Details of the Target

General Information of Target

Target ID LDTP02300
Target Name Alpha-2-antiplasmin (SERPINF2)
Gene Name SERPINF2
Gene ID 5345
Synonyms
AAP; PLI; Alpha-2-antiplasmin; Alpha-2-AP; Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ
TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL
ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE
QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF
WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV
LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF
QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF
EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM
EEDYPQFGSPK
Target Bioclass
Other
Family
Serpin family
Subcellular location
Secreted
Function Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
Uniprot ID
P08697
Ensemble ID
ENST00000324015.7
HGNC ID
HGNC:9075

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.H146L .
ICC137 SNV: p.S23Y DBIA    Probe Info 
LS180 SNV: p.S101T .
MDST8 SNV: p.S432I DBIA    Probe Info 
SW756 SNV: p.E42Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-5
 Probe Info  		10.00  LDD0394  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C152(0.82)  LDD0533  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
BTD
 Probe Info  		N.A.  LDD0004  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C152(0.96)  LDD1507  [7]
 LDCM0216  AC100 HCT 116 C152(0.82)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C152(1.05)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C152(0.86)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C152(0.80)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C152(0.79)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C152(0.83)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C152(0.78)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C152(0.67)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C152(0.71)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C152(0.76)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C152(1.06)  LDD1509  [7]
 LDCM0227  AC110 HCT 116 C152(0.69)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C152(0.73)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C152(0.88)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C152(1.21)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C152(1.37)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C152(1.29)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C152(1.34)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C152(1.23)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C152(1.29)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C152(1.37)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C152(0.99)  LDD1510  [7]
 LDCM0238  AC120 HCT 116 C152(1.15)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C152(1.11)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C152(1.15)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C152(1.03)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C152(1.16)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C152(1.15)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C152(1.14)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C152(1.22)  LDD0562  [3]
 LDCM0263  AC143 HCT 116 C152(1.27)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C152(0.94)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C152(0.84)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C152(1.20)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C152(0.94)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C152(0.80)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C152(1.27)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C152(1.00)  LDD1513  [7]
 LDCM0271  AC150 HCT 116 C152(1.24)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C152(1.13)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C152(1.30)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C152(0.84)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C152(1.06)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C152(1.12)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C152(1.40)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C152(0.98)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C152(0.94)  LDD1515  [7]
 LDCM0278  AC19 HEK-293T C152(0.99)  LDD1517  [7]
 LDCM0280  AC20 HEK-293T C152(0.96)  LDD1519  [7]
 LDCM0283  AC23 HEK-293T C152(1.13)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C152(0.96)  LDD1523  [7]
 LDCM0285  AC25 HCT 116 C152(1.39)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C152(1.34)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C152(1.29)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C152(0.77)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C152(0.95)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C152(1.04)  LDD1529  [7]
 LDCM0291  AC30 HCT 116 C152(1.33)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C152(1.92)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C152(1.66)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C152(1.39)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C152(1.24)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C152(1.02)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C152(0.98)  LDD1536  [7]
 LDCM0300  AC39 HEK-293T C152(1.12)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C152(0.94)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C152(0.97)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C152(0.97)  LDD1542  [7]
 LDCM0305  AC43 HEK-293T C152(1.05)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C152(1.06)  LDD1545  [7]
 LDCM0309  AC47 HEK-293T C152(1.08)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C152(1.07)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C152(0.84)  LDD1550  [7]
 LDCM0314  AC51 HEK-293T C152(1.02)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C152(1.10)  LDD1554  [7]
 LDCM0318  AC55 HEK-293T C152(1.01)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C152(0.98)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C152(0.85)  LDD1559  [7]
 LDCM0322  AC59 HEK-293T C152(1.06)  LDD1561  [7]
 LDCM0324  AC60 HEK-293T C152(1.00)  LDD1563  [7]
 LDCM0327  AC63 HEK-293T C152(1.08)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C152(1.04)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C152(1.04)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C152(1.03)  LDD1569  [7]
 LDCM0365  AC98 HCT 116 C152(0.75)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C152(0.91)  LDD0683  [3]
 LDCM0356  AKOS034007680 HEK-293T C152(1.00)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C152(0.96)  LDD1514  [7]
 LDCM0367  CL1 HCT 116 C152(0.80)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C152(0.91)  LDD0685  [3]
 LDCM0370  CL101 HEK-293T C152(1.07)  LDD1574  [7]
 LDCM0372  CL103 HEK-293T C152(0.95)  LDD1576  [7]
 LDCM0374  CL105 HEK-293T C152(0.96)  LDD1578  [7]
