Details of the Target

General Information of Target

Target ID LDTP13201
Target Name Vesicle transport through interaction with t-SNAREs homolog 1B (VTI1B)
Gene Name VTI1B
Gene ID 10490
Synonyms
VTI1; VTI1L; VTI1L1; VTI2; Vesicle transport through interaction with t-SNAREs homolog 1B; Vesicle transport v-SNARE protein Vti1-like 1; Vti1-rp1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRTSKDKRDVYYRLAKENGWRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLS
QKIGGQGSGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKGCPADLVVCDGAPD
VTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCA
KPRSSRNSSIEAFAVCQGYDPPEGFIPDLSKPLLDHSYDPDFNQLDGPTRIIVPFVTCGD
LSSYDSDRSYPLDLEGGSEYKYTPPTQPPISPPYQEACTLKRKGQLAKEIRPQDCPISRV
DTFPQPLAAPQCHTLLAPEMEDNEMSCSP
Target Bioclass
Transporter and channel
Family
VTI1 family
Subcellular location
Early endosome membrane
Function
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.
Uniprot ID
Q9UEU0
Ensemble ID
ENST00000554659.6
HGNC ID
HGNC:17793

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K190(5.22); K80(6.65)  LDD0277  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C163
 Probe Info  		7.57  LDD1843  [3]
C165
 Probe Info  		55.33  LDD1845  [3]
C296
 Probe Info  		12.64  LDD1966  [3]
C362
 Probe Info  		32.22  LDD2023  [3]
C388
 Probe Info  		39.95  LDD2047  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Tyrosine-protein phosphatase non-receptor type 5 (PTPN5) Protein-tyrosine phosphatase family P54829
Ribonuclease kappa (RNASEK) RNase K family Q6P5S7
Tripartite motif-containing protein 59 (TRIM59) TRIM/RBCC family Q8IWR1
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Monocarboxylate transporter 2 (SLC16A7) Monocarboxylate porter (TC 2.A.1.13) family O60669
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-4 (STX4) Syntaxin family Q12846
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 234 (TMEM234) TMEM234 family Q8WY98
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity immunoglobulin gamma Fc receptor I (FCGR1A) Immunoglobulin superfamily P12314
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Low-density lipoprotein receptor class A domain-containing protein 1 (LDLRAD1) LDLR family Q5T700
Nesprin-4 (SYNE4) Nesprin family Q8N205
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Protein MANBAL (MANBAL) UPF0239 family Q9NQG1
NKG2-A/NKG2-B type II integral membrane protein (KLRC1) . P26715
Protein KASH5 (KASH5) . Q8N6L0
Transmembrane protein 51 (TMEM51) . Q9NW97

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587