Details of the Target

General Information of Target

Target ID LDTP07875
Target Name Ubiquitin carboxyl-terminal hydrolase 34 (USP34)
Gene Name USP34
Gene ID 9736
Synonyms
KIAA0570; KIAA0729; Ubiquitin carboxyl-terminal hydrolase 34; EC 3.4.19.12; Deubiquitinating enzyme 34; Ubiquitin thioesterase 34; Ubiquitin-specific-processing protease 34
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCENCADLVEVLNEISDVEGGDGLQLRKEHTLKIFTYINSWTQRQCLCCFKEYKHLEIFN
QVVCALINLVIAQVQVLRDQLCKHCTTINIDSTWQDESNQAEEPLNIDRECNEGSTERQK
SIEKKSNSTRICNLTEEESSKSSDPFSLWSTDEKEKLLLCVAKIFQIQFPLYTAYKHNTH
PTIEDISTQESNILGAFCDMNDVEVPLHLLRYVCLFCGKNGLSLMKDCFEYGTPETLPFL
IAHAFITVVSNIRIWLHIPAVMQHIIPFRTYVIRYLCKLSDQELRQSAARNMADLMWSTV
KEPLDTTLCFDKESLDLAFKYFMSPTLTMRLAGLSQITNQLHTFNDVCNNESLVSDTETS
IAKELADWLISNNVVEHIFGPNLHIEIIKQCQVILNFLAAEGRLSTQHIDCIWAAAQLKH
CSRYIHDLFPSLIKNLDPVPLRHLLNLVSALEPSVHTEQTLYLASMLIKALWNNALAAKA
QLSKQSSFASLLNTNIPIGNKKEEEELRRTAPSPWSPAASPQSSDNSDTHQSGGSDIEMD
EQLINRTKHVQQRLSDTEESMQGSSDETANSGEDGSSGPGSSSGHSDGSSNEVNSSHASQ
SAGSPGSEVQSEDIADIEALKEEDEDDDHGHNPPKSSCGTDLRNRKLESQAGICLGDSQG
MSERNGTSSGTGKDLVFNTESLPSVDNRMRMLDACSHSEDPEHDISGEMNATHIAQGSQE
SCITRTGDFLGETIGNELFNCRQFIGPQHHHHHHHHHHHHDGHMVDDMLSADDVSCSSSQ
VSAKSEKNMADFDGEESGCEEELVQINSHAELTSHLQQHLPNLASIYHEHLSQGPVVHKH
QFNSNAVTDINLDNVCKKGNTLLWDIVQDEDAVNLSEGLINEAEKLLCSLVCWFTDRQIR
MRFIEGCLENLGNNRSVVISLRLLPKLFGTFQQFGSSYDTHWITMWAEKELNMMKLFFDN
LVYYIQTVREGRQKHALYSHSAEVQVRLQFLTCVFSTLGSPDHFRLSLEQVDILWHCLVE
DSECYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHLCNLA
RLATSAYDGCSNSELCGMDQFWGIALRAQSGDVSRAAIQYINSYYINGKTGLEKEQEFIS
KCMESLMIASSSLEQESHSSLMVIERGLLMLKTHLEAFRRRFAYHLRQWQIEGTGISSHL
KALSDKQSLPLRVVCQPAGLPDKMTIEMYPSDQVADLRAEVTHWYENLQKEQINQQAQLQ
EFGQSNRKGEFPGGLMGPVRMISSGHELTTDYDEKALHELGFKDMQMVFVSLGAPRRERK
GEGVQLPASCLPPPQKDNIPMLLLLQEPHLTTLFDLLEMLASFKPPSGKVAVDDSESLRC
EELHLHAENLSRRVWELLMLLPTCPNMLMAFQNISDEQSNDGFNWKELLKIKSAHKLLYA
LEIIEALGKPNRRIRRESTGSYSDLYPDSDDSSEDQVENSKNSWSCKFVAAGGLQQLLEI
FNSGILEPKEQESWTVWQLDCLACLLKLICQFAVDPSDLDLAYHDVFAWSGIAESHRKRT
WPGKSRKAAGDHAKGLHIPRLTEVFLVLVQGTSLIQRLMSVAYTYDNLAPRVLKAQSDHR
SRHEVSHYSMWLLVSWAHCCSLVKSSLADSDHLQDWLKKLTLLIPETAVRHESCSGLYKL
SLSGLDGGDSINRSFLLLAASTLLKFLPDAQALKPIRIDDYEEEPILKPGCKEYFWLLCK
LVDNIHIKDASQTTLLDLDALARHLADCIRSREILDHQDGNVEDDGLTGLLRLATSVVKH
KPPFKFSREGQEFLRDIFNLLFLLPSLKDRQQPKCKSHSSRAAAYDLLVEMVKGSVENYR
LIHNWVMAQHMQSHAPYKWDYWPHEDVRAECRFVGLTNLGATCYLASTIQQLYMIPEARQ
AVFTAKYSEDMKHKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQKDMT
EFFTDLITKIEEMSPELKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVRCQVADMKN
IYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMK
