Details of the Target

General Information of Target

Target ID LDTP05772
Target Name FAS-associated death domain protein (FADD)
Gene Name FADD
Gene ID 8772
Synonyms
MORT1; FAS-associated death domain protein; FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHT
ELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLK
VSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEV
QQARDLQNRSGAMSPMSWNSDASTSEAS
Target Bioclass
Other
Function
Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Uniprot ID
Q13158
Ensemble ID
ENST00000301838.5
HGNC ID
HGNC:3573

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K125(5.13); K149(8.75)  LDD0277  [1]
DBIA
 Probe Info  		C27(2.42)  LDD3310  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
NHS
 Probe Info  		N.A.  LDD0010  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
NAIA_5
 Probe Info  		C168(0.00); C27(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C168(0.81); C98(1.04)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C168(1.18); C98(1.00)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C98(1.05)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C168(0.84); C98(1.01)  LDD1510  [10]
 LDCM0246  AC128 PaTu 8988t C105(1.32); C98(1.32)  LDD1125  [11]
 LDCM0247  AC129 PaTu 8988t C105(0.92); C98(0.92)  LDD1126  [11]
 LDCM0249  AC130 PaTu 8988t C105(1.62); C98(1.62)  LDD1128  [11]
 LDCM0250  AC131 PaTu 8988t C105(1.18); C98(1.18)  LDD1129  [11]
 LDCM0251  AC132 PaTu 8988t C105(0.90); C98(0.90)  LDD1130  [11]
 LDCM0252  AC133 PaTu 8988t C105(1.12); C98(1.12)  LDD1131  [11]
 LDCM0253  AC134 PaTu 8988t C105(0.99); C98(0.99)  LDD1132  [11]
 LDCM0254  AC135 PaTu 8988t C105(1.10); C98(1.10)  LDD1133  [11]
 LDCM0255  AC136 PaTu 8988t C105(1.18); C98(1.18)  LDD1134  [11]
 LDCM0256  AC137 PaTu 8988t C105(1.22); C98(1.22)  LDD1135  [11]
 LDCM0257  AC138 PaTu 8988t C105(1.24); C98(1.24)  LDD1136  [11]
 LDCM0258  AC139 PaTu 8988t C105(0.99); C98(0.99)  LDD1137  [11]
 LDCM0259  AC14 HEK-293T C168(0.92); C98(0.94)  LDD1512  [10]
 LDCM0260  AC140 PaTu 8988t C105(1.47); C98(1.47)  LDD1139  [11]
 LDCM0261  AC141 PaTu 8988t C105(1.43); C98(1.43)  LDD1140  [11]
 LDCM0262  AC142 PaTu 8988t C105(1.75); C98(1.75)  LDD1141  [11]
 LDCM0263  AC143 PaTu 8988t C105(1.90); C98(1.90)  LDD1142  [11]
 LDCM0264  AC144 PaTu 8988t C105(1.43); C98(1.43)  LDD1143  [11]
 LDCM0265  AC145 PaTu 8988t C105(1.52); C98(1.52)  LDD1144  [11]
 LDCM0266  AC146 PaTu 8988t C105(1.36); C98(1.36)  LDD1145  [11]
 LDCM0267  AC147 PaTu 8988t C105(1.66); C98(1.66)  LDD1146  [11]
 LDCM0268  AC148 PaTu 8988t C105(1.20); C98(1.20)  LDD1147  [11]
 LDCM0269  AC149 PaTu 8988t C105(1.30); C98(1.30)  LDD1148  [11]
 LDCM0270  AC15 HEK-293T C168(1.07); C98(0.99)  LDD1513  [10]
 LDCM0271  AC150 PaTu 8988t C105(1.28); C98(1.28)  LDD1150  [11]
 LDCM0272  AC151 PaTu 8988t C105(0.92); C98(0.92)  LDD1151  [11]
 LDCM0273  AC152 PaTu 8988t C105(1.21); C98(1.21)  LDD1152  [11]
 LDCM0274  AC153 PaTu 8988t C105(1.28); C98(1.28)  LDD1153  [11]
 LDCM0621  AC154 PaTu 8988t C105(0.99); C98(0.99)  LDD2166  [11]
 LDCM0622  AC155 PaTu 8988t C105(1.17); C98(1.17)  LDD2167  [11]
 LDCM0623  AC156 PaTu 8988t C105(1.47); C98(1.47)  LDD2168  [11]
 LDCM0624  AC157 PaTu 8988t C105(1.34); C98(1.34)  LDD2169  [11]
