Details of the Target

General Information of Target

Target ID LDTP12395
Target Name Large ribosomal subunit protein mL40 (MRPL40)
Gene Name MRPL40
Gene ID 64976
Synonyms
NLVCF; URIM; Large ribosomal subunit protein mL40; 39S ribosomal protein L40, mitochondrial; L40mt; MRP-L40; Nuclear localization signal-containing protein deleted in velocardiofacial syndrome; Up-regulated in metastasis
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKESRLVEDTFTIDEVSEVLNG
LQAVVHSEVESELINTAYTNVLLLRQLFAQAEKWYLKLQTDISELENRELLEQVAEFEKA
EITSSNKKPILDVTKPKLAPLNEGGTAELLNKEILRLQEENEKLKSRLKTIEIQATNALD
EKSKLEKALQDLQLDQGNQKDFIKAQDLSNLENTVAALKSEFQKTLNDKTENQKSLEENL
ATAKHDLLRVQEQLHMAEKELEKKFQQTAAYRNMKEILTKKNDQIKDLRKRLAQYEPED
Target Bioclass
Other
Family
Mitochondrion-specific ribosomal protein mL40 family
Subcellular location
Mitochondrion
Uniprot ID
Q9NQ50
Ensemble ID
ENST00000333130.4
HGNC ID
HGNC:14491

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K163(10.00)  LDD0277  [1]
5E-2FA
 Probe Info  		N.A.  LDD2235  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [2]
SF
 Probe Info  		N.A.  LDD0028  [3]
1d-yne
 Probe Info  		K77(0.00); K69(0.00)  LDD0357  [4]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C002
 Probe Info  		6.45  LDD1712  [5]
C063
 Probe Info  		17.51  LDD1760  [5]
C087
 Probe Info  		11.31  LDD1779  [5]
C158
 Probe Info  		9.19  LDD1838  [5]
C218
 Probe Info  		29.04  LDD1892  [5]
C277
 Probe Info  		8.75  LDD1947  [5]
C313
 Probe Info  		16.11  LDD1980  [5]
C322
 Probe Info  		6.19  LDD1988  [5]
C343
 Probe Info  		14.32  LDD2005  [5]
C348
 Probe Info  		16.22  LDD2009  [5]
C350
 Probe Info  		24.93  LDD2011  [5]
C354
 Probe Info  		9.71  LDD2015  [5]
C355
 Probe Info  		25.63  LDD2016  [5]
C407
 Probe Info  		11.55  LDD2064  [5]
FFF probe11
 Probe Info  		20.00  LDD0471  [6]
FFF probe14
 Probe Info  		20.00  LDD0477  [6]
BD-F
 Probe Info  		T179(0.00); Y178(0.00); P176(0.00)  LDD0024  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
4 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652