Details of the Target

General Information of Target

Target ID LDTP08254
Target Name Ubiquitin carboxyl-terminal hydrolase 48 (USP48)
Gene Name USP48
Gene ID 84196
Synonyms
USP31; Ubiquitin carboxyl-terminal hydrolase 48; EC 3.4.19.12; Deubiquitinating enzyme 48; Ubiquitin thioesterase 48; Ubiquitin-specific peptidase 48; Ubiquitin-specific protease 48; Ubiquitin-specific-processing protease 48
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVCRRNCKGNPNCLVGIGE
HIWLGEIDENSFHNIDDPNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLC
PSTCSDYMLGDGIQEEKDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALGLDTGQQQ
DAQEFSKLFMSLLEDTLSKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELE
LNIQGHKQLTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFV
FDRQTGHKKKLNTYIGFSEILDMEPYVEHKGGSYVYELSAVLIHRGVSAYSGHYIAHVKD
PQSGEWYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRKPKCGKGTHCSRNAYMLVYRL
QTQEKPNTTVQVPAFLQELVDRDNSKFEEWCIEMAEMRKQSVDKGKAKHEEVKELYQRLP
AGAEPYEFVSLEWLQKWLDESTPTKPIDNHACLCSHDKLHPDKISIMKRISEYAADIFYS
RYGGGPRLTVKALCKECVVERCRILRLKNQLNEDYKTVNNLLKAAVKGSDGFWVGKSSLR
SWRQLALEQLDEQDGDAEQSNGKMNGSTLNKDESKEERKEEEELNFNEDILCPHGELCIS
ENERRLVSKEAWSKLQQYFPKAPEFPSYKECCSQCKILEREGEENEALHKMIANEQKTSL
PNLFQDKNRPCLSNWPEDTDVLYIVSQFFVEEWRKFVRKPTRCSPVSSVGNSALLCPHGG
LMFTFASMTKEDSKLIALIWPSEWQMIQKLFVVDHVIKITRIEVGDVNPSETQYISEPKL
CPECREGLLCQQQRDLREYTQATIYVHKVVDNKKVMKDSAPELNVSSSETEEDKEEAKPD
GEKDPDFNQSNGGTKRQKISHQNYIAYQKQVIRRSMRHRKVRGEKALLVSANQTLKELKI
QIMHAFSVAPFDQNLSIDGKILSDDCATLGTLGVIPESVILLKADEPIADYAAMDDVMQV
CMPEEGFKGTGLLGH
Target Bioclass
Enzyme
Family
Peptidase C19 family
Subcellular location
Cytoplasm
Function
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.
Uniprot ID
Q86UV5
Ensemble ID
ENST00000308271.14
HGNC ID
HGNC:18533

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.P121Q DBIA    Probe Info 
AN3CA Deletion: p.L233CfsTer9 DBIA    Probe Info 
BICR22 SNV: p.G779R DBIA    Probe Info 
CAL33 SNV: p.C39Ter .
DOTC24510 SNV: p.E641Q DBIA    Probe Info 
HCT15 SNV: p.G59C .