 LDCM0376  CL107 HEK-293T C152(0.98)  LDD1580  [7]
 LDCM0378  CL109 HEK-293T C152(1.07)  LDD1582  [7]
 LDCM0379  CL11 HCT 116 C152(0.93)  LDD0696  [3]
 LDCM0381  CL111 HEK-293T C152(0.97)  LDD1585  [7]
 LDCM0382  CL112 HCT 116 C152(1.04)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C152(1.78)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C152(1.93)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C152(0.97)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C152(1.88)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C152(1.03)  LDD1591  [7]
 LDCM0389  CL119 HEK-293T C152(1.03)  LDD1593  [7]
 LDCM0390  CL12 HCT 116 C152(0.62)  LDD0707  [3]
 LDCM0392  CL121 HEK-293T C152(1.09)  LDD1596  [7]
 LDCM0394  CL123 HEK-293T C152(0.88)  LDD1598  [7]
 LDCM0396  CL125 HEK-293T C152(1.29)  LDD1600  [7]
 LDCM0398  CL127 HEK-293T C152(1.04)  LDD1602  [7]
 LDCM0400  CL13 HCT 116 C152(0.84)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C152(0.86)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C152(0.76)  LDD0719  [3]
 LDCM0404  CL17 HCT 116 C152(1.05)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C152(1.09)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C152(1.05)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C152(0.76)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C152(0.88)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C152(1.01)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C152(0.99)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C152(0.87)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C152(1.09)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C152(1.35)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C152(1.08)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C152(1.16)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C152(0.94)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C152(0.86)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C152(0.71)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C152(0.99)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C152(1.03)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C152(0.84)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C152(0.78)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C152(0.83)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C152(0.91)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C152(0.72)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C152(0.77)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C152(0.81)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C152(0.73)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C152(0.64)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C152(0.68)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C152(0.65)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C152(0.60)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C152(0.92)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C152(1.06)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C152(0.61)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C152(0.84)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C152(0.66)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C152(0.64)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C152(0.92)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C152(0.69)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C152(0.69)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C152(0.72)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C152(0.55)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C152(0.48)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C152(0.57)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C152(0.85)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C152(0.69)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C152(0.69)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C152(0.84)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C152(0.86)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C152(0.77)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C152(0.71)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C152(0.50)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C152(1.16)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C152(1.59)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C152(1.42)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C152(2.00)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C152(1.27)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C152(0.99)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C152(0.84)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C152(0.89)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C152(1.17)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C152(0.82)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C152(1.51)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C152(1.41)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C152(1.28)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C152(1.26)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C152(1.55)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C152(1.30)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C152(0.81)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C152(0.90)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C152(1.46)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C152(1.86)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C152(1.84)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C152(1.23)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C152(1.13)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C152(1.21)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C152(1.32)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C152(1.35)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C152(1.40)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C152(1.49)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C152(0.75)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C152(1.21)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C152(1.14)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C152(1.01)  LDD1690  [7]
 LDCM0490  CL95 HEK-293T C152(0.96)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C152(0.94)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C152(0.93)  LDD1695  [7]
 LDCM0494  CL99 HEK-293T C152(1.04)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C152(1.00)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C152(1.00)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C152(0.49)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C152(0.99)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C152(0.87)  LDD1497  [7]
 LDCM0024  KB05 IGR37 C88(3.68)  LDD3314  [8]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ocriplasmin BiotechDrug DB08888
Copper . DB09130

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840