Details of the Target
General Information of Target
| Target ID | LDTP06471 | |||||
|---|---|---|---|---|---|---|
| Target Name | Chitinase-3-like protein 2 (CHI3L2) | |||||
| Gene Name | CHI3L2 | |||||
| Gene ID | 1117 | |||||
| Synonyms |
Chitinase-3-like protein 2; Chondrocyte protein 39; YKL-39 |
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| 3D Structure | ||||||
| Sequence |
MGATTMDQKSLWAGVVVLLLLQGGSAYKLVCYFTNWSQDRQEPGKFTPENIDPFLCSHLI
YSFASIENNKVIIKDKSEVMLYQTINSLKTKNPKLKILLSIGGYLFGSKGFHPMVDSSTS RLEFINSIILFLRNHNFDGLDVSWIYPDQKENTHFTVLIHELAEAFQKDFTKSTKERLLL TAGVSAGRQMIDNSYQVEKLAKDLDFINLLSFDFHGSWEKPLITGHNSPLSKGWQDRGPS SYYNVEYAVGYWIHKGMPSEKVVMGIPTYGHSFTLASAETTVGAPASGPGAAGPITESSG FLAYYEICQFLKGAKITRLQDQQVPYAVKGNQWVGYDDVKSMETKVQFLKNLNLGGAMIW SIDMDDFTGKSCNQGPYPLVQAVKRSLGSL |
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| Target Bioclass |
Enzyme
|
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| Family |
Glycosyl hydrolase 18 family
|
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| Subcellular location |
Secreted
|
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| Function | Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
TH211 Probe Info |
 |
Y326(20.00) | LDD0260 | [1] | |
|
DBIA Probe Info |
 |
C372(4.46) | LDD3397 | [2] | |
|
Johansson_61 Probe Info |
 |
_(20.00) | LDD1487 | [3] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0036 | [4] | |
|
Lodoacetamide azide Probe Info |
 |
N.A. | LDD0037 | [4] | |
|
Compound 10 Probe Info |
 |
N.A. | LDD2216 | [5] | |
|
Compound 11 Probe Info |
 |
N.A. | LDD2213 | [5] | |
Competitor(s) Related to This Target
References