 LDCM0276  AC17 HEK-293T C168(1.00); C98(1.01)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C168(0.96); C98(0.95)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C98(0.88)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C168(1.10); C98(0.96)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C168(0.87); C98(1.00)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C168(0.89); C98(1.00)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C168(0.92); C98(0.95)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C168(1.01); C98(0.90)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C168(1.14); C98(1.01)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C168(0.91); C98(1.08)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C168(0.86); C98(0.95)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C98(1.03)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C168(0.71); C98(1.04)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C168(0.98); C98(1.07)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C98(1.01)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C168(0.89); C98(0.93)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C168(0.94); C98(1.11)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C168(0.94); C98(0.95)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C168(1.03); C98(1.09)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C168(1.07); C98(0.95)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C98(1.04)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C168(0.75); C98(1.06)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C168(0.99); C98(0.97)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C168(0.89); C98(0.91)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C168(1.14); C98(1.07)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C168(0.70); C98(0.97)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C168(1.44); C98(1.06)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C168(0.95); C98(1.02)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C168(1.23); C98(1.12)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C98(1.02)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C168(0.87); C98(0.99)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C168(0.91); C98(1.14)  LDD1546  [10]
 LDCM0308  AC46 PaTu 8988t C105(1.26); C98(1.31)  LDD1187  [11]
 LDCM0309  AC47 PaTu 8988t C105(0.96); C98(1.38)  LDD1188  [11]
 LDCM0310  AC48 PaTu 8988t C105(1.32); C98(1.84)  LDD1189  [11]
 LDCM0311  AC49 PaTu 8988t C105(1.10); C98(1.40)  LDD1190  [11]
 LDCM0312  AC5 HEK-293T C168(1.00); C98(1.10)  LDD1551  [10]
 LDCM0313  AC50 PaTu 8988t C105(1.16); C98(1.32)  LDD1192  [11]
 LDCM0314  AC51 PaTu 8988t C105(1.14); C98(1.30)  LDD1193  [11]
 LDCM0315  AC52 PaTu 8988t C105(0.92); C98(1.40)  LDD1194  [11]
 LDCM0316  AC53 PaTu 8988t C105(1.28); C98(1.42)  LDD1195  [11]
 LDCM0317  AC54 PaTu 8988t C105(1.06); C98(1.07)  LDD1196  [11]
 LDCM0318  AC55 PaTu 8988t C105(1.43); C98(2.48)  LDD1197  [11]
 LDCM0319  AC56 PaTu 8988t C105(0.87); C98(0.96)  LDD1198  [11]
 LDCM0320  AC57 PaTu 8988t C105(0.77); C98(0.77)  LDD1199  [11]
 LDCM0321  AC58 PaTu 8988t C105(1.02); C98(1.02)  LDD1200  [11]
 LDCM0322  AC59 PaTu 8988t C105(1.34); C98(1.34)  LDD1201  [11]
 LDCM0323  AC6 HEK-293T C168(1.09); C98(0.98)  LDD1562  [10]
 LDCM0324  AC60 PaTu 8988t C105(1.27); C98(1.27)  LDD1203  [11]
 LDCM0325  AC61 PaTu 8988t C105(0.68); C98(0.68)  LDD1204  [11]
 LDCM0326  AC62 PaTu 8988t C105(0.71); C98(0.71)  LDD1205  [11]
 LDCM0327  AC63 PaTu 8988t C105(0.92); C98(0.92)  LDD1206  [11]
 LDCM0328  AC64 PaTu 8988t C105(1.16); C98(1.16)  LDD1207  [11]
 LDCM0329  AC65 PaTu 8988t C105(1.39); C98(1.39)  LDD1208  [11]
 LDCM0330  AC66 PaTu 8988t C105(0.88); C98(0.88)  LDD1209  [11]
 LDCM0331  AC67 PaTu 8988t C105(0.86); C98(0.86)  LDD1210  [11]