KMS27 Deletion: p.T422_P426del DBIA    Probe Info 
KU1919 SNV: p.M415V DBIA    Probe Info 
KYSE510 SNV: p.F538L DBIA    Probe Info 
LN18 SNV: p.Q225R DBIA    Probe Info 
MOLT4 SNV: p.A535V IA-alkyne    Probe Info 
NCIH1155 SNV: p.A356T DBIA    Probe Info 
T98G SNV: p.V812I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y162(6.24)  LDD0257  [2]
STPyne
 Probe Info  		K9(10.00)  LDD0277  [3]
MCL-4
 Probe Info  		2.20  LDD0049  [4]
AHL-Pu-1
 Probe Info  		C986(2.76)  LDD0168  [5]
HHS-475
 Probe Info  		Y924(1.26)  LDD0264  [6]
DBIA
 Probe Info  		C850(1.95); C39(7.82); C652(1.16); C658(1.16)  LDD0080  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C145(0.00); C850(0.00); C451(0.00); C986(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C145(0.00); C986(0.00); C39(0.00); C290(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C145(0.00); C986(0.00); C39(0.00); C290(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
IPM
 Probe Info  		C39(0.00); C841(0.00)  LDD0005  [11]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		14.60  LDD0443  [16]
NAIA_5
 Probe Info  		C145(0.00); C986(0.00); C39(0.00); C290(0.00)  LDD2223  [9]
HHS-465
 Probe Info  		N.A.  LDD2240  [17]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.86  LDD0476  [18]
FFF probe3
 Probe Info  		6.55  LDD0465  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C986(2.76)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C409(2.19); C986(2.58)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C120(0.62); C124(0.62); C214(1.12); C270(1.07)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C120(0.83); C124(0.83); C214(0.80); C270(0.67)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C691(0.57); C120(0.37); C124(0.50); C270(1.08)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C691(0.66); C120(0.39); C124(0.64); C270(0.84)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C691(0.64); C120(0.32); C124(0.50); C270(1.02)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C691(0.46); C120(0.29); C124(0.46); C270(1.00)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C691(0.50); C120(0.30); C124(0.52); C270(0.94)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C691(0.42); C120(0.34); C124(0.50); C270(1.28)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C691(0.47); C120(0.38); C124(0.51); C270(1.20)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C691(0.42); C120(0.28); C124(0.47); C270(1.14)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C691(0.68); C120(0.38); C124(0.56); C270(1.05)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C691(0.69); C120(0.43); C124(0.58); C270(1.03)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C120(0.95); C124(0.95); C214(0.90); C270(0.69)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C691(0.70); C120(0.53); C124(0.65); C270(1.14)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C691(0.59); C120(0.47); C124(0.67); C270(0.97)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C691(0.50); C120(0.37); C124(0.73); C270(0.80)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C691(0.96); C120(0.91); C124(0.91); C270(0.93)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C691(0.90); C120(1.00); C124(0.80); C270(0.79)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C691(0.75); C120(0.82); C124(0.77); C270(0.71)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C691(0.73); C120(0.99); C124(0.79); C270(0.82)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C691(0.84); C120(0.86); C124(0.86); C270(0.84)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C691(0.99); C120(1.00); C124(0.85); C270(0.89)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C691(0.87); C120(0.90); C124(0.76); C270(0.85)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C120(0.94); C124(0.94); C214(0.73); C270(0.87)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C691(0.86); C120(1.10); C124(0.75); C270(0.88)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C691(1.27); C120(0.91); C124(0.92); C270(0.89)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C691(1.06); C120(0.90); C124(0.83); C270(0.88)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C691(1.17); C120(0.78); C124(0.88); C270(1.11)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C691(1.38); C120(0.93); C124(0.94); C270(0.92)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C691(1.02); C120(1.05); C124(0.97); C270(0.84)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C691(1.13); C120(0.85); C124(0.76); C270(0.81)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C691(0.94); C120(0.91); C124(0.83); C270(0.80)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C691(0.80); C120(1.27); C124(1.27); C270(1.14)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C691(1.05); C120(1.18); C124(1.18); C270(1.06)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C691(0.89); C120(0.95); C124(0.95); C270(0.84)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C691(1.02); C120(1.27); C124(1.27); C270(1.12)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C691(1.00); C120(1.28); C124(1.28); C270(0.86)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C691(0.94); C120(1.02); C124(1.02); C270(0.94)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C691(0.77); C120(1.03); C124(1.03); C270(0.80)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C691(0.96); C120(1.10); C124(1.10); C270(0.84)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C691(