Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment33  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 51 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 15.8
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 3.1
 LDTP05992  Bleomycin hydrolase (BLMH) C73 2.1
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.4
 LDTP02502  Thioredoxin (TXN) C32 1.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.3
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.3
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 1.3
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 1.2
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.1
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 1.1
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.0
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.0
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.0
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.0
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.0
 LDTP02672  Elongation factor 2 (EEF2) C136 1.0
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.9
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 0.9
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.9
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 0.9
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 0.9
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 0.9
 LDTP04689  Adenosine kinase (ADK) C353 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.9
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.9
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 0.9
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 0.9
 LDTP04374  Dynamin-2 (DNM2) C27 0.9
 LDTP02672  Elongation factor 2 (EEF2) C41 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 0.9
 LDTP03400  Deoxycytidine kinase (DCK) C45 0.9
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.8
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 0.8
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 0.8
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.8
 LDTP05289  AMP deaminase 2 (AMPD2) C107 0.8
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.8
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.7
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.7
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 0.7
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 0.6
 LDTP09446  Ribonuclease H2 subunit C (RNASEH2C) C34 0.5
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.5
Transporter and channel
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 3.7
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 3.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 2.6
 LDTP04801  Gasdermin-D (GSDMD) C268 1.1
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.1
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.1
 LDTP13661  Sorting nexin-6 (SNX6) C264 0.9
 LDTP00501  Exportin-1 (XPO1) C34 0.9
 LDTP01574  Importin-7 (IPO7) C757 0.8
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.8
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.5
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.2
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 1.1
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.0
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.9
Other
Click to Show/Hide to Show 40 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 2.1
 LDTP04092  Crk-like protein (CRKL) C249 1.5
 LDTP14195  FH1/FH2 domain-containing protein 1 (FHOD1) C502 1.5
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.4
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 1.3
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.3
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.2
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.1
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 1.0
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.0
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.0
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.0
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.0
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 0.9
 LDTP10864  Calponin-2 (CNN2) C164 0.9
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 0.9
 LDTP10864  Calponin-2 (CNN2) C215 0.9
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 0.9
 LDTP02205  Tubulin beta chain (TUBB) C239 0.9
 LDTP13580  Coronin-1C (CORO1C) C420 0.9
 LDTP02205  Tubulin beta chain (TUBB) C354 0.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.9
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 0.9
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 0.9
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 0.9
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 0.8
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.8
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 0.8
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 0.8
 LDTP04902  Actin-related protein 3 (ACTR3) C235 0.8
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 0.8
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) C207 0.8
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.7
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.7
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 0.7
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 0.7
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.6
 LDTP03244  Cofilin-1 (CFL1) C80 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.