 LDCM0334  AC7 HEK-293T C168(0.97); C98(1.11)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C168(0.84); C98(1.07)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C168(0.97); C98(1.01)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C168(0.90); C98(1.05)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C168(1.13); C98(1.04)  LDD1514  [10]
 LDCM0630  CCW28-3 231MFP C98(2.26); C98(0.57); C105(0.57)  LDD2214  [12]
 LDCM0367  CL1 PaTu 8988t C105(0.90); C98(0.90)  LDD1246  [11]
 LDCM0368  CL10 PaTu 8988t C105(0.86); C98(0.86)  LDD1247  [11]
 LDCM0369  CL100 HEK-293T C98(1.02)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C168(1.08); C98(0.97)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C98(1.20)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C98(1.05)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C98(0.99)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C168(1.09); C98(0.98)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C98(1.07)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C98(0.93)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C98(1.04)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C168(1.10); C98(1.04)  LDD1582  [10]
 LDCM0379  CL11 PaTu 8988t C105(1.16); C98(1.16)  LDD1258  [11]
 LDCM0380  CL110 HEK-293T C98(1.31)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C98(1.19)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C98(1.18)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C168(0.96); C98(1.06)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C98(1.25)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C98(1.08)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C98(0.93)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C168(0.98); C98(1.04)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C98(1.07)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C98(1.07)  LDD1593  [10]
 LDCM0390  CL12 PaTu 8988t C105(1.22); C98(1.22)  LDD1269  [11]
 LDCM0391  CL120 HEK-293T C98(0.96)  LDD1595  [10]
 LDCM0392  CL121 PaTu 8988t C105(1.50); C98(1.79)  LDD1271  [11]
 LDCM0393  CL122 PaTu 8988t C105(0.81); C98(0.92)  LDD1272  [11]
 LDCM0394  CL123 PaTu 8988t C105(1.20); C98(2.46)  LDD1273  [11]
 LDCM0395  CL124 PaTu 8988t C105(1.23); C98(1.51)  LDD1274  [11]
 LDCM0396  CL125 PaTu 8988t C105(0.89); C98(0.89)  LDD1275  [11]
 LDCM0397  CL126 PaTu 8988t C105(0.97); C98(0.97)  LDD1276  [11]
 LDCM0398  CL127 PaTu 8988t C105(0.80); C98(0.80)  LDD1277  [11]
 LDCM0399  CL128 PaTu 8988t C105(0.74); C98(0.74)  LDD1278  [11]
 LDCM0400  CL13 PaTu 8988t C105(0.41); C98(0.41)  LDD1279  [11]
 LDCM0401  CL14 PaTu 8988t C105(0.47); C98(0.47)  LDD1280  [11]
 LDCM0402  CL15 PaTu 8988t C105(0.95); C98(0.95)  LDD1281  [11]
 LDCM0403  CL16 PaTu 8988t C105(0.66); C98(0.66)  LDD1282  [11]
 LDCM0404  CL17 PaTu 8988t C105(0.72); C98(0.72)  LDD1283  [11]
 LDCM0405  CL18 PaTu 8988t C105(0.52); C98(0.52)  LDD1284  [11]
 LDCM0406  CL19 PaTu 8988t C105(0.42); C98(0.42)  LDD1285  [11]
 LDCM0407  CL2 PaTu 8988t C105(1.05); C98(1.05)  LDD1286  [11]
 LDCM0408  CL20 PaTu 8988t C105(0.33); C98(0.33)  LDD1287  [11]
 LDCM0409  CL21 PaTu 8988t C105(0.74); C98(0.74)  LDD1288  [11]
 LDCM0410  CL22 PaTu 8988t C105(0.45); C98(0.45)  LDD1289  [11]
 LDCM0411  CL23 PaTu 8988t C105(0.47); C98(0.47)  LDD1290  [11]
 LDCM0412  CL24 PaTu 8988t C105(0.58); C98(0.58)  LDD1291  [11]
 LDCM0413  CL25 PaTu 8988t C105(0.69); C98(0.69)  LDD1292  [11]
 LDCM0414  CL26 PaTu 8988t C105(0.40); C98(0.40)  LDD1293  [11]
 LDCM0415  CL27 PaTu 8988t C105(0.72); C98(0.72)  LDD1294  [11]
 LDCM0416  CL28 PaTu 8988t C105(0.35); C98(0.35)  LDD1295  [11]
 LDCM0417  CL29 PaTu 8988t C105(0.32); C98(0.32)  LDD1296  [11]
