Details of the Target

General Information of Target

Target ID LDTP10221
Target Name TBC1 domain family member 31 (TBC1D31)
Gene Name TBC1D31
Gene ID 93594
Synonyms
WDR67; TBC1 domain family member 31; WD repeat-containing protein 67
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPHVCLSGFGSGCCPGWAPS
MGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGPCGEYGCDLTCNHGGCQE
VARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEGGFVCECGPGMQLSADRHSCQ
DTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNT
VGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQPRQHPSKMLLLLPEAGRPALSPGH
SPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLL
QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR
CEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPEC
PSGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPE
LACPREEWRLGPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSV
SCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVA
CSPVDCPITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCE
KVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNC
SSCPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGA
SPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASA
LSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
Uniprot ID
Q96DN5
Ensemble ID
ENST00000287380.6
HGNC ID
HGNC:30888

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.N1045H .
IM95 SNV: p.K905R DBIA    Probe Info 
JHH1 SNV: p.M650L DBIA    Probe Info 
JURKAT SNV: p.S958L .
NCIH358 SNV: p.L623V .
RKO Insertion: p.V101CfsTer5 .
SW1116 SNV: p.E861K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Johansson_61
 Probe Info  		_(5.02)  LDD1487  [1]
IPM
 Probe Info  		C621(4.13)  LDD1701  [2]
DBIA
 Probe Info  		C197(4.75); C202(4.75)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
TFBX
 Probe Info  		C916(0.00); C908(0.00)  LDD0148  [5]
YN-1
 Probe Info  		E825(0.00); E832(0.00); C296(0.00)  LDD0447  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C197(2.21); C202(2.21)  LDD1093  [3]
 LDCM0215  AC10 PaTu 8988t C197(1.46); C202(1.46)  LDD1094  [3]
 LDCM0216  AC100 PaTu 8988t C197(1.10); C202(1.10)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C197(1.05); C202(1.05)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C197(1.04); C202(1.04)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C197(1.12); C202(1.12)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C197(1.04); C202(1.04)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C197(1.06); C202(1.06)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C197(1.02); C202(1.02)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C197(1.05); C202(1.05)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C197(1.02); C202(1.02)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C197(0.92); C202(0.92)  LDD1104  [3]
 LDCM0226  AC11 PaTu 8988t C197(1.53); C202(1.53)  LDD1105  [3]
 LDCM0227  AC110 PaTu 8988t C197(1.05); C202(1.05)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C197(0.91); C202(0.91)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C197(0.96); C202(0.96)  LDD1108  [3]
 LDCM0230  AC113 PaTu 8988t C197(0.86); C202(0.86)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C197(0.98); C202(0.98)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C197(1.15); C202(1.15)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C197(1.01); C202(1.01)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C197(1.02); C202(1.02)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C197(1.05); C202(1.05)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C197(1.08); C202(1.08)  LDD1115  [3]
 LDCM0237  AC12 PaTu 8988t C197(1.75); C202(1.75)  LDD1116  [3]
 LDCM0238  AC120 PaTu 8988t C197(0.91); C202(0.91)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C197(0.97); C202(0.97)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C197(1.01); C202(1.01)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C197(0.97); C202(0.97)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C197(1.05); C202(1.05)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C197(1.08); C202(1.08)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C197(0.97); C202(0.97)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C197(1.09); C202(1.09)  LDD1124  [3]
 LDCM0246  AC128 PaTu 8988t C197(1.20); C202(1.20)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C197(1.11); C202(1.11)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C197(1.24); C202(1.24)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C197(1.32); C202(1.32)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C197(1.06); C202(1.06)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C197(1.20); C202(1.20)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C197(1.08); C202(1.08)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C197(1.12); C202(1.12)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C197(1.12); C202(1.12)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C197(1.07); C202(1.07)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C197(1.07); C202(1.07)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C197(1.14); C202(1.14)  LDD1137  [3]
 LDCM0259  AC14 PaTu 8988t C197(1.29); C202(1.29)  LDD1138  [3]
 LDCM0260  AC140 PaTu 8988t C197(1.28); C202(1.28)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C197(1.14); C202(1.14)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C197(1.24); C202(1.24)  LDD1141  [3]
 LDCM0270  AC15 PaTu 8988t C197(1.66); C202(1.66)  LDD1149  [3]
 LDCM0276  AC17 HEK-293T C296(1.00); C916(0.86)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C296(0.93)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C296(0.88)  LDD1517  [7]
 LDCM0279  AC2 PaTu 8988t C197(1.37); C202(1.37)  LDD1158  [3]
 LDCM0280  AC20 HEK-293T C296(0.89)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C296(0.90)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C296(1.05)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C296(1.05)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C296(0.92)  LDD1523  [7]
