Details of the Target

General Information of Target

Target ID LDTP11990
Target Name Cytosolic iron-sulfur assembly component 3 (CIAO3)
Gene Name CIAO3
Gene ID 64428
Synonyms
NARFL; PRN; Cytosolic iron-sulfur assembly component 3; Cytosolic Fe-S cluster assembly factor NARFL; Iron-only hydrogenase-like protein 1; IOP1; Nuclear prelamin A recognition factor-like protein; Protein related to Narf
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT
IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI
RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELA
DDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEG
LRESLSFYISLNDEAVSLDDA
Target Bioclass
Enzyme
Family
NARF family
Function
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.
Uniprot ID
Q9H6Q4
Ensemble ID
ENST00000251588.7
HGNC ID
HGNC:14179

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.G47E .
HEC1 SNV: p.A187T .
HEC1B Insertion: p.L251AfsTer88 .
LS180 SNV: p.C385Y .
MCC13 SNV: p.S287F .
MFE319 SNV: p.R172Ter .
OAW28 SNV: p.R255I .
REH SNV: p.C24Y DBIA    Probe Info 
RL952 Deletion: p.I146Ter .
TE10 SNV: p.G7R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C179(0.76)  LDD2109  [2]
Johansson_61
 Probe Info  		_(4.66)  LDD1487  [3]
AHL-Pu-1
 Probe Info  		C300(2.37)  LDD0170  [4]
TFBX
 Probe Info  		C179(2.53)  LDD0312  [5]
DBIA
 Probe Info  		C71(2.60); C77(2.60); C74(2.60)  LDD0080  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C270(0.00); C300(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C270(0.00); C453(0.00); C300(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [5]
NAIA_4
 Probe Info  		0.00; C453(0.00)  LDD2226  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C300(2.37)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C300(2.66)  LDD0171  [4]
 LDCM0561  Abegg_cp(-)-10 HeLa C179(2.53)  LDD0312  [5]
 LDCM0214  AC1 HCT 116 C71(1.32); C74(1.32)  LDD0531  [6]
 LDCM0215  AC10 PaTu 8988t C190(1.13); C195(1.13)  LDD1094  [6]
 LDCM0216  AC100 HEK-293T C71(0.61); C74(0.61)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C71(0.85); C74(0.85)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C71(0.57); C74(0.57)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C71(0.49); C74(0.49)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C71(0.57); C74(0.57)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C71(1.46); C74(1.46)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C71(1.27); C74(1.27)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C71(0.63); C74(0.63)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C71(0.93); C74(0.93)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C71(1.13); C74(1.13)  LDD0823  [6]
 LDCM0226  AC11 PaTu 8988t C190(1.13); C195(1.13)  LDD1105  [6]
 LDCM0227  AC110 HEK-293T C71(0.42); C74(0.42)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C71(0.49); C74(0.49)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C71(0.42); C74(0.42)  LDD0827  [6]
 LDCM0230  AC113 PaTu 8988t C190(0.68); C195(0.68)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C190(0.61); C195(0.61)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C190(0.97); C195(0.97)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C190(0.99); C195(0.99)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C190(0.52); C195(0.52)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C190(0.93); C195(0.93)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C190(0.69); C195(0.69)  LDD1115  [6]
 LDCM0237  AC12 PaTu 8988t C190(1.16); C195(1.16)  LDD1116  [6]
 LDCM0238  AC120 PaTu 8988t C190(0.82); C195(0.82)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C190(0.61); C195(0.61)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C190(0.92); C195(0.92)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C190(0.88); C195(0.88)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C190(1.49); C195(1.49)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C190(1.18); C195(1.18)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C190(0.92); C195(0.92)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C190(0.97); C195(0.97)  LDD1124  [6]
 LDCM0246  AC128 HEK-293T C71(1.06); C74(1.06)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C71(0.67); C74(0.67)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C71(0.72); C74(0.72)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C71(1.03); C74(1.03)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C71(0.91); C74(0.91)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C71(0.56); C74(0.56)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C71(0.60); C74(0.60)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C71(0.59); C74(0.59)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C71(0.50); C74(0.50)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C71(0.45); C74(0.45)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C71(0.42); C74(0.42)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C71(0.44); C74(0.44)  LDD0856  [6]
 LDCM0259  AC14 PaTu 8988t C190(1.19); C195(1.19)  LDD1138  [6]
 LDCM0260  AC140 HEK-293T C71(0.56); C74(0.56)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C71(0.47); C74(0.47)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C71(0.47); C74(0.47)  LDD0860  [6]
 LDCM0263  AC143 HEK-293T C71(0.70); C74(0.70)  LDD0861  [6]
 LDCM0264  AC144 HEK-293T C71(0.48); C74(0.48)  LDD0862  [6]
 LDCM0265  AC145 HEK-293T C71(0.48); C74(0.48)  LDD0863  [6]
 LDCM0266  AC146 HEK-293T C71(0.53); C74(0.53)  LDD0864  [6]
 LDCM0267  AC147 HEK-293T C71(0.46); C74(0.46)  LDD0865  [6]
 LDCM0268  AC148 HEK-293T C71(0.60); C74(0.60)  LDD0866  [6]
 LDCM0269  AC149 HEK-293T C71(1.05); C74(1.05)  LDD0867  [6]
 LDCM0270  AC15 PaTu 8988t C190(0.99); C195(0.99)  LDD1149  [6]
