1.41)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C206(1.03); C226(0.91); C32(1.04); C360(3.94)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C206(1.12); C226(0.99); C32(1.00); C360(0.82)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C206(1.21); C226(0.99); C32(1.04); C360(0.98)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C206(1.87); C271(1.08); C360(1.65); C368(1.96)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C206(1.37); C271(1.33); C360(2.15); C368(2.82)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C206(1.03); C271(1.36); C360(1.51); C368(1.41)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C206(0.98); C271(1.08); C360(1.96); C368(2.42)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C206(1.78); C271(1.06); C360(2.07); C368(2.37)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C206(0.74); C226(0.44); C271(2.31); C32(0.45)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C206(1.12); C271(1.20); C360(2.49); C368(2.98)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C206(0.99); C271(1.22); C360(2.53); C368(3.27)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C206(0.99); C226(1.26); C32(1.26); C360(0.82)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C206(0.91); C226(1.32); C32(1.32); C360(0.95)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C206(1.14); C226(1.31); C32(1.31); C360(0.70)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C206(0.94); C226(1.01); C32(1.01); C360(0.89)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C206(0.85); C226(1.02); C32(1.02); C360(0.74)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C206(1.04); C226(1.20); C271(1.07); C32(0.85)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C206(0.97); C226(1.31); C271(1.17); C32(0.80)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C206(1.54); C226(1.67); C271(1.15); C32(1.00)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C206(1.20); C226(0.46); C271(1.20); C32(0.52)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C206(1.61); C226(1.26); C271(1.29); C32(0.78)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C206(1.28); C271(1.29); C32(1.45); C360(0.93)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C206(0.83); C271(1.26); C32(0.97); C360(1.02)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C206(0.82); C271(1.16); C32(0.82); C360(1.73)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C206(0.89); C271(1.09); C32(1.05); C360(0.97)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C226(1.42); C271(1.06); C32(1.26); C360(0.91)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C226(0.83); C271(1.20); C32(1.06); C360(0.92)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C226(1.02); C271(1.15); C32(1.05); C360(1.19)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C226(1.21); C271(0.97); C32(1.22); C360(1.09)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C206(1.20); C226(0.55); C271(1.17); C32(0.65)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C206(1.04); C226(0.73); C271(1.20); C32(0.61)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C206(0.67); C226(0.41); C271(1.50); C32(0.47)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C206(1.81); C226(1.31); C32(1.49); C61(1.17)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C206(0.91); C226(1.00); C32(0.97); C61(0.97)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C206(1.65); C226(1.17); C32(1.29); C61(1.05)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C206(0.73); C226(0.96); C32(1.01); C61(1.14)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C206(0.99); C226(1.08); C271(1.19); C32(0.88)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C206(1.03); C226(1.08); C32(1.11); C61(1.02)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C206(0.81); C226(0.94); C32(1.06); C61(0.83)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C206(0.89); C226(1.08); C32(1.33); C61(0.98)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C206(0.81); C226(0.97); C32(1.25); C61(1.21)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C206(1.24); C226(1.20); C32(1.03); C61(1.04)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C206(0.89); C226(1.01); C32(1.15); C61(0.93)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C206(0.87); C226(0.98); C32(1.13); C61(0.99)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C206(0.93); C226(0.97); C32(1.03); C61(0.92)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C206(1.61); C226(1.41); C32(1.47); C61(0.87)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C206(0.93); C226(1.17); C32(1.28); C61(1.09)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C206(1.08); C226(0.57); C271(1.13); C32(0.89)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C206(0.78); C226(1.03); C32(1.18); C61(0.63)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C360(1.02); C368(0.99); C369(1.03); C61(1.03)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C360(0.95); C368(0.86); C369(0.91); C61(1.04)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C360(1.57); C368(1.17); C369(1.35); C61(1.02)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C360(0.99); C368(0.97); C369(0.96); C61(0.99)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C360(0.97); C368(0.92); C369(0.98); C61(1.08)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C360(0.96); C368(0.86); C369(0.97); C61(1.03)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C360(1.16); C368(0.97); C369(1.07); C61(1.00)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C360(1.16); C368(0.82); C369(1.22); C61(0.83)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C206(0.88); C226(0.45); C271(1.08); C32(0.64)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C360(0.87); C368(0.89); C369(0.96); C61(1.02)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C360(1.03); C368(0.87); C369(1.16); C61(0.89)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C360(0.73); C368(0.68); C369(1.02); C61(0.91)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C360(0.68); C368(0.71); C369(1.06); C61(0.88)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C360(0.90); C368(0.81); C369(1.01); C61(1.05)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C360(1.13); C368(0.89); C369(1.19); C61(1.19)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C206(1.08); C226(1.22); C271(2.61); C32(1.34)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C206(0.95); C226(1