 LDCM0285  AC25 PaTu 8988t C197(0.82); C202(0.82)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C197(0.90); C202(0.90)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C197(0.91); C202(0.91)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C197(0.88); C202(0.88)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C197(0.87); C202(0.87)  LDD1168  [3]
 LDCM0290  AC3 PaTu 8988t C197(1.30); C202(1.30)  LDD1169  [3]
 LDCM0291  AC30 PaTu 8988t C197(0.95); C202(0.95)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C197(0.86); C202(0.86)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C197(0.97); C202(0.97)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C197(1.04); C202(1.04)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C197(1.11); C202(1.11)  LDD1174  [3]
 LDCM0296  AC35 PaTu 8988t C197(1.02); C202(1.02)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C197(0.90); C202(0.90)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C197(1.14); C202(1.14)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C197(1.40); C202(1.40)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C197(1.23); C202(1.23)  LDD1179  [3]
 LDCM0301  AC4 PaTu 8988t C197(1.15); C202(1.15)  LDD1180  [3]
 LDCM0302  AC40 PaTu 8988t C197(1.46); C202(1.46)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C197(1.01); C202(1.01)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C197(1.07); C202(1.07)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C197(1.46); C202(1.46)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C197(1.66); C202(1.66)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C197(1.48); C202(1.48)  LDD1186  [3]
 LDCM0308  AC46 HEK-293T C296(0.94)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C296(1.02)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C296(0.93)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C296(0.91); C916(1.02)  LDD1550  [7]
 LDCM0312  AC5 PaTu 8988t C197(1.67); C202(1.67)  LDD1191  [3]
 LDCM0313  AC50 HEK-293T C296(1.02)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C296(1.10)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C296(0.98)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C296(0.90)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C296(0.90)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C296(1.04)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C296(0.84)  LDD1558  [7]
 LDCM0320  AC57 PaTu 8988t C197(1.11); C202(1.11)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C197(0.98); C202(0.98)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C197(0.99); C202(0.99)  LDD1201  [3]
 LDCM0323  AC6 PaTu 8988t C197(1.34); C202(1.34)  LDD1202  [3]
 LDCM0324  AC60 PaTu 8988t C197(1.21); C202(1.21)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C197(0.96); C202(0.96)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C197(1.02); C202(1.02)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C197(1.08); C202(1.08)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C197(1.13); C202(1.13)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C197(0.92); C202(0.92)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C197(1.05); C202(1.05)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C197(1.07); C202(1.07)  LDD1210  [3]
 LDCM0332  AC68 PaTu 8988t C197(1.18); C202(1.18)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C197(1.01); C202(1.01)  LDD1212  [3]
 LDCM0334  AC7 PaTu 8988t C197(1.07); C202(1.07)  LDD1213  [3]
 LDCM0335  AC70 PaTu 8988t C197(1.42); C202(1.42)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C197(1.27); C202(1.27)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C197(1.23); C202(1.23)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C197(0.94); C202(0.94)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C197(1.23); C202(1.23)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C197(1.22); C202(1.22)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C197(1.09); C202(1.09)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C197(0.96); C202(0.96)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C197(1.20); C202(1.20)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C197(1.04); C202(1.04)  LDD1223  [3]
 LDCM0345  AC8 PaTu 8988t C197(1.14); C202(1.14)  LDD1224  [3]
 LDCM0346  AC80 PaTu 8988t C197(0.99); C202(0.99)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C197(1.43); C202(1.43)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C197(1.13); C202(1.13)  LDD1227  [3]
 LDCM0365  AC98 PaTu 8988t C197(1.07); C202(1.07)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C197(1.13); C202(1.13)  LDD1245  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C197(1.24); C202(1.24)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C197(1.41); C202(1.41)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C197(1.39); C202(1.39)  LDD1154  [3]
 LDCM0367  CL1 HEK-293T C296(1.04)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C296(0.82)  LDD1572  [7]
 LDCM0369  CL100 PaTu 8988t C197(1.40); C202(1.40)  LDD1248  [3]
 LDCM0370  CL101 PaTu 8988t C197(1.78); C202(1.78)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C197(2.17); C202(2.17)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C197(1.58); C202(1.58)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C197(1.43); C202(1.43)  LDD1252  [3]
 LDCM0374  CL105 HEK-293T C296(0.98)  LDD1578  [7]
 LDCM0376  CL107 HEK-293T C296(0.75)  LDD1580  [7]
 LDCM0378  CL109 HEK-293T C296(0.84)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C296(1.26)  LDD1583  [7]
 LDCM0381  CL111 HEK-293T C296(0.94)  LDD1585  [7]
 LDCM0382  CL112 PaTu 8988t C197(0.84); C202(0.84)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C197(0.84); C202(0.84)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C197(0.80); C202(0.80)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C197(1.02); C202(1.02)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C197(1.03); C202(1.03)  LDD1265  [3]
 LDCM0387  CL117 PaTu 8988t C197(1.10); C202(1.10)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C197(1.16); C202(1.16)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C197(1.06); C202(1.06)  LDD1268  [3]
 LDCM0390  CL12 HEK-293T C296(1.15)  LDD1594  [7]
 LDCM0391  CL120 PaTu 8988t C197(1.07); C202(1.07)  LDD1270  [3]
 LDCM0392  CL121 HEK-293T C296(0.88)  LDD1596  [7]
 LDCM0394  CL123 HEK-293T C296(0.69)  LDD1598  [7]