 LDCM0271  AC150 HEK-293T C71(0.61); C74(0.61)  LDD0869  [6]
 LDCM0272  AC151 HEK-293T C71(0.58); C74(0.58)  LDD0870  [6]
 LDCM0273  AC152 HEK-293T C71(0.59); C74(0.59)  LDD0871  [6]
 LDCM0274  AC153 HEK-293T C71(0.64); C74(0.64)  LDD0872  [6]
 LDCM0621  AC154 HEK-293T C71(0.76); C74(0.76)  LDD2162  [6]
 LDCM0622  AC155 HEK-293T C71(0.69); C74(0.69)  LDD2163  [6]
 LDCM0623  AC156 HEK-293T C71(0.53); C74(0.53)  LDD2164  [6]
 LDCM0624  AC157 HEK-293T C71(0.53); C74(0.53)  LDD2165  [6]
 LDCM0276  AC17 HCT 116 C74(0.94)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C74(1.44)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C74(1.77)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C71(1.11); C74(1.11)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C74(1.74)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C74(1.20)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C74(1.30)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C74(1.08)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C74(2.03)  LDD0601  [6]
 LDCM0285  AC25 PaTu 8988t C190(0.93); C195(0.93)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C190(1.13); C195(1.13)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C190(0.93); C195(0.93)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C190(1.31); C195(1.31)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C190(1.21); C195(1.21)  LDD1168  [6]
 LDCM0290  AC3 HCT 116 C71(1.09); C74(1.09)  LDD0607  [6]
 LDCM0291  AC30 PaTu 8988t C190(0.96); C195(0.96)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C190(1.08); C195(1.08)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C190(1.27); C195(1.27)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C190(1.11); C195(1.11)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C190(1.40); C195(1.40)  LDD1174  [6]
 LDCM0296  AC35 HEK-293T C300(1.25); C246(1.03); C270(1.03)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C300(1.39); C246(1.05); C270(0.98); C453(1.01)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C300(0.98); C246(1.08); C453(1.10); C385(1.03)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C246(1.07)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C300(0.89); C246(1.14); C385(1.24); C195(0.83)  LDD1539  [9]
 LDCM0301  AC4 HCT 116 C71(0.99); C74(0.99)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C300(0.97); C246(0.93); C453(1.13)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C246(1.00); C453(0.91)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C246(1.07); C195(1.11)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C300(0.87); C246(0.98); C270(1.02)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C300(0.93); C246(0.97); C270(1.00); C453(1.01)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C300(0.96); C246(1.10); C453(1.21); C385(0.97)  LDD1546  [9]
 LDCM0308  AC46 HCT 116 C71(1.47); C74(1.47)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C71(1.04); C74(1.04)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C71(1.69); C74(1.69)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C71(1.54); C74(1.54)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C71(1.20); C74(1.20)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C71(1.18); C74(1.18)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C71(0.87); C74(0.87)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C71(1.08); C74(1.08)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C71(1.77); C74(1.77)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C71(0.94); C74(0.94)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C71(1.76); C74(1.76)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C71(1.64); C74(1.64)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C71(1.11); C74(1.11)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C71(1.08); C74(1.08)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C71(0.99); C74(0.99)  LDD0920  [6]
 LDCM0323  AC6 PaTu 8988t C190(1.12); C195(1.12)  LDD1202  [6]
 LDCM0324  AC60 HEK-293T C71(0.90); C74(0.90)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C71(0.56); C74(0.56)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C71(0.82); C74(0.82)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C71(0.72); C74(0.72)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C71(0.84); C74(0.84)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C71(0.67); C74(0.67)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C71(0.91); C74(0.91)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C71(0.74); C74(0.74)  LDD0929  [6]
 LDCM0332  AC68 HCT 116 C71(1.84); C74(1.84)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C71(1.01); C74(1.01)  LDD0650  [6]
 LDCM0334  AC7 PaTu 8988t C190(0.96); C195(0.96)  LDD1213  [6]
 LDCM0335  AC70 HCT 116 C71(0.84); C74(0.84)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C71(0.83); C74(0.83)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C71(1.31); C74(1.31)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C71(1.07); C74(1.07)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C71(0.92); C74(0.92)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C71(0.95); C74(0.95)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C71(0.99); C74(0.99)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C71(1.16); C74(1.16)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C71(0.80); C74(0.80)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C71(0.88); C74(0.88)  LDD0661  [6]
 LDCM0345  AC8 PaTu 8988t C190(0.99); C195(0.99)  LDD1224  [6]
 LDCM0346  AC80 HCT 116 C71(0.86); C74(0.86)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C71(0.92); C74(0.92)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C71(0.92); C74(0.92)  LDD0665  [6]