EKVNTHFSFPLRLDMTPYTEDFLMGKSERKEGFKEVSDHSKDSESYEYDLIGVTVHTGTA
DGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFDSAQLASECFGGEMTTKTYDSVTDKF
MDFSFEKTHSAYMLFYKRMEPEEENGREYKFDVSSELLEWIWHDNMQFLQDKNIFEHTYF
GFMWQLCSCIPSTLPDPKAVSLMTAKLSTSFVLETFIHSKEKPTMLQWIELLTKQFNNSQ
AACEWFLDRMADDDWWPMQILIKCPNQIVRQMFQRLCIHVIQRLRPVHAHLYLQPGMEDG
SDDMDTSVEDIGGRSCVTRFVRTLLLIMEHGVKPHSKHLTEYFAFLYEFAKMGEEESQFL
LSLQAISTMVHFYMGTKGPENPQVEVLSEEEGEEEEEEEDILSLAEEKYRPAALEKMIAL
VALLVEQSRSERHLTLSQTDMAALTGGKGFPFLFQHIRDGINIRQTCNLIFSLCRYNNRL
AEHIVSMLFTSIAKLTPEAANPFFKLLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPS
QCLDWLAVQTPRNKLAHSWVLQNMENWVERFLLAHNYPRVRTSAAYLLVSLIPSNSFRQM
FRSTRSLHIPTRDLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMT
YCLISKTEKLMFSTYFMDLWNLFQPKLSEPAIATNHNKQALLSFWYNVCADCPENIRLIV
QNPVVTKNIAFNYILADHDDQDVVLFNRGMLPAYYGILRLCCEQSPAFTRQLASHQNIQW
AFKNLTPHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRS
CWTTLISAFRILLESDEDRLLVVFNRGLILMTESFNTLHMMYHEATACHVTGDLVELLSI
FLSVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLTLLNSYSPPELRNACIDVLKELVLL
SPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMCLL
PTMVETSKGKDDVYDRMLLDYFFSYHQFIHLLCRVAINCEKFTETLVKLSVLVAYEGLPL
HLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEYIKCILMDERTFLNNNIVYTFMTHF
LLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGDLRALALLL
SVHTPKQLNPALIPTLQELLSKCRTCLQQRNSLQEQEAKERKTKDDEGATPIKRRRVSSD
EEHTVDSCISDMKTETREVLTPTSTSDNETRDSSIIDPGTEQDLPSPENSSVKEYRMEVP
SSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEESEFPSTSISAVLSDL
ADLRSCDGQALPSQDPEVALSLSCGHSRGLFSHMQQHDILDTLCRTIESTIHVVTRISGK
GNQAAS
Target Bioclass
Enzyme
Family
Peptidase C19 family
Function
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Uniprot ID
Q70CQ2
Ensemble ID
ENST00000398571.7
HGNC ID
HGNC:20066

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.Y1229H; p.Q1325H DBIA    Probe Info 
786O SNV: p.D1749Y DBIA    Probe Info 
AU565 SNV: p.L3312V; p.S3332Ter DBIA    Probe Info 
CAL120 SNV: p.S1066T DBIA    Probe Info 
CALU1 SNV: p.V2680G .
GB1 SNV: p.F2550L DBIA    Probe Info 
HCC1395 SNV: p.D624H DBIA    Probe Info 
HCT116 SNV: p.Q2340H DBIA    Probe Info 
HCT15 SNV: p.R274M; p.R1830Ter; p.N2901S DBIA    Probe Info 
HEC1 SNV: p.G3090V DBIA    Probe Info 
HEC1B SNV: p.G3090V .
ICC3 SNV: p.V1856F DBIA    Probe Info 
IGROV1 SNV: p.P634L; p.G731W DBIA    Probe Info 
IM95 SNV: p.R1037Q DBIA    Probe Info 
JURKAT SNV: p.R1958K .
KYSE30 SNV: p.R3154L DBIA    Probe Info 
LN18 SNV: p.V3124L DBIA    Probe Info 
LS180 SNV: p.Q2726L DBIA    Probe Info 
MELJUSO SNV: p.G3509E DBIA    Probe Info 
MEWO SNV: p.S490F DBIA    Probe Info 
MM1S SNV: p.Y1964C .