 LDCM0396  CL125 PaTu 8988t C197(1.15); C202(1.15)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C197(1.06); C202(1.06)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C197(1.07); C202(1.07)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C197(1.01); C202(1.01)  LDD1278  [3]
 LDCM0400  CL13 HEK-293T C296(1.11)  LDD1604  [7]
 LDCM0402  CL15 HEK-293T C296(0.80)  LDD1606  [7]
 LDCM0404  CL17 HEK-293T C296(0.72); C916(1.24)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C296(1.10)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C296(0.97)  LDD1610  [7]
 LDCM0408  CL20 HEK-293T C296(1.13)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C296(0.65)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C296(1.08)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C296(1.26)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C296(1.25)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C296(0.93)  LDD1617  [7]
 LDCM0415  CL27 HEK-293T C296(0.90)  LDD1619  [7]
 LDCM0417  CL29 HEK-293T C296(0.84); C916(0.98)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C296(1.06)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C296(1.15)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C296(0.98)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C296(1.01)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C296(0.61)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C296(0.99)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C296(1.09)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C296(1.28)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C296(0.96)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C296(0.98)  LDD1632  [7]
 LDCM0431  CL41 HEK-293T C296(0.83); C916(1.12)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C296(0.96)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C296(0.86)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C296(1.15)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C296(0.81)  LDD1639  [7]
 LDCM0436  CL46 PaTu 8988t C197(0.94); C202(0.94)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C197(1.04); C202(1.04)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C197(1.05); C202(1.05)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C197(1.06); C202(1.06)  LDD1318  [3]
 LDCM0440  CL5 HEK-293T C296(0.94); C916(1.05)  LDD1644  [7]
 LDCM0441  CL50 PaTu 8988t C197(1.09); C202(1.09)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C197(1.13); C202(1.13)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C197(1.23); C202(1.23)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C197(1.30); C202(1.30)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C197(1.20); C202(1.20)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C197(0.87); C202(0.87)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C197(0.73); C202(0.73)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C197(1.94); C202(1.94)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C197(1.77); C202(1.77)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C197(1.91); C202(1.91)  LDD1329  [3]
 LDCM0451  CL6 HEK-293T C296(0.96)  LDD1654  [7]
 LDCM0452  CL60 PaTu 8988t C197(1.71); C202(1.71)  LDD1331  [3]
 LDCM0453  CL61 HEK-293T C296(1.17)  LDD1656  [7]
 LDCM0455  CL63 HEK-293T C296(0.92)  LDD1658  [7]
 LDCM0457  CL65 HEK-293T C296(0.84); C916(1.09)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C296(1.18)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C296(1.05)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C296(0.90)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C296(0.92)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C296(0.91)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C296(1.14)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C296(1.22)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C296(1.18)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C296(1.12)  LDD1669  [7]
 LDCM0469  CL76 PaTu 8988t C197(1.26); C202(1.26)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C197(1.07); C202(1.07)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C197(1.19); C202(1.19)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C197(1.02); C202(1.02)  LDD1351  [3]
 LDCM0473  CL8 HEK-293T C296(0.78)  LDD1676  [7]
 LDCM0474  CL80 PaTu 8988t C197(1.23); C202(1.23)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C197(1.27); C202(1.27)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C197(1.51); C202(1.51)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C197(1.43); C202(1.43)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C197(1.40); C202(1.40)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C197(1.00); C202(1.00)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C197(1.20); C202(1.20)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C197(1.63); C202(1.63)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C197(1.30); C202(1.30)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C197(1.41); C202(1.41)  LDD1362  [3]
 LDCM0484  CL9 HEK-293T C296(0.96)  LDD1687  [7]
 LDCM0485  CL90 PaTu 8988t C197(1.60); C202(1.60)  LDD1364  [3]
 LDCM0486  CL91 PaTu 8988t C197(1.25); C202(1.25)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C197(1.34); C202(1.34)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C197(1.27); C202(1.27)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C197(1.75); C202(1.75)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C197(4.14); C202(4.14)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C197(1.48); C202(1.48)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C197(1.84); C202(1.84)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C197(1.90); C202(1.90)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C197(1.33); C202(1.33)  LDD1373  [3]
 LDCM0495  E2913 HEK-293T C296(1.12)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C296(1.04)  LDD1671  [7]
 LDCM0615  Fragment63-R Jurkat _(5.02)  LDD1487  [1]
 LDCM0022  KB02 HCT 116 C197(4.75); C202(4.75)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C197(2.70); C202(2.70)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C197(4.39); C202(4.39)  LDD0082  [3]

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402