0.84); C120(1.00); C124(1.00); C270(0.92)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C691(0.95); C120(1.06); C124(1.06); C270(0.88)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C691(0.86); C120(1.08); C124(1.08); C270(0.76)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C691(0.87); C120(1.15); C124(1.15); C270(0.76)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C120(0.85); C124(0.85); C214(1.31); C270(0.76)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C691(0.79); C120(1.16); C124(1.16); C270(0.68)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C691(0.83); C120(1.21); C124(1.21); C270(0.69)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C691(1.18); C120(1.31); C124(1.31); C270(0.96)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C691(0.87); C120(0.82); C124(0.82); C692(0.87)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C692(0.66); C695(0.67); C124(0.73); C120(0.73)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C692(0.76); C695(0.77); C512(0.80); C514(0.80)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C692(0.56); C695(0.59); C691(0.66); C124(0.74)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C692(0.62); C695(0.64); C691(0.67); C120(0.71)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C692(0.46); C695(0.52); C691(0.54); C124(0.68)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C692(0.51); C695(0.55); C691(0.55); C120(0.60)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C270(0.64); C273(0.64); C120(0.80); C124(0.80)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C120(0.81); C692(0.82); C691(0.83); C695(0.84)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C692(0.78); C691(0.79); C695(0.80); C120(0.84)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C691(0.55); C692(0.56); C695(0.57); C120(0.65)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C692(0.44); C691(0.45); C695(0.45); C124(0.68)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C691(0.60); C120(0.80); C124(0.80); C290(0.87)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C691(0.60); C120(0.79); C124(0.81); C290(0.89)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C691(0.79); C120(0.87); C124(0.98); C290(0.98)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C691(0.88); C120(0.85); C124(0.85); C290(1.01)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C451(0.88); C120(0.88); C39(0.89); C270(0.92)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C120(0.68); C692(0.68); C695(0.68); C290(0.72)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C692(0.80); C695(0.80); C290(0.84); C120(0.87)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C214(0.71); C120(0.76); C124(0.76); C270(0.88)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C512(0.83); C514(0.83); C290(0.87); C120(0.88)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C290(0.80); C120(0.83); C124(0.84); C451(0.87)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C290(0.86); C39(0.90); C451(0.96); C692(0.98)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C512(0.83); C514(0.83); C692(0.85); C695(0.85)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C512(0.79); C514(0.79); C451(0.91); C39(0.92)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C270(0.84); C273(0.84); C692(0.86); C695(0.86)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C451(0.76); C120(0.83); C124(0.83); C270(0.83)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C120(0.74); C124(0.74); C451(0.79); C692(0.80)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C120(0.79); C124(0.79); C214(0.83); C692(0.85)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C120(0.72); C124(0.72); C451(0.77); C692(0.83)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C214(0.76); C120(0.80); C124(0.80); C451(0.81)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C692(0.70); C695(0.70); C120(0.70); C124(0.70)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C120(0.69); C124(0.69); C451(0.73); C692(0.84)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C451(0.62); C692(0.67); C695(0.67); C120(0.67)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C120(0.67); C124(0.67); C692(0.70); C695(0.70)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C692(0.65); C695(0.65); C120(0.74); C124(0.74)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C652(0.80); C658(0.80); C850(0.90); C39(1.01)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C120(0.87); C124(0.87); C850(0.89); C512(0.92)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C512(0.84); C514(0.84); C850(0.87); C451(0.96)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C270(0.84); C273(0.84); C512(0.91); C514(0.91)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C652(0.79); C658(0.79); C512(0.85); C514(0.85)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C120(0.60); C124(0.60); C451(0.83); C39(0.95)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C120(0.81); C124(0.81); C692(0.87); C695(0.87)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C652(0.79); C658(0.79); C120(0.85); C124(0.85)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C120(0.94); C124(0.94); C270(0.96); C273(0.96)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C270(0.82); C273(0.82); C652(0.82); C658(0.82)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C652(0.63); C658(0.63); C120(0.82); C124(0.82)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C652(0.61); C658(0.61); C120(0.75