.09); C271(0.86); C32(1.33)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C206(1.14); C226(1.28); C271(0.93); C32(1.49)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C206(1.12); C226(1.31); C271(0.93); C32(1.22)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C206(1.18); C226(0.78); C271(1.23); C32(0.72)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C206(1.08); C226(1.09); C271(0.86); C32(1.03)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C206(1.08); C226(1.07); C271(0.66); C32(1.04)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C206(1.17); C226(1.02); C271(0.79); C32(1.12)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C206(1.08); C226(0.96); C271(0.51); C32(1.19)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C206(0.85); C226(0.89); C271(0.39); C32(1.17)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C206(1.00); C226(1.05); C271(0.80); C32(0.92)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C206(0.87); C226(1.05); C271(0.44); C32(1.12)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C206(0.91); C226(0.93); C271(0.84); C32(1.03)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C206(0.87); C226(0.97); C271(0.58); C32(1.02)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C206(0.87); C226(1.10); C271(0.52); C32(1.17)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C206(1.11); C226(0.49); C271(1.09); C32(0.58)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C206(0.81); C226(1.11); C271(0.73); C32(0.88)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C206(1.39); C226(1.31); C32(1.31); C360(0.87)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C206(0.96); C226(0.83); C32(0.83); C360(0.73)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C206(1.10); C226(0.87); C32(0.87); C360(0.67)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C206(1.23); C226(1.39); C32(1.39); C360(1.15)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C206(0.94); C226(0.77); C32(0.77); C360(0.93)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C206(0.87); C226(0.78); C32(0.78); C360(0.79)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C206(1.13); C226(0.96); C32(0.96); C360(0.88)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C206(0.91); C226(0.83); C32(0.83); C360(0.92)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C206(0.89); C226(0.83); C32(0.83); C360(0.81)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C206(1.33); C226(0.67); C271(1.24); C32(0.94)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C206(1.11); C226(1.08); C32(1.08); C360(0.84)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C206(1.41); C226(1.25); C32(1.25); C360(0.70)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C206(0.98); C226(0.94); C32(0.94); C360(0.98)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C206(1.02); C226(0.89); C32(0.89); C360(0.90)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C206(0.88); C226(0.89); C32(0.89); C360(0.60)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C206(0.93); C226(0.63); C271(1.22); C32(0.61)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C206(0.82); C226(0.76); C271(1.21); C32(0.68)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C206(0.82); C226(0.63); C271(1.49); C32(0.59)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C206(0.96); C226(0.82); C271(1.48); C32(0.99)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C206(2.41); C226(0.84); C32(0.52); C360(0.87)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C206(0.91); C226(0.73); C271(1.34); C32(0.78)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C206(1.09); C226(0.96); C271(1.16); C32(1.10)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C206(1.37); C226(1.24); C271(1.23); C32(1.25)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C206(1.08); C226(0.88); C271(1.26); C32(1.01)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C206(0.77); C226(0.88); C271(1.41); C32(0.73)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C206(1.02); C226(0.66); C271(1.39); C32(0.66)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C206(0.70); C226(0.77); C271(1.90); C32(0.76)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C206(0.71); C226(0.74); C271(1.24); C32(0.74)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C206(1.03); C226(0.87); C271(1.40); C32(0.92)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C206(1.14); C226(0.87); C271(1.31); C32(0.91)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C206(0.53); C226(0.98); C32(0.61); C360(0.96)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C206(0.83); C226(0.75); C271(1.12); C32(0.76)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C206(1.05); C226(1.09); C360(1.22); C368(1.22)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C206(1.55); C226(1.04); C360(1.56); C368(1.56)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C206(1.49); C226(1.34); C360(1.30); C368(1.30)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C206(1.14); C226(1.25); C360(1.84); C368(1.84)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C206(1.23); C226(0.93); C360(2.77); C368(2.77)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C206(1.48); C226(0.87); C360(1.33); C368(1.33)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C206(1.59); C226(1.21); C360(2.17); C368(2.17)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C206(1.01); C226(1.06); C360(1.68); C368(1.68)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C206(1.28); C226(1.00); C360(1.75); C368(1.75)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C334(1.10); C156(0.76); C206(0.86); C369(0.87)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C206(0.65); C226(0.66); C32(0.66); C360(0.62)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C360(0.88); C368(0.81); C369(0.99); C61(0.86)  LDD1025  [3]
 LDCM0617  Fragment63-S Jurkat _(4.65)  LDD1490  [2]
 LDCM0022  KB02 HCT 116 C360(11.65); C369(11.65); C368(3.41); C32(2.27)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C360(4.07); C369(4.07); C368(1.23); C32(1.87)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C360(5.09); C369(5.09); C368(3.33); C32(2.72)  LDD0082  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C32(0.89)  LDD2207  [11]
 LDCM0112  W16 Hep-G2 C32(0.94)  LDD0239  [8]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ademetionine Small molecular drug DB00118

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.