Details of the Target

General Information of Target

Target ID LDTP07050
Target Name DDB1- and CUL4-associated factor 10 (DCAF10)
Gene Name DCAF10
Gene ID 79269
Synonyms
WDR32; DDB1- and CUL4-associated factor 10; WD repeat-containing protein 32
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFPFGPHSPGGDGSAGAGAEEPTPHEGQAAATGPPSPLHPGADATHPPPPARSPRRPGAP
SLSPAPRSGELGLPGAPESSTASAPGEPSPPSPPCRRPGPDCRAKSRGRHGLGAGLGGPG
ARLFGWLKERSLGRGLFVDPARDNFRTMTSLYGSIHPADSVYLSTRTHGAVFNLEYSPDG
SVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLR
KLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHKKFFHTRF
LMRMRLTPDCSKMLISTSSGYLLILHDLDLTKSLEVGSYPILRARRTTSSSDLTTSSSSS
GPRVSGSPCHHSDSNSSEKHMSRASQREGVSPRNSLEVVTPEVLGESDHGNCITSLQLHP
KGWATLLRCSSNSDDEECTCVYEFQEGAPVRPVSPRCSLRLTHYIEEANVGRGYIKELCF
SPDGRMISSPHGYGIRLLGFDKQCSELVDCLPKEASPLRVIRSLYSHNDVVLTTKFSPTH
CQIASGCLSGRVSLYQPKF
Target Bioclass
Other
Family
WD repeat DCAF10 family
Function May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Uniprot ID
Q5QP82
Ensemble ID
ENST00000377724.8
HGNC ID
HGNC:23686