); C124(0.75)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C270(0.85); C273(0.85); C692(0.89); C695(0.89)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C270(0.80); C273(0.80); C290(0.93); C451(0.95)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C270(0.71); C273(0.71); C512(0.92); C514(0.92)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C270(0.52); C273(0.52); C691(0.61); C692(0.66)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C120(0.64); C124(0.64); C451(0.75); C214(0.83)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C270(0.54); C273(0.54); C691(0.63); C692(0.71)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C290(1.01); C512(1.02); C514(1.02); C270(1.03)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C270(0.77); C273(0.77); C691(0.88); C290(0.93)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C692(0.70); C695(0.70); C691(0.70); C270(0.70)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C270(0.70); C273(0.70); C691(0.76); C692(0.78)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C270(0.56); C273(0.56); C692(0.68); C695(0.68)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C270(0.40); C273(0.40); C691(0.64); C692(0.70)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C652(0.38); C658(0.38); C691(0.67); C692(0.67)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C652(0.52); C658(0.52); C270(0.56); C273(0.56)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C652(0.33); C658(0.33); C692(0.59); C695(0.59)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C270(0.66); C273(0.66); C692(0.78); C695(0.78)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C652(0.55); C658(0.55); C691(0.56); C120(0.59)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C120(0.69); C124(0.69); C652(0.74); C658(0.74)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C652(0.36); C658(0.36); C691(0.53); C692(0.54)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C652(0.38); C658(0.38); C691(0.55); C120(0.58)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C652(0.41); C658(0.41); C691(0.48); C692(0.51)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C652(0.37); C658(0.37); C691(0.56); C692(0.59)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C652(0.37); C658(0.37); C691(0.63); C692(0.64)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C652(0.26); C658(0.26); C692(0.50); C695(0.50)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C691(0.52); C270(0.70); C273(0.70); C692(0.81)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C691(0.44); C214(0.74); C270(0.81); C273(0.81)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C270(0.79); C273(0.79); C120(0.88); C124(0.88)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C270(0.48); C273(0.48); C691(0.50); C214(0.64)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C691(0.59); C270(0.73); C273(0.73); C512(0.93)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C691(0.47); C270(0.65); C273(0.65); C652(0.73)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C691(0.34); C270(0.43); C273(0.43); C214(0.65)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C691(0.37); C270(0.40); C273(0.40); C214(0.83)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C270(0.31); C273(0.31); C691(0.34); C214(0.59)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C691(0.38); C270(0.67); C273(0.67); C214(0.83)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C691(0.43); C270(0.53); C273(0.53); C652(0.71)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C691(0.55); C270(0.70); C273(0.70); C512(0.86)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C691(0.51); C214(0.77); C270(0.78); C273(0.78)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C270(0.74); C273(0.74); C692(0.87); C695(0.87)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C691(0.45); C270(0.81); C273(0.81); C692(0.81)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C691(0.79); C214(0.84); C290(0.84); C451(0.89)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C270(0.37); C273(0.37); C691(0.40); C214(0.70)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C691(0.37); C692(0.37); C695(0.37); C120(0.61)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C691(0.47); C692(0.47); C695(0.47); C120(0.55)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C691(0.57); C692(0.57); C695(0.57); C120(0.62)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C691(0.60); C692(0.60); C695(0.60); C120(0.78)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C120(0.75); C124(0.75); C270(0.76); C273(0.76)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C120(0.60); C124(0.60); C270(0.75); C273(0.75)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C691(0.50); C692(0.50); C695(0.50); C120(0.63)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C270(0.69); C273(0.69); C120(0.99); C124(0.99)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C691(0.35); C692(0.35); C695(0.35); C120(0.61)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C691(0.39); C692(0.39); C695(0.39); C120(0.61)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C691(0.58); C692(0.58); C695(0.58); C120(0.65)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C691(0.77); C692(0.77); C695(0.77); C451(0.77)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C120(0.62); C124(0.62); C270(0.75); C273(0.75)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C691(0.49); C692(0.49); C695(0.49); C120(0.67)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C691(0.39); C692(0.39); C695(0.39); C270(0.63)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C120(0.29); C691(0.30); C692(0.30); C695(0.30)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C120(0.51); C124(0.62); C691(0.72); C692(0.72)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C120(0.87); C124(0.87); C214(0.79); C270(0.88)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C692(0.78); C695(0.78); C270(0.87); C273(0.87)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C270(0.44); C273(0.44); C214(0.63); C120(0.70)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C39(1.04); C691(1.09); C695(1.09); C54(1.08)  