MOLT4 SNV: p.I58F IA-alkyne    Probe Info 
NALM6 SNV: p.T3122A DBIA    Probe Info 
NCIH1155 Insertion: p.S126IfsTer8 DBIA    Probe Info 
NCIH1703 SNV: p.T1753A DBIA    Probe Info 
NCIH196 SNV: p.S3470C .
NCIH2122 SNV: p.C1330F DBIA    Probe Info 
NCIH2286 SNV: p.L823F DBIA    Probe Info 
RH41 SNV: p.P497H DBIA    Probe Info 
RKO SNV: p.H1030R; p.R1319Q DBIA    Probe Info 
SHP77 SNV: p.P2597S .
SJSA1 SNV: p.G1273Ter DBIA    Probe Info 
SKMEL28 SNV: p.S2292N DBIA    Probe Info 
TOV21G SNV: p.R690Q DBIA    Probe Info 
VMRCRCW SNV: p.S142I DBIA    Probe Info 
YSCCC SNV: p.F3468L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.71  LDD0402  [1]
Johansson_61
 Probe Info  		_(12.37)  LDD1485  [2]
AHL-Pu-1
 Probe Info  		C3455(2.09); C741(3.02)  LDD0169  [3]
Acrolein
 Probe Info  		H1764(0.00); C1768(0.00); H1577(0.00)  LDD0222  [4]
DBIA
 Probe Info  		C3486(1.51); C3504(1.51); C46(1.17); C48(1.17)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C111(0.00); C1674(0.00); C132(0.00); C741(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C1961(0.00); C2364(0.00); C1674(0.00); C1768(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C1674(0.00); C741(0.00); C638(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
IPM
 Probe Info  		C160(0.00); C214(0.00); C1486(0.00)  LDD0005  [8]
TFBX
 Probe Info  		C907(0.00); C3326(0.00); C160(0.00); C741(0.00)  LDD0148  [9]
VSF
 Probe Info  		N.A.  LDD0007  [8]
W1
 Probe Info  		C132(0.00); C907(0.00)  LDD0236  [10]
AOyne
 Probe Info  		11.90  LDD0443  [11]
NAIA_5
 Probe Info  		C132(0.00); C1952(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C3455(2.09); C741(3.02)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C111(1.27); C2931(1.01); C160(1.27); C1739(1.11)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C2931(1.66); C1739(1.01); C214(1.04); C217(1.04)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C2931(0.95); C1768(0.73); C1952(1.01); C214(0.85)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C2931(1.07); C1768(0.86); C1952(1.02); C214(0.75)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C2931(0.91); C1768(0.65); C1952(0.90); C214(0.87)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C2931(1.05); C1768(1.05); C1952(1.07); C214(0.86)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C2931(0.85); C1768(0.88); C1952(1.08); C214(0.88)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C2931(1.11); C1768(0.77); C1952(0.99); C214(0.82)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C2931(0.95); C1768(0.79); C1952(1.02); C214(0.74)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C2931(1.02); C1768(0.46); C1952(1.16); C214(0.84)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C2931(0.90); C1768(1.02); C1952(1.07); C214(0.87)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C2931(0.94); C1768(0.88); C1952(0.94); C214(0.88)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C2931(1.54); C1739(0.99); C214(0.98); C217(0.98)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C2931(0.93); C1768(1.19); C1952(1.26); C214(0.84)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C2931(0.83); C1768(1.14); C1952(1.21); C214(0.96)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C2931(1.02); C1768(0.67); C1952(1.01); C214(0.77)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1739(0.88); C1952(0.98); C2062(0.98); C2065(0.98)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1739(0.96); C1952(0.96); C2062(1.14); C2065(1.31)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1739(1.02); C1952(0.90); C2062(1.17); C2065(1.15)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1739(1.02); C1952(0.99); C2062(1.11); C2065(1.29)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1739(0.95); C1952(0.97); C2062(1.09); C2065(1.05)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1739(0.96); C1952(0.94); C2062(0.87); C2065(0.94)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1739(0.95); C1952(1.00); C2062(1.04); C2065(1.16)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C2931(1.17); C1739(0.99); C214(0.90); C217(0.90)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1739(1.05); C1952(0.97); C2062(0.97); C2065(1.08)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1739(0.95); C1952(1.04); C2062(0.91); C2065(0.84)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1739(0.98); C1952(0.98); C2062(1.00); C2065(1.10)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1739(0.97); C1952(0.98); C2062(1.00); C2065(0.89)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1739(0.94); C1952(1.00); C2062(1.12); C2065(1.17)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1739(0.89); C1952(1.08); C2062(0.85); C2065(0.96)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1739(0.92); C1952(1.01); C2062(0.99); C2065(1.12)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1739(0.90); C1952(0.97); C2062(1.00); C2065(1.05)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C2931(1.53); C2062(1.00); C2065(1.00); C2343(0.78)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C2931(1.07); C2062(0.69); C2065(0.69); C2343(0.76)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C2931(0.90); C2062(0.75); C2065(0.75); C2343(0.72)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C2931(0.95); C2062(1.01); C2065(1.01); C2343(0.73)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C2931(0.95); C2062(0.92); C2065(0.92); C2343(0.61)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C2931(1.13); C2062(0.82); C2065(0.82); C2343(0.75)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