 LDCM0349  AC83 HEK-293T C71(0.97); C74(0.97)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C71(0.54); C74(0.54)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C71(0.59); C74(0.59)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C71(0.73); C74(0.73)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C71(0.68); C74(0.68)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C71(0.47); C74(0.47)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C71(0.37); C74(0.37)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C71(0.43); C74(0.43)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C71(0.61); C74(0.61)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C71(0.48); C74(0.48)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C71(0.54); C74(0.54)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C71(0.44); C74(0.44)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C71(0.52); C74(0.52)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C71(0.39); C74(0.39)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C71(0.29); C74(0.29)  LDD0962  [6]
 LDCM0365  AC98 HEK-293T C71(1.08); C74(1.08)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C71(0.71); C74(0.71)  LDD0964  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C190(0.96); C195(0.96)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C190(1.07); C195(1.07)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C190(1.18); C195(1.18)  LDD1154  [6]
 LDCM0156  Aniline NCI-H1299 11.55  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C385(1.21); C395(1.21); C399(1.21); C71(1.16)  LDD2171  [6]
 LDCM0632  CL-Sc Hep-G2 C300(2.12)  LDD2227  [8]
 LDCM0368  CL10 HEK-293T C246(1.18)  LDD1572  [9]
 LDCM0369  CL100 HCT 116 C71(1.48); C74(1.48)  LDD0686  [6]
 LDCM0370  CL101 PaTu 8988t C190(1.26); C195(1.26)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C190(1.29); C195(1.29)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C190(1.15); C195(1.15)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C190(1.30); C195(1.30)  LDD1252  [6]
 LDCM0374  CL105 HCT 116 C74(1.26)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C74(1.49)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C74(1.31)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C74(1.41)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C74(2.89)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C300(0.98); C246(1.22); C385(1.34); C195(0.90)  LDD1583  [9]
 LDCM0380  CL110 HCT 116 C74(1.68)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C74(1.24)  LDD0698  [6]
 LDCM0382  CL112 PaTu 8988t C190(1.06); C195(1.06)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C190(1.16); C195(1.16)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C190(1.30); C195(1.30)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C190(1.07); C195(1.07)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C190(1.03); C195(1.03)  LDD1265  [6]
 LDCM0388  CL118 HEK-293T C246(0.96)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C300(1.01); C246(1.03)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C300(1.09); C246(1.09); C453(1.30)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C246(1.10); C195(1.02)  LDD1595  [9]
 LDCM0392  CL121 HCT 116 C71(2.50); C74(2.50)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C71(1.10); C74(1.10)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C71(2.14); C74(2.14)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C71(1.50); C74(1.50)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C71(1.02); C74(1.02)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C71(1.09); C74(1.09)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C71(1.17); C74(1.17)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C71(1.17); C74(1.17)  LDD0997  [6]
 LDCM0401  CL14 HEK-293T C246(1.21)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C300(1.00); C246(0.91)  LDD1606  [9]
 LDCM0403  CL16 HCT 116 C71(1.06); C74(1.06)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C71(2.68); C74(2.68)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C71(1.40); C74(1.40)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C71(1.53); C74(1.53)  LDD0723  [6]
 LDCM0407  CL2 HEK-293T C246(1.21)  LDD1611  [9]
 LDCM0408  CL20 HCT 116 C71(1.25); C74(1.25)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C71(1.81); C74(1.81)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C71(2.36); C74(2.36)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C71(1.36); C74(1.36)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C71(2.02); C74(2.02)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C71(2.34); C74(2.34)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C71(2.54); C74(2.54)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C71(1.59); C74(1.59)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C71(1.59); C74(1.59)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C71(1.50); C74(1.50)  LDD0734  [6]
 LDCM0418  CL3 HEK-293T C300(0.92); C246(1.02)  LDD1622  [9]
 LDCM0419  CL30 HCT 116 C71(1.50); C74(1.50)  LDD0736  [6]