LDD2171  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C290(1.60)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C451(0.91); C290(0.99); C512(1.05); C514(1.05)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C451(0.91); C270(0.92); C273(0.92); C652(0.96)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C120(0.65); C124(0.65); C451(0.88); C512(0.99)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C214(0.75); C270(0.79); C273(0.79); C120(0.83)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C270(0.85); C273(0.85); C692(0.89); C695(0.89)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C850(0.90); C214(0.92); C512(0.94); C514(0.94)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C270(0.80); C273(0.80); C512(0.86); C514(0.86)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C692(0.78); C695(0.78); C270(0.78); C273(0.78)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C270(0.62); C273(0.62); C692(0.67); C695(0.67)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C270(0.69); C273(0.69); C692(0.72); C695(0.72)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C270(0.64); C273(0.64); C692(0.67); C695(0.67)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C692(0.82); C695(0.82); C120(0.92); C270(0.93)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C652(0.69); C658(0.69); C270(0.71); C273(0.71)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C692(0.67); C695(0.67); C270(0.82); C273(0.82)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C512(0.90); C514(0.90); C451(0.91); C692(0.91)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C451(0.87); C270(1.01); C273(1.01); C290(1.01)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C120(0.65); C124(0.65); C692(0.67); C695(0.67)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C451(0.78); C120(0.82); C124(0.82); C270(0.89)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C120(0.78); C124(0.78); C451(0.79); C512(0.89)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C451(0.72); C120(0.73); C124(0.73); C270(0.79)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C692(0.81); C695(0.81); C652(0.85); C658(0.85)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C652(0.82); C658(0.82); C39(0.89); C290(0.96)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C652(0.68); C658(0.68); C120(0.91); C124(0.91)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C270(0.66); C273(0.66); C652(0.72); C658(0.72)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C652(0.65); C658(0.65); C270(0.88); C273(0.88)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C850(1.30); C39(1.30); C451(1.36); C120(1.46)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C270(0.74); C273(0.74); C691(0.82); C692(0.89)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C692(0.77); C695(0.77); C691(0.78); C270(0.86)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C270(0.68); C273(0.68); C691(0.73); C692(0.81)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C652(0.37); C658(0.37); C214(0.80); C120(0.95)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C652(0.72); C658(0.72); C120(0.77); C124(0.77)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C120(0.73); C124(0.73); C270(0.75); C273(0.75)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C652(0.42); C658(0.42); C692(0.64); C695(0.64)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C652(0.60); C658(0.60); C270(0.74); C273(0.74)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C290(0.99); C692(1.01); C39(1.02); C691(1.07)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C120(0.96); C124(0.96); C270(0.98); C273(0.98)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C120(0.74); C124(0.74); C692(0.82); C695(0.82)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C691(0.74); C451(0.96); C692(1.06); C695(1.06)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C120(0.58); C124(0.58); C270(0.70); C273(0.70)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C270(0.64); C273(0.64); C120(0.86); C124(0.86)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C692(0.92); C691(0.95); C695(0.95); C850(1.01)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C270(0.65); C273(0.65); C691(0.66); C451(0.81)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C270(0.71); C273(0.71); C451(0.85); C691(0.85)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C270(0.45); C273(0.45); C512(0.74); C514(0.74)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C120(0.70); C124(0.70); C270(0.71); C273(0.71)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C691(0.86); C120(0.81); C124(0.81); C270(0.59)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C691(1.14); C120(0.87); C124(0.87); C270(0.69)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C691(0.91