C2931(1.32); C2062(0.82); C2065(0.82); C2343(0.81)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C2931(1.30); C2062(0.69); C2065(0.69); C2343(0.75)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C2931(0.98); C2062(0.81); C2065(0.81); C2343(0.63)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C2931(1.33); C2062(0.88); C2065(0.88); C2343(0.72)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C2931(1.12); C2062(0.73); C2065(0.73); C2343(1.18)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C2931(1.17); C2062(0.86); C2065(0.86); C2343(0.59)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C2931(1.50); C1739(1.13); C214(1.20); C217(1.20)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C2931(1.04); C2062(0.91); C2065(0.91); C2343(0.94)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C2931(0.99); C2062(1.02); C2065(1.02); C2343(0.69)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C2931(1.04); C2062(0.78); C2065(0.78); C2343(0.69)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C1090(0.93); C1096(0.93); C111(0.95); C2931(1.01)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C2364(0.76); C638(0.84); C46(0.93); C48(0.93)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C111(0.46); C638(0.61); C46(0.77); C48(0.77)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C638(0.72); C111(0.73); C2364(0.85); C46(0.87)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C638(0.72); C46(0.83); C48(0.83); C49(0.83)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C638(0.61); C111(0.65); C2364(0.67); C1090(0.87)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C638(0.59); C2364(0.69); C111(0.74); C46(0.89)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C638(0.71); C46(0.91); C48(0.91); C49(0.91)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C638(0.69); C111(0.79); C1739(0.89); C46(0.90)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C638(0.60); C2931(0.84); C111(0.88); C2364(0.91)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C638(0.52); C2364(0.78); C111(0.84); C46(0.85)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C2364(0.59); C638(0.65); C46(0.87); C48(0.87)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C1090(0.97); C1096(0.97); C111(0.94); C2931(2.11)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C1090(1.26); C1096(1.26); C111(0.85); C2931(1.16)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C1090(1.44); C1096(1.44); C111(1.06); C2931(0.80)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C1090(1.14); C1096(1.14); C111(0.84); C2931(0.98)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C2931(0.80); C214(0.81); C638(0.85); C3193(0.89)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1090(0.64); C1096(0.64); C2364(0.67); C214(0.73)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C2364(0.62); C214(0.76); C3193(0.89); C132(0.96)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C638(0.82); C46(0.82); C48(0.82); C49(0.82)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C2364(0.84); C214(0.86); C856(0.87); C132(0.96)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C3193(0.78); C214(0.79); C2364(0.81); C132(0.98)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C2364(0.68); C132(0.87); C214(0.90); C3193(0.97)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C2364(0.75); C214(0.76); C3193(0.77); C638(0.85)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C2364(0.67); C1090(0.75); C1096(0.75); C214(0.78)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C2364(0.76); C2861(0.77); C2862(0.77); C1090(0.90)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C2343(0.74); C2861(0.79); C2862(0.79); C1739(0.91)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C1768(0.68); C2062(0.86); C2065(0.86); C2861(0.88)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C1768(0.65); C2861(0.88); C2862(0.88); C1739(0.97)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1768(0.53); C2861(0.77); C2862(0.77); C2343(0.91)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C46(0.80); C48(0.80); C49(0.80); C638(0.85)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1768(0.58); C2062(0.58); C2065(0.58); C2861(0.71)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C2062(0.76); C2065(0.76); C2343(0.85); C2861(0.87)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C2343(0.64); C2861(0.66); C2862(0.66); C2062(0.74)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C1768(0.64); C2861(0.82); C2862(0.82); C2343(0.84)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C2861(0.68); C2862(0.68); C2062(0.79); C2065(0.79)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C638(0.88); C132(0.92); C160(0.95); C1952(1.00)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C2364(0.79); C160(0.80); C1952(0.99); C132(1.03)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C2364(0.66); C160(0.82); C132(0.88); C214(0.92)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C160(0.85); C638(0.91); C2364(0.92); C1952(1.00)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C2364(0.85); C132(0.89); C638(0.91); C160(1.02)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C46(0.75); C48(0.75); C49(0.75); C638(0.83)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C2364(0.77); C638(0.86); C160(0.93); C132(0.97)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C160(0.94); C132(0.99); C1952(1.00); C1739(1.02)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C638(0.94); C160(0.98); C46(1.06); C48(1.06)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