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.L306S DBIA    Probe Info 
GB2 SNV: p.N375S .
HEC1B SNV: p.Ter560YextTer15 .
MFE280 SNV: p.C429R DBIA    Probe Info 
MOLT4 SNV: p.S14Ter; p.G18E IA-alkyne    Probe Info 
NCIH196 SNV: p.V399I .
NCIH358 SNV: p.K293N .
SNU5 SNV: p.H110R .
TOV21G SNV: p.P47H; p.P64T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K128(6.67)  LDD0277  [1]
Johansson_61
 Probe Info  		_(20.00)  LDD1487  [2]
IPM
 Probe Info  		C369(2.39)  LDD1702  [3]
DBIA
 Probe Info  		C504(1.04); C510(1.04)  LDD0078  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		C310(0.00); C369(0.00)  LDD0148  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C102(0.97)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C102(0.92)  LDD0532  [4]
 LDCM0226  AC11 HCT 116 C102(0.89)  LDD0543  [4]
 LDCM0237  AC12 HCT 116 C102(0.95)  LDD0554  [4]
 LDCM0259  AC14 HCT 116 C102(0.62)  LDD0576  [4]
 LDCM0270  AC15 HCT 116 C102(0.68)  LDD0587  [4]
 LDCM0276  AC17 HCT 116 C102(0.37)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C102(0.45)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C102(0.43)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C102(0.90)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C102(0.41)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C102(0.44)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C102(0.42)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C102(0.47)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C102(0.31)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C102(1.06)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C102(1.03)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C102(1.08)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C102(1.14)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C102(1.01)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C102(0.87)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C102(0.91)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C102(0.96)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C102(1.01)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C102(1.18)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C102(1.30)  LDD0612  [4]
 LDCM0296  AC35 HEK-293T C228(1.00)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C228(0.81)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C479(0.98); C228(0.57)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C479(1.04); C228(1.05); C213(1.20)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C479(0.86); C228(0.94)  LDD1539  [10]
 LDCM0301  AC4 HCT 116 C102(0.89)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C479(0.93); C228(0.88); C310(1.08)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C228(1.22)  LDD1542  [10]
 LDCM0305  AC43 HEK-293T C228(0.79)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C228(1.02)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C479(1.12); C228(0.95)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C479(1.05); C228(1.17); C213(1.01)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C479(0.97); C228(0.99)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C479(0.90); C228(1.03); C310(1.09)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C228(0.91)  LDD1550  [10]
 LDCM0312  AC5 HCT 116 C102(0.79)  LDD0629  [4]
 LDCM0314  AC51 HEK-293T C228(0.95)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C228(0.85)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C479(1.11); C228(0.68)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C479(1.14); C228(0.87); C213(1.10)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C479(0.94); C228(0.89)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C479(0.85); C228(0.65); C310(1.07)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C228(0.89)  LDD1559  [10]
 LDCM0322  AC59 HEK-293T C228(1.21)  LDD1561  [10]
 LDCM0323  AC6 HCT 116 C102(0.86)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C228(0.83)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C479(1.08); C228(0.59)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C479(1.03); C228(0.99); C213(0.94)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C479(0.84); C228(0.95)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C479(0.92); C228(0.75); C310(1.02)  LDD1567  [10]
 LDCM0332  AC68 HCT 116 C102(0.92)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C102(1.27)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C102(0.81)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C102(1.49)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C102(0.88)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C102(1.39)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C102(1.69)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C102(1.69)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C102(1.99)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C102(1.24)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C102(1.35)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C102(1.10)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C102(1.27)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C102(0.81)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C102(1.35)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C102(1.42)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C102(2.23)  LDD0665  [4]
 LDCM0248  AKOS034007472 HCT 116 C102(0.73)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C102(1.10)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C102(0.67)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C504(1.04); C510(1.04)  LDD0078  [4]
 LDCM0367  CL1 HEK-293T C479(1.04); C412(0.81); C228(0.78); C541(1.09)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C479(1.11); C228(1.36); C213(1.35)  LDD1572  [10]
 LDCM0369  CL100 HCT 116 C102(1.16)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C102(0.74)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C102(0.75)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C102(0.63)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C102(0.74)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C102(0.45)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C102(0.43)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C102(0.47)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C102(0.40)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C102(0.50)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C479(0.93); C228(1.56)  LDD1583  [10]
 LDCM0380  CL110 HCT 116 C102(0.35)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C102(0.41)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C102(1.11)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C102(1.04)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C102(0.98)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C102(1.03)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C102(0.88)  LDD0703  [4]
 LDCM0387  CL117 HEK-293T C479(1.08); C412(1.07); C228(0.70); C541(1.04)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C479(0.99); C412(0.94); C228(1.11)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C479(0.93); C228(1.05); C213(0.90)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C479(1.20); C228(0.75); C310(1.24)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C479(1.01); C228(0.88)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C479(1.08); C412(0.70); C228(0.93); C541(0.94)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C479(1.10); C412(0.83); C228(0.91)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C479(1.15); C228(1.37); C213(0.90)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C479(0.65); C228(1.35)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C479(1.10); C412(0.85); C228(0.96); C541(0.93)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C479(1.04); C412(0.79); C228(1.05)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C479(0.88); C228(1.03); C213(0.86)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C479(0.81); C228(0.89)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C479(1.08); C412(0.87); C228(0.82); C541(1.15)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C479(1.02); C412(1.08); C228(1.26)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C479(1.04); C228(0.67); C213(1.16)  LDD1606  [10]
 LDCM0403  CL16 HCT 116 C102(1.08)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C102(0.85)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C102(1.09)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C102(0.86)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C479(0.97); C412(0.83); C228(0.90)  LDD1611  [10]
 LDCM0408  CL20 HCT 116 C102(0.90)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C102(0.82)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C102(0.82)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C102(0.99)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C102(1.05)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C102(0.97)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C102(1.03)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C102(0.84)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C102(1.03)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C102(0.78)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C479(0.88); C228(0.92); C213(1.05)  LDD1622  [10]
 LDCM0419  CL30 HCT 116 C102(0.83)  LDD0736  [4]
 LDCM0420  CL31 PaTu 8988t C429(1.24); C440(1.24)  LDD1299  [4]
 LDCM0421  CL32 HCT 116 C102(1.11)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C102(1.26)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C102(0.86)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C102(0.93)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C102(0.76)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C102(0.84)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C102(0.90)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C479(0.95); C228(1.08)  LDD1633  [10]
 LDCM0430  CL40 HCT 116 C102(0.96)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C102(0.78)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C102(0.70)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C102(0.77)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C102(0.76)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C102(0.77)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C102(0.94)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C102(0.78)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C102(0.81)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C102(0.63)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C228(0.96)  LDD1644  [10]
 LDCM0441  CL50 HCT 116 C102(0.83)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C102(0.74)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C102(0.83)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C102(0.83)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C102(0.96)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C102(0.76)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C102(0.81)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C102(0.72)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C102(0.88)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C102(0.66)  LDD0767  [4]
 LDCM0452  CL60 HCT 116 C102(0.66)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C102(1.09)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C102(1.00)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C102(0.78)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C102(0.67)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C102(0.77)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C102(0.80)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C102(1.10)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C102(0.78)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C102(1.01)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C228(0.95)  LDD1665  [10]
 LDCM0463  CL70 HCT 116 C102(0.92)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C102(1.13)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C102(0.89)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C102(0.83)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C102(0.99)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C479(0.96); C228(1.06)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C228(0.88)  LDD1673  [10]
 LDCM0472  CL79 HEK-293T C228(0.92)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C228(1.08)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C228(1.15)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C479(1.17); C228(0.76)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C479(1.09); C228(1.46); C213(1.06)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C479(1.02); C228(0.73)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C479(1.11); C228(0.76); C310(1.13)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C479(1.07); C412(0.96); C228(0.99); C541(0.92)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C479(1.16); C412(0.70); C228(0.80)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C479(1.06); C228(0.97); C213(0.79)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C479(0.96); C228(0.71)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C228(1.01)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C479(0.97); C228(0.61)  LDD1687  [10]
 LDCM0486  CL91 HCT 116 C102(0.95)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C102(1.21)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C102(0.87)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C102(1.06)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C102(1.01)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C102(0.83)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C102(0.87)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C102(1.20)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C102(1.16)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C479(0.86); C228(0.83); C213(1.14)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C369(2.39)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C102(0.80)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C102(0.87)  LDD0744  [4]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1487  [2]
 LDCM0022  KB02 HEK-293T C228(0.92)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C228(1.14)  LDD1497  [10]
 LDCM0024  KB05 UACC257 C102(1.95)  LDD3325  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LIM/homeobox protein Lhx4 (LHX4) . Q969G2

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840