); C120(0.72); C124(0.72); C270(0.79)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C691(1.07); C120(0.85); C124(0.85); C270(0.77)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C691(0.97); C120(0.84); C124(0.84); C270(0.82)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C691(0.70); C120(0.82); C124(0.82); C270(0.69)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C691(1.04); C120(0.98); C124(0.98); C270(1.24)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C691(1.06); C120(0.82); C124(0.82); C270(0.81)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C691(1.05); C120(0.78); C124(0.78); C214(1.11)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C691(0.88); C120(0.63); C124(0.63); C214(1.33)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C691(0.82); C120(0.77); C124(0.77); C214(0.77)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C691(0.96); C120(0.78); C124(0.78); C214(1.06)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C691(0.85); C120(0.72); C124(0.72); C214(1.29)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C691(1.00); C120(0.95); C124(0.95); C214(0.76)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C691(0.95); C120(0.71); C124(0.71); C214(0.93)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C691(0.75); C120(0.78); C124(0.78); C214(1.01)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C691(1.23); C120(0.99); C124(0.99); C270(1.18)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C691(0.92); C120(0.82); C124(0.82); C214(0.81)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C691(1.44); C120(0.94); C124(0.94); C214(0.95)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C691(1.26); C120(1.39); C124(1.39); C214(1.29)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C691(1.09); C120(0.73); C124(0.73); C214(1.22)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C691(1.16); C120(0.80); C124(0.80); C214(1.22)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C691(1.15); C120(0.76); C124(0.76); C214(0.65)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C120(1.53); C124(1.53); C270(1.67); C273(1.67)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C120(1.28); C124(1.28); C270(1.57); C273(1.57)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C120(1.24); C124(1.24); C270(1.61); C273(1.61)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C120(1.27); C124(1.27); C270(1.15); C273(1.15)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C691(1.33); C120(0.96); C124(0.96); C270(1.07)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C120(1.40); C124(1.40); C270(1.38); C273(1.38)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C120(1.35); C124(1.35); C270(1.31); C273(1.31)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C120(1.39); C124(1.39); C270(1.47); C273(1.47)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C120(1.78); C124(1.78); C270(2.06); C273(2.06)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C120(1.43); C124(1.43); C270(1.63); C273(1.63)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C120(1.33); C124(1.33); C270(1.40); C273(1.40)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C120(1.15); C124(1.15); C270(1.40); C273(1.40)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C120(1.37); C124(1.37); C270(1.53); C273(1.53)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C120(1.25); C124(1.25); C270(1.34); C273(1.34)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C120(1.15); C124(1.15); C270(1.19); C273(1.19)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C691(1.17); C120(0.90); C124(0.90); C270(0.82)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C120(1.20); C124(1.20); C270(1.31); C273(1.31)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C691(1.19); C120(0.84); C124(0.84); C214(0.70)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C691(1.22); C120(0.91); C124(0.91); C214(0.75)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C691(1.02); C120(0.81); C124(0.81); C214(0.74)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C691(1.10); C120(0.75); C124(0.75); C214(0.76)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C691(0.97); C120(0.83); C124(0.83); C214(0.96)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C691(1.04); C120(0.94); C124(0.94); C214(0.82)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C691(1.00); C120(0.72); C124(0.72); C214(0.91)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C691(1.21); C120(0.73); C124(0.73); C214(1.00)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C691(1.14); C120(0.77); C124(0.77); C214(0.61)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C691(1.25); C120(0.96); C124(0.96); C270(0.76)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C691(0.96); C120(0.81); C124(0.81); C214(0.70)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C691(0.97); C120(0.73); C124(0.73); C214(0.67)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C691(1.07); C120(0.79); C124(0.79); C214(0.60)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C691(1.20); C120(0.96); C124(0.96); C214(0.90)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C691(1.10); C120(0.92); C124(0.92); C214(0.91)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C691(1.12); C120(0.92); C124(0.92); C214(1.27)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C691(1.06); C120(1.12); C124(1.12); C214(1.56)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C691(1.07); C120(0.80); C124(0.