C1952(1.01); C160(1.11); C46(1.16); C48(1.16)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C132(0.87); C2364(0.95); C160(1.02); C1952(1.02)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C132(0.83); C2364(0.86); C160(1.01); C1952(1.04)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C1090(0.84); C1096(0.84); C2364(0.95); C214(0.96)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C2931(0.80); C132(0.85); C2364(0.96); C1952(0.97)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C2931(0.75); C132(0.89); C214(0.92); C217(0.92)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C2364(1.01); C132(1.01); C214(1.12); C217(1.12)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C46(0.79); C48(0.79); C49(0.79); C638(0.84)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C2364(0.79); C132(0.82); C638(0.89); C1090(0.94)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C132(0.80); C638(0.81); C2364(0.81); C2941(0.89)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C1090(0.78); C1096(0.78); C2931(0.80); C638(0.86)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C1768(0.73); C132(0.84); C2364(0.88); C638(0.91)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C638(0.75); C1768(0.77); C132(0.80); C2364(0.92)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C1768(0.81); C638(0.92); C132(0.97); C2364(0.98)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C1768(0.71); C132(0.93); C2931(0.93); C638(0.96)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C2364(0.77); C214(0.80); C217(0.80); C2941(1.07)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C2364(0.93); C214(0.94); C217(0.94); C46(1.02)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C214(0.87); C217(0.87); C2941(1.07); C46(1.11)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C2941(0.72); C638(0.87); C214(0.97); C217(0.97)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C214(0.78); C217(0.78); C2364(0.78); C2941(1.01)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C214(0.67); C217(0.67); C2364(0.93); C2941(1.00)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C214(0.86); C217(0.86); C2941(0.96); C856(1.14)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C214(0.76); C217(0.76); C2364(1.08); C2941(1.10)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C214(0.85); C217(0.85); C2941(0.98); C2364(1.12)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C214(0.67); C217(0.67); C2941(1.10); C46(1.10)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C214(0.69); C217(0.69); C2364(0.96); C46(1.08)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C214(0.65); C217(0.65); C2364(1.10); C2941(1.12)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C2931(0.75); C2941(0.76); C1768(0.94); C214(0.94)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C1768(0.65); C2931(0.80); C2941(0.81); C46(0.95)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C638(0.72); C2941(0.77); C856(0.99); C214(1.02)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C2062(0.66); C2065(0.66); C1739(0.83); C2931(0.83)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C2931(0.71); C2941(0.89); C214(0.91); C217(0.91)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C46(0.76); C48(0.76); C49(0.76); C2941(0.88)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C2931(0.90); C1090(1.42); C1096(1.42); C1768(0.89)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C2931(0.76); C46(0.88); C48(0.88); C49(0.88)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C2931(0.84); C2062(0.85); C2065(0.85); C2941(0.86)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C2931(0.75); C2062(0.77); C2065(0.77); C2941(0.80)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C2941(0.87); C1739(0.91); C1768(0.91); C2931(0.92)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C214(0.73); C217(0.73); C2062(0.76); C2065(0.76)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C214(0.84); C217(0.84); C2931(0.86); C1768(0.87)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C2941(0.64); C638(0.75); C214(0.92); C217(0.92)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C2931(0.89); C2941(0.89); C214(0.97); C217(0.97)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C1090(0.45); C1096(0.45); C1739(0.75); C2931(0.84)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C2062(0.73); C2065(0.73); C2931(0.79); C2941(1.01)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C2062(0.92); C2065(0.92); C1768(0.94); C111(0.97)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C111(0.80); C2062(0.87); C2065(0.87); C214(1.02)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C214(0.86); C217(0.86); C111(0.94); C2062(0.95)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C1768(0.98); C111(1.03); C214(1.04); C217(1.04)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C2931(0.79); C214(0.92); C217(0.92); C1768(0.95)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C111(0.85); C214(0.92); C217(0.92); C1952(0.92)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C214(0.98); C217(0.98); C1768(1.03); C1952(1.09)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C2062(0.74); C2065(0.74); C111(0.81); C2931(0.88)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C638(1.02); C1768(1.03); C214(1.03); C217(1.03)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C1768(0.88); C214(1.00); C217(1.00); C638(1.09)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1768(0.78); C2062(0.87); C2065(0.87); C214(0.88)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C214(0.79); C217(0.79); C638(0.80); C1768(0.87)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C214(0.73); C217(0.73); C2062(0.92); C2065(0.92)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C638(0.84); C1768(0.85); C214(0.87); C217(0.87)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C2062(0.84); C2065(0.84); C214(0.89); C217(0.89)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C2941(0.60); C214(0.75); C217(0.75); C856(0.80)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C1768(0.70); C2364(0.70); C214(0.80); C217(0.80)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C2931(1.26); C1739(1.04); C214(0.94); C217(0.94)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C2941(0.61); C214(0.84); C217(0.84); C638(0.94)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C638(0.68); C46(0.81); C48(0.81); C49(0.81)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 10.20  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C3486(1.51); C3504(1.51); C46(1.17); C48(1.17)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa H1764(0.00); C1768(0.00); H1577(0.00)  LDD0222  [4]
 LDCM0632  CL-Sc Hep-G2 C741(0.34)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C2931(0.82); C638(0.94); C160(1.00); C48(1.01)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C2931(0.72); C1768(0.85); C638(0.91); C160(1.01)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C46(0.79); C48(0.79); C49(0.79); C638(0.83)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C638(0.54); C2941(0.70); C856(0.99); C2861(1.04)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C638(0.54); C2941(0.75); C46(0.88); C48(0.88)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C638(0.59); C2941(0.66); C46(0.85); C48(0.85)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C638(0.57); C2941(0.77); C46(0.93); C48(0.93)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C3193(0.88); C856(0.89); C214(0.91); C638(0.91)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C3193(0.68); C856(0.75); C2364(0.81); C214(0.81)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C3193(0.73); C214(0.81); C638(0.84); C856(0.85)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C638(0.85); C3193(0.89); C214(0.92); C2364(1.12)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C856(0.81); C214(0.84); C638(0.87); C3193(0.89)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C2931(0.72); C638(0.76); C1768(0.87); C2941(0.94)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C214(0.70); C2364(0.82); C3193(0.82); C638(0.86)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C2364(0.72); C214(0.77); C132(0.96); C638(0.97)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C2364(0.81); C2941(0.82); C2861(0.89); C2862(0.89)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C2062(0.72); C2065(0.72); C2343(0.76); C2861(0.82)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C2861(0.67); C2862(0.67); C2062(0.81); C2065(0.81)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C2062(0.56); C2065(0.56); C2861(0.70); C2862(0.70)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C2861(0.74); C2862(0.74); C2062(0.80); C2065(0.80)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C638(0.66); C46(0.92); C48(0.92); C2364(0.96)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C638(0.87); C132(0.98); C160(1.02); C1952(1.02)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C160(0.99); C1952(1.05); C132(1.07); C214(1.10)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C2931(0.85); C638(1.02); C46(1.07); C2364(1.08)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C160(0.91); C1952(0.92); C214(0.97); C217(0.97)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C1768(0.51); C1952(0.87); C2364(0.89); C132(0.93)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C1768(0.79); C132(0.89); C638(0.94); C2364(0.97)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C1768(0.39); C2364(0.80); C2931(0.86); C638(0.98)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C1768(0.44); C2931(0.84); C2364(0.90); C132(0.91)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C214(0.78); C217(0.78); C2364(0.84); C856(0.93)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C856(0.89); C2364(0.92); C214(0.94); C217(0.94)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C214(0.75); C217(0.75); C2364(0.82); C856(0.83)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C214(0.79); C217(0.79); C856(0.98); C2941(1.03)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C2931(0.78); C46(0.82); C1768(0.93); C638(0.97)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C2931(0.82); C160(0.87); C1768(0.90); C638(0.92)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C2931(0.77); C46(0.82); C638(0.82); C160(0.96)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C2343(0.79); C160(0.85); C2941(0.97); C2861(1.00)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C111(0.71); C2364(0.87); C46(0.94); C48(0.94)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C2861(0.81); C2862(0.81); C111(0.89); C46(1.00)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C46(0.90); C48(0.90); C49(0.90); C2364(0.94)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C2931(0.69); C160(0.85); C48(0.91); C49(0.91)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C46(0.83); C48(0.83); C49(0.83); C2861(0.97)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C46(0.75); C48(0.75); C49(0.75); C2861(0.98)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C111(0.69); C46(0.73); C48(0.73); C49(0.73)