 LDCM0418  CL3 PaTu 8988t C105(1.16); C98(1.16)  LDD1297  [11]
 LDCM0419  CL30 PaTu 8988t C105(0.66); C98(0.66)  LDD1298  [11]
 LDCM0420  CL31 PaTu 8988t C105(0.88); C98(0.88)  LDD1299  [11]
 LDCM0421  CL32 PaTu 8988t C105(0.84); C98(0.84)  LDD1300  [11]
 LDCM0422  CL33 PaTu 8988t C105(0.79); C98(0.79)  LDD1301  [11]
 LDCM0423  CL34 PaTu 8988t C105(0.90); C98(0.90)  LDD1302  [11]
 LDCM0424  CL35 PaTu 8988t C105(0.81); C98(0.81)  LDD1303  [11]
 LDCM0425  CL36 PaTu 8988t C105(1.10); C98(1.10)  LDD1304  [11]
 LDCM0426  CL37 PaTu 8988t C105(0.67); C98(0.67)  LDD1305  [11]
 LDCM0428  CL39 PaTu 8988t C105(0.88); C98(0.88)  LDD1307  [11]
 LDCM0429  CL4 PaTu 8988t C105(1.06); C98(1.06)  LDD1308  [11]
 LDCM0430  CL40 PaTu 8988t C105(0.95); C98(0.95)  LDD1309  [11]
 LDCM0431  CL41 PaTu 8988t C105(0.71); C98(0.71)  LDD1310  [11]
 LDCM0432  CL42 PaTu 8988t C105(0.52); C98(0.52)  LDD1311  [11]
 LDCM0433  CL43 PaTu 8988t C105(0.32); C98(0.32)  LDD1312  [11]
 LDCM0434  CL44 PaTu 8988t C105(0.63); C98(0.63)  LDD1313  [11]
 LDCM0435  CL45 PaTu 8988t C105(1.13); C98(1.13)  LDD1314  [11]
 LDCM0436  CL46 PaTu 8988t C105(0.87); C98(0.87)  LDD1315  [11]
 LDCM0437  CL47 PaTu 8988t C105(0.75); C98(0.75)  LDD1316  [11]
 LDCM0438  CL48 PaTu 8988t C105(0.82); C98(0.82)  LDD1317  [11]
 LDCM0439  CL49 PaTu 8988t C105(1.28); C98(1.28)  LDD1318  [11]
 LDCM0440  CL5 PaTu 8988t C105(0.56); C98(0.56)  LDD1319  [11]
 LDCM0441  CL50 PaTu 8988t C105(1.03); C98(1.03)  LDD1320  [11]
 LDCM0442  CL51 PaTu 8988t C105(1.06); C98(1.06)  LDD1321  [11]
 LDCM0443  CL52 PaTu 8988t C105(0.87); C98(0.87)  LDD1322  [11]
 LDCM0444  CL53 PaTu 8988t C105(1.38); C98(1.38)  LDD1323  [11]
 LDCM0445  CL54 PaTu 8988t C105(0.72); C98(0.72)  LDD1324  [11]
 LDCM0446  CL55 PaTu 8988t C105(1.11); C98(1.11)  LDD1325  [11]
 LDCM0447  CL56 PaTu 8988t C105(0.34); C98(0.34)  LDD1326  [11]
 LDCM0448  CL57 PaTu 8988t C105(0.44); C98(0.44)  LDD1327  [11]
 LDCM0449  CL58 PaTu 8988t C105(0.82); C98(0.82)  LDD1328  [11]
 LDCM0450  CL59 PaTu 8988t C105(0.52); C98(0.52)  LDD1329  [11]
 LDCM0451  CL6 PaTu 8988t C105(1.18); C98(1.18)  LDD1330  [11]
 LDCM0452  CL60 PaTu 8988t C105(0.63); C98(0.63)  LDD1331  [11]
 LDCM0453  CL61 HEK-293T C168(0.97); C98(0.96)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C98(1.01)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C98(1.00)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C98(1.07)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C168(0.93); C98(1.11)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C168(1.16); C98(1.08)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C98(1.06)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C168(1.13); C98(1.08)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C168(0.99); C98(1.21)  LDD1664  [10]
 LDCM0462  CL7 PaTu 8988t C105(0.90); C98(0.90)  LDD1341  [11]
 LDCM0463  CL70 HEK-293T C168(0.77); C98(0.96)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C168(1.33); C98(1.17)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C168(1.40); C98(1.06)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C168(0.88); C98(0.92)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C98(1.04)  LDD1670  [10]
 LDCM0469  CL76 PaTu 8988t C105(1.40); C98(1.40)  LDD1348  [11]
 LDCM0470  CL77 PaTu 8988t C105(0.98); C98(0.98)  LDD1349  [11]
 LDCM0471  CL78 PaTu 8988t C105(0.85); C98(0.85)  LDD1350  [11]
 LDCM0472  CL79 PaTu 8988t C105(1.08); C98(1.08)  LDD1351  [11]
 LDCM0473  CL8 PaTu 8988t C105(2.92); C98(2.92)  LDD1352  [11]
 LDCM0474  CL80 PaTu 8988t C105(0.94); C98(0.94)  LDD1353  [11]