 LDCM0420  CL31 HEK-293T C71(0.80); C74(0.80)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C71(0.73); C74(0.73)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C71(0.67); C74(0.67)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C71(0.72); C74(0.72)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C71(0.58); C74(0.58)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C71(0.77); C74(0.77)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C71(0.60); C74(0.60)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C71(0.21); C74(0.21)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C246(0.91); C195(1.10)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C71(0.45); C74(0.45)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C71(0.20); C74(0.20)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C71(0.24); C74(0.24)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C71(0.23); C74(0.23)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C71(0.58); C74(0.58)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C71(0.34); C74(0.34)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C71(0.79); C74(0.79)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C71(0.92); C74(0.92)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C71(0.88); C74(0.88)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C71(0.86); C74(0.86)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C246(0.88); C453(1.07)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C71(0.55); C74(0.55)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C71(0.15); C74(0.15)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C71(1.28); C74(1.28)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C71(1.21); C74(1.21)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C71(0.75); C74(0.75)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C71(0.74); C74(0.74)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C71(1.10); C74(1.10)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C71(1.01); C74(1.01)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C71(1.04); C74(1.04)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C71(0.66); C74(0.66)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C246(1.05); C195(0.82)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C71(0.56); C74(0.56)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C71(0.82); C74(0.82)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C71(0.57); C74(0.57)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C71(0.44); C74(0.44)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C71(0.60); C74(0.60)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C71(0.45); C74(0.45)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C71(0.53); C74(0.53)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C71(0.55); C74(0.55)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C71(0.39); C74(0.39)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C71(0.65); C74(0.65)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C300(1.11); C246(0.89); C270(1.03)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C71(0.67); C74(0.67)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C71(0.46); C74(0.46)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C71(0.70); C74(0.70)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C71(0.45); C74(0.45)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C71(0.19); C74(0.19)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C246(0.99); C195(0.98)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C246(0.91); C453(0.99)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C246(0.99); C195(0.94)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C300(0.91); C246(0.88); C270(1.05)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C300(0.75); C246(0.86); C270(1.13); C453(1.03)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C300(1.17); C246(0.88); C270(1.01); C453(1.02)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C300(1.10); C246(0.92); C453(1.24); C385(1.12)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C246(1.00)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C300(0.80); C246(1.04); C385(1.38); C195(0.77)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C300(0.94); C246(0.85); C453(1.02)  LDD1681  [9]
 LDCM0480  CL86 HEK-293T C246(0.94)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C300(0.83); C246(0.83)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C246(0.84); C195(1.16)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C246(0.88); C453(1.16)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C300(0.89); C246(1.04); C453(1.26); C385(1.35)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C246(0.89); C195(0.91)  LDD1688  [9]
 LDCM0486  CL91 HCT 116 C71(1.07); C74(1.07)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C71(1.01); C74(1.01)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C71(0.90); C74(0.90)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C71(1.38); C74(1.38)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C71(1.08); C74(1.08)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C71(1.46); C74(1.46)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C71(2.24); C74(2.24)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C71(1.19); C74(1.19)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C71(1.23); C74(1.23)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C300(1.39); C246(1.04)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C71(0.23); C74(0.23)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C71(0.53); C74(0.53)  LDD1025  [6]
 LDCM0615  Fragment63-R Jurkat _(4.66)  LDD1487  [3]
 LDCM0022  KB02 HCT 116 C71(2.60); C77(2.60); C74(2.60)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C71(3.70); C77(3.70); C74(3.70)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C71(2.61); C77(2.61); C74(2.61)  LDD0082  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C179(0.76)  LDD2109  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C179(0.92)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C179(1.00)  LDD2140  [2]
 LDCM0131  RA190 MM1.R C300(1.10)  LDD0304  [10]
 LDCM0021  THZ1 HCT 116 C385(1.21); C395(1.21); C399(1.21); C71(1.16)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MMS19 nucleotide excision repair protein homolog (MMS19) MET18/MMS19 family Q96T76

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.