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C2364(0.62); C638(0.95); C2861(0.97); C2862(0.97)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C111(0.70); C2931(1.54); C1739(1.52); C2062(1.19)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C111(0.70); C2931(1.26); C1739(1.26); C2062(1.77)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C111(0.74); C2931(1.25); C1739(1.03); C2062(1.04)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C111(0.92); C2931(1.21); C1739(1.17); C2062(1.01)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C111(0.83); C2931(1.75); C1739(1.39); C2062(1.27)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C111(0.71); C2931(1.68); C1739(1.64); C2062(1.29)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C111(1.23); C2931(0.66); C160(0.90); C1768(1.20)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C111(0.90); C2931(1.26); C1739(1.57); C2062(1.20)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C111(1.14); C2931(1.13); C160(0.96); C1768(1.61)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C111(1.51); C2931(1.02); C160(1.03); C1768(1.75)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C111(0.89); C2931(1.22); C160(1.00); C1768(1.07)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C111(1.60); C2931(2.00); C160(0.97); C1768(1.25)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C111(1.18); C2931(1.73); C160(1.03); C1768(1.29)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C111(0.97); C2931(1.45); C160(0.87); C1768(1.14)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C111(0.69); C2931(1.36); C160(1.09); C1768(1.65)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C111(1.12); C2931(1.38); C160(0.97); C1768(1.66)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C111(1.10); C2931(0.65); C160(0.97); C1768(1.02)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C111(0.86); C2931(1.06); C160(0.92); C1768(1.34)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C111(0.73); C2931(1.34); C160(0.96); C1768(1.32)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C111(1.00); C2931(2.45); C160(0.85); C1768(2.37)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C111(1.14); C2931(1.57); C160(1.02); C1768(1.41)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C111(1.35); C2931(1.25); C160(1.00); C1768(1.33)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C111(1.14); C2931(1.58); C160(1.12); C1768(1.39)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1090(0.86); C1096(0.86); C2931(1.36); C132(1.41)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1090(0.79); C1096(0.79); C2931(0.90); C132(0.89)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1090(0.81); C1096(0.81); C2931(0.83); C132(0.94)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1090(1.18); C1096(1.18); C2931(1.13); C132(0.99)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C111(1.07); C2931(0.78); C160(1.03); C1768(1.03)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1090(0.94); C1096(0.94); C2931(1.05); C132(0.96)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1090(0.67); C1096(0.67); C2931(1.07); C132(0.92)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1090(0.71); C1096(0.71); C2931(1.15); C132(0.98)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1090(0.75); C1096(0.75); C2931(1.11); C132(0.99)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1090(0.98); C1096(0.98); C2931(1.04); C132(0.87)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1090(0.72); C1096(0.72); C2931(1.07); C132(0.95)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1090(0.70); C1096(0.70); C2931(1.26); C132(0.80)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1090(1.49); C1096(1.49); C2931(0.96); C132(0.86)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1090(0.81); C1096(0.81); C2931(1.18); C132(0.92)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1090(0.74); C1096(0.74); C2931(0.99); C132(0.88)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C111(1.76); C2931(0.86); C160(1.01); C1768(1.06)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1090(0.76); C1096(0.76); C2931(1.05); C132(0.87)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C2931(1.18); C1768(0.96); C1952(1.01); C2062(1.28)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C2931(1.23); C1768(0.87); C1952(0.93); C2062(1.61)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C2931(1.44); C1768(1.00); C1952(0.90); C2062(0.92)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C2931(1.78); C1768(0.84); C1952(1.00); C2062(1.60)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C2931(1.37); C1768(0.95); C1952(1.02); C2062(1.67)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C2931(1.83); C1768(1.32); C1952(0.98); C2062(1.35)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C2931(1.35); C1768(1.24); C1952(0.96); C2062(1.20)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C2931(1.40); C1768(0.87); C1952(1.00); C2062(1.50)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C2931(1.32); C1768(0.81); C1952(0.99); C2062(1.82)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C111(1.44); C2931(0.78); C160(1.18); C1768(0.98)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C2931(1.25); C1768(0.85); C1952(1.01); C2062(1.27)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C2931(1.40); C1768(1.06); C1952(0.98); C2062(1.13)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C2931(1.19); C1768(0.94); C1952(0.84); C2062(1.31)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C2931(1.83); C1768(0.84); C1952(1.