 LDCM0475  CL81 PaTu 8988t C105(0.88); C98(0.88)  LDD1354  [11]
 LDCM0476  CL82 PaTu 8988t C105(1.30); C98(1.30)  LDD1355  [11]
 LDCM0477  CL83 PaTu 8988t C105(0.82); C98(0.82)  LDD1356  [11]
 LDCM0478  CL84 PaTu 8988t C105(0.84); C98(0.84)  LDD1357  [11]
 LDCM0479  CL85 PaTu 8988t C105(0.77); C98(0.77)  LDD1358  [11]
 LDCM0480  CL86 PaTu 8988t C105(0.85); C98(0.85)  LDD1359  [11]
 LDCM0481  CL87 PaTu 8988t C105(0.75); C98(0.75)  LDD1360  [11]
 LDCM0482  CL88 PaTu 8988t C105(1.07); C98(1.07)  LDD1361  [11]
 LDCM0483  CL89 PaTu 8988t C105(0.81); C98(0.81)  LDD1362  [11]
 LDCM0484  CL9 PaTu 8988t C105(0.74); C98(0.74)  LDD1363  [11]
 LDCM0485  CL90 PaTu 8988t C105(0.91); C98(0.91)  LDD1364  [11]
 LDCM0486  CL91 HEK-293T C98(1.00)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C168(0.71); C98(1.11)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C168(0.74); C98(1.18)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C168(0.81); C98(1.06)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C168(1.07); C98(1.65)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C168(1.00); C98(1.17)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C168(1.02); C98(1.04)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C98(1.13)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C98(1.07)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C98(1.11)  LDD1698  [10]
 LDCM0625  F8 Ramos C168(0.73)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C168(6.57)  LDD2190  [13]
 LDCM0575  Fragment13 MDA-MB-231 C98(1.63)  LDD1469  [14]
 LDCM0576  Fragment14 Ramos C168(0.45)  LDD2193  [13]
 LDCM0578  Fragment27 MDA-MB-231 C98(0.64)  LDD1474  [14]
 LDCM0586  Fragment28 Ramos C168(0.29)  LDD2198  [13]
 LDCM0587  Fragment29 Ramos C98(1.31)  LDD1476  [14]
 LDCM0589  Fragment31 MDA-MB-231 C98(0.87)  LDD1477  [14]
 LDCM0468  Fragment33 HEK-293T C98(1.00)  LDD1671  [10]
 LDCM0596  Fragment38 MDA-MB-231 C98(1.51)  LDD1480  [14]
 LDCM0427  Fragment51 PaTu 8988t C105(0.75); C98(0.75)  LDD1306  [11]
 LDCM0569  Fragment7 Ramos C168(0.75)  LDD2186  [13]
 LDCM0022  KB02 MDA-MB-231 C98(20.00)  LDD1460  [14]
 LDCM0023  KB03 HEK-293T C168(2.01); C98(1.11)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C27(2.42)  LDD3310  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C98(0.26)  LDD2206  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C98(2.32); C98(0.91)  LDD2207  [15]
 LDCM0170  Structure8 Ramos 20.00  LDD0433  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-8 (CASP8) Peptidase C14A family Q14790
Parkinson disease protein 7 (PARK7) Peptidase C56 family Q99497
Serine/threonine-protein kinase PLK1 (PLK1) Ser/Thr protein kinase family P53350
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) TKL Ser/Thr protein kinase family Q13546
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Methyl-CpG-binding domain protein 4 (MBD4) . O95243
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 6 (FASLG) Tumor necrosis factor family P48023
Tumor necrosis factor receptor superfamily member 6 (FAS) . P25445
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BTG1 (BTG1) BTG family P62324
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Zinc finger CCHC domain-containing protein 12 (ZCCHC12) ZCCHC12 family Q6PEW1
FAS-associated death domain protein (FADD) . Q13158
Myeloid differentiation primary response protein MyD88 (MYD88) . Q99836
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) . Q15628

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
16 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.