80); C214(1.13)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C691(1.17); C120(0.85); C124(0.85); C214(1.63)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C691(0.69); C120(1.19); C124(1.19); C270(0.57)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C691(1.13); C120(0.77); C124(0.77); C214(1.57)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C691(1.32); C120(0.92); C124(0.92); C214(1.07)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C691(1.31); C120(1.03); C124(1.03); C214(1.45)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C691(1.16); C120(0.85); C124(0.85); C214(0.95)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C691(1.03); C120(0.93); C124(0.93); C214(1.01)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C691(0.93); C120(0.78); C124(0.78); C214(0.89)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C691(1.12); C120(0.91); C124(0.91); C214(0.88)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C691(1.26); C120(1.12); C124(1.12); C214(1.01)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C691(1.41); C120(1.10); C124(1.10); C214(1.22)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C691(1.21); C120(0.97); C124(0.97); C214(1.22)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C691(1.12); C120(0.93); C124(0.93); C270(0.90)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C691(0.98); C120(1.12); C124(1.12); C214(1.07)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C120(0.81); C124(0.81); C214(0.80); C270(0.98)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C120(0.92); C124(0.92); C214(0.99); C270(0.98)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C120(0.73); C124(0.73); C214(1.12); C270(1.01)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C120(0.82); C124(0.82); C214(1.70); C270(1.34)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C120(0.94); C124(0.94); C214(1.07); C270(1.06)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C120(0.67); C124(0.67); C214(0.90); C270(0.91)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C120(0.78); C124(0.78); C214(0.82); C270(0.98)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C120(0.70); C124(0.70); C214(0.73); C270(1.02)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C120(0.71); C124(0.71); C214(0.70); C270(1.04)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C850(0.92)  LDD2228  [9]
 LDCM0495  E2913 HEK-293T C39(0.86); C451(0.98); C252(0.94); C1021(0.92)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C409(0.99)  LDD1702  [20]
 LDCM0625  F8 Ramos C39(0.93); C850(0.55); C290(1.33)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C39(1.47); C850(0.46); C290(0.97)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C39(0.33); C850(2.33); C290(1.13)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C39(1.27); C850(1.74); C290(0.95)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C39(0.80); C850(0.84); C290(0.79)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C39(0.78); C850(0.65); C290(1.01)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C39(2.06); C850(1.34)  LDD2194  [21]
 LDCM0580  Fragment21 MDA-MB-231 C39(1.37)  LDD1473  [22]
 LDCM0582  Fragment23 Ramos C39(2.00); C850(0.57); C290(1.03)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C39(1.01); C290(0.84)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C39(1.10); C850(0.23); C290(0.58)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C39(1.03); C850(0.83); C290(0.61)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C39(1.31)  LDD1478  [22]
 LDCM0590  Fragment32 Ramos C39(0.99); C850(0.42); C290(0.91)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C691(1.22); C120(0.81); C124(0.81); C214(0.89)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C39(0.84); C850(2.20); C290(1.13)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C39(1.07); C850(0.56); C290(1.37)  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C691(1.34); C120(0.95); C124(0.95); C214(0.69)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C39(0.98); C850(0.43); C290(1.05)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C39(1.58); C850(0.52); C290(0.56)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C39(6.92); C850(0.61); C290(1.16)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C39(2.38); C850(0.59); C290(1.65)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y924(1.26)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y924(0.26)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y924(0.56)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y924(0.44)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y924(1.06)  LDD0268  [6]
 LDCM0022  KB02 HCT 116 C850(1.95); C39(7.82); C652(1.16); C658(1.16)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C850(1.18); C39(1.35); C652(1.70); C658(1.70)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C850(1.35); C39(1.03); C652(0.91); C658(0.91)  LDD0082  [7]
 LDCM0006  Micheliolide M9-ENL1 2.20  LDD0049  [4]
 LDCM0109  NEM HeLa N.A.  LDD0226  [14]
 LDCM0627  NUDT7-COV-1 HEK-293T C850(0.07)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C850(0.07)  LDD2207  [23]
 LDCM0170  Structure8 Ramos 4.99  LDD0433  [24]
 LDCM0021  THZ1 HCT 116 C39(1.04); C691(1.09); C695(1.09); C54(1.08)  LDD2173  [7]
 LDCM0112  W16 Hep-G2 C39(1.11)  LDD0239  [15]
 LDCM0113  W17 Hep-G2 C39(4.13)  LDD0240  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
24 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.