01); C2062(1.42)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C2931(1.47); C1768(0.89); C1952(0.93); C2062(1.23)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C2931(1.52); C132(1.01); C1739(0.91); C1768(0.99)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C2931(1.05); C132(1.00); C1739(0.86); C1768(0.90)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C2931(0.76); C132(1.01); C1739(1.00); C1768(1.04)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C2931(1.55); C132(1.00); C1739(1.01); C1768(1.52)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C111(0.97); C2931(0.95); C160(1.32); C1768(1.15)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C2931(1.22); C132(1.01); C1739(1.08); C1768(1.37)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C2931(1.53); C132(1.09); C1739(1.03); C1768(1.06)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C2931(2.17); C132(0.93); C1739(1.14); C1768(1.14)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C2931(1.72); C132(1.04); C1739(1.11); C1768(0.87)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C2931(1.73); C132(1.05); C1739(1.30); C1768(0.88)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C2931(1.30); C132(0.91); C1739(0.90); C1768(0.83)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C2931(1.16); C132(0.85); C1739(1.02); C1768(1.18)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C2931(1.01); C132(1.08); C1739(1.06); C1768(1.21)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C2931(1.45); C132(0.95); C1739(1.08); C1768(1.07)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C2931(1.80); C132(0.90); C1739(1.56); C1768(1.59)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C111(1.48); C2931(0.88); C160(0.98); C1768(1.00)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C2931(1.22); C132(1.05); C1739(1.06); C1768(1.18)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C111(1.12); C2931(1.04); C160(1.18); C1739(1.00)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C111(1.51); C2931(1.03); C160(1.01); C1739(1.12)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C111(1.01); C2931(1.05); C160(0.99); C1739(1.17)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C111(1.27); C2931(1.19); C160(1.00); C1739(1.06)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C111(1.01); C2931(1.10); C160(1.01); C1739(1.13)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C111(1.68); C2931(1.05); C160(1.07); C1739(1.08)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C111(1.66); C2931(1.14); C160(1.10); C1739(1.16)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C111(1.21); C2931(1.40); C160(1.14); C1739(1.10)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C111(1.36); C2931(1.32); C160(1.22); C1739(1.13)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C111(0.90); C1768(0.95); C2364(1.07); C1380(1.00)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1674(3.81)  LDD1702  [13]
 LDCM0625  F8 Ramos C160(0.69); C1768(1.07); C2931(0.96); C1961(1.14)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C1768(0.29); C2931(0.81); C132(1.81); C907(0.66)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C160(0.34); C1961(0.61); C1674(9.48); C132(0.83)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C1768(0.85); C2931(0.80); C132(1.67); C907(1.08)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C160(0.32); C1768(0.57); C2931(1.01); C1674(0.79)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C2931(1.00); C132(1.78); C907(1.02); C741(2.02)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C2931(0.74); C132(1.54); C907(1.28); C741(1.57)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C160(0.57); C2931(0.78); C1674(0.89); C132(1.02)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C160(0.96); C1768(0.31); C2931(1.00); C1674(0.86)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C160(0.96); C1768(0.64); C1674(0.98); C132(0.82)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C160(1.09); C1768(0.40); C2931(0.75); C1674(0.83)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C160(0.69); C1768(1.63); C1674(0.91); C132(1.13)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C1768(0.35); C1674(0.81); C132(1.07); C907(0.73)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C160(1.74); C1768(0.16); C2931(0.68); C1674(1.35)  LDD2201  [14]
 LDCM0468  Fragment33 HCT 116 C2931(1.47); C1768(0.98); C1952(0.76); C2062(1.44)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C160(0.59); C1768(0.29); C2931(0.63); C1674(2.03)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C160(4.60); C1768(1.63); C2931(1.11); C1674(2.85)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C111(0.86); C2931(1.65); C160(1.04); C1768(1.44)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C160(0.50); C1768(0.57); C2931(0.77); C132(1.24)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C160(2.32); C1768(0.28); C1674(0.59); C132(1.32)  LDD2205  [14]
 LDCM0615  Fragment63-R Jurkat _(4.04)  LDD1487  [2]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [2]
 LDCM0569  Fragment7 Jurkat _(12.37)  LDD1485  [2]
 LDCM0571  Fragment9 Ramos C907(1.11); C741(0.89); C348(1.25)  LDD2188  [14]
 LDCM0022  KB02 HEK-293T C111(0.95); C638(0.88); C1768(1.00); C2364(0.87)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C1486(69.40); C160(10.53); C132(5.35); C3326(615.31)  LDD0209  [15]
 LDCM0024  KB05 COLO792 C638(2.00)  LDD3310  [16]
 LDCM0021  THZ1 HCT 116 C3486(1.18); C3504(1.18); C638(